Isavuconazonium Sulfate
Tier C — Watch / tradeIsavuconazonium Sulfate · all drugs expiring in 2029 →
Targets：CYP51
Brand：Cresemba
Indications (approved)：Mucorales infection, Aspergillus infection, Cryptosporidiosis, Fungal infection
Regional status
Synthetic routes & intermediates1 routes
Routes are ordered originator first, then optimised / process (non-patent) routes; each lists steps, overall yield and the intermediate table (code / CAS / name) — ready for supplier sourcing and RFQ. Rendered by this site from structured data; no third-party route graphics used.
| Code | CAS No. | Intermediate |
|---|---|---|
| ISAV-001 | 17392-83-5Available | methyl (R)-2-hydroxypropanoate |
| ISAV-002 | 135206-87-0Available | (R)-2-hydroxy-1-morpholinopropan-1-one |
| ISAV-003 | 135270-08-5Available | (2R)-1-morpholino-2-((tetrahydro-2H-pyran-2-yl)oxy)propan-1-one |
| ISAV-004 | 399-94-0Available | 2-bromo-1,4-difluorobenzene |
| ISAV-005 | 241479-69-6Available | (2R)-1-(2,5-difluorophenyl)-2-((tetrahydro-2H-pyran-2-yl)oxy)propan-1-one |
| ISAV-006 | 241479-70-9Available | 2-((1R)-1-(2-(2,5-difluorophenyl)oxiran-2-yl)ethoxy)tetrahydro-2H-pyran |
| ISAV-007 | 288-88-0Available | 1H-1,2,4-triazole |
| ISAV-008 | 241479-71-0Available | (3R)-2-(2,5-difluorophenyl)-3-((tetrahydro-2H-pyran-2-yl)oxy)-1-(1H-1,2,4-triazol-1-yl)butan-2-ol |
| ISAV-009 | 241479-72-1Available | (2R,3R)-2-(2,5-difluorophenyl)-1-(1H-1,2,4-triazol-1-yl)butane-2,3-diol |
| ISAV-010 | 241479-73-2Available | 1-(((2R,3S)-2-(2,5-difluorophenyl)-3-methyloxiran-2-yl)methyl)-1H-1,2,4-triazole |
| ISAV-011 | 241479-74-3Available | (2S,3R)-3-(2,5-difluorophenyl)-3-hydroxy-2-methyl-4-(1H-1,2,4-triazol-1-yl)butanenitrile |
| ISAV-012 | 368421-58-3Available | (2R,3R)-3-(2,5-difluorophenyl)-3-hydroxy-2-methyl-4-(1H-1,2,4-triazol-1-yl)butanethioamide |
| ISAV-013 | 20099-89-2Available | 4-(2-bromoacetyl)benzonitrile |
| ISAV-014 | 241479-67-4Available | 4-(2-((2R,3R)-3-(2,5-difluorophenyl)-3-hydroxy-4-(1H-1,2,4-triazol-1-yl)butan-2-yl)thiazol-4-yl)benzonitrile |
| ISAV-015 | 338990-31-1Available | (2-(((1-chloroethoxy)carbonyl)(methyl)amino)pyridin-3-yl)methyl 2-((tert-butoxycarbonyl)(methyl)amino)acetate |
| ISAV-016 | 338990-63-9Available | 4-(1-(((3-((2-((tert-butoxycarbonyl)(methyl)amino)acetoxy)methyl)pyridin-2-yl)(methyl)carbamoyl)oxy)ethyl)-1-((2R,3R)-3-(4-(4-cyanophenyl)thiazol-2-yl)-2-(2,5-difluorophenyl)-2-hydroxybutyl)-1H-1,2,4-triazol-4-ium chloride |
| ISAV-017 | 2942-59-8Available | 2-chloronicotinic acid |
| ISAV-018 | 49609-84-9Available | 2-chloronicotinoyl chloride |
| ISAV-019 | 232951-83-6Available | tert-butyl 2-chloronicotinate |
| ISAV-020 | 338990-70-8Available | tert-butyl 2-(methylamino)nicotinate |
| ISAV-021 | 32399-12-5Available | (2-(methylamino)pyridin-3-yl)methanol |
| ISAV-022 | 50893-53-3Available | 1-chloroethyl carbonochloridate |
Frequently asked questions
What are the approved indications of Isavuconazonium Sulfate?
Approved indications include: Mucorales infection, Aspergillus infection, Cryptosporidiosis, Fungal infection.
When does the Isavuconazonium Sulfate patent expire?
Based on public sources, the Isavuconazonium Sulfate patent expires in 2029.
How many synthesis routes are recorded for Isavuconazonium Sulfate?
1 synthesis routes are recorded; the shortest is 17 steps with 32.8 g total yield. Intermediates in each route carry codes and CAS numbers.
Where can I buy Isavuconazonium Sulfate intermediates?
22 intermediate CAS of Isavuconazonium Sulfate are available through the Unibest supply network — see the route tables on this page and request a quote per CAS.
How do I get a quote for Isavuconazonium Sulfate intermediates?
Open the CAS profile of the target intermediate from this page, or submit an RFQ directly — the CAS enters the matching flow automatically and the supply network responds with quotes.
Source: cross-verified data (structured fields only) · 2026-09-29