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Lurasidone Hydrochloride

Tier B — Position early

Lurasidone Hydrochloride · all drugs expiring in 2028 →

Sumitomo Dainippon Pharma Co., Ltd.
Originator
2010
First approval
2028
Expiry (public)
$1.95B ▲
Peak sales
Small molecule
Type

Targets：5-HT7, 5-HT2A, 5-HT1A, DRD2

Brand：Latuda

Indications (approved)：Major depressive disorder, Schizophrenia, Mania, Depressive disorder

Regional status

US
Approved
2010-10-28
EU
Approved
2014-03-20
China
Approved
2019-01-24
Japan
Approved
2020-03-25

Factories producing this API1

Factories registered as producing this API in our sourcing network (RFQ records + product master), sorted by RFQ activity; the snapshot carries no cost or customer data.

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Synthetic routes & intermediates6 routes

Originator routes × 1Optimised (non-patent) × 4Process routes × 1

Routes are ordered originator first, then optimised / process (non-patent) routes; each lists steps, overall yield and the intermediate table (code / CAS / name) — ready for supplier sourcing and RFQ. Rendered by this site from structured data; no third-party route graphics used.

OriginatorRoute 1Steps 4 · Total yield /
Synthetic routes & intermediates Route 1
CodeCAS No.Intermediate
LURA-00487691-87-03-(piperazin-1-yl)benzo[d]isothiazole
LURA-005-(3aR,7aR)-4'-(benzo[d]isothiazol-3-yl)octahydrospiro[isoindole-2,1'-piperazin]-2-ium methanesulfonate
LURA-0062054161-88-3(3aR,4S,7R,7aS)-hexahydro-1H-4,7-methanoisoindole-1,3(2H)-dione
LURA-00171749-03-6(3aR,7aR)-hexahydroisobenzofuran-1,3-dione
LURA-00265376-05-8Available((1R,2R)-cyclohexane-1,2-diyl)dimethanol
LURA-003186204-35-3Available((1R,2R)-cyclohexane-1,2-diyl)bis(methylene) dimethanesulfonate
OptimisedRoute 2Steps 4 · Total yield /
Synthetic routes & intermediates Route 2
CodeCAS No.Intermediate
LURA-007110-17-8Availablefumaric acid
LURA-00877-79-22,5-dihydrothiophene 1,1-dioxide
LURA-00988-98-2cyclohex-4-ene-1,2-dicarboxylic acid
LURA-0101687-30-5cyclohexane-1,2-dicarboxylic acid
LURA-01158574-95-1(R)-1-phenylethan-1-aminium (1R,2S)-2-carboxycyclohexane-1-carboxylate
LURA-0122305-32-0(1R,2S)-cyclohexane-1,2-dicarboxylic acid
OptimisedRoute 3Steps 3 · Total yield /
Synthetic routes & intermediates Route 3
CodeCAS No.Intermediate
LURA-00487691-87-03-(piperazin-1-yl)benzo[d]isothiazole
LURA-0131421374-92-6((1R,2R)-2-(aminomethyl)cyclohexyl)methanol
LURA-0141792220-25-7(3aR,4S,7R,7aS)-hexahydro-4,7-methanoisobenzofuran-1,3-dione
LURA-0151421374-93-7(3aR,4S,7R,7aS)-2-(((1R,2R)-2-(hydroxymethyl)cyclohexyl)methyl)hexahydro-1H-4,7-methanoisoindole-1,3(2H)-dione
LURA-0161421374-94-8((1R,2R)-2-(((3aR,4S,7R,7aS)-1,3-dioxooctahydro-2H-4,7-methanoisoindol-2-yl)methyl)cyclohexyl)methyl methanesulfonate
OptimisedRoute 4Steps 5 · Total yield /
Synthetic routes & intermediates Route 4
CodeCAS No.Intermediate
LURA-0062054161-88-3(3aR,4S,7R,7aS)-hexahydro-1H-4,7-methanoisoindole-1,3(2H)-dione
LURA-017186204-35-3Available((1R,2R)-cyclohexane-1,2-diyl)bis(methylene) dimethanesulfonate
LURA-018111-42-22,2'-azanediylbis(ethan-1-ol)
LURA-019-((1R,2R)-2-((bis(2-hydroxyethyl)amino)methyl)cyclohexyl)methyl methanesulfonate
LURA-0201421374-97-1(3aR,4S,7R,7aS)-2-(((1R,2R)-2-((bis(2-hydroxyethyl)amino)methyl)cyclohexyl)methyl)hexahydro-1H-4,7-methanoisoindole-1,3(2H)-dione
LURA-0211421374-98-2((((1R,2R)-2-(((3aR,4S,7R,7aS)-1,3-dioxooctahydro-2H-4,7-methanoisoindol-2-yl)methyl)cyclohexyl)methyl)azanediyl)bis(ethane-2,1-diyl) dimethanesulfonate
LURA-02223031-78-9benzo[d]isothiazol-3-amine
OptimisedRoute 5Steps 3 · Total yield 4.5 g
Synthetic routes & intermediates Route 5
CodeCAS No.Intermediate
LURA-00487691-87-03-(piperazin-1-yl)benzo[d]isothiazole
LURA-005-(3aR,7aR)-4'-(benzo[d]isothiazol-3-yl)octahydrospiro[isoindole-2,1'-piperazin]-2-ium methanesulfonate
LURA-0062054161-88-3(3aR,4S,7R,7aS)-hexahydro-1H-4,7-methanoisoindole-1,3(2H)-dione
LURA-017186204-35-3Available((1R,2R)-cyclohexane-1,2-diyl)bis(methylene) dimethanesulfonate
ProcessRoute 6Steps 1 · Total yield 4.5 g (Lurasidone)
Synthetic routes & intermediates Route 6
CodeCAS No.Intermediate
LURA-02414805-29-9Availableexo-Hexahydro-1H-4,7-methanoisoindole-1,3(2H)-dioneexo-Norbornane-2,3-dicarboximide
LURA-023-[(1R,2R)-2-[[4-(1,2-Benzothiazol-3-yl)piperazin-1-yl]methyl]cyclohexyl]methyl methanesulfonate

Frequently asked questions

What are the approved indications of Lurasidone Hydrochloride?

Approved indications include: Major depressive disorder, Schizophrenia, Mania, Depressive disorder.

When does the Lurasidone Hydrochloride patent expire?

Based on public sources, the Lurasidone Hydrochloride patent expires in 2028.

How many synthesis routes are recorded for Lurasidone Hydrochloride?

6 synthesis routes are recorded; the shortest is 1 steps with 4.5 g (Lurasidone) total yield. Intermediates in each route carry codes and CAS numbers.

Where can I buy Lurasidone Hydrochloride intermediates?

4 intermediate CAS of Lurasidone Hydrochloride are available through the Unibest supply network — see the route tables on this page and request a quote per CAS.

How do I get a quote for Lurasidone Hydrochloride intermediates?

Open the CAS profile of the target intermediate from this page, or submit an RFQ directly — the CAS enters the matching flow automatically and the supply network responds with quotes.

Source: cross-verified data (structured fields only) · 2026-09-29