Memantine Hydrochloride/Donepezil Hydrochloride
Tier C — Watch / tradeMemantine Hydrochloride/Donepezil Hydrochloride
Targets：NMDAR, AChE
Brand：Arimenda, Namzaric
Indications (approved)：Alzheimer's disease
Regional status
Factories producing this API11
Factories registered as producing this API in our sourcing network (RFQ records + product master), sorted by RFQ activity; the snapshot carries no cost or customer data.
11 producing factories on file — sign in to view the named list (factory details are not shown to guests).
Sign in to view factories →Synthetic routes & intermediates10 routes
Routes are ordered originator first, then optimised / process (non-patent) routes; each lists steps, overall yield and the intermediate table (code / CAS / name) — ready for supplier sourcing and RFQ. Rendered by this site from structured data; no third-party route graphics used.
| Code | CAS No. | Intermediate |
|---|---|---|
| MEMA-001 | 702-79-4 | (1r,3r,5s,7s)-1,3-dimethyladamantane |
| MEMA-002 | 941-37-7 | (1r,3R,5S,7r)-1-bromo-3,5-dimethyladamantane |
| MEMA-003 | 19982-07-1 | N-((1r,3R,5S,7r)-3,5-dimethyladamantan-1-yl)acetamide |
| Code | CAS No. | Intermediate |
|---|---|---|
| DONE-001 | 1126-09-6Available | ethyl piperidine-4-carboxylate |
| DONE-002 | 100-44-7 | (chloromethyl)benzene |
| DONE-003 | 24228-40-8 | ethyl 1-benzylpiperidine-4-carboxylate |
| DONE-004 | 67686-01-5 | (1-benzylpiperidin-4-yl)methanol |
| DONE-005 | 22065-85-6 | 1-benzylpiperidine-4-carbaldehyde |
| DONE-006 | 2107-69-9 | 5,6-dimethoxy-2,3-dihydro-1H-inden-1-one |
| DONE-007 | 120014-07-5 | (E)-2-((1-benzylpiperidin-4-yl)methylene)-5,6-dimethoxy-2,3-dihydro-1H-inden-1-one |
| Code | CAS No. | Intermediate |
|---|---|---|
| MEMA-002 | 941-37-7 | (1r,3R,5S,7r)-1-bromo-3,5-dimethyladamantane |
| Code | CAS No. | Intermediate |
|---|---|---|
| MEMA-004 | 707-37-9 | (1r,3R,5S,7r)-3,5-dimethyladamantan-1-ol |
| MEMA-005 | 707-36-8 | (1r,3R,5S,7r)-1-chloro-3,5-dimethyladamantane |
| MEMA-006 | 351329-88-9 | N-((1r,3R,5S,7r)-3,5-dimethyladamantan-1-yl)formamide |
| MEMA-001 | 702-79-4 | (1r,3r,5s,7s)-1,3-dimethyladamantane |
| Code | CAS No. | Intermediate |
|---|---|---|
| MEMA-001 | 702-79-4 | (1r,3r,5s,7s)-1,3-dimethyladamantane |
| MEMA-003 | 19982-07-1 | N-((1r,3R,5S,7r)-3,5-dimethyladamantan-1-yl)acetamide |
| Code | CAS No. | Intermediate |
|---|---|---|
| MEMA-002 | 941-37-7 | (1r,3R,5S,7r)-1-bromo-3,5-dimethyladamantane |
| MEMA-007 | 1074-82-4 | potassium 1,3-dioxoisoindolin-2-ide |
| MEMA-008 | 1204184-74-6 | 2-((1r,3R,5S,7r)-3,5-dimethyladamantan-1-yl)isoindoline-1,3-dione |
| Code | CAS No. | Intermediate |
|---|---|---|
| DONE-006 | 2107-69-9 | 5,6-dimethoxy-2,3-dihydro-1H-inden-1-one |
| DONE-009 | 872-85-5 | isonicotinaldehyde |
| DONE-010 | 4803-74-1 | (E)-5,6-dimethoxy-2-(pyridin-4-ylmethylene)-2,3-dihydro-1H-inden-1-one |
| DONE-011 | 4803-57-0 | 5,6-dimethoxy-2-(pyridin-4-ylmethyl)-2,3-dihydro-1H-inden-1-one |
| DONE-012 | 120014-30-4 | 5,6-dimethoxy-2-(piperidin-4-ylmethyl)-2,3-dihydro-1H-inden-1-one |
| DONE-013 | 100-39-0 | (bromomethyl)benzene |
| Code | CAS No. | Intermediate |
|---|---|---|
| DONE-005 | 22065-85-6 | 1-benzylpiperidine-4-carbaldehyde |
| DONE-006 | 2107-69-9 | 5,6-dimethoxy-2,3-dihydro-1H-inden-1-one |
| DONE-007 | 120014-07-5 | (E)-2-((1-benzylpiperidin-4-yl)methylene)-5,6-dimethoxy-2,3-dihydro-1H-inden-1-one |
| DONE-014 | 3612-20-2 | 1-benzylpiperidin-4-one |
| DONE-015 | 105-39-5 | ethyl 2-chloroacetate |
| DONE-016 | 943969-54-8 | ethyl 6-benzyl-1-oxa-6-azaspiro[2.5]octane-2-carboxylate |
| DONE-017 | 943969-55-9 | sodium 6-benzyl-1-oxa-6-azaspiro[2.5]octane-2-carboxylate |
| Code | CAS No. | Intermediate |
|---|---|---|
| DONE-002 | 100-44-7 | (chloromethyl)benzene |
| DONE-009 | 872-85-5 | isonicotinaldehyde |
| DONE-012 | 120014-30-4 | 5,6-dimethoxy-2-(piperidin-4-ylmethyl)-2,3-dihydro-1H-inden-1-one |
| DONE-018 | 2747-08-2 | 2-bromo-5,6-dimethoxy-2,3-dihydro-1H-inden-1-one |
| DONE-019 | - | 5,6-dimethoxy-3'-(pyridin-4-yl)spiro[indene-2,2'-oxiran]-1(3H)-one |
| Code | CAS No. | Intermediate |
|---|---|---|
| DONE-006 | 2107-69-9 | 5,6-dimethoxy-2,3-dihydro-1H-inden-1-one |
| DONE-009 | 872-85-5 | isonicotinaldehyde |
| DONE-013 | 100-39-0 | (bromomethyl)benzene |
| DONE-020 | 223397-73-7 | 1-benzyl-4-formylpyridin-1-ium bromide |
| DONE-021 | 923571-17-9 | (E)-1-benzyl-4-((5,6-dimethoxy-1-oxo-1H-inden-2(3H)-ylidene)methyl)pyridin-1-ium bromide |
| DONE-022 | 923571-20-4 | (E)-2-((1-benzyl-1,2,3,6-tetrahydropyridin-4-yl)methylene)-5,6-dimethoxy-2,3-dihydro-1H-inden-1-one |
Frequently asked questions
What are the approved indications of Memantine Hydrochloride/Donepezil Hydrochloride?
Approved indications include: Alzheimer's disease.
When does the Memantine Hydrochloride/Donepezil Hydrochloride patent expire?
No public expiry year is available for Memantine Hydrochloride/Donepezil Hydrochloride yet; this page updates once verified.
How many synthesis routes are recorded for Memantine Hydrochloride/Donepezil Hydrochloride?
10 synthesis routes are recorded; the shortest is 2 steps with 61 g total yield. Intermediates in each route carry codes and CAS numbers.
Where can I buy Memantine Hydrochloride/Donepezil Hydrochloride intermediates?
1 intermediate CAS of Memantine Hydrochloride/Donepezil Hydrochloride are available through the Unibest supply network — see the route tables on this page and request a quote per CAS.
How do I get a quote for Memantine Hydrochloride/Donepezil Hydrochloride intermediates?
Open the CAS profile of the target intermediate from this page, or submit an RFQ directly — the CAS enters the matching flow automatically and the supply network responds with quotes.
Source: cross-verified data (structured fields only) · 2026-09-29