Onvansertib
Tier C — Watch / tradeOnvansertib
Targets：PLK1
Indications (approved)：Pancreatic cancer, Renal cell carcinoma, Breast cancer, 三阴性乳腺癌, 炎性乳腺癌, Metastatic breast cancer, Small cell lung cancer, 胰腺导管癌
Regional status
Synthetic routes & intermediates1 routes
Routes are ordered originator first, then optimised / process (non-patent) routes; each lists steps, overall yield and the intermediate table (code / CAS / name) — ready for supplier sourcing and RFQ. Rendered by this site from structured data; no third-party route graphics used.
| Code | CAS No. | Intermediate |
|---|---|---|
| NMS-1286937 | - | - |
| NMS-1286937-001 | 886762-08-9 | 5-bromo-2-(trifluoromethoxy)aniline |
| NMS-1286937-002 | 109-01-3Available | 1-methylpiperazine |
| NMS-1286937-003 | 1034618-02-4 | 5-(4-methylpiperazin-1-yl)-2-(trifluoromethoxy)aniline |
| NMS-1286937-004 | 1034618-00-2 | 1-(5-(4-methylpiperazin-1-yl)-2-(trifluoromethoxy)phenyl)guanidine |
| NMS-1286937-005 | - | (Z)-ethyl 6-((dimethylamino)methylene)-1-(2-hydroxyethyl)-7-oxo-4,5,6,7-tetrahydro-1H-indazole-3-carboxylate |
| NMS-1286937-006 | 1034617-39-4 | ethyl 1-(2-hydroxyethyl)-8-((5-(4-methylpiperazin-1-yl)-2-(trifluoromethoxy)phenyl)amino)-4,5-dihydro-1H-pyrazolo[4,3-h]quinazoline-3-carboxylate |
| NMS-1286937-007 | 1034617-42-9 | potassium 1-(2-hydroxyethyl)-8-((5-(4-methylpiperazin-1-yl)-2-(trifluoromethoxy)phenyl)amino)-4,5-dihydro-1H-pyrazolo[4,3-h]quinazoline-3-carboxylate |
| NMS-1286937-008 | 75574-76-4 | ammonium 1H-benzo[d][1,2,3]triazole-1-carboxylate |
| NMS-1286937-009 | 802541-12-4 | ethyl 2-(3-ethoxy-2-oxocyclohex-3-en-1-yl)-2-oxoacetate |
| NMS-1286937-010 | 802541-15-7 | ethyl 1-(2-hydroxyethyl)-7-oxo-4,5,6,7-tetrahydro-1H-indazole-3-carboxylate |
Frequently asked questions
What are the approved indications of Onvansertib?
Approved indications include: Pancreatic cancer, Renal cell carcinoma, Breast cancer, 三阴性乳腺癌, 炎性乳腺癌, Metastatic breast cancer, Small cell lung cancer, 胰腺导管癌.
When does the Onvansertib patent expire?
No public expiry year is available for Onvansertib yet; this page updates once verified.
How many synthesis routes are recorded for Onvansertib?
1 synthesis routes are recorded; the shortest is 7 steps with 1.32 g total yield. Intermediates in each route carry codes and CAS numbers.
Where can I buy Onvansertib intermediates?
1 intermediate CAS of Onvansertib are available through the Unibest supply network — see the route tables on this page and request a quote per CAS.
How do I get a quote for Onvansertib intermediates?
Open the CAS profile of the target intermediate from this page, or submit an RFQ directly — the CAS enters the matching flow automatically and the supply network responds with quotes.
Source: cross-verified data (structured fields only) · 2026-10-09