Gandotinib

Tier C — Watch / trade

Gandotinib

Eli Lilly and Company

Originator

First approval

Expiry (public)

No sales data

Peak sales

Small molecule

Type

Targets：JAK2

Indications (approved)：Haematological malignancy, Myelofibrosis, Myeloproliferative neoplasm, Essential thrombocythaemia, Polycythaemia vera

Regional status

Phase II

2012-05-22

Phase II

2012-05-22

China

Japan

Synthetic routes & intermediates3 routes

Originator routes × 1Optimised (non-patent) × 2Process routes × 0

Routes are ordered originator first, then optimised / process (non-patent) routes; each lists steps, overall yield and the intermediate table (code / CAS / name) — ready for supplier sourcing and RFQ. Rendered by this site from structured data; no third-party route graphics used.

OriginatorRoute 1Steps 8 · Total yield 89.9 kg

GAND-0015469-69-2GAND-00218871-66-4GAND-00368675-27-4GAND-004299411-67-9GAND-0051229236-80-9GAND-0061229236-83-2GAND-0071229236-85-4GAND-008141459-53-2GAND-009—GAND-010175711-83-8GAND-0117400-27-3GAND-0121118-61-2Gandotinib1229236-86-5API · Gandotinib

Code	CAS No.	Intermediate
GAND-001	5469-69-2 Available	6-chloropyridazin-3-amine
GAND-002	18871-66-4	1,1-dimethoxy-N,N-dimethylethanamine
GAND-003	68675-27-4	(E)-N'-(6-chloropyridazin-3-yl)-N,N-dimethylacetimidamide
GAND-004	299411-67-9	2-chloro-1-(4-chloro-2-fluorophenyl)ethanone
GAND-005	1229236-80-9	(4-chloro-2-fluorophenyl)(6-chloro-2-methylimidazo[1,2-b]pyridazin-3-yl)methanone
GAND-006	1229236-83-2	(4-chloro-2-fluorophenyl)(6-chloro-2-methyl-8-(morpholinomethyl)imidazo[1,2-b]pyridazin-3-yl)methanone
GAND-007	1229236-85-4	4-((6-chloro-3-(4-chloro-2-fluorobenzyl)-2-methylimidazo[1,2-b]pyridazin-8-yl)methyl)morpholine
GAND-008	141459-53-2	1-(tert-butyl)-3-methyl-1H-pyrazol-5-amine
GAND-009	-	3-(4-chloro-2-fluorobenzyl)-N-(1-(4-methoxybenzyl)-3-methyl-1H-pyrazol-5-yl)-2-methyl-8-(morpholinomethyl)imidazo[1,2-b]pyridazin-6-amine
GAND-010	175711-83-8	1-(4-chloro-2-fluorophenyl)ethanone
GAND-011	7400-27-3	tert-butylhydrazine hydrochloride
GAND-012	1118-61-2	(E)-3-aminobut-2-enenitrile
Gandotinib	1229236-86-5	3-(4-chloro-2-fluorobenzyl)-2-methyl-N-(5-methyl-1H-pyrazol-3-yl)-8-(morpholinomethyl)imidazo[1,2-b]pyridazin-6-amine

OptimisedRoute 2Steps 4 · Total yield /

GAND-0015469-69-2GAND-0071229236-85-4GAND-013609-15-4GAND-01414714-18-2GAND-0151422006-65-2GAND-01687417-71-8GAND-01787417-71-8API · Gandotinib

Code	CAS No.	Intermediate
GAND-001	5469-69-2 Available	6-chloropyridazin-3-amine
GAND-007	1229236-85-4	4-((6-chloro-3-(4-chloro-2-fluorobenzyl)-2-methylimidazo[1,2-b]pyridazin-8-yl)methyl)morpholine
GAND-013	609-15-4 Available	ethyl 2-chloro-3-oxobutanoate
GAND-014	14714-18-2	ethyl 6-chloro-2-methylimidazo[1,2-b]pyridazine-3-carboxylate
GAND-015	1422006-65-2	ethyl 6-chloro-2-methyl-8-(morpholinomethyl)imidazo[1,2-b]pyridazine-3-carboxylate
GAND-016	87417-71-8	4-((6-chloro-2-methylimidazo[1,2-b]pyridazin-8-yl)methyl)morpholine
GAND-017	87417-71-8	4-((6-chloro-2-methylimidazo[1,2-b]pyridazin-8-yl)methyl)morpholine

OptimisedRoute 3Steps 12 · Total yield 0.246 g

GAND-00368675-27-4GAND-004299411-67-9GAND-0051229236-80-9GAND-0061229236-83-2GAND-01787417-71-8GAND-0184702-13-0GAND-0191229236-81-0GAND-0201229236-82-1GAND-0215414-19-7GAND-0221229236-84-3GAND-023949556-61-0GAND-024—GAND-025870-46-2GAND-026123-11-5GAND-027150767-00-3GAND-028150767-00-3GAND-029412327-07-2Gandotinib1229236-86-5API · Gandotinib

Code	CAS No.	Intermediate
GAND-003	68675-27-4	(E)-N'-(6-chloropyridazin-3-yl)-N,N-dimethylacetimidamide
GAND-004	299411-67-9	2-chloro-1-(4-chloro-2-fluorophenyl)ethanone
GAND-005	1229236-80-9	(4-chloro-2-fluorophenyl)(6-chloro-2-methylimidazo[1,2-b]pyridazin-3-yl)methanone
GAND-006	1229236-83-2	(4-chloro-2-fluorophenyl)(6-chloro-2-methyl-8-(morpholinomethyl)imidazo[1,2-b]pyridazin-3-yl)methanone
GAND-017	87417-71-8	4-((6-chloro-2-methylimidazo[1,2-b]pyridazin-8-yl)methyl)morpholine
GAND-018	4702-13-0	2-(1,3-dioxoisoindolin-2-yl)acetic acid
GAND-019	1229236-81-0	2-((6-chloro-3-(4-chloro-2-fluorobenzoyl)-2-methylimidazo[1,2-b]pyridazin-8-yl)methyl)isoindoline-1,3-dione
GAND-020	1229236-82-1	(8-(aminomethyl)-6-chloro-2-methylimidazo[1,2-b]pyridazin-3-yl)(4-chloro-2-fluorophenyl)methanone
GAND-021	5414-19-7	1-bromo-2-(2-bromoethoxy)ethane
GAND-022	1229236-84-3	(4-chloro-2-fluorophenyl)(6-chloro-2-methyl-8-(morpholinomethyl)imidazo[1,2-b]pyridazin-3-yl)methanol
GAND-023	949556-61-0	1-(4-methoxybenzyl)-3-methyl-1H-pyrazol-5-amine
GAND-024	-	3-(4-chloro-2-fluorobenzyl)-N-(1-(4-methoxybenzyl)-3-methyl-1H-pyrazol-5-yl)-2-methyl-8-(morpholinomethyl)imidazo[1,2-b]pyridazin-6-amine
GAND-025	870-46-2	tert-butyl hydrazinecarboxylate
GAND-026	123-11-5	4-methoxybenzaldehyde
GAND-027	150767-00-3	tert-butyl 2-(4-methoxybenzyl)hydrazinecarboxylate
GAND-028	150767-00-3	tert-butyl 2-(4-methoxybenzyl)hydrazinecarboxylate
GAND-029	412327-07-2	(4-methoxybenzyl)hydrazine
Gandotinib	1229236-86-5	3-(4-chloro-2-fluorobenzyl)-2-methyl-N-(5-methyl-1H-pyrazol-3-yl)-8-(morpholinomethyl)imidazo[1,2-b]pyridazin-6-amine

Frequently asked questions

What are the approved indications of Gandotinib?

Approved indications include: Haematological malignancy, Myelofibrosis, Myeloproliferative neoplasm, Essential thrombocythaemia, Polycythaemia vera.

When does the Gandotinib patent expire?

No public expiry year is available for Gandotinib yet; this page updates once verified.

How many synthesis routes are recorded for Gandotinib?

3 synthesis routes are recorded; the shortest is 4 steps with / total yield. Intermediates in each route carry codes and CAS numbers.

Where can I buy Gandotinib intermediates?

2 intermediate CAS of Gandotinib are available through the Unibest supply network — see the route tables on this page and request a quote per CAS.

How do I get a quote for Gandotinib intermediates?

Open the CAS profile of the target intermediate from this page, or submit an RFQ directly — the CAS enters the matching flow automatically and the supply network responds with quotes.

Source: cross-verified data (structured fields only) · 2026-10-18