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Lonafarnib

Tier C — Watch / trade

Lonafarnib

MSD (Merck Sharp & Dohme)
Originator
2020
First approval
-
Expiry (public)
No sales data
Peak sales
Small molecule
Type

Targets：Ftase

Brand：Zokinvy, ZOKINVY

Indications (approved)：早衰综合征

Regional status

US
Approved
2020-11-20
EU
Approved
2022-07-18
China
-
Japan
Approved
2024-01-18

Synthetic routes & intermediates3 routes

Originator routes × 1Optimised (non-patent) × 2Process routes × 0

Routes are ordered originator first, then optimised / process (non-patent) routes; each lists steps, overall yield and the intermediate table (code / CAS / name) — ready for supplier sourcing and RFQ. Rendered by this site from structured data; no third-party route graphics used.

OriginatorRoute 2Steps 9 · Total yield 5.44 g
LONA-008157688-46-5LONA-009193276-76-5LONA-010193276-77-6LONA-011562883-39-0LONA-012—LONA-013—LONA-014679842-23-0LONA-015679842-25-2LONA-016679842-29-6LONA-017679842-27-4LONA-018272107-22-9LONA-019141699-59-4LONA-020273216-60-7LONA-021—API · Lonafarnib
CodeCAS No.Intermediate
LONA-008157688-46-52-(1-(tert-butoxycarbonyl)piperidin-4-yl)acetic acid
LONA-009193276-76-5tert-butyl (R)-4-(2-(4-(3,10-dibromo-8-chloro-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-yl)piperidin-1-yl)-2-oxoethyl)piperidine-1-carboxylate
LONA-010193276-77-6(R)-1-(4-(3,10-dibromo-8-chloro-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-yl)piperidin-1-yl)-2-(piperidin-4-yl)ethan-1-one
LONA-011562883-39-03-bromo-8-chloro-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridine
LONA-012-3-bromo-8-chloro-7-nitro-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridine
LONA-013-3-bromo-8-chloro-9-nitro-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridine
LONA-014679842-23-03-bromo-8-chloro-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridin-7-amine
LONA-015679842-25-23-bromo-8-chloro-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridin-9-amine
LONA-016679842-29-63,10-dibromo-8-chloro-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridin-7-amine
LONA-017679842-27-43,10-dibromo-8-chloro-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridin-9-amine
LONA-018272107-22-93,10-dibromo-8-chloro-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridine
LONA-019141699-59-4Availabletert-butyl 4-((methylsulfonyl)oxy)piperidine-1-carboxylate
LONA-020273216-60-7tert-butyl (R)-4-(3,10-dibromo-8-chloro-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-yl)piperidine-1-carboxylate
LONA-021-tert-butyl (R)-4-(2-(4-(3,10-dibromo-8-chloro-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-yl)piperidin-1-yl)-2-oxoethyl)piperidine-1-carboxylate acetyl-L-phenylalaninate
OptimisedRoute 1Steps 9 · Total yield 1.4 g
LONA-001165740-12-5LONA-002193276-34-5LONA-003193276-44-7LONA-004193276-45-8LONA-005193276-46-9LONA-006193276-47-0LONA-007193276-49-2LONA-008157688-46-5LONA-009193276-76-5LONA-010193276-77-6API · Lonafarnib
CodeCAS No.Intermediate
LONA-001165740-12-5ethyl 4-(3-bromo-8-chloro-5,6-dihydro-11H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-ylidene)piperidine-1-carboxylate
LONA-002193276-34-5ethyl 4-(3-bromo-8-chloro-9-nitro-5,6-dihydro-11H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-ylidene)piperidine-1-carboxylate
LONA-003193276-44-7ethyl 4-(9-amino-3-bromo-8-chloro-5,6-dihydro-11H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-ylidene)piperidine-1-carboxylate
LONA-004193276-45-8ethyl 4-(9-amino-3,10-dibromo-8-chloro-5,6-dihydro-11H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-ylidene)piperidine-1-carboxylate
LONA-005193276-46-9ethyl 4-(3,10-dibromo-8-chloro-5,6-dihydro-11H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-ylidene)piperidine-1-carboxylate
LONA-006193276-47-03,10-dibromo-8-chloro-11-(piperidin-4-ylidene)-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridine
LONA-007193276-49-2(R)-3,10-dibromo-8-chloro-11-(piperidin-4-yl)-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridine
LONA-008157688-46-52-(1-(tert-butoxycarbonyl)piperidin-4-yl)acetic acid
LONA-009193276-76-5tert-butyl (R)-4-(2-(4-(3,10-dibromo-8-chloro-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-yl)piperidin-1-yl)-2-oxoethyl)piperidine-1-carboxylate
LONA-010193276-77-6(R)-1-(4-(3,10-dibromo-8-chloro-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-yl)piperidin-1-yl)-2-(piperidin-4-yl)ethan-1-one
OptimisedRoute 3Steps 3 · Total yield /
LONA-006193276-47-0LONA-007193276-49-2LONA-022102096-25-3LONA-023—LONA-024193276-47-0API · Lonafarnib
CodeCAS No.Intermediate
LONA-006193276-47-03,10-dibromo-8-chloro-11-(piperidin-4-ylidene)-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridine
LONA-007193276-49-2(R)-3,10-dibromo-8-chloro-11-(piperidin-4-yl)-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridine
LONA-022102096-25-3Available2,2,2-trifluoroethyl isobutyrate
LONA-023-1-(4-(3,10-dibromo-8-chloro-5,6-dihydro-11H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-ylidene)piperidin-1-yl)-2-methylpropan-1-one
LONA-024193276-47-03,10-dibromo-8-chloro-11-(piperidin-4-ylidene)-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridine

Frequently asked questions

What are the approved indications of Lonafarnib?

Approved indications include: 早衰综合征.

When does the Lonafarnib patent expire?

No public expiry year is available for Lonafarnib yet; this page updates once verified.

How many synthesis routes are recorded for Lonafarnib?

3 synthesis routes are recorded; the shortest is 3 steps with / total yield. Intermediates in each route carry codes and CAS numbers.

Where can I buy Lonafarnib intermediates?

2 intermediate CAS of Lonafarnib are available through the Unibest supply network — see the route tables on this page and request a quote per CAS.

How do I get a quote for Lonafarnib intermediates?

Open the CAS profile of the target intermediate from this page, or submit an RFQ directly — the CAS enters the matching flow automatically and the supply network responds with quotes.

Source: cross-verified data (structured fields only) · 2026-09-29