Trichlormethiazide

Tier C — Watch / trade

Trichlormethiazide

Merck & Co Inc

Originator

1960

First approval

Expiry (public)

No sales data

Peak sales

Small molecule

Type

Targets：Thiazide-sensitive sodium-chloride cotransporter

Brand：Naqua, Achletin, Methahydrin, Tolcasone, Tachionin, Triflumen, Fluitran

Indications (approved)：Hypertension, Oedema

Regional status

Approved

1960-03-09

China

Japan

Synthetic routes & intermediates2 routes

Originator routes × 0Optimised (non-patent) × 2Process routes × 0

Routes are ordered originator first, then optimised / process (non-patent) routes; each lists steps, overall yield and the intermediate table (code / CAS / name) — ready for supplier sourcing and RFQ. Rendered by this site from structured data; no third-party route graphics used.

OptimisedRoute 1Steps 8 · Total yield /

Trichlormethiazide-001—Trichlormethiazide-002—Trichlormethiazide-003—Trichlormethiazide-004—Trichlormethiazide-00590003-74-0Trichlormethiazide-0062904-45-2Trichlormethiazide-007—Trichlormethiazide-008861067-16-5Trichlormethiazide-009—Trichlormethiazide-010—Trichlormethiazide-011—Trichlormethiazide-012—API · Trichlormethiazide

Code	CAS No.	Intermediate
Trichlormethiazide-001	-	4-Amino-6-chlorobenzene-1,3-disulfonyl dichloride
Trichlormethiazide-002	-	2,2-Dichloroacetic acid chloride
Trichlormethiazide-003	-	Dichloroacetic anhydride
Trichlormethiazide-004	-	4-Chloro-6-(2,2-dichloroacetamido)benzene-1,3-disulfonyl dichloride
Trichlormethiazide-005	90003-74-0	2,2-Dichloro-N-(5-chloro-2,4-disulfamoylphenyl)acetamide
Trichlormethiazide-006	2904-45-2	6-Chloro-3-(dichloromethyl)-1,1-dioxo-1,2-dihydro-1lambda6,2,4-benzothiadiazine-7-sulfonamide
Trichlormethiazide-007	-	2,2-Dichloroacetonitrile
Trichlormethiazide-008	861067-16-5	Ethyl 2,2-dichloroethanimidoate hydrochloride
Trichlormethiazide-009	-	2,2-Dichloro-1,1,1-triethoxyethane
Trichlormethiazide-010	-	4-Amino-6-chlorobenzene-1,3-disulfonamide
Trichlormethiazide-011	-	Dichloroacetaldehyde
Trichlormethiazide-012	-	1,1-Dichloro-2,2-diethoxyethane

OptimisedRoute 2Steps 2 · Total yield /

Trichlormethiazide-001—Trichlormethiazide-011—Trichlormethiazide-013—API · Trichlormethiazide

Code	CAS No.	Intermediate
Trichlormethiazide-001	-	4-Amino-6-chlorobenzene-1,3-disulfonyl dichloride
Trichlormethiazide-011	-	Dichloroacetaldehyde
Trichlormethiazide-013	-	4-Chloro-6-[(E)-(2,2-dichloroethylidene)amino]benzene-1,3-disulfonyl dichloride

Frequently asked questions

What are the approved indications of Trichlormethiazide?

Approved indications include: Hypertension, Oedema.

When does the Trichlormethiazide patent expire?

No public expiry year is available for Trichlormethiazide yet; this page updates once verified.

How many synthesis routes are recorded for Trichlormethiazide?

2 synthesis routes are recorded; the shortest is 2 steps with / total yield. Intermediates in each route carry codes and CAS numbers.

Where can I buy Trichlormethiazide intermediates?

All intermediates in Trichlormethiazide routes have CAS profiles — you can submit an RFQ per CAS and it enters the Unibest matching pool.

How do I get a quote for Trichlormethiazide intermediates?

Open the CAS profile of the target intermediate from this page, or submit an RFQ directly — the CAS enters the matching flow automatically and the supply network responds with quotes.

Source: cross-verified data (structured fields only) · 2026-09-29