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Iruplinalkib
Tier C — Watch / tradeIruplinalkib
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Originator
2023
First approval
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Expiry (public)
No sales data
Peak sales
Small molecule
Type
Targets：ALK, ROS
Indications (approved)：Non-small cell lung cancer
Regional status
US
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EU
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China
Approved
2023-06-27
Japan
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Synthetic routes & intermediates4 routes
Originator routes × 0Optimised (non-patent) × 4Process routes × 0
Routes are ordered originator first, then optimised / process (non-patent) routes; each lists steps, overall yield and the intermediate table (code / CAS / name) — ready for supplier sourcing and RFQ. Rendered by this site from structured data; no third-party route graphics used.
OptimisedRoute 1Steps 9 · Total yield /
(I)909096-1-a3612-20-2(II)909096-1-a105-56-6(III)909096-1-a—(IV)909096-1-a—(V)909096-1-a—(VI)909096-1-a—(VII)909096-1-a—(VIII)909096-1-a448-19-1(IX)909096-1-a—(X)909096-1-a—(XI)909096-1-a,(XI)909096-1-b1197953-49-3(XII)909096-1-a—(XIII)909096-1-a50-00-0API · Iruplinalkib
| Code | CAS No. | Intermediate |
|---|---|---|
| (I)909096-1-a | 3612-20-2 | 1-(Phenylmethyl)-4-piperidinone |
| (II)909096-1-a | 105-56-6Available | 3-Ethoxy-3-oxopropanenitrile |
| (III)909096-1-a | - | 2,4-Dioxo-9-(phenylmethyl)-3,9-diazaspiro[5.5]undecane-1,5-dicarbonitrile |
| (IV)909096-1-a | - | 1'-Benzylspiro[3,7-diazabicyclo[3.3.1]nonane-9,4'-piperidine]-2,4,6,8-tetrone |
| (V)909096-1-a | - | 9-(Phenylmethyl)-3,9-diazaspiro[5.5]undecane-2,4-dione |
| (VI)909096-1-a | - | 3-Benzyl-3,9-diazaspiro[5.5]undecane |
| (VII)909096-1-a | - | 3-Boc-3,9-diazaspiro[5.5]undecane |
| (VIII)909096-1-a | 448-19-1 | 4-Fluoro-2-methoxy-1-nitrobenzene |
| (IX)909096-1-a | - | tert-Butyl 9-(3-methoxy-4-nitrophenyl)-3,9-diazaspiro[5.5]undecane-3-carboxylate |
| (X)909096-1-a | - | tert-Butyl 9-(4-amino-3-methoxyphenyl)-3,9-diazaspiro[5.5]undecane-3-carboxylate |
| (XI)909096-1-a,(XI)909096-1-b | 1197953-49-3Available | (2-((2,5-Dichloropyrimidin-4-yl)amino)phenyl)dimethylphosphine oxide |
| (XII)909096-1-a | - | 5-Chloro-N2-[4-(3,9-diazaspiro[5.5]undecan-3-yl)-2-methoxyphenyl]-N4-[2-(dimethylphosphoryl)phenyl]pyrimidine-2,4-diamine |
| (XIII)909096-1-a | 50-00-0Available | Formaldehyde |
OptimisedRoute 2Steps 3 · Total yield /
(XI)909096-1-a,(XI)909096-1-b1197953-49-3(XIV)909096-1-b762-04-9(XIX)909096-1-b5750-76-5(XV)909096-1-b75-16-1(XVI)909096-1-b7211-39-4(XVII)909096-1-b615-43-0(XVIII)909096-1-b1197953-47-1API · Iruplinalkib
| Code | CAS No. | Intermediate |
|---|---|---|
| (XI)909096-1-a,(XI)909096-1-b | 1197953-49-3Available | (2-((2,5-Dichloropyrimidin-4-yl)amino)phenyl)dimethylphosphine oxide |
| (XIV)909096-1-b | 762-04-9 | 1-Ethoxyphosphonoyloxy ethane |
| (XIX)909096-1-b | 5750-76-5 | 2,4,5-Trichloropyrimidine |
| (XV)909096-1-b | 75-16-1Available | Bromo(methyl)magnesium |
| (XVI)909096-1-b | 7211-39-4 | Dimethyl(oxo)phosphanium |
| (XVII)909096-1-b | 615-43-0 | 2-Aminophenyl iodide |
| (XVIII)909096-1-b | 1197953-47-1Available | (2-Aminophenyl)dimethylphosphine oxide |
OptimisedRoute 3Steps 4 · Total yield /
(I)909096-2-a—(II)909096-2-a,(II)909096-2-b448-19-1(III)909096-2-a—(IV)909096-2-a74-88-4(V)909096-2-a—(VI)909096-2-a—(VII)909096-2-a1197953-49-3(VIII)909096-2-a—(IX)909096-2-a—(X)909096-2-a,(X)909096-2-b50-00-0(XI)909096-2-a,(XI)909096-2-b—API · Iruplinalkib
| Code | CAS No. | Intermediate |
|---|---|---|
| (I)909096-2-a | - | 3-Benzyl-3,9-diazaspiro[5.5]undecane |
| (II)909096-2-a,(II)909096-2-b | 448-19-1 | 4-Fluoro-2-methoxy-1-nitrobenzene |
| (III)909096-2-a | - | 3-Benzyl-9-(3-methoxy-4-nitrophenyl)-3,9-diazaspiro[5.5]undecane |
| (IV)909096-2-a | 74-88-4Available | Iodomethane |
| (V)909096-2-a | - | 3-Benzyl-9-(3-methoxy-4-nitrophenyl)-3-methyl-3,9-diazaspiro[5.5]undecan-3-ium iodide |
| (VI)909096-2-a | - | 2-Methoxy-4-(9-methyl-3,9-diazaspiro[5.5]undec-3-yl)benzenamine |
| (VII)909096-2-a | 1197953-49-3Available | (2-((2,5-Dichloropyrimidin-4-yl)amino)phenyl)dimethylphosphine oxide |
| (VIII)909096-2-a | - | tert-Butyl 9-(3-methoxy-4-nitrophenyl)-3,9-diazaspiro[5.5]undecane-3-carboxylate |
| (IX)909096-2-a | - | 3-(3-Methoxy-4-nitrophenyl)-3,9-diazaspiro[5.5]undecane |
| (X)909096-2-a,(X)909096-2-b | 50-00-0Available | Formaldehyde |
| (XI)909096-2-a,(XI)909096-2-b | - | 3-(3-Methoxy-4-nitrophenyl)-9-methyl-3,9-diazaspiro[5.5]undecane |
OptimisedRoute 4Steps 3 · Total yield /
(II)909096-2-a,(II)909096-2-b448-19-1(X)909096-2-a,(X)909096-2-b50-00-0(XI)909096-2-a,(XI)909096-2-b—(XII)909096-2-b—(XIII)909096-2-b—(XIV)909096-2-b—API · Iruplinalkib
| Code | CAS No. | Intermediate |
|---|---|---|
| (II)909096-2-a,(II)909096-2-b | 448-19-1 | 4-Fluoro-2-methoxy-1-nitrobenzene |
| (X)909096-2-a,(X)909096-2-b | 50-00-0Available | Formaldehyde |
| (XI)909096-2-a,(XI)909096-2-b | - | 3-(3-Methoxy-4-nitrophenyl)-9-methyl-3,9-diazaspiro[5.5]undecane |
| (XII)909096-2-b | - | 3-Boc-3,9-diazaspiro[5.5]undecane |
| (XIII)909096-2-b | - | 9-Methyl-3,9-Diazaspiro[5.5]undecane-3-carboxylic acid 1,1-dimethylethyl ester |
| (XIV)909096-2-b | - | 3-Methyl-3,9-diazaspiro[5.5]undecane |
Frequently asked questions
What are the approved indications of Iruplinalkib?
Approved indications include: Non-small cell lung cancer.
When does the Iruplinalkib patent expire?
No public expiry year is available for Iruplinalkib yet; this page updates once verified.
How many synthesis routes are recorded for Iruplinalkib?
4 synthesis routes are recorded; the shortest is 3 steps with / total yield. Intermediates in each route carry codes and CAS numbers.
Where can I buy Iruplinalkib intermediates?
6 intermediate CAS of Iruplinalkib are available through the Unibest supply network — see the route tables on this page and request a quote per CAS.
How do I get a quote for Iruplinalkib intermediates?
Open the CAS profile of the target intermediate from this page, or submit an RFQ directly — the CAS enters the matching flow automatically and the supply network responds with quotes.
Source: cross-verified data (structured fields only) · 2026-09-29