Cinacalcet Hydrochloride

Tier B — Position early

Amgen

Originator

2004

First approval

Expiry (public)

$1.97B ▲

Peak sales

Small molecule

Type

Targets：CaSR

Brand：Mimpara, Sensipar/Mimpara, Parareg, Regpara, Sensipar

Indications (approved)：Hypercalcaemia, Secondary hyperparathyroidism, Hyperparathyroidism

Regional status

Withdrawn

China

Approved

2014-06-27

Japan

Approved

2007-10-19

Factories producing this API1

Factories registered as producing this API in our sourcing network (RFQ records + product master), sorted by RFQ activity; the snapshot carries no cost or customer data.

1 producing factories on file — sign in to view the named list (factory details are not shown to guests).

Synthetic routes & intermediates5 routes

Originator routes × 1Optimised (non-patent) × 3Process routes × 1

Routes are ordered originator first, then optimised / process (non-patent) routes; each lists steps, overall yield and the intermediate table (code / CAS / name) — ready for supplier sourcing and RFQ. Rendered by this site from structured data; no third-party route graphics used.

OriginatorRoute 1Steps 5 · Total yield 29.2 kg

CINA-001401-78-5CINA-002107-19-7CINA-00365126-85-4CINA-00478573-45-2CINA-00521172-41-8CINA-0063886-70-2API · Cinacalcet Hydrochloride

Code	CAS No.	Intermediate
CINA-001	401-78-5	1-bromo-3-(trifluoromethyl)benzene
CINA-002	107-19-7 Available	prop-2-yn-1-ol
CINA-003	65126-85-4	3-(3-(trifluoromethyl)phenyl)prop-2-yn-1-ol
CINA-004	78573-45-2	3-(3-(trifluoromethyl)phenyl)propan-1-ol
CINA-005	21172-41-8	3-(3-(trifluoromethyl)phenyl)propanal
CINA-006	3886-70-2	(R)-1-(naphthalen-1-yl)ethan-1-amine

OptimisedRoute 2Steps 5 · Total yield /

CINA-001401-78-5CINA-00478573-45-2CINA-0063886-70-2CINA-007140-88-5CINA-008113048-68-3CINA-009113048-69-4CINA-01082258-76-2API · Cinacalcet Hydrochloride

Code	CAS No.	Intermediate
CINA-001	401-78-5	1-bromo-3-(trifluoromethyl)benzene
CINA-004	78573-45-2	3-(3-(trifluoromethyl)phenyl)propan-1-ol
CINA-006	3886-70-2	(R)-1-(naphthalen-1-yl)ethan-1-amine
CINA-007	140-88-5 Available	ethyl acrylate
CINA-008	113048-68-3	ethyl (E)-3-(3-(trifluoromethyl)phenyl)acrylate
CINA-009	113048-69-4	(E)-3-(3-(trifluoromethyl)phenyl)prop-2-en-1-ol
CINA-010	82258-76-2	1-(3-chloropropyl)-3-(trifluoromethyl)benzene

OptimisedRoute 3Steps 4 · Total yield 25.8 g

CINA-0063886-70-2CINA-011454-89-7CINA-012108-24-7CINA-013—CINA-014585-50-2CINA-0151005450-55-4API · Cinacalcet Hydrochloride

Code	CAS No.	Intermediate
CINA-006	3886-70-2	(R)-1-(naphthalen-1-yl)ethan-1-amine
CINA-011	454-89-7	3-(trifluoromethyl)benzaldehyde
CINA-012	108-24-7	acetic anhydride
CINA-013	-	(E)-3-(3-(trifluoromethyl)phenyl)acrylic acid
CINA-014	585-50-2	3-(3-(trifluoromethyl)phenyl)propanoic acid
CINA-015	1005450-55-4	(R)-N-(1-(naphthalen-1-yl)ethyl)-3-(3-(trifluoromethyl)phenyl)propanamide

OptimisedRoute 5Steps 7 · Total yield 10.2 g

CINA-020941-98-0CINA-02138280-76-1CINA-022126936-03-6CINA-02321172-43-0CINA-0241206633-34-2CINA-0251025064-33-8CINA-0261025064-35-0API · Cinacalcet Hydrochloride

Code	CAS No.	Intermediate
CINA-020	941-98-0	1-(naphthalen-1-yl)ethan-1-one
CINA-021	38280-76-1	(E)-N-methyl-1-(naphthalen-1-yl)ethan-1-imine
CINA-022	126936-03-6	N-methyl-1-(naphthalen-1-yl)ethan-1-amine hydrochloride
CINA-023	21172-43-0	3-(3-(trifluoromethyl)phenyl)propyl methanesulfonate
CINA-024	1206633-34-2	N-methyl-N-(1-(naphthalen-1-yl)ethyl)-3-(3-(trifluoromethyl)phenyl)propan-1-amine
CINA-025	1025064-33-8	N-(1-(naphthalen-1-yl)ethyl)-3-(3-(trifluoromethyl)phenyl)propan-1-amine
CINA-026	1025064-35-0	(R)-N-(1-(naphthalen-1-yl)ethyl)-3-(3-(trifluoromethyl)phenyl)propan-1-amine (2R,3R)-2,3-bis((4-methylbenzoyl)oxy)succinate

ProcessRoute 4Steps 5 · Total yield 371 g

CINA-0063886-70-2CINA-014585-50-2CINA-0151005450-55-4CINA-01698-16-8CINA-017107-13-1CINA-01827916-89-8CINA-019199803-47-9API · Cinacalcet Hydrochloride

Code	CAS No.	Intermediate
CINA-006	3886-70-2	(R)-1-(naphthalen-1-yl)ethan-1-amine
CINA-014	585-50-2	3-(3-(trifluoromethyl)phenyl)propanoic acid
CINA-015	1005450-55-4	(R)-N-(1-(naphthalen-1-yl)ethyl)-3-(3-(trifluoromethyl)phenyl)propanamide
CINA-016	98-16-8	3-(trifluoromethyl)aniline
CINA-017	107-13-1 Available	acrylonitrile
CINA-018	27916-89-8	2-chloro-3-(3-(trifluoromethyl)phenyl)propanenitrile
CINA-019	199803-47-9	2-chloro-3-(3-(trifluoromethyl)phenyl)propanoic acid

Frequently asked questions

What are the approved indications of Cinacalcet Hydrochloride?

Approved indications include: Hypercalcaemia, Secondary hyperparathyroidism, Hyperparathyroidism.

When does the Cinacalcet Hydrochloride patent expire?

No public expiry year is available for Cinacalcet Hydrochloride yet; this page updates once verified.

How many synthesis routes are recorded for Cinacalcet Hydrochloride?

5 synthesis routes are recorded; the shortest is 4 steps with 25.8 g total yield. Intermediates in each route carry codes and CAS numbers.

Where can I buy Cinacalcet Hydrochloride intermediates?

3 intermediate CAS of Cinacalcet Hydrochloride are available through the Unibest supply network — see the route tables on this page and request a quote per CAS.

How do I get a quote for Cinacalcet Hydrochloride intermediates?

Open the CAS profile of the target intermediate from this page, or submit an RFQ directly — the CAS enters the matching flow automatically and the supply network responds with quotes.

Source: cross-verified data (structured fields only) · 2026-09-29