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Pasireotide Diaspartate

Tier C — Watch / trade

Pasireotide Diaspartate

Novartis
Originator
2012
First approval
-
Expiry (public)
No sales data
Peak sales
Small molecule
Type

Targets：SSTR3, SSTR1, SSTR5, SSTR2

Brand：Signifor

Indications (approved)：Cushing's syndrome, Pituitary ACTH hypersecretion

Regional status

US
Approved
2012-12-14
EU
Approved
2012-04-24
China
Approved
2015-05-27
Japan
Discontinued
2011-11-04

Synthetic routes & intermediates3 routes

Originator routes × 1Optimised (non-patent) × 2Process routes × 0

Routes are ordered originator first, then optimised / process (non-patent) routes; each lists steps, overall yield and the intermediate table (code / CAS / name) — ready for supplier sourcing and RFQ. Rendered by this site from structured data; no third-party route graphics used.

OriginatorRoute 1Steps 13 · Total yield 3.1 g
Synthetic routes & intermediates Route 1
CodeCAS No.Intermediate
PASI-001--
PASI-002--
PASI-003--
PASI-004--
PASI-005--
PASI-006187223-15-0(2S,4R)-1-(((9H-fluoren-9-yl)methoxy)carbonyl)-4-(((2-((tert-butoxycarbonyl)amino)ethyl)carbamoyl)oxy)pyrrolidine-2-carboxylic acid
PASI-007--
PASI-008--
PASI-009--
PASI-0101499-56-5(2S,4R)-methyl 4-hydroxypyrrolidine-2-carboxylate
PASI-011122350-59-81-((9H-fluoren-9-yl)methyl) 2-methyl (2S,4R)-4-hydroxypyrrolidine-1,2-dicarboxylate
PASI-012556796-28-21-((9H-fluoren-9-yl)methyl) 2-methyl (2S,4R)-4-((chlorocarbonyl)oxy)pyrrolidine-1,2-dicarboxylate
PASI-01357260-73-8Availabletert-butyl (2-aminoethyl)carbamate
PASI-014187223-14-91-((9H-fluoren-9-yl)methyl) 2-methyl (2S,4R)-4-(((2-((tert-butoxycarbonyl)amino)ethyl)carbamoyl)oxy)pyrrolidine-1,2-dicarboxylate
PASI-015556796-29-3(2S,4R)-4-(((2-((tert-butoxycarbonyl)amino)ethyl)carbamoyl)oxy)pyrrolidine-2-carboxylic acid
OptimisedRoute 2Steps 10 · Total yield 5.133 g
Synthetic routes & intermediates Route 2
CodeCAS No.Intermediate
PASI-006187223-15-0(2S,4R)-1-(((9H-fluoren-9-yl)methoxy)carbonyl)-4-(((2-((tert-butoxycarbonyl)amino)ethyl)carbamoyl)oxy)pyrrolidine-2-carboxylic acid
PASI-016187223-14-91-((9H-fluoren-9-yl)methyl) 2-methyl (2S,4R)-4-(((2-((tert-butoxycarbonyl)amino)ethyl)carbamoyl)oxy)pyrrolidine-1,2-dicarboxylate
PASI-017--
PASI-018--
PASI-019--
PASI-020--
PASI-021--
PASI-0221527478-88-1-
PASI-023-#N/A
OptimisedRoute 3Steps 9 · Total yield /
Synthetic routes & intermediates Route 3
CodeCAS No.Intermediate
PASI-024-(E)-prop-1-en-1-yl (((9H-fluoren-9-yl)methoxy)carbonyl)-L-lysinate
PASI-025--
PASI-026--
PASI-027--
PASI-028--
PASI-0291427038-62-7(2-((tert-butoxycarbonyl)amino)ethyl)carbamic acid
PASI-030--
PASI-031--
PASI-032--
PASI-033--

Frequently asked questions

What are the approved indications of Pasireotide Diaspartate?

Approved indications include: Cushing's syndrome, Pituitary ACTH hypersecretion.

When does the Pasireotide Diaspartate patent expire?

No public expiry year is available for Pasireotide Diaspartate yet; this page updates once verified.

How many synthesis routes are recorded for Pasireotide Diaspartate?

3 synthesis routes are recorded; the shortest is 9 steps with / total yield. Intermediates in each route carry codes and CAS numbers.

Where can I buy Pasireotide Diaspartate intermediates?

1 intermediate CAS of Pasireotide Diaspartate are available through the Unibest supply network — see the route tables on this page and request a quote per CAS.

How do I get a quote for Pasireotide Diaspartate intermediates?

Open the CAS profile of the target intermediate from this page, or submit an RFQ directly — the CAS enters the matching flow automatically and the supply network responds with quotes.

Source: cross-verified data (structured fields only) · 2026-09-29