Plinabulin
Tier C — Watch / tradePlinabulin
Targets：GEF-H1, Tubulin
Indications (approved)：Non-small cell lung cancer, Neutropenia, Multiple myeloma, Lung cancer, Small cell lung cancer, Merkel细胞癌, Bladder cancer, Melanoma
Regional status
Synthetic routes & intermediates2 routes
Routes are ordered originator first, then optimised / process (non-patent) routes; each lists steps, overall yield and the intermediate table (code / CAS / name) — ready for supplier sourcing and RFQ. Rendered by this site from structured data; no third-party route graphics used.
| Code | CAS No. | Intermediate |
|---|---|---|
| PLIN-001 | 3027-05-2 | 1,4-diacetylpiperazine-2,5-dione |
| PLIN-002 | 100-52-7Available | benzaldehyde |
| PLIN-003 | 30166-30-4 | (Z)-1-acetyl-3-benzylidenepiperazine-2,5-dione |
| PLIN-004 | 714273-83-3 | 5-(tert-butyl)-1H-imidazole-4-carbaldehyde |
| Code | CAS No. | Intermediate |
|---|---|---|
| PLIN-001 | 3027-05-2 | 1,4-diacetylpiperazine-2,5-dione |
| PLIN-002 | 100-52-7Available | benzaldehyde |
| PLIN-004 | 714273-83-3 | 5-(tert-butyl)-1H-imidazole-4-carbaldehyde |
| PLIN-005 | 17094-34-7 | ethyl 4,4-dimethyl-3-oxopentanoate |
| PLIN-006 | 29509-07-7 | ethyl 2-chloro-4,4-dimethyl-3-oxopentanoate |
| PLIN-007 | 75-12-7 | formamide |
| PLIN-008 | 51721-21-2 | ethyl 5-(tert-butyl)-1H-imidazole-4-carboxylate |
| PLIN-009 | 51721-22-3 | (5-(tert-butyl)-1H-imidazol-4-yl)methanol |
| PLIN-010 | 714273-84-4 | (Z)-1-acetyl-3-((5-(tert-butyl)-1H-imidazol-4-yl)methylene)piperazine-2,5-dione |
Frequently asked questions
What are the approved indications of Plinabulin?
Approved indications include: Non-small cell lung cancer, Neutropenia, Multiple myeloma, Lung cancer, Small cell lung cancer, Merkel细胞癌, Bladder cancer, Melanoma.
When does the Plinabulin patent expire?
No public expiry year is available for Plinabulin yet; this page updates once verified.
How many synthesis routes are recorded for Plinabulin?
2 synthesis routes are recorded; the shortest is 2 steps with 0.80 mg (Plinabulin) total yield. Intermediates in each route carry codes and CAS numbers.
Where can I buy Plinabulin intermediates?
1 intermediate CAS of Plinabulin are available through the Unibest supply network — see the route tables on this page and request a quote per CAS.
How do I get a quote for Plinabulin intermediates?
Open the CAS profile of the target intermediate from this page, or submit an RFQ directly — the CAS enters the matching flow automatically and the supply network responds with quotes.
Source: cross-verified data (structured fields only) · 2026-10-10