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Ertapenem Sodium

Tier C — Watch / trade

Ertapenem Sodium

Merck & Co Inc
Originator
2001
First approval
-
Expiry (public)
$0.6B ▲
Peak sales
Small molecule
Type

Targets:PBPs

Brand:Invanz

Indications (approved):Complicated skin and skin structure infection, Intra-abdominal infection, Bacteraemia, Urinary tract infection, Community-acquired pneumonia, Pyelonephritis, Bacterial infection, Gram-negative bacterial infection

Regional status

US
Approved
2001-11-21
EU
Approved
2002-04-18
China
Approved
2005-09-12
Japan
-

Synthetic routes & intermediates4 routes

Originator routes × 1Optimised (non-patent) × 2Process routes × 1

Routes are ordered originator first, then optimised / process (non-patent) routes; each lists steps, overall yield and the intermediate table (code / CAS / name) — ready for supplier sourcing and RFQ. Rendered by this site from structured data; no third-party route graphics used.

OriginatorRoute 1Steps 8 · Total yield /
ERTA-001121-92-6ERTA-002106-95-6ERTA-003779-80-6ERTA-00456768-05-9ERTA-005145352-54-1ERTA-006153774-27-7ERTA-0071355671-99-6ERTA-008133808-94-3ERTA-009153774-28-8ERTA-0102033-24-1ERTA-011107560-22-5ERTA-012117893-97-7ERTA-0132524-64-3API · Ertapenem Sodium
CodeCAS No.Intermediate
ERTA-001121-92-63-nitrobenzoic acid
ERTA-002106-95-6Available3-bromoprop-1-ene
ERTA-003779-80-6allyl 3-nitrobenzoate
ERTA-00456768-05-9allyl 3-aminobenzoate
ERTA-005145352-54-1(2S,4S)-4-(acetylthio)-1-((allyloxy)carbonyl)pyrrolidine-2-carboxylic acid
ERTA-006153774-27-7allyl (2S,4S)-4-(acetylthio)-2-((3-((allyloxy)carbonyl)phenyl)carbamoyl)pyrrolidine-1-carboxylate
ERTA-0071355671-99-6allyl (2S,4S)-2-((3-((allyloxy)carbonyl)phenyl)carbamoyl)-4-mercaptopyrrolidine-1-carboxylate
ERTA-008133808-94-3allyl (4R,5R,6S)-3-((diphenoxyphosphoryl)oxy)-6-((R)-1-hydroxyethyl)-4-methyl-7-oxo-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylate
ERTA-009153774-28-8allyl (4R,5S,6S)-3-(((3S,5S)-1-((allyloxy)carbonyl)-5-((3-((allyloxy)carbonyl)phenyl)carbamoyl)pyrrolidin-3-yl)thio)-6-((R)-1-hydroxyethyl)-4-methyl-7-oxo-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylate
ERTA-0102033-24-12,2-dimethyl-1,3-dioxane-4,6-dione
ERTA-011107560-22-5allyl (R)-2-diazo-4-((2R,3S)-3-((R)-1-hydroxyethyl)-4-oxoazetidin-2-yl)-3-oxopentanoate
ERTA-012117893-97-7allyl (4R,5R,6S)-6-((R)-1-hydroxyethyl)-4-methyl-3,7-dioxo-1-azabicyclo[3.2.0]heptane-2-carboxylate
ERTA-0132524-64-3diphenyl phosphorochloridate
OptimisedRoute 2Steps 4 · Total yield 26.4 g
ERTA-01490822-24-5ERTA-015104873-15-6ERTA-01614254-41-2ERTA-0171349768-81-5ERTA-018202467-69-4ERTA-019202467-70-7API · Ertapenem Sodium
CodeCAS No.Intermediate
ERTA-01490822-24-5(R)-2-diazo-4-((2R,3S)-3-((R)-1-hydroxyethyl)-4-oxoazetidin-2-yl)-3-oxopentanoic 4-nitrobenzoic anhydride
ERTA-015104873-15-6(4R,5R,6S)-6-((R)-1-hydroxyethyl)-4-methyl-3,7-dioxo-1-azabicyclo[3.2.0]heptane-2-carboxylic 4-nitrobenzoic anhydride
ERTA-01614254-41-2bis(2,4-dichlorophenyl) phosphorochloridate
ERTA-0171349768-81-5(4R,5R,6S)-3-((bis(2,4-dichlorophenoxy)phosphoryl)oxy)-6-((R)-1-hydroxyethyl)-4-methyl-7-oxo-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylic 4-nitrobenzoic anhydride
ERTA-018202467-69-43-((2S,4S)-4-mercapto-1-(((4-nitrobenzyl)oxy)carbonyl)pyrrolidine-2-carboxamido)benzoic acid
ERTA-019202467-70-73-((2S,4S)-4-(((4R,5S,6S)-6-((R)-1-hydroxyethyl)-4-methyl-2-(((4-nitrobenzyl)oxy)carbonyl)-7-oxo-1-azabicyclo[3.2.0]hept-2-en-3-yl)thio)-1-(((4-nitrobenzyl)oxy)carbonyl)pyrrolidine-2-carboxamido)benzoic acid
OptimisedRoute 3Steps 2 · Total yield /
ERTA-02090776-59-3ERTA-021219909-83-8ERTA-022866186-69-8API · Ertapenem Sodium
CodeCAS No.Intermediate
ERTA-02090776-59-34-nitrobenzyl (4R,5R,6S)-3-((diphenoxyphosphoryl)oxy)-6-((R)-1-hydroxyethyl)-4-methyl-7-oxo-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylate
ERTA-021219909-83-83-((2S,4S)-4-mercaptopyrrolidine-2-carboxamido)benzoic acid hydrochloride
ERTA-022866186-69-81,1,3,3-tetramethylguanidine 3-((2S,4S)-4-(((4R,5S,6S)-6-((R)-1-hydroxyethyl)-4-methyl-2-(((4-nitrobenzyl)oxy)carbonyl)-7-oxo-1-azabicyclo[3.2.0]hept-2-en-3-yl)thio)pyrrolidine-2-carboxamido)benzoate
ProcessRoute 4Steps 5 · Total yield 1.88 kg
ERTA-023—ERTA-024—ERTA-025—ERTA-026—ERTA-02799-05-8ERTA-028—ERTA-029219909-83-8API · Ertapenem Sodium
CodeCAS No.Intermediate
ERTA-023-(2S,4R)-1-(diisopropoxyphosphoryl)-4-hydroxypyrrolidine-2-carboxylic acid
ERTA-024-(2S,4R)-1-(diisopropoxyphosphoryl)-4-hydroxypyrrolidine-2-carboxylic diphenylphosphinic anhydride
ERTA-025-(2S,4R)-1-(diisopropoxyphosphoryl)-4-((methylsulfonyl)oxy)pyrrolidine-2-carboxylic diphenylphosphinic anhydride
ERTA-026-diisopropyl ((1S,4S)-3-oxo-2-thia-5-azabicyclo[2.2.1]heptan-5-yl)phosphonate
ERTA-02799-05-83-aminobenzoic acid
ERTA-028-3-((2S,4S)-1-(diisopropoxyphosphoryl)-4-mercaptopyrrolidine-2-carboxamido)benzoic acid
ERTA-029219909-83-83-((2S,4S)-4-mercaptopyrrolidine-2-carboxamido)benzoic acid hydrochloride

Frequently asked questions

What are the approved indications of Ertapenem Sodium?

Approved indications include: Complicated skin and skin structure infection, Intra-abdominal infection, Bacteraemia, Urinary tract infection, Community-acquired pneumonia, Pyelonephritis, Bacterial infection, Gram-negative bacterial infection.

When does the Ertapenem Sodium patent expire?

No public expiry year is available for Ertapenem Sodium yet; this page updates once verified.

How many synthesis routes are recorded for Ertapenem Sodium?

4 synthesis routes are recorded; the shortest is 2 steps with / total yield. Intermediates in each route carry codes and CAS numbers.

Where can I buy Ertapenem Sodium intermediates?

1 intermediate CAS of Ertapenem Sodium are available through the Unibest supply network — see the route tables on this page and request a quote per CAS.

How do I get a quote for Ertapenem Sodium intermediates?

Open the CAS profile of the target intermediate from this page, or submit an RFQ directly — the CAS enters the matching flow automatically and the supply network responds with quotes.

Source: cross-verified data (structured fields only) · 2026-09-29