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Diclofenac Sodium
Tier C — Watch / tradeDiclofenac Sodium
Novartis
Originator
1974
First approval
-
Expiry (public)
$0.2B ▲
Peak sales
Small molecule
Type
Targets：COXs
Brand：ProSorb-D, Abitren, Rectos, Dicloreum CR, Dimethaid-D, Voltarol Ophtha, Dicloabak, Voltarène, Voltaren gel, Zorvolex, Pennsaid, Feitas Z, Instanac TPM, Naboal, Pennsaid Gel, Pennsaid Viscous Solution, Voltaren Ofta, Voltaren Tape L, Dyloject, Diclofelite CR, Voveran, Dynapar, DicloFoam, Voltaren, Voltaren Tape, Doroxan, Voltaren lotion, Voltarol, Pennsaid Plus, Dealgic
Indications (approved)：Osteoarthritis, Rheumatoid arthritis, Ankylosing spondylitis
Regional status
US
Phase II
2009-09-01
EU
Approved
1974-01-11
China
Approved
1988-01-01
Japan
Approved
1974-02-01
Factories producing this API1
Factories registered as producing this API in our sourcing network (RFQ records + product master), sorted by RFQ activity; the snapshot carries no cost or customer data.
1 producing factories on file — sign in to view the named list (factory details are not shown to guests).
Sign in to view factories →Synthetic routes & intermediates10 routes
Originator routes × 0Optimised (non-patent) × 10Process routes × 0
Routes are ordered originator first, then optimised / process (non-patent) routes; each lists steps, overall yield and the intermediate table (code / CAS / name) — ready for supplier sourcing and RFQ. Rendered by this site from structured data; no third-party route graphics used.
OptimisedRoute 1Steps 6 · Total yield /
(I)91353-2-a59473-45-9(II)91353-2-a106130-20-5(III)91353-2-a106112-65-6(IV)91353-2-a106112-66-7(V)91353-2-a608-31-1(VI)91353-2-a106112-69-0(VII)91353-2-a106112-68-9(VIII)91353-2-a—API · Diclofenac Sodium
| Code | CAS No. | Intermediate |
|---|---|---|
| (I)91353-2-a | 59473-45-9 | 1-(Chloromethyl)-2-iodobenzene |
| (II)91353-2-a | 106130-20-5 | 2-(2-Iodophenyl)[14C]acetonitrile |
| (III)91353-2-a | 106112-65-6 | 2-(2-Iodophenyl)[14C]acetic acid |
| (IV)91353-2-a | 106112-66-7 | 2-(2-Iodophenyl)[14C]acetic acid methyl ester |
| (V)91353-2-a | 608-31-1 | 2,6-Dichloroaniline |
| (VI)91353-2-a | 106112-69-0 | 2-[2-(2,6-Dichlorophenylamino)phenyl][14C]acetic acid methyl ester |
| (VII)91353-2-a | 106112-68-9 | 2-[2-(2,6-Dichlorophenylamino)phenyl][14C]acetic acid |
| (VIII)91353-2-a | - | 2-[2-(2,6-Dichlorophenylamino)phenyl][14C]acetic acid sodium salt |
OptimisedRoute 2Steps 5 · Total yield /
(I)91353-3-a15307-93-4(II)91353-3-a35928-65-5(III)91353-3-a83281-93-0(IV)91353-3-a83281-96-3(IX)91353-3-a83281-95-2(V)91353-3-a83281-94-1(VI)91353-3-a—(VII)91353-3-a15362-40-0(VIII)91353-3-a15307-86-5API · Diclofenac Sodium
| Code | CAS No. | Intermediate |
|---|---|---|
| (I)91353-3-a | 15307-93-4 | 2,6-Dichloro-N-phenylphenylamine |
| (II)91353-3-a | 35928-65-5 | 2-(Methylsulfanyl)acetyl chloride |
| (III)91353-3-a | 83281-93-0 | N-(2,6-Dichlorophenyl)-2-(methylsulfanyl)-N-phenylacetamide |
| (IV)91353-3-a | 83281-96-3 | N-(2,6-Dichlorophenyl)-2-(methylsulfinyl)-N-phenylacetamide |
| (IX)91353-3-a | 83281-95-2 | 2-[2-(2,6-Dichlorophenylamino)phenyl]-2-(methylsulfanyl)acetic acid |
| (V)91353-3-a | 83281-94-1 | 1-(2,6-Dichlorophenyl)-3-(methylsulfanyl)-2,3-dihydro-1H-indol-2-one |
| (VI)91353-3-a | - | 2-Chloro-N-(2,6-dichlorophenyl)-2-(methylsulfanyl)-N-phenylacetamide |
| (VII)91353-3-a | 15362-40-0 | 1-(2,6-Dichlorophenyl)-2,3-dihydro-1H-indol-2-one |
| (VIII)91353-3-a | 15307-86-5 | 2-[2-(2,6-Dichlorophenylamino)phenyl]acetic acid |
OptimisedRoute 3Steps 4 · Total yield /
(I)91353-4-a608-31-1(II)91353-4-a103-80-0(III)91353-4-a304884-75-1(IV)91353-4-a1443460-18-1(V)91353-4-a15362-40-0(VI)91353-4-a15308-01-7API · Diclofenac Sodium
| Code | CAS No. | Intermediate |
|---|---|---|
| (I)91353-4-a | 608-31-1 | 2,6-Dichloroaniline |
| (II)91353-4-a | 103-80-0 | 2-Phenylacetyl chloride |
| (III)91353-4-a | 304884-75-1 | N-(2,6-Dichlorophenyl)-2-phenylacetamide |
| (IV)91353-4-a | 1443460-18-1 | N-Chloro-N-(2,6-dichlorophenyl)-2-phenylacetamide |
| (V)91353-4-a | 15362-40-0 | 1-(2,6-Dichlorophenyl)-2,3-dihydro-1H-indol-2-one |
| (VI)91353-4-a | 15308-01-7 | 2-Chloro-N-(2,6-dichlorophenyl)-N-phenylacetamide |
OptimisedRoute 4Steps 2 · Total yield /
(I)91353-5-a608-31-1(IIa)91353-5-a57486-69-8(IIb)91353-5-a57486-68-7(III)91353-5-a15307-78-5API · Diclofenac Sodium
| Code | CAS No. | Intermediate |
|---|---|---|
| (I)91353-5-a | 608-31-1 | 2,6-Dichloroaniline |
| (IIa)91353-5-a | 57486-69-8 | Methyl (2-bromophenyl)acetate |
| (IIb)91353-5-a | 57486-68-7 | Methyl (2-chlorophenyl)acetate |
| (III)91353-5-a | 15307-78-5 | 2-[2-(2,6-Dichlorophenylamino)phenyl]acetic acid methyl ester |
OptimisedRoute 5Steps 3 · Total yield /
(Ia)91353-6-a611-19-8(Ib)91353-6-a611-17-6(II)91353-6-a64-18-6(III)91353-6-a2444-36-2(IV)91353-6-a95-49-8(V)91353-6-a608-31-1(VI)91353-6-a15307-86-5API · Diclofenac Sodium
| Code | CAS No. | Intermediate |
|---|---|---|
| (Ia)91353-6-a | 611-19-8 | 2-Chlorobenzyl chloride |
| (Ib)91353-6-a | 611-17-6 | 1-(Bromomethyl)-2-chlorobenzene |
| (II)91353-6-a | 64-18-6 | Formic acid |
| (III)91353-6-a | 2444-36-2 | (2-Chlorophenyl)acetic acid |
| (IV)91353-6-a | 95-49-8 | 1-Chloranyl-2-methylbenzene |
| (V)91353-6-a | 608-31-1 | 2,6-Dichloroaniline |
| (VI)91353-6-a | 15307-86-5 | 2-[2-(2,6-Dichlorophenylamino)phenyl]acetic acid |
OptimisedRoute 6Steps 6 · Total yield /
(I)91353-7-a101-41-7(II)91353-7-a30095-98-8(III)91353-7-a35613-44-6(IV)91353-7-a3559-26-0(V)91353-7-a87-65-0(VI)91353-7-a2270982-77-7(VII)91353-7-a2270982-78-8API · Diclofenac Sodium
| Code | CAS No. | Intermediate |
|---|---|---|
| (I)91353-7-a | 101-41-7 | 2-Phenylacetic acid methyl ester |
| (II)91353-7-a | 30095-98-8 | Methyl (2-nitrophenyl)acetate |
| (III)91353-7-a | 35613-44-6 | Methyl (2-aminophenyl)acetate |
| (IV)91353-7-a | 3559-26-0 | Methyl (2-benzamidophenyl)acetate |
| (V)91353-7-a | 87-65-0 | 2,6-Dichlorophenol |
| (VI)91353-7-a | 2270982-77-7 | Methyl (2-[(E)-[(2,6-dichlorophenoxy)(phenyl)methylidene]amino]phenyl)acetate |
| (VII)91353-7-a | 2270982-78-8 | Methyl [2-[benzoyl(2,6-dichlorophenyl)amino]phenyl]acetate |
OptimisedRoute 7Steps 3 · Total yield /
(I)91353-8-a3342-78-7(II)91353-8-a35613-44-6(III)91353-8-a2376804-75-8(IV)91353-8-a87-65-0(V)91353-8-a15307-86-5API · Diclofenac Sodium
| Code | CAS No. | Intermediate |
|---|---|---|
| (I)91353-8-a | 3342-78-7 | (2-Aminophenyl)acetic acid |
| (II)91353-8-a | 35613-44-6 | Methyl (2-aminophenyl)acetate |
| (III)91353-8-a | 2376804-75-8 | Methyl [2-(2-bromopropanamido)phenyl]acetate |
| (IV)91353-8-a | 87-65-0 | 2,6-Dichlorophenol |
| (V)91353-8-a | 15307-86-5 | 2-[2-(2,6-Dichlorophenylamino)phenyl]acetic acid |
OptimisedRoute 8Steps 5 · Total yield /
(I)91353-9-a62-53-3(II)91353-9-a79-04-9(III)91353-9-a587-65-5(IV)91353-9-a87-65-0(V)91353-9-a15307-93-4(VI)91353-9-a15308-01-7(VII)91353-9-a15362-40-0API · Diclofenac Sodium
| Code | CAS No. | Intermediate |
|---|---|---|
| (I)91353-9-a | 62-53-3Available | Aminobenzene |
| (II)91353-9-a | 79-04-9Available | 2-Chloranylethanoyl chloride |
| (III)91353-9-a | 587-65-5 | 2-Chloro-N-phenylacetamide |
| (IV)91353-9-a | 87-65-0 | 2,6-Dichlorophenol |
| (V)91353-9-a | 15307-93-4 | 2,6-Dichloro-N-phenylphenylamine |
| (VI)91353-9-a | 15308-01-7 | 2-Chloro-N-(2,6-dichlorophenyl)-N-phenylacetamide |
| (VII)91353-9-a | 15362-40-0 | 1-(2,6-Dichlorophenyl)-2,3-dihydro-1H-indol-2-one |
OptimisedRoute 9Steps 4 · Total yield /
(I)91353-10-a101-41-7(II)91353-10-a30095-98-8(III)91353-10-a35613-44-6(IV)91353-10-a3336-41-2(V)91353-10-a87-65-0(VI)91353-10-a105-39-5(VII)91353-10-a40311-72-6(VIII)91353-10-a79-04-9API · Diclofenac Sodium
| Code | CAS No. | Intermediate |
|---|---|---|
| (I)91353-10-a | 101-41-7 | 2-Phenylacetic acid methyl ester |
| (II)91353-10-a | 30095-98-8 | Methyl (2-nitrophenyl)acetate |
| (III)91353-10-a | 35613-44-6 | Methyl (2-aminophenyl)acetate |
| (IV)91353-10-a | 3336-41-2 | 3,5-Dichloro-4-hydroxybenzoic acid |
| (V)91353-10-a | 87-65-0 | 2,6-Dichlorophenol |
| (VI)91353-10-a | 105-39-5 | 2-Chloroacetic acid ethyl ester |
| (VII)91353-10-a | 40311-72-6 | Ethyl (2,6-dichlorophenoxy)acetate |
| (VIII)91353-10-a | 79-04-9Available | 2-Chloranylethanoyl chloride |
OptimisedRoute 10Steps 6 · Total yield /
(I)91353-11-a62-53-3(II)91353-11-a79-11-8(III)91353-11-a587-65-5(IV)91353-11-a87-65-0(V)91353-11-a146607-19-4(VI)91353-11-a210979-27-4(VII)91353-11-a15308-01-7(VIII)91353-11-a15362-40-0API · Diclofenac Sodium
| Code | CAS No. | Intermediate |
|---|---|---|
| (I)91353-11-a | 62-53-3Available | Aminobenzene |
| (II)91353-11-a | 79-11-8 | 2-Chloroacetic acid |
| (III)91353-11-a | 587-65-5 | 2-Chloro-N-phenylacetamide |
| (IV)91353-11-a | 87-65-0 | 2,6-Dichlorophenol |
| (V)91353-11-a | 146607-19-4 | 2-(2,6-Dichlorophenoxy)-N-phenylacetamide |
| (VI)91353-11-a | 210979-27-4 | N-(2,6-Dichlorophenyl)-2-hydroxy-N-phenylacetamide |
| (VII)91353-11-a | 15308-01-7 | 2-Chloro-N-(2,6-dichlorophenyl)-N-phenylacetamide |
| (VIII)91353-11-a | 15362-40-0 | 1-(2,6-Dichlorophenyl)-2,3-dihydro-1H-indol-2-one |
Frequently asked questions
What are the approved indications of Diclofenac Sodium?
Approved indications include: Osteoarthritis, Rheumatoid arthritis, Ankylosing spondylitis.
When does the Diclofenac Sodium patent expire?
No public expiry year is available for Diclofenac Sodium yet; this page updates once verified.
How many synthesis routes are recorded for Diclofenac Sodium?
10 synthesis routes are recorded; the shortest is 2 steps with / total yield. Intermediates in each route carry codes and CAS numbers.
Where can I buy Diclofenac Sodium intermediates?
2 intermediate CAS of Diclofenac Sodium are available through the Unibest supply network — see the route tables on this page and request a quote per CAS.
How do I get a quote for Diclofenac Sodium intermediates?
Open the CAS profile of the target intermediate from this page, or submit an RFQ directly — the CAS enters the matching flow automatically and the supply network responds with quotes.
Source: cross-verified data (structured fields only) · 2026-09-29