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Fondaparinux Sodium
Tier C — Watch / tradeFondaparinux Sodium
-
Originator
2001
First approval
-
Expiry (public)
$0.44B ▲
Peak sales
Small molecule
Type
Targets：SERPINC1, PT, F10
Brand：Arixtra, Quixidar
Indications (approved)：Pulmonary embolism, Venous thrombosis, Myocardial infarction, Angina pectoris, Thromboembolism, Liver disease
Regional status
US
Approved
2001-12-07
EU
Approved
2002-03-20
China
Approved
2008-01-01
Japan
Approved
2007-04-18
Synthetic routes & intermediates5 routes
Originator routes × 1Optimised (non-patent) × 4Process routes × 0
Routes are ordered originator first, then optimised / process (non-patent) routes; each lists steps, overall yield and the intermediate table (code / CAS / name) — ready for supplier sourcing and RFQ. Rendered by this site from structured data; no third-party route graphics used.
OriginatorRoute 1Steps 10 · Total yield 166 mg
FOND-00187907-35-5FOND-002114869-95-3FOND-00387907-09-3FOND-004114869-96-4FOND-005114869-97-5FOND-00687907-05-9FOND-007114869-98-6FOND-008114869-99-7FOND-00955682-50-3FOND-010114870-00-7FOND-011114903-05-8FOND-012114870-01-8FOND-013114870-02-9API · Fondaparinux Sodium
| Code | CAS No. | Intermediate |
|---|---|---|
| FOND-001 | 87907-35-5 | benzyl ((2S,3R,4R,5S,6R)-4-(benzyloxy)-5-hydroxy-6-(hydroxymethyl)-2-methoxytetrahydro-2H-pyran-3-yl)carbamate |
| FOND-002 | 114869-95-3 | ((2R,3S,4R,5R,6S)-4-(benzyloxy)-5-(((benzyloxy)carbonyl)amino)-3-hydroxy-6-methoxytetrahydro-2H-pyran-2-yl)methyl acetate |
| FOND-003 | 87907-09-3 | methyl (5R,6S,7S)-7-(benzyloxy)-2-(tert-butoxy)-6-(2-chloroacetoxy)-2-methyltetrahydro-5H-[1,3]dioxolo[4,5-b]pyran-5-carboxylate |
| FOND-004 | 114869-96-4 | methyl (2R,3S,4S,5R,6R)-5-acetoxy-6-(((2R,3S,4R,5R,6S)-2-(acetoxymethyl)-4-(benzyloxy)-5-(((benzyloxy)carbonyl)amino)-6-methoxytetrahydro-2H-pyran-3-yl)oxy)-4-(benzyloxy)-3-(2-chloroacetoxy)tetrahydro-2H-pyran-2-carboxylate |
| FOND-005 | 114869-97-5 | methyl (2R,3S,4S,5R,6R)-5-acetoxy-6-(((2R,3S,4R,5R,6S)-2-(acetoxymethyl)-4-(benzyloxy)-5-(((benzyloxy)carbonyl)amino)-6-methoxytetrahydro-2H-pyran-3-yl)oxy)-4-(benzyloxy)-3-hydroxytetrahydro-2H-pyran-2-carboxylate |
| FOND-006 | 87907-05-9 | methyl (2S,3S,4S,5R,6R)-6-(((2R,4R,5R,6R)-4-acetoxy-2-(acetoxymethyl)-5-azido-6-bromotetrahydro-2H-pyran-3-yl)oxy)-4,5-bis(benzyloxy)-3-(2-chloroacetoxy)tetrahydro-2H-pyran-2-carboxylate |
| FOND-007 | 114869-98-6 | methyl (2R,3S,4S,5R,6R)-5-acetoxy-3-(((2R,3R,4R,6R)-4-acetoxy-6-(acetoxymethyl)-3-azido-5-(((2R,3R,4S,5S,6S)-3,4-bis(benzyloxy)-5-(2-chloroacetoxy)-6-(methoxycarbonyl)tetrahydro-2H-pyran-2-yl)oxy)tetrahydro-2H-pyran-2-yl)oxy)-6-(((2R,3S,4R,5R,6S)-2-(acetoxymethyl)-4-(benzyloxy)-5-(((benzyloxy)carbonyl)amino)-6-methoxytetrahydro-2H-pyran-3-yl)oxy)-4-(benzyloxy)tetrahydro-2H-pyran-2-carboxylate |
| FOND-008 | 114869-99-7 | methyl (2R,3S,4S,5R,6R)-5-acetoxy-3-(((2R,3R,4R,6R)-4-acetoxy-6-(acetoxymethyl)-3-azido-5-(((2R,3R,4S,5S,6S)-3,4-bis(benzyloxy)-5-hydroxy-6-(methoxycarbonyl)tetrahydro-2H-pyran-2-yl)oxy)tetrahydro-2H-pyran-2-yl)oxy)-6-(((2R,3S,4R,5R,6S)-2-(acetoxymethyl)-4-(benzyloxy)-5-(((benzyloxy)carbonyl)amino)-6-methoxytetrahydro-2H-pyran-3-yl)oxy)-4-(benzyloxy)tetrahydro-2H-pyran-2-carboxylate |
| FOND-009 | 55682-50-3 | ((2R,3S,4R,5R,6R)-5-azido-3,4-bis(benzyloxy)-6-bromotetrahydro-2H-pyran-2-yl)methyl acetate |
| FOND-010 | 114870-00-7 | methyl (2R,3S,4S,5R,6R)-5-acetoxy-3-(((2R,3R,4R,6R)-4-acetoxy-6-(acetoxymethyl)-5-(((2R,3R,4S,5S,6S)-5-(((2R,3R,4R,5S,6R)-6-(acetoxymethyl)-3-azido-4,5-bis(benzyloxy)tetrahydro-2H-pyran-2-yl)oxy)-3,4-bis(benzyloxy)-6-(methoxycarbonyl)tetrahydro-2H-pyran-2-yl)oxy)-3-azidotetrahydro-2H-pyran-2-yl)oxy)-6-(((2R,3S,4R,5R,6S)-2-(acetoxymethyl)-4-(benzyloxy)-5-(((benzyloxy)carbonyl)amino)-6-methoxytetrahydro-2H-pyran-3-yl)oxy)-4-(benzyloxy)tetrahydro-2H-pyran-2-carboxylate |
| FOND-011 | 114903-05-8 | (2S,3S,4S,5R,6R)-3-(((2R,3R,4R,5S,6R)-3-azido-4,5-bis(benzyloxy)-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)oxy)-6-(((2R,4R,5R,6R)-5-azido-6-(((2R,3S,4R,5R,6R)-4-(benzyloxy)-6-(((2R,3S,4R,5R,6S)-4-(benzyloxy)-5-(((benzyloxy)carbonyl)amino)-2-(hydroxymethyl)-6-methoxytetrahydro-2H-pyran-3-yl)oxy)-2-carboxy-5-hydroxytetrahydro-2H-pyran-3-yl)oxy)-4-hydroxy-2-(hydroxymethyl)tetrahydro-2H-pyran-3-yl)oxy)-4,5-bis(benzyloxy)tetrahydro-2H-pyran-2-carboxylic acid |
| FOND-012 | 114870-01-8 | sodium (2S,3S,4S,5R,6R)-3-(((2R,3R,4R,5S,6R)-3-azido-4,5-bis(benzyloxy)-6-((sulfonatooxy)methyl)tetrahydro-2H-pyran-2-yl)oxy)-6-(((2R,4R,5R,6R)-5-azido-6-(((2R,3S,4S,5R,6R)-4-(benzyloxy)-6-(((2R,3S,4R,5R,6S)-4-(benzyloxy)-5-(((benzyloxy)carbonyl)amino)-6-methoxy-2-((sulfonatooxy)methyl)tetrahydro-2H-pyran-3-yl)oxy)-2-carboxylato-5-(sulfonatooxy)tetrahydro-2H-pyran-3-yl)oxy)-4-(sulfonatooxy)-2-((sulfonatooxy)methyl)tetrahydro-2H-pyran-3-yl)oxy)-4,5-bis(benzyloxy)tetrahydro-2H-pyran-2-carboxylate |
| FOND-013 | 114870-02-9 | sodium (2S,3S,4R,5R,6R)-3-(((2R,3R,4R,5S,6R)-3-amino-4,5-dihydroxy-6-((sulfonatooxy)methyl)tetrahydro-2H-pyran-2-yl)oxy)-6-(((2R,4R,5R,6R)-5-amino-6-(((2R,3S,4S,5R,6R)-6-(((2R,3S,4R,5R,6S)-5-amino-4-hydroxy-6-methoxy-2-((sulfonatooxy)methyl)tetrahydro-2H-pyran-3-yl)oxy)-2-carboxylato-4-hydroxy-5-(sulfonatooxy)tetrahydro-2H-pyran-3-yl)oxy)-4-(sulfonatooxy)-2-((sulfonatooxy)methyl)tetrahydro-2H-pyran-3-yl)oxy)-4,5-dihydroxytetrahydro-2H-pyran-2-carboxylate |
OptimisedRoute 2Steps 16 · Total yield 12 mg
FOND-013114870-02-9FOND-01413265-84-4FOND-015139437-39-1FOND-01667546-20-7FOND-017—FOND-018136172-58-2FOND-019157896-03-2FOND-020135415-92-8FOND-02199541-26-1FOND-02299541-27-2FOND-0231574590-12-7FOND-024150284-29-0FOND-025501089-97-0FOND-0261429189-56-9FOND-027704210-18-4FOND-028501092-87-1FOND-029—FOND-030100906-19-2FOND-03187907-02-6API · Fondaparinux Sodium
| Code | CAS No. | Intermediate |
|---|---|---|
| FOND-013 | 114870-02-9 | sodium (2S,3S,4R,5R,6R)-3-(((2R,3R,4R,5S,6R)-3-amino-4,5-dihydroxy-6-((sulfonatooxy)methyl)tetrahydro-2H-pyran-2-yl)oxy)-6-(((2R,4R,5R,6R)-5-amino-6-(((2R,3S,4S,5R,6R)-6-(((2R,3S,4R,5R,6S)-5-amino-4-hydroxy-6-methoxy-2-((sulfonatooxy)methyl)tetrahydro-2H-pyran-3-yl)oxy)-2-carboxylato-4-hydroxy-5-(sulfonatooxy)tetrahydro-2H-pyran-3-yl)oxy)-4-(sulfonatooxy)-2-((sulfonatooxy)methyl)tetrahydro-2H-pyran-3-yl)oxy)-4,5-dihydroxytetrahydro-2H-pyran-2-carboxylate |
| FOND-014 | 13265-84-4 | (2R,3S,4R)-2-(hydroxymethyl)-3,4-dihydro-2H-pyran-3,4-diol |
| FOND-015 | 139437-39-1 | (1R,2S,3S,4R,5S)-4-iodo-6,8-dioxabicyclo[3.2.1]octane-2,3-diol |
| FOND-016 | 67546-20-7 | (1R,2S,3R,4R,5S)-4-azido-6,8-dioxabicyclo[3.2.1]octane-2,3-diol |
| FOND-017 | - | (1R,2S,3R,4R,5S)-4-azido-2,3-bis(benzyloxy)-6,8-dioxabicyclo[3.2.1]octane |
| FOND-018 | 136172-58-2 | ((2R,3S,4R,5R)-6-acetoxy-5-azido-3,4-bis(benzyloxy)tetrahydro-2H-pyran-2-yl)methyl acetate |
| FOND-019 | 157896-03-2 | ((2R,3S,4R,5R)-5-azido-3,4-bis(benzyloxy)-6-hydroxytetrahydro-2H-pyran-2-yl)methyl acetate |
| FOND-020 | 135415-92-8 | ((2R,3S,4R,5R)-5-azido-3,4-bis(benzyloxy)-6-(2,2,2-trichloro-1-iminoethoxy)tetrahydro-2H-pyran-2-yl)methyl acetate |
| FOND-021 | 99541-26-1 | methyl (2S,3S,4S,5R,6R)-6-(((1R,3R,4R,5S)-3-acetoxy-4-azido-6,8-dioxabicyclo[3.2.1]octan-2-yl)oxy)-4,5-bis(benzyloxy)-3-hydroxytetrahydro-2H-pyran-2-carboxylate |
| FOND-022 | 99541-27-2 | methyl (2S,3S,4S,5R,6R)-6-(((1R,3R,4R,5S)-3-acetoxy-4-azido-6,8-dioxabicyclo[3.2.1]octan-2-yl)oxy)-3-(((2R,3R,4R,5S,6R)-6-(acetoxymethyl)-3-azido-4,5-bis(benzyloxy)tetrahydro-2H-pyran-2-yl)oxy)-4,5-bis(benzyloxy)tetrahydro-2H-pyran-2-carboxylate |
| FOND-023 | 1574590-12-7 | methyl (2S,3S,4S,5R,6R)-6-(((2R,4R,5R)-4-acetoxy-2-(acetoxymethyl)-5-azido-6-hydroxytetrahydro-2H-pyran-3-yl)oxy)-3-(((2R,3R,4R,5S,6R)-6-(acetoxymethyl)-3-azido-4,5-bis(benzyloxy)tetrahydro-2H-pyran-2-yl)oxy)-4,5-bis(benzyloxy)tetrahydro-2H-pyran-2-carboxylate |
| FOND-024 | 150284-29-0 | methyl (2S,3S,4S,5R,6R)-6-(((2R,4R,5R)-4-acetoxy-2-(acetoxymethyl)-5-azido-6-(2,2,2-trichloro-1-iminoethoxy)tetrahydro-2H-pyran-3-yl)oxy)-3-(((2R,3R,4R,5S,6R)-6-(acetoxymethyl)-3-azido-4,5-bis(benzyloxy)tetrahydro-2H-pyran-2-yl)oxy)-4,5-bis(benzyloxy)tetrahydro-2H-pyran-2-carboxylate |
| FOND-025 | 501089-97-0 | methyl (2R,3S,4S,5R,6R)-6-(((2R,3S,4R,5R,6S)-5-azido-2-((benzoyloxy)methyl)-4-(benzyloxy)-6-methoxytetrahydro-2H-pyran-3-yl)oxy)-5-(benzoyloxy)-4-(benzyloxy)-3-hydroxytetrahydro-2H-pyran-2-carboxylate |
| FOND-026 | 1429189-56-9 | methyl (2S,3S,4S,5R,6R)-6-(((2R,4R,5R,6R)-4-acetoxy-2-(acetoxymethyl)-5-azido-6-(((2R,3S,4S,5R,6R)-6-(((2R,3S,4R,5R,6S)-5-azido-2-((benzoyloxy)methyl)-4-(benzyloxy)-6-methoxytetrahydro-2H-pyran-3-yl)oxy)-5-(benzoyloxy)-4-(benzyloxy)-2-(methoxycarbonyl)tetrahydro-2H-pyran-3-yl)oxy)tetrahydro-2H-pyran-3-yl)oxy)-3-(((2R,3R,4R,5S,6R)-6-(acetoxymethyl)-3-azido-4,5-bis(benzyloxy)tetrahydro-2H-pyran-2-yl)oxy)-4,5-bis(benzyloxy)tetrahydro-2H-pyran-2-carboxylate |
| FOND-027 | 704210-18-4 | (2S,3S,4S,5R,6R)-3-(((2R,3R,4R,5S,6R)-3-azido-4,5-bis(benzyloxy)-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)oxy)-6-(((2R,4R,5R,6R)-5-azido-6-(((2R,3S,4R,5R,6R)-6-(((2R,3S,4R,5R,6S)-5-azido-4-(benzyloxy)-2-(hydroxymethyl)-6-methoxytetrahydro-2H-pyran-3-yl)oxy)-4-(benzyloxy)-2-carboxy-5-hydroxytetrahydro-2H-pyran-3-yl)oxy)-4-hydroxy-2-(hydroxymethyl)tetrahydro-2H-pyran-3-yl)oxy)-4,5-bis(benzyloxy)tetrahydro-2H-pyran-2-carboxylic acid |
| FOND-028 | 501092-87-1 | sodium (2S,3S,4S,5R,6R)-3-(((2R,3R,4R,5S,6R)-3-azido-4,5-bis(benzyloxy)-6-((sulfonatooxy)methyl)tetrahydro-2H-pyran-2-yl)oxy)-6-(((2R,4R,5R,6R)-5-azido-6-(((2R,3S,4S,5R,6R)-6-(((2R,3S,4R,5R,6S)-5-azido-4-(benzyloxy)-6-methoxy-2-((sulfonatooxy)methyl)tetrahydro-2H-pyran-3-yl)oxy)-4-(benzyloxy)-2-carboxylato-5-(sulfonatooxy)tetrahydro-2H-pyran-3-yl)oxy)-4-(sulfonatooxy)-2-((sulfonatooxy)methyl)tetrahydro-2H-pyran-3-yl)oxy)-4,5-bis(benzyloxy)tetrahydro-2H-pyran-2-carboxylate |
| FOND-029 | - | methyl (2S,3S,4S,5R,6S)-4,5-bis(benzyloxy)-6-bromo-3-(2-chloroacetoxy)tetrahydro-2H-pyran-2-carboxylate |
| FOND-030 | 100906-19-2 | (1R,3R,4R,5S)-4-azido-2-hydroxy-6,8-dioxabicyclo[3.2.1]octan-3-yl acetate |
| FOND-031 | 87907-02-6 | methyl (2S,3S,4S,5R,6R)-6-(((1R,3R,4R,5S)-3-acetoxy-4-azido-6,8-dioxabicyclo[3.2.1]octan-2-yl)oxy)-4,5-bis(benzyloxy)-3-(2-chloroacetoxy)tetrahydro-2H-pyran-2-carboxylate |
OptimisedRoute 3Steps 12 · Total yield 16 g
FOND-025501089-97-0FOND-0261429189-56-9FOND-03287907-34-4FOND-033139573-22-1FOND-034162678-87-7FOND-035175978-55-9FOND-036501088-17-1FOND-0371839603-10-9FOND-0381429189-52-5FOND-039697795-82-7FOND-0401491156-91-2FOND-0411491156-81-0FOND-042—FOND-0431491156-92-3FOND-0441491156-79-6API · Fondaparinux Sodium
| Code | CAS No. | Intermediate |
|---|---|---|
| FOND-025 | 501089-97-0 | methyl (2R,3S,4S,5R,6R)-6-(((2R,3S,4R,5R,6S)-5-azido-2-((benzoyloxy)methyl)-4-(benzyloxy)-6-methoxytetrahydro-2H-pyran-3-yl)oxy)-5-(benzoyloxy)-4-(benzyloxy)-3-hydroxytetrahydro-2H-pyran-2-carboxylate |
| FOND-026 | 1429189-56-9 | methyl (2S,3S,4S,5R,6R)-6-(((2R,4R,5R,6R)-4-acetoxy-2-(acetoxymethyl)-5-azido-6-(((2R,3S,4S,5R,6R)-6-(((2R,3S,4R,5R,6S)-5-azido-2-((benzoyloxy)methyl)-4-(benzyloxy)-6-methoxytetrahydro-2H-pyran-3-yl)oxy)-5-(benzoyloxy)-4-(benzyloxy)-2-(methoxycarbonyl)tetrahydro-2H-pyran-3-yl)oxy)tetrahydro-2H-pyran-3-yl)oxy)-3-(((2R,3R,4R,5S,6R)-6-(acetoxymethyl)-3-azido-4,5-bis(benzyloxy)tetrahydro-2H-pyran-2-yl)oxy)-4,5-bis(benzyloxy)tetrahydro-2H-pyran-2-carboxylate |
| FOND-032 | 87907-34-4 | benzyl ((4aR,6S,7R,8R,8aS)-8-(benzyloxy)-6-methoxy-2-phenylhexahydropyrano[3,2-d][1,3]dioxin-7-yl)carbamate |
| FOND-033 | 139573-22-1 | (4aR,6S,7R,8R,8aS)-8-(benzyloxy)-6-methoxy-2-phenylhexahydropyrano[3,2-d][1,3]dioxin-7-amine |
| FOND-034 | 162678-87-7 | (4aR,6S,7R,8R,8aS)-7-azido-8-(benzyloxy)-6-methoxy-2-phenylhexahydropyrano[3,2-d][1,3]dioxine |
| FOND-035 | 175978-55-9 | (2R,3S,4R,5R,6S)-5-azido-4-(benzyloxy)-2-(hydroxymethyl)-6-methoxytetrahydro-2H-pyran-3-ol |
| FOND-036 | 501088-17-1 | ((2R,3S,4R,5R,6S)-5-azido-4-(benzyloxy)-3-hydroxy-6-methoxytetrahydro-2H-pyran-2-yl)methyl benzoate |
| FOND-037 | 1839603-10-9 | (2S,3R,4S,5R,6S)-5-acetoxy-6-(acetoxymethyl)-4-(benzyloxy)-2-(p-tolylthio)tetrahydro-2H-pyran-3-yl benzoate |
| FOND-038 | 1429189-52-5 | (2S,3R,4S,5R,6S)-5-acetoxy-6-(acetoxymethyl)-2-(((2R,3S,4R,5R,6S)-5-azido-2-((benzoyloxy)methyl)-4-(benzyloxy)-6-methoxytetrahydro-2H-pyran-3-yl)oxy)-4-(benzyloxy)tetrahydro-2H-pyran-3-yl benzoate |
| FOND-039 | 697795-82-7 | (2S,3R,4S,5R,6S)-2-(((2R,3S,4R,5R,6S)-5-azido-2-((benzoyloxy)methyl)-4-(benzyloxy)-6-methoxytetrahydro-2H-pyran-3-yl)oxy)-4-(benzyloxy)-5-hydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-3-yl benzoate |
| FOND-040 | 1491156-91-2 | (2R,3S,4S,5R,6R)-6-(((2R,3S,4R,5R,6S)-5-azido-2-((benzoyloxy)methyl)-4-(benzyloxy)-6-methoxytetrahydro-2H-pyran-3-yl)oxy)-5-(benzoyloxy)-4-(benzyloxy)-3-hydroxytetrahydro-2H-pyran-2-carboxylic acid |
| FOND-041 | 1491156-81-0 | methyl (2S,3S,4S,5R,6R)-6-(((2R,4R,5R)-4-acetoxy-2-(acetoxymethyl)-5-azido-6-(p-tolylthio)tetrahydro-2H-pyran-3-yl)oxy)-3-(((2R,3R,4R,5S,6R)-6-(acetoxymethyl)-3-azido-4,5-bis(benzyloxy)tetrahydro-2H-pyran-2-yl)oxy)-4,5-bis(benzyloxy)tetrahydro-2H-pyran-2-carboxylate |
| FOND-042 | - | (2S,3R,4S,5R,6S)-5-acetoxy-4-(benzyloxy)-6-(hydroxymethyl)-2-(p-tolylthio)tetrahydro-2H-pyran-3-yl benzoate |
| FOND-043 | 1491156-92-3 | methyl (2S,3S,4S,5R,6R)-3-(((2R,3R,4R,5S,6R)-3-azido-4,5-bis(benzyloxy)-6-(((4-methoxybenzyl)oxy)methyl)tetrahydro-2H-pyran-2-yl)oxy)-6-(((2R,4R,5R)-5-azido-4-((4-methoxybenzyl)oxy)-2-(((4-methoxybenzyl)oxy)methyl)-6-(p-tolylthio)tetrahydro-2H-pyran-3-yl)oxy)-4,5-bis(benzyloxy)tetrahydro-2H-pyran-2-carboxylate |
| FOND-044 | 1491156-79-6 | methyl (2S,3S,4S,5R,6R)-3-(((2R,3R,4R,5S,6R)-3-azido-4,5-bis(benzyloxy)-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)oxy)-6-(((2R,4R,5R)-5-azido-4-hydroxy-2-(hydroxymethyl)-6-(p-tolylthio)tetrahydro-2H-pyran-3-yl)oxy)-4,5-bis(benzyloxy)tetrahydro-2H-pyran-2-carboxylate |
OptimisedRoute 4Steps 5 · Total yield 200 mg
FOND-0261429189-56-9FOND-028501092-87-1FOND-045—FOND-0461402823-52-2FOND-0471402823-51-1API · Fondaparinux Sodium
| Code | CAS No. | Intermediate |
|---|---|---|
| FOND-026 | 1429189-56-9 | methyl (2S,3S,4S,5R,6R)-6-(((2R,4R,5R,6R)-4-acetoxy-2-(acetoxymethyl)-5-azido-6-(((2R,3S,4S,5R,6R)-6-(((2R,3S,4R,5R,6S)-5-azido-2-((benzoyloxy)methyl)-4-(benzyloxy)-6-methoxytetrahydro-2H-pyran-3-yl)oxy)-5-(benzoyloxy)-4-(benzyloxy)-2-(methoxycarbonyl)tetrahydro-2H-pyran-3-yl)oxy)tetrahydro-2H-pyran-3-yl)oxy)-3-(((2R,3R,4R,5S,6R)-6-(acetoxymethyl)-3-azido-4,5-bis(benzyloxy)tetrahydro-2H-pyran-2-yl)oxy)-4,5-bis(benzyloxy)tetrahydro-2H-pyran-2-carboxylate |
| FOND-028 | 501092-87-1 | sodium (2S,3S,4S,5R,6R)-3-(((2R,3R,4R,5S,6R)-3-azido-4,5-bis(benzyloxy)-6-((sulfonatooxy)methyl)tetrahydro-2H-pyran-2-yl)oxy)-6-(((2R,4R,5R,6R)-5-azido-6-(((2R,3S,4S,5R,6R)-6-(((2R,3S,4R,5R,6S)-5-azido-4-(benzyloxy)-6-methoxy-2-((sulfonatooxy)methyl)tetrahydro-2H-pyran-3-yl)oxy)-4-(benzyloxy)-2-carboxylato-5-(sulfonatooxy)tetrahydro-2H-pyran-3-yl)oxy)-4-(sulfonatooxy)-2-((sulfonatooxy)methyl)tetrahydro-2H-pyran-3-yl)oxy)-4,5-bis(benzyloxy)tetrahydro-2H-pyran-2-carboxylate |
| FOND-045 | - | sodium (2S,3S,4S,5R,6R)-3-(((2R,3R,4R,5S,6R)-3-azido-4,5-bis(benzyloxy)-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)oxy)-6-(((2R,4R,5R,6R)-5-azido-6-(((2R,3S,4R,5R,6R)-6-(((2R,3S,4R,5R,6S)-5-azido-4-(benzyloxy)-2-(hydroxymethyl)-6-methoxytetrahydro-2H-pyran-3-yl)oxy)-4-(benzyloxy)-2-carboxylato-5-hydroxytetrahydro-2H-pyran-3-yl)oxy)-4-hydroxy-2-(hydroxymethyl)tetrahydro-2H-pyran-3-yl)oxy)-4,5-bis(benzyloxy)tetrahydro-2H-pyran-2-carboxylate |
| FOND-046 | 1402823-52-2 | sodium (2S,3S,4S,5R,6R)-3-(((2R,3R,4R,5S,6R)-3-amino-4,5-bis(benzyloxy)-6-((sulfonatooxy)methyl)tetrahydro-2H-pyran-2-yl)oxy)-6-(((2R,4R,5R,6R)-5-amino-6-(((2R,3S,4S,5R,6R)-6-(((2R,3S,4R,5R,6S)-5-amino-4-(benzyloxy)-6-methoxy-2-((sulfonatooxy)methyl)tetrahydro-2H-pyran-3-yl)oxy)-4-(benzyloxy)-2-carboxylato-5-(sulfonatooxy)tetrahydro-2H-pyran-3-yl)oxy)-4-(sulfonatooxy)-2-((sulfonatooxy)methyl)tetrahydro-2H-pyran-3-yl)oxy)-4,5-bis(benzyloxy)tetrahydro-2H-pyran-2-carboxylate |
| FOND-047 | 1402823-51-1 | sodium (2S,3S,4S,5R,6R)-4,5-bis(benzyloxy)-6-(((2R,4R,5R,6R)-6-(((2R,3S,4S,5R,6R)-4-(benzyloxy)-6-(((2R,3S,4R,5R,6S)-4-(benzyloxy)-6-methoxy-5-(sulfonatoamino)-2-((sulfonatooxy)methyl)tetrahydro-2H-pyran-3-yl)oxy)-2-carboxylato-5-(sulfonatooxy)tetrahydro-2H-pyran-3-yl)oxy)-5-(sulfonatoamino)-4-(sulfonatooxy)-2-((sulfonatooxy)methyl)tetrahydro-2H-pyran-3-yl)oxy)-3-(((2R,3R,4R,5S,6R)-4,5-bis(benzyloxy)-3-(sulfonatoamino)-6-((sulfonatooxy)methyl)tetrahydro-2H-pyran-2-yl)oxy)tetrahydro-2H-pyran-2-carboxylate |
OptimisedRoute 5Steps 4 · Total yield 6.4 g
FOND-0261429189-56-9FOND-0471402823-51-1FOND-048—FOND-049—API · Fondaparinux Sodium
| Code | CAS No. | Intermediate |
|---|---|---|
| FOND-026 | 1429189-56-9 | methyl (2S,3S,4S,5R,6R)-6-(((2R,4R,5R,6R)-4-acetoxy-2-(acetoxymethyl)-5-azido-6-(((2R,3S,4S,5R,6R)-6-(((2R,3S,4R,5R,6S)-5-azido-2-((benzoyloxy)methyl)-4-(benzyloxy)-6-methoxytetrahydro-2H-pyran-3-yl)oxy)-5-(benzoyloxy)-4-(benzyloxy)-2-(methoxycarbonyl)tetrahydro-2H-pyran-3-yl)oxy)tetrahydro-2H-pyran-3-yl)oxy)-3-(((2R,3R,4R,5S,6R)-6-(acetoxymethyl)-3-azido-4,5-bis(benzyloxy)tetrahydro-2H-pyran-2-yl)oxy)-4,5-bis(benzyloxy)tetrahydro-2H-pyran-2-carboxylate |
| FOND-047 | 1402823-51-1 | sodium (2S,3S,4S,5R,6R)-4,5-bis(benzyloxy)-6-(((2R,4R,5R,6R)-6-(((2R,3S,4S,5R,6R)-4-(benzyloxy)-6-(((2R,3S,4R,5R,6S)-4-(benzyloxy)-6-methoxy-5-(sulfonatoamino)-2-((sulfonatooxy)methyl)tetrahydro-2H-pyran-3-yl)oxy)-2-carboxylato-5-(sulfonatooxy)tetrahydro-2H-pyran-3-yl)oxy)-5-(sulfonatoamino)-4-(sulfonatooxy)-2-((sulfonatooxy)methyl)tetrahydro-2H-pyran-3-yl)oxy)-3-(((2R,3R,4R,5S,6R)-4,5-bis(benzyloxy)-3-(sulfonatoamino)-6-((sulfonatooxy)methyl)tetrahydro-2H-pyran-2-yl)oxy)tetrahydro-2H-pyran-2-carboxylate |
| FOND-048 | - | (2S,3S,4S,5R,6R)-3-(((2R,3R,4R,5S,6R)-3-azido-4,5-bis(benzyloxy)-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)oxy)-6-(((2R,4R,5R,6R)-5-azido-6-(((2R,3S,4R,5R,6R)-6-(((2R,3S,4R,5R,6S)-5-azido-4-(benzyloxy)-2-(hydroxymethyl)-6-methoxytetrahydro-2H-pyran-3-yl)oxy)-4-(benzyloxy)-5-hydroxy-2-(methoxycarbonyl)tetrahydro-2H-pyran-3-yl)oxy)-4-hydroxy-2-(hydroxymethyl)tetrahydro-2H-pyran-3-yl)oxy)-4,5-bis(benzyloxy)tetrahydro-2H-pyran-2-carboxylic acid |
| FOND-049 | - | (2S,3S,4S,5R,6R)-3-(((2R,3R,4R,5S,6R)-3-amino-4,5-bis(benzyloxy)-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)oxy)-6-(((2R,4R,5R,6R)-5-amino-6-(((2R,3S,4R,5R,6R)-6-(((2R,3S,4R,5R,6S)-5-amino-4-(benzyloxy)-2-(hydroxymethyl)-6-methoxytetrahydro-2H-pyran-3-yl)oxy)-4-(benzyloxy)-5-hydroxy-2-(methoxycarbonyl)tetrahydro-2H-pyran-3-yl)oxy)-4-hydroxy-2-(hydroxymethyl)tetrahydro-2H-pyran-3-yl)oxy)-4,5-bis(benzyloxy)tetrahydro-2H-pyran-2-carboxylic acid |
Frequently asked questions
What are the approved indications of Fondaparinux Sodium?
Approved indications include: Pulmonary embolism, Venous thrombosis, Myocardial infarction, Angina pectoris, Thromboembolism, Liver disease.
When does the Fondaparinux Sodium patent expire?
No public expiry year is available for Fondaparinux Sodium yet; this page updates once verified.
How many synthesis routes are recorded for Fondaparinux Sodium?
5 synthesis routes are recorded; the shortest is 4 steps with 6.4 g total yield. Intermediates in each route carry codes and CAS numbers.
Where can I buy Fondaparinux Sodium intermediates?
All intermediates in Fondaparinux Sodium routes have CAS profiles — you can submit an RFQ per CAS and it enters the Unibest matching pool.
How do I get a quote for Fondaparinux Sodium intermediates?
Open the CAS profile of the target intermediate from this page, or submit an RFQ directly — the CAS enters the matching flow automatically and the supply network responds with quotes.
Source: cross-verified data (structured fields only) · 2026-09-29