Conjugated Estrogens/Bazedoxifene Acetate
Tier C — Watch / tradeConjugated Estrogens/Bazedoxifene Acetate
Targets：ERα, ERβ
Brand：Aprela, Duavee, Duavive
Indications (approved)：Oestrogen deficiency syndrome, Osteoporosis, Vasomotor symptoms
Regional status
Factories producing this API13
Factories registered as producing this API in our sourcing network (RFQ records + product master), sorted by RFQ activity; the snapshot carries no cost or customer data.
13 producing factories on file — sign in to view the named list (factory details are not shown to guests).
Sign in to view factories →Synthetic routes & intermediates5 routes
Routes are ordered originator first, then optimised / process (non-patent) routes; each lists steps, overall yield and the intermediate table (code / CAS / name) — ready for supplier sourcing and RFQ. Rendered by this site from structured data; no third-party route graphics used.
| Code | CAS No. | Intermediate |
|---|---|---|
| BAZE-001 | 51388-20-6 | 4-(benzyloxy)aniline hydrochloride |
| BAZE-002 | 35081-45-9 | 1-(4-(benzyloxy)phenyl)-2-bromopropan-1-one |
| BAZE-003 | 198479-63-9 | 5-(benzyloxy)-2-(4-(benzyloxy)phenyl)-3-methyl-1H-indole |
| BAZE-004 | 80494-75-3 | ethyl 2-(4-(chloromethyl)phenoxy)acetate |
| BAZE-005 | 198479-82-2 | ethyl 2-(4-((5-(benzyloxy)-2-(4-(benzyloxy)phenyl)-3-methyl-1H-indol-1-yl)methyl)phenoxy)acetate |
| BAZE-006 | 198479-95-7 | 2-(4-((5-(benzyloxy)-2-(4-(benzyloxy)phenyl)-3-methyl-1H-indol-1-yl)methyl)phenoxy)ethanol |
| BAZE-007 | 198480-07-8 | 5-(benzyloxy)-2-(4-(benzyloxy)phenyl)-1-(4-(2-bromoethoxy)benzyl)-3-methyl-1H-indole |
| BAZE-008 | 111-49-9 | azepane |
| BAZE-009 | 198480-21-6 | 1-(4-(2-(azepan-1-yl)ethoxy)benzyl)-5-(benzyloxy)-2-(4-(benzyloxy)phenyl)-3-methyl-1H-indole |
| Code | CAS No. | Intermediate |
|---|---|---|
| BAZE-003 | 198479-63-9 | 5-(benzyloxy)-2-(4-(benzyloxy)phenyl)-3-methyl-1H-indole |
| BAZE-009 | 198480-21-6 | 1-(4-(2-(azepan-1-yl)ethoxy)benzyl)-5-(benzyloxy)-2-(4-(benzyloxy)phenyl)-3-methyl-1H-indole |
| BAZE-010 | 123-08-0Available | 4-hydroxybenzaldehyde |
| BAZE-011 | 26487-67-2 | 1-(2-chloroethyl)azepane hydrochloride |
| BAZE-012 | 223251-09-0 | 4-(2-(azepan-1-yl)ethoxy)benzaldehyde |
| BAZE-013 | 223251-16-9 | (4-(2-(azepan-1-yl)ethoxy)phenyl)methanol |
| BAZE-014 | 223251-25-0 | 1-(2-(4-(chloromethyl)phenoxy)ethyl)azepane hydrochloride |
| Code | CAS No. | Intermediate |
|---|---|---|
| BAZE-003 | 198479-63-9 | 5-(benzyloxy)-2-(4-(benzyloxy)phenyl)-3-methyl-1H-indole |
| BAZE-008 | 111-49-9 | azepane |
| BAZE-009 | 198480-21-6 | 1-(4-(2-(azepan-1-yl)ethoxy)benzyl)-5-(benzyloxy)-2-(4-(benzyloxy)phenyl)-3-methyl-1H-indole |
| BAZE-015 | 623-05-2 | 4-(hydroxymethyl)phenol |
| BAZE-016 | 107-14-2Available | 2-chloroacetonitrile |
| BAZE-017 | 123226-38-0 | 2-(4-(hydroxymethyl)phenoxy)acetonitrile |
| BAZE-018 | 112772-83-5 | 2-(4-(chloromethyl)phenoxy)acetonitrile |
| BAZE-019 | 1251936-40-9 | 2-(4-((5-(benzyloxy)-2-(4-(benzyloxy)phenyl)-3-methyl-1H-indol-1-yl)methyl)phenoxy)acetonitrile |
| BAZE-020 | 1251936-41-0 | 2-(4-((5-(benzyloxy)-2-(4-(benzyloxy)phenyl)-3-methyl-1H-indol-1-yl)methyl)phenoxy)acetic acid |
| BAZE-021 | 1251936-42-1 | 1-(azepan-1-yl)-2-(4-((5-(benzyloxy)-2-(4-(benzyloxy)phenyl)-3-methyl-1H-indol-1-yl)methyl)phenoxy)ethan-1-one |
| BAZE-022 | 198481-32-2 | 1-(4-(2-(azepan-1-yl)ethoxy)benzyl)-2-(4-hydroxyphenyl)-3-methyl-1H-indol-5-ol |
| Code | CAS No. | Intermediate |
|---|---|---|
| BAZE-002 | 35081-45-9 | 1-(4-(benzyloxy)phenyl)-2-bromopropan-1-one |
| BAZE-009 | 198480-21-6 | 1-(4-(2-(azepan-1-yl)ethoxy)benzyl)-5-(benzyloxy)-2-(4-(benzyloxy)phenyl)-3-methyl-1H-indole |
| BAZE-010 | 123-08-0Available | 4-hydroxybenzaldehyde |
| BAZE-012 | 223251-09-0 | 4-(2-(azepan-1-yl)ethoxy)benzaldehyde |
| BAZE-023 | 111-49-9 | azepane |
| BAZE-024 | 106-93-4Available | 1,2-dibromoethane |
| BAZE-025 | 792862-79-4 | 1-(2-bromoethyl)azepane |
| BAZE-026 | 6373-46-2 | 4-(benzyloxy)aniline |
| BAZE-027 | 1401206-96-9 | N-(4-(2-(azepan-1-yl)ethoxy)benzyl)-4-(benzyloxy)aniline |
| Code | CAS No. | Intermediate |
|---|---|---|
| BAZE-009 | 198480-21-6 | 1-(4-(2-(azepan-1-yl)ethoxy)benzyl)-5-(benzyloxy)-2-(4-(benzyloxy)phenyl)-3-methyl-1H-indole |
| BAZE-028 | 1609541-17-4 | 1-(2-(4-((1-(4-(benzyloxy)phenyl)hydrazinyl)methyl)phenoxy)ethyl)azepane |
| BAZE-029 | 1465262-23-0 | 1-(benzyloxy)-4-(prop-1-yn-1-yl)benzene |
Frequently asked questions
What are the approved indications of Conjugated Estrogens/Bazedoxifene Acetate?
Approved indications include: Oestrogen deficiency syndrome, Osteoporosis, Vasomotor symptoms.
When does the Conjugated Estrogens/Bazedoxifene Acetate patent expire?
No public expiry year is available for Conjugated Estrogens/Bazedoxifene Acetate yet; this page updates once verified.
How many synthesis routes are recorded for Conjugated Estrogens/Bazedoxifene Acetate?
5 synthesis routes are recorded; the shortest is 2 steps with 2 g total yield. Intermediates in each route carry codes and CAS numbers.
Where can I buy Conjugated Estrogens/Bazedoxifene Acetate intermediates?
3 intermediate CAS of Conjugated Estrogens/Bazedoxifene Acetate are available through the Unibest supply network — see the route tables on this page and request a quote per CAS.
How do I get a quote for Conjugated Estrogens/Bazedoxifene Acetate intermediates?
Open the CAS profile of the target intermediate from this page, or submit an RFQ directly — the CAS enters the matching flow automatically and the supply network responds with quotes.
Source: cross-verified data (structured fields only) · 2026-09-29