Anagrelide Hydrochloride Hydrate

Tier C — Watch / trade

Shire Pharmaceuticals

Originator

1997

First approval

Expiry (public)

$0.11B ▲

Peak sales

Small molecule

Type

Targets：PDE3

Brand：Anagrelide CR, Thromboreductin, Agrylin, CR anagrelide, Xagrid

Indications (approved)：Essential thrombocythaemia, Myeloproliferative neoplasm

Regional status

Approved

1997-03-14

Approved

2004-11-15

China

Approved

2024-02-23

Japan

Approved

2014-09-26

Synthetic routes & intermediates5 routes

Originator routes × 1Optimised (non-patent) × 4Process routes × 0

Routes are ordered originator first, then optimised / process (non-patent) routes; each lists steps, overall yield and the intermediate table (code / CAS / name) — ready for supplier sourcing and RFQ. Rendered by this site from structured data; no third-party route graphics used.

OriginatorRoute 1Steps 4 · Total yield /

ANAG-00115258-72-7ANAG-002459-73-4ANAG-00350608-25-8ANAG-004349150-82-9ANAG-00561834-95-5API · Anagrelide Hydrochloride Hydrate

Code	CAS No.	Intermediate
ANAG-001	15258-72-7	1-chloro-2-(chloromethyl)-3-nitrobenzene
ANAG-002	459-73-4	ethyl glycinate
ANAG-003	50608-25-8	ethyl 2-((2-chloro-6-nitrobenzyl)amino)acetate
ANAG-004	349150-82-9	ethyl 2-((2-amino-6-chlorobenzyl)amino)acetate
ANAG-005	61834-95-5	6-chloro-3,5-dihydroimidazo[2,1-b]quinazolin-2(1H)-one

OptimisedRoute 2Steps 7 · Total yield /

ANAG-00687-61-6ANAG-00787-61-6ANAG-0082112-22-3ANAG-00970380-49-3ANAG-010105-36-2ANAG-01185325-11-7ANAG-01270406-92-7ANAG-013—API · Anagrelide Hydrochloride Hydrate

Code	CAS No.	Intermediate
ANAG-006	87-61-6	1,2,3-trichlorobenzene
ANAG-007	87-61-6	1,2,3-trichlorobenzene
ANAG-008	2112-22-3	2,3-dichloro-6-nitrobenzonitrile
ANAG-009	70380-49-3	(2,3-dichloro-6-nitrophenyl)methanamine
ANAG-010	105-36-2 Available	ethyl 2-bromoacetate
ANAG-011	85325-11-7	ethyl 2-((2,3-dichloro-6-nitrobenzyl)amino)acetate
ANAG-012	70406-92-7	ethyl 2-((6-amino-2,3-dichlorobenzyl)amino)acetate
ANAG-013	-	6,7-dichloro-3,5-dihydroimidazo[2,1-b]quinazolin-2(1H)-one hydrobromide

OptimisedRoute 3Steps 10 · Total yield /

ANAG-01270406-92-7ANAG-014108-42-9ANAG-015302-17-0ANAG-016—ANAG-0176344-05-4ANAG-0181677-47-0ANAG-01920776-60-7ANAG-02070380-51-7ANAG-02185325-13-9ANAG-022—ANAG-02370381-75-8ANAG-02468475-42-3API · Anagrelide Hydrochloride Hydrate

Code	CAS No.	Intermediate
ANAG-012	70406-92-7	ethyl 2-((6-amino-2,3-dichlorobenzyl)amino)acetate
ANAG-014	108-42-9	3-chloroaniline
ANAG-015	302-17-0	2,2,2-trichloroethane-1,1-diol
ANAG-016	-	(E)-N-(3-chlorophenyl)-3-hydroxyacrylamide
ANAG-017	6344-05-4	4-chloroindoline-2,3-dione
ANAG-018	1677-47-0	4,5-dichloroindoline-2,3-dione
ANAG-019	20776-60-7	6-amino-2,3-dichlorobenzoic acid
ANAG-020	70380-51-7	(6-amino-2,3-dichlorophenyl)methanol
ANAG-021	85325-13-9	3,4-dichloro-2-(chloromethyl)aniline hydrochloride
ANAG-022	-	aminomethyl propionate hydrochloride
ANAG-023	70381-75-8	ethyl 2-(5,6-dichloro-2-imino-1,2-dihydroquinazolin-3(4H)-yl)acetate hydrobromide
ANAG-024	68475-42-3	6,7-dichloro-3,5-dihydroimidazo[2,1-b]quinazolin-2(1H)-one

OptimisedRoute 4Steps 5 · Total yield /

ANAG-01185325-11-7ANAG-01270406-92-7ANAG-022—ANAG-02370381-75-8ANAG-0256334-18-5ANAG-02675618-41-6API · Anagrelide Hydrochloride Hydrate

Code	CAS No.	Intermediate
ANAG-011	85325-11-7	ethyl 2-((2,3-dichloro-6-nitrobenzyl)amino)acetate
ANAG-012	70406-92-7	ethyl 2-((6-amino-2,3-dichlorobenzyl)amino)acetate
ANAG-022	-	aminomethyl propionate hydrochloride
ANAG-023	70381-75-8	ethyl 2-(5,6-dichloro-2-imino-1,2-dihydroquinazolin-3(4H)-yl)acetate hydrobromide
ANAG-025	6334-18-5	2,3-dichlorobenzaldehyde
ANAG-026	75618-41-6	2,3-dichloro-6-nitrobenzaldehyde

OptimisedRoute 5Steps 6 · Total yield 59.48 g

ANAG-01270406-92-7ANAG-022—ANAG-02750-45-3ANAG-02838594-42-2ANAG-029393078-37-0ANAG-030192124-88-2ANAG-03170380-50-6API · Anagrelide Hydrochloride Hydrate

Code	CAS No.	Intermediate
ANAG-012	70406-92-7	ethyl 2-((6-amino-2,3-dichlorobenzyl)amino)acetate
ANAG-022	-	aminomethyl propionate hydrochloride
ANAG-027	50-45-3	2,3-dichlorobenzoic acid
ANAG-028	38594-42-2	(2,3-dichlorophenyl)methanol
ANAG-029	393078-37-0	(2,3-dichloro-6-nitrophenyl)methanol
ANAG-030	192124-88-2	1,2-dichloro-3-(chloromethyl)-4-nitrobenzene
ANAG-031	70380-50-6	ethyl 2-((2,3-dichloro-6-nitrobenzyl)amino)acetate hydrochloride

Frequently asked questions

What are the approved indications of Anagrelide Hydrochloride Hydrate?

Approved indications include: Essential thrombocythaemia, Myeloproliferative neoplasm.

When does the Anagrelide Hydrochloride Hydrate patent expire?

No public expiry year is available for Anagrelide Hydrochloride Hydrate yet; this page updates once verified.

How many synthesis routes are recorded for Anagrelide Hydrochloride Hydrate?

5 synthesis routes are recorded; the shortest is 4 steps with / total yield. Intermediates in each route carry codes and CAS numbers.

Where can I buy Anagrelide Hydrochloride Hydrate intermediates?

1 intermediate CAS of Anagrelide Hydrochloride Hydrate are available through the Unibest supply network — see the route tables on this page and request a quote per CAS.

How do I get a quote for Anagrelide Hydrochloride Hydrate intermediates?

Open the CAS profile of the target intermediate from this page, or submit an RFQ directly — the CAS enters the matching flow automatically and the supply network responds with quotes.

Source: cross-verified data (structured fields only) · 2026-09-29