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Bilastine

Tier C — Watch / trade

Bilastine

Faes Farma
Originator
2010
First approval
-
Expiry (public)
$0.11B ▲
Peak sales
Small molecule
Type

Targets：HRH1

Brand：Ilaxten, Bilanoa, Bitosen, Bilaxten, Bilatex, Blexten

Indications (approved)：Urticaria, Allergic rhinitis, Dermatitis, Pruritus, Eczema, Allergic conjunctivitis, Perennial allergic rhinitis, Seasonal allergic rhinitis

Regional status

US
No progress
2018-04-07
EU
Approved
2010-01-01
China
Approved
2023-06-21
Japan
Approved
2016-09-28

Factories producing this API1

Factories registered as producing this API in our sourcing network (RFQ records + product master), sorted by RFQ activity; the snapshot carries no cost or customer data.

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Synthetic routes & intermediates5 routes

Originator routes × 1Optimised (non-patent) × 4Process routes × 0

Routes are ordered originator first, then optimised / process (non-patent) routes; each lists steps, overall yield and the intermediate table (code / CAS / name) — ready for supplier sourcing and RFQ. Rendered by this site from structured data; no third-party route graphics used.

OriginatorRoute 1Steps 3 · Total yield 3.5 g
Synthetic routes & intermediates Route 1
CodeCAS No.Intermediate
BALI-00138385-95-4Available2-(piperidin-4-yl)-1H-benzo[d]imidazole
BALI-002-4-(2-(4,5-dihydrooxazol-2-yl)propan-2-yl)phenethyl 4-methylbenzenesulfonate
BALI-003-2-(2-(4-(2-(4-(1H-benzo[d]imidazol-2-yl)piperidin-1-yl)ethyl)phenyl)propan-2-yl)-4,5-dihydrooxazole
BALI-004-2-(2-(4-(2-(4-(1-(2-ethoxyethyl)-1H-benzo[d]imidazol-2-yl)piperidin-1-yl)ethyl)phenyl)propan-2-yl)-4,5-dihydrooxazole
OptimisedRoute 2Steps 8 · Total yield 1.84 g
Synthetic routes & intermediates Route 2
CodeCAS No.Intermediate
BALI-00595-54-5Availablebenzene-1,2-diamine
BALI-006498-94-2Availablepiperidine-4-carboxylic acid
BALI-00738385-95-4Available2-(piperidin-4-yl)-1H-benzo[d]imidazole
BALI-008953071-73-3Availabletert-butyl 4-(1H-benzo[d]imidazol-2-yl)piperidine-1-carboxylate
BALI-00998139-68-5Available2-ethoxyethyl methanesulfonate
BALI-0101181267-36-6Availabletert-butyl 4-(1-(2-ethoxyethyl)-1H-benzo[d]imidazol-2-yl)piperidine-1-carboxylate
BALI-011110963-63-8Available1-(2-ethoxyethyl)-2-(piperidin-4-yl)-1H-benzo[d]imidazole
BALI-0121181267-34-4Availableethyl 2-methyl-2-(4-(2-((methylsulfonyl)oxy)ethyl)phenyl)propanoate
BALI-013202189-79-5Availableethyl 2-(4-(2-(4-(1-(2-ethoxyethyl)-1H-benzo[d]imidazol-2-yl)piperidin-1-yl)ethyl)phenyl)-2-methylpropanoate
BALI-0144654-39-1Available2-(4-bromophenyl)ethan-1-ol
BALI-01531469-16-6Available((1-ethoxy-2-methylprop-1-en-1-yl)oxy)trimethylsilane
BALI-0161181267-31-1Availableethyl 2-(4-(2-hydroxyethyl)phenyl)-2-methylpropanoate
OptimisedRoute 3Steps 4 · Total yield 7 g
Synthetic routes & intermediates Route 3
CodeCAS No.Intermediate
BALI-011110963-63-8Available1-(2-ethoxyethyl)-2-(piperidin-4-yl)-1H-benzo[d]imidazole
BALI-013202189-79-5Availableethyl 2-(4-(2-(4-(1-(2-ethoxyethyl)-1H-benzo[d]imidazol-2-yl)piperidin-1-yl)ethyl)phenyl)-2-methylpropanoate
BALI-01757625-74-8Availablemethyl 2-methyl-2-phenylpropanoate
BALI-01879-04-9Available2-chloroacetyl chloride
BALI-0191638785-19-9Availablemethyl 2-(4-(2-chloroacetyl)phenyl)-2-methylpropanoate
BALI-0201638785-20-2Availablemethyl 2-(4-(2-(4-(1-(2-ethoxyethyl)-1H-benzo[d]imidazol-2-yl)piperidin-1-yl)acetyl)phenyl)-2-methylpropanoate
OptimisedRoute 4Steps 5 · Total yield 0.466/g
Synthetic routes & intermediates Route 4
CodeCAS No.Intermediate
BALI-0144654-39-1Available2-(4-bromophenyl)ethan-1-ol
BALI-01531469-16-6Available((1-ethoxy-2-methylprop-1-en-1-yl)oxy)trimethylsilane
BALI-0161181267-31-1Availableethyl 2-(4-(2-hydroxyethyl)phenyl)-2-methylpropanoate
BALI-021114369-15-2Available4-bromophenethyl methanesulfonate
BALI-0221126-09-6Availableethyl piperidine-4-carboxylate
BALI-023-ethyl 1-(2-(4-bromophenyl)-2-oxoethyl)piperidine-4-carboxylate fumarate
BALI-02495893-89-3AvailableN1-(2-ethoxyethyl)benzene-1,2-diamine
BALI-0251567835-74-8Available2-(1-(4-bromophenethyl)piperidin-4-yl)-1-(2-ethoxyethyl)-1H-benzo[d]imidazole
OptimisedRoute 5Steps 2 · Total yield /
Synthetic routes & intermediates Route 5
CodeCAS No.Intermediate
BALI-026-2-(2-(4-bromophenyl)propan-2-yl)-4,5-dihydrooxazole
BALI-027-2-(2-(4-(2-bromoethyl)phenyl)propan-2-yl)-4,5-dihydrooxazole
BALI-028-2-(4-(2-(4,5-dihydrooxazol-2-yl)propan-2-yl)phenyl)ethan-1-ol

Frequently asked questions

What are the approved indications of Bilastine?

Approved indications include: Urticaria, Allergic rhinitis, Dermatitis, Pruritus, Eczema, Allergic conjunctivitis, Perennial allergic rhinitis, Seasonal allergic rhinitis.

When does the Bilastine patent expire?

No public expiry year is available for Bilastine yet; this page updates once verified.

How many synthesis routes are recorded for Bilastine?

5 synthesis routes are recorded; the shortest is 2 steps with / total yield. Intermediates in each route carry codes and CAS numbers.

Where can I buy Bilastine intermediates?

20 intermediate CAS of Bilastine are available through the Unibest supply network — see the route tables on this page and request a quote per CAS.

How do I get a quote for Bilastine intermediates?

Open the CAS profile of the target intermediate from this page, or submit an RFQ directly — the CAS enters the matching flow automatically and the supply network responds with quotes.

Source: cross-verified data (structured fields only) · 2026-09-29