Donepezil Hydrochloride

Tier B — Position early

Eisai Co., Ltd.

Originator

1996

First approval

Expiry (public)

$4.35B ▲

Peak sales

Small molecule

Type

Targets：AChE

Brand：Eranz, Aricept D, ADLARITY, Memac, Aricept Evess, Aricept, Memorit, Aricept ODT

Indications (approved)：Lewy body dementia, Alzheimer's disease, Dementia

Regional status

Approved

1996-11-25

Approved

2009-12-22

China

Approved

2001-01-01

Japan

Approved

1999-10-08

Synthetic routes & intermediates5 routes

Originator routes × 1Optimised (non-patent) × 4Process routes × 0

Routes are ordered originator first, then optimised / process (non-patent) routes; each lists steps, overall yield and the intermediate table (code / CAS / name) — ready for supplier sourcing and RFQ. Rendered by this site from structured data; no third-party route graphics used.

OriginatorRoute 1Steps 5 · Total yield 0.36 g

DONE-0011126-09-6DONE-002100-44-7DONE-00324228-40-8DONE-00467686-01-5DONE-00522065-85-6DONE-0062107-69-9DONE-007120014-07-5API · Donepezil Hydrochloride

Code	CAS No.	Intermediate
DONE-001	1126-09-6 Available	ethyl piperidine-4-carboxylate
DONE-002	100-44-7	(chloromethyl)benzene
DONE-003	24228-40-8	ethyl 1-benzylpiperidine-4-carboxylate
DONE-004	67686-01-5	(1-benzylpiperidin-4-yl)methanol
DONE-005	22065-85-6	1-benzylpiperidine-4-carbaldehyde
DONE-006	2107-69-9	5,6-dimethoxy-2,3-dihydro-1H-inden-1-one
DONE-007	120014-07-5	(E)-2-((1-benzylpiperidin-4-yl)methylene)-5,6-dimethoxy-2,3-dihydro-1H-inden-1-one

OptimisedRoute 2Steps 4 · Total yield 10.00 g

DONE-0062107-69-9DONE-009872-85-5DONE-0104803-74-1DONE-0114803-57-0DONE-012120014-30-4DONE-013100-39-0API · Donepezil Hydrochloride

Code	CAS No.	Intermediate
DONE-006	2107-69-9	5,6-dimethoxy-2,3-dihydro-1H-inden-1-one
DONE-009	872-85-5	isonicotinaldehyde
DONE-010	4803-74-1	(E)-5,6-dimethoxy-2-(pyridin-4-ylmethylene)-2,3-dihydro-1H-inden-1-one
DONE-011	4803-57-0	5,6-dimethoxy-2-(pyridin-4-ylmethyl)-2,3-dihydro-1H-inden-1-one
DONE-012	120014-30-4	5,6-dimethoxy-2-(piperidin-4-ylmethyl)-2,3-dihydro-1H-inden-1-one
DONE-013	100-39-0	(bromomethyl)benzene

OptimisedRoute 3Steps 5 · Total yield 0.90 g

DONE-00522065-85-6DONE-0062107-69-9DONE-007120014-07-5DONE-0143612-20-2DONE-015105-39-5DONE-016943969-54-8DONE-017943969-55-9API · Donepezil Hydrochloride

Code	CAS No.	Intermediate
DONE-005	22065-85-6	1-benzylpiperidine-4-carbaldehyde
DONE-006	2107-69-9	5,6-dimethoxy-2,3-dihydro-1H-inden-1-one
DONE-007	120014-07-5	(E)-2-((1-benzylpiperidin-4-yl)methylene)-5,6-dimethoxy-2,3-dihydro-1H-inden-1-one
DONE-014	3612-20-2	1-benzylpiperidin-4-one
DONE-015	105-39-5	ethyl 2-chloroacetate
DONE-016	943969-54-8	ethyl 6-benzyl-1-oxa-6-azaspiro[2.5]octane-2-carboxylate
DONE-017	943969-55-9	sodium 6-benzyl-1-oxa-6-azaspiro[2.5]octane-2-carboxylate

OptimisedRoute 4Steps 3 · Total yield /

DONE-002100-44-7DONE-009872-85-5DONE-012120014-30-4DONE-0182747-08-2DONE-019—API · Donepezil Hydrochloride

Code	CAS No.	Intermediate
DONE-002	100-44-7	(chloromethyl)benzene
DONE-009	872-85-5	isonicotinaldehyde
DONE-012	120014-30-4	5,6-dimethoxy-2-(piperidin-4-ylmethyl)-2,3-dihydro-1H-inden-1-one
DONE-018	2747-08-2	2-bromo-5,6-dimethoxy-2,3-dihydro-1H-inden-1-one
DONE-019	-	5,6-dimethoxy-3'-(pyridin-4-yl)spiro[indene-2,2'-oxiran]-1(3H)-one

OptimisedRoute 5Steps 4 · Total yield 80.00 g

DONE-0062107-69-9DONE-009872-85-5DONE-013100-39-0DONE-020223397-73-7DONE-021923571-17-9DONE-022923571-20-4API · Donepezil Hydrochloride

Code	CAS No.	Intermediate
DONE-006	2107-69-9	5,6-dimethoxy-2,3-dihydro-1H-inden-1-one
DONE-009	872-85-5	isonicotinaldehyde
DONE-013	100-39-0	(bromomethyl)benzene
DONE-020	223397-73-7	1-benzyl-4-formylpyridin-1-ium bromide
DONE-021	923571-17-9	(E)-1-benzyl-4-((5,6-dimethoxy-1-oxo-1H-inden-2(3H)-ylidene)methyl)pyridin-1-ium bromide
DONE-022	923571-20-4	(E)-2-((1-benzyl-1,2,3,6-tetrahydropyridin-4-yl)methylene)-5,6-dimethoxy-2,3-dihydro-1H-inden-1-one

Frequently asked questions

What are the approved indications of Donepezil Hydrochloride?

Approved indications include: Lewy body dementia, Alzheimer's disease, Dementia.

When does the Donepezil Hydrochloride patent expire?

No public expiry year is available for Donepezil Hydrochloride yet; this page updates once verified.

How many synthesis routes are recorded for Donepezil Hydrochloride?

5 synthesis routes are recorded; the shortest is 3 steps with / total yield. Intermediates in each route carry codes and CAS numbers.

Where can I buy Donepezil Hydrochloride intermediates?

1 intermediate CAS of Donepezil Hydrochloride are available through the Unibest supply network — see the route tables on this page and request a quote per CAS.

How do I get a quote for Donepezil Hydrochloride intermediates?

Open the CAS profile of the target intermediate from this page, or submit an RFQ directly — the CAS enters the matching flow automatically and the supply network responds with quotes.

Source: cross-verified data (structured fields only) · 2026-09-29