Oxymetazoline Hydrochloride

Tier C — Watch / trade

Originator

1964

First approval

Expiry (public)

No sales data

Peak sales

Small molecule

Type

Targets：ADRA1A

Brand：Nasivin, Rhinofrenol, Nasivine, Iliadin, Oxilin, Sinerol, Nezeril, Rhofade, Afrin, Rhinolitan, Afrazine, Hazol, Nesivine, Nafrine

Indications (approved)：Nasal congestion, Congestion

Regional status

Phase II

2012-12-01

No progress

2014-11-01

China

Approved

1992-01-01

Japan

Approved

2007-08-01

Synthetic routes & intermediates2 routes

Originator routes × 0Optimised (non-patent) × 2Process routes × 0

Routes are ordered originator first, then optimised / process (non-patent) routes; each lists steps, overall yield and the intermediate table (code / CAS / name) — ready for supplier sourcing and RFQ. Rendered by this site from structured data; no third-party route graphics used.

OptimisedRoute 1Steps 5 · Total yield 7.5g(Oxymetazoline hydrochloride (API))

Oxymetazoline Hydrochloride-001—Oxymetazoline Hydrochloride-002107-30-2Oxymetazoline Hydrochloride-00323500-79-0Oxymetazoline Hydrochloride-00455699-10-0Oxymetazoline Hydrochloride-0051191945-77-3Oxymetazoline Hydrochloride-0061491-59-4Oxymetazoline Hydrochloride-00755699-13-3Oxymetazoline Hydrochloride-00814034-59-4Oxymetazoline Hydrochloride-00943702-89-2API · Oxymetazoline Hydrochloride

Code	CAS No.	Intermediate
Oxymetazoline Hydrochloride-001	-	4-tert-Butyl-2,6-dimethylbenzene-1,3-diol
Oxymetazoline Hydrochloride-002	107-30-2 Available	1-Chloro-1-methoxymethane
Oxymetazoline Hydrochloride-003	23500-79-0	6-tert-Butyl-3-(chloromethyl)-2,4-dimethylphenol
Oxymetazoline Hydrochloride-004	55699-10-0	(4-tert-Butyl-3-hydroxy-2,6-dimethylphenyl)acetonitrile
Oxymetazoline Hydrochloride-005	1191945-77-3	4,5-Dihydro-1H-imidazole-2-thiol
Oxymetazoline Hydrochloride-006	1491-59-4	6-tert-Butyl-3-(4,5-dihydro-1H-imidazol-2-ylmethyl)-2,4-dimethylphenol
Oxymetazoline Hydrochloride-007	55699-13-3	2-(4-tert-Butyl-3-hydroxy-2,6-dimethylphenyl)acetamide
Oxymetazoline Hydrochloride-008	14034-59-4	Ethane-1,2-diamine 4-methylbenzenesulfonate
Oxymetazoline Hydrochloride-009	43702-89-2	Ethane-1,2-diamine hydrobromide

OptimisedRoute 2Steps 6 · Total yield 26g(Oxymetazoline hydrochloride (API))

Oxymetazoline Hydrochloride-00455699-10-0Oxymetazoline Hydrochloride-010107-15-3Oxymetazoline Hydrochloride-011871-78-3Oxymetazoline Hydrochloride-0061491-59-4Oxymetazoline Hydrochloride-01255699-17-7Oxymetazoline Hydrochloride-01355699-12-2Oxymetazoline Hydrochloride-00814034-59-4Oxymetazoline Hydrochloride-00755699-13-3Oxymetazoline Hydrochloride-0142576-47-8Oxymetazoline Hydrochloride-015106-93-4Oxymetazoline Hydrochloride-016—API · Oxymetazoline Hydrochloride

Code	CAS No.	Intermediate
Oxymetazoline Hydrochloride-004	55699-10-0	(4-tert-Butyl-3-hydroxy-2,6-dimethylphenyl)acetonitrile
Oxymetazoline Hydrochloride-010	107-15-3	Ethane-1,2-diamine
Oxymetazoline Hydrochloride-011	871-78-3	N-[2-(Acetamido)ethyl]acetamide
Oxymetazoline Hydrochloride-006	1491-59-4	6-tert-Butyl-3-(4,5-dihydro-1H-imidazol-2-ylmethyl)-2,4-dimethylphenol
Oxymetazoline Hydrochloride-012	55699-17-7	(4-tert-Butyl-3-hydroxy-2,6-dimethylphenyl)acetyl chloride
Oxymetazoline Hydrochloride-013	55699-12-2	(4-tert-Butyl-3-hydroxy-2,6-dimethylphenyl)acetic acid
Oxymetazoline Hydrochloride-008	14034-59-4	Ethane-1,2-diamine 4-methylbenzenesulfonate
Oxymetazoline Hydrochloride-007	55699-13-3	2-(4-tert-Butyl-3-hydroxy-2,6-dimethylphenyl)acetamide
Oxymetazoline Hydrochloride-014	2576-47-8	2-Bromoethanamine hydrobromide
Oxymetazoline Hydrochloride-015	106-93-4 Available	Ethylene dibromide
Oxymetazoline Hydrochloride-016	-	Ethyl 2-(4-tert-butyl-3-hydroxy-2,6-dimethylphenyl)ethanimidoate hydrochloride

Frequently asked questions

What are the approved indications of Oxymetazoline Hydrochloride?

Approved indications include: Nasal congestion, Congestion.

When does the Oxymetazoline Hydrochloride patent expire?

No public expiry year is available for Oxymetazoline Hydrochloride yet; this page updates once verified.

How many synthesis routes are recorded for Oxymetazoline Hydrochloride?

2 synthesis routes are recorded; the shortest is 5 steps with 7.5g(Oxymetazoline hydrochloride (API)) total yield. Intermediates in each route carry codes and CAS numbers.

Where can I buy Oxymetazoline Hydrochloride intermediates?

2 intermediate CAS of Oxymetazoline Hydrochloride are available through the Unibest supply network — see the route tables on this page and request a quote per CAS.

How do I get a quote for Oxymetazoline Hydrochloride intermediates?

Open the CAS profile of the target intermediate from this page, or submit an RFQ directly — the CAS enters the matching flow automatically and the supply network responds with quotes.

Source: cross-verified data (structured fields only) · 2026-09-29