Levothyroxine Sodium

Tier B — Position early

AbbVie

Originator

2000

First approval

Expiry (public)

$1.33B ▲

Peak sales

Small molecule

Type

Targets：THR

Brand：Euthyrox, Tirosint-Sol, Puran T4, Levo-T, Levothroid, Unithroid, Letrox, Synthroid, Eferox, Eutirox, Levoxyl, Novothyrox

Indications (approved)：Coma, 粘液性水肿昏迷, Hypothyroidism, Thyroid cancer, Hyperthyroidism

Regional status

Approved

2000-08-21

Phase III

2004-03-01

China

Approved

2000-01-01

Japan

Synthetic routes & intermediates4 routes

Originator routes × 0Optimised (non-patent) × 4Process routes × 0

Routes are ordered originator first, then optimised / process (non-patent) routes; each lists steps, overall yield and the intermediate table (code / CAS / name) — ready for supplier sourcing and RFQ. Rendered by this site from structured data; no third-party route graphics used.

OptimisedRoute 1Steps 4 · Total yield /

Levothyroxine Sodium-001—Levothyroxine Sodium-002—Levothyroxine Sodium-0031027-28-7Levothyroxine Sodium-004—Levothyroxine Sodium-00530804-52-5API · Levothyroxine Sodium

Code	CAS No.	Intermediate
Levothyroxine Sodium-001	-	(-)-alpha-Amino-p-hydroxyhydrocinnamic acid
Levothyroxine Sodium-002	-	3,5-Diiodo-L-tyrosine
Levothyroxine Sodium-003	1027-28-7	(2S)-2-acetamido-3-(4-hydroxy-3,5-diiodophenyl)propanoic acid
Levothyroxine Sodium-004	-	Ethyl N-acetyl-3,5-diiodo-L-tyrosinate
Levothyroxine Sodium-005	30804-52-5	ethyl (2S)-2-acetamido-3-[4-(4-hydroxy-3,5-diiodophenoxy)-3,5-diiodophenyl]propanoate

OptimisedRoute 2Steps 9 · Total yield /

Levothyroxine Sodium-001—Levothyroxine Sodium-00617360-11-1Levothyroxine Sodium-00720767-00-4Levothyroxine Sodium-00829358-99-4Levothyroxine Sodium-009903509-20-6Levothyroxine Sodium-010—Levothyroxine Sodium-01183290-90-8Levothyroxine Sodium-012440667-78-7Levothyroxine Sodium-013886203-79-8Levothyroxine Sodium-014—API · Levothyroxine Sodium

Code	CAS No.	Intermediate
Levothyroxine Sodium-001	-	(-)-alpha-Amino-p-hydroxyhydrocinnamic acid
Levothyroxine Sodium-006	17360-11-1	(2S)-2-amino-3-(4-hydroxy-3,5-dinitrophenyl)propanoic acid
Levothyroxine Sodium-007	20767-00-4	(2S)-2-acetamido-3-(4-hydroxy-3,5-dinitrophenyl)propanoic acid
Levothyroxine Sodium-008	29358-99-4	ethyl (2S)-2-acetamido-3-(4-hydroxy-3,5-dinitrophenyl)propanoate
Levothyroxine Sodium-009	903509-20-6	ethyl (2S)-2-acetamido-3-(4-{[(4-methylbenzene)sulfonyl]oxy}-3,5-dinitrophenyl)propanoate
Levothyroxine Sodium-010	-	4-Hydroxyanisole
Levothyroxine Sodium-011	83290-90-8	ethyl (2S)-2-acetamido-3-[4-(4-methoxyphenoxy)-3,5-dinitrophenyl]propanoate
Levothyroxine Sodium-012	440667-78-7	ethyl (2S)-3-[3,5-diamino-4-(4-methoxyphenoxy)phenyl]-2-acetamidopropanoate
Levothyroxine Sodium-013	886203-79-8	(2S)-3-[3,5-diiodo-4-(4-methoxyphenoxy)phenyl]-2-acetamidopropanoic acid
Levothyroxine Sodium-014	-	3,5-Diiodo-4-(4-hydroxyphenoxy)-L-phenylalanine

OptimisedRoute 3Steps 5 · Total yield 56.8g(Levothyroxine (API))

Levothyroxine Sodium-002—Levothyroxine Sodium-015—Levothyroxine Sodium-0166293-71-6Levothyroxine Sodium-01794345-95-6Levothyroxine Sodium-014—Levothyroxine Sodium-01851-48-9API · Levothyroxine Sodium

Code	CAS No.	Intermediate
Levothyroxine Sodium-002	-	3,5-Diiodo-L-tyrosine
Levothyroxine Sodium-015	-	Copper(2+) bis[(2S)-2-amino-3-(4-hydroxy-3,5-diiodophenyl)propanoate]
Levothyroxine Sodium-016	6293-71-6	Bis(4-methoxyphenyl)iodanium iodide
Levothyroxine Sodium-017	94345-95-6	3,5-Diiodo-O-(4-methoxyphenyl)-L-tyrosine
Levothyroxine Sodium-014	-	3,5-Diiodo-4-(4-hydroxyphenoxy)-L-phenylalanine
Levothyroxine Sodium-018	51-48-9	O-(4-Hydroxy-3,5-diiodophenyl)-3,5-diiodo-L-tyrosine

OptimisedRoute 4Steps 1 · Total yield 4.9g(Levothyroxine Sodium-020)

Levothyroxine Sodium-004—Levothyroxine Sodium-0191426-58-0Levothyroxine Sodium-02083249-56-3API · Levothyroxine Sodium

Code	CAS No.	Intermediate
Levothyroxine Sodium-004	-	Ethyl N-acetyl-3,5-diiodo-L-tyrosinate
Levothyroxine Sodium-019	1426-58-0	Bis(4-methoxyphenyl)iodanium tetrafluoridoborate(1-)
Levothyroxine Sodium-020	83249-56-3	Ethyl N-acetyl-3,5-diiodo-O-(4-methoxyphenyl)-L-tyrosinate

Frequently asked questions

What are the approved indications of Levothyroxine Sodium?

Approved indications include: Coma, 粘液性水肿昏迷, Hypothyroidism, Thyroid cancer, Hyperthyroidism.

When does the Levothyroxine Sodium patent expire?

No public expiry year is available for Levothyroxine Sodium yet; this page updates once verified.

How many synthesis routes are recorded for Levothyroxine Sodium?

4 synthesis routes are recorded; the shortest is 1 steps with 4.9g(Levothyroxine Sodium-020) total yield. Intermediates in each route carry codes and CAS numbers.

Where can I buy Levothyroxine Sodium intermediates?

All intermediates in Levothyroxine Sodium routes have CAS profiles — you can submit an RFQ per CAS and it enters the Unibest matching pool.

How do I get a quote for Levothyroxine Sodium intermediates?

Open the CAS profile of the target intermediate from this page, or submit an RFQ directly — the CAS enters the matching flow automatically and the supply network responds with quotes.

Source: cross-verified data (structured fields only) · 2026-09-29