← Back to patent-cliff list
Dalpiciclib Isethionate
Tier C — Watch / tradeDalpiciclib Isethionate
-
Originator
2021
First approval
-
Expiry (public)
No sales data
Peak sales
Small molecule
Type
Targets：CDK6, CDK4
Indications (approved)：Breast cancer, Metastatic breast cancer
Regional status
US
-
EU
-
China
Approved
2021-12-31
Japan
-
Synthetic routes & intermediates4 routes
Originator routes × 0Optimised (non-patent) × 3Process routes × 1
Routes are ordered originator first, then optimised / process (non-patent) routes; each lists steps, overall yield and the intermediate table (code / CAS / name) — ready for supplier sourcing and RFQ. Rendered by this site from structured data; no third-party route graphics used.
OptimisedRoute 2Steps 8 · Total yield 261g(Dalpiciclib Isethionate-014)
Dalpiciclib Isethionate-0091016636-76-2Dalpiciclib Isethionate-0101637781-16-8Dalpiciclib Isethionate-011111-34-2Dalpiciclib Isethionate-0121637781-17-9Dalpiciclib Isethionate-0131980822-15-8Dalpiciclib Isethionate-0141980822-14-7Dalpiciclib Isethionate-0151637781-10-2Dalpiciclib Isethionate-0161637781-11-3Dalpiciclib Isethionate-017—Dalpiciclib Isethionate-01853939-30-3Dalpiciclib Isethionate-019286961-14-6Dalpiciclib Isethionate-020—API · Dalpiciclib Isethionate
| Code | CAS No. | Intermediate |
|---|---|---|
| Dalpiciclib Isethionate-009 | 1016636-76-2Available | 6-Bromo-2-chloro-8-cyclopentyl-5-methylpyrido[2,3-d]pyrimidin-7-one |
| Dalpiciclib Isethionate-010 | 1637781-16-8 | tert-Butyl 4-[6-[(6-bromo-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidin-2-yl)amino]pyridin-3-yl]piperidine-1-carboxylate |
| Dalpiciclib Isethionate-011 | 111-34-2Available | 1-(Vinyloxy)butane |
| Dalpiciclib Isethionate-012 | 1637781-17-9 | tert-Butyl 4-(6-[[6-(1-butoxyethenyl)-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidin-2-yl]amino]pyridin-3-yl)piperidine-1-carboxylate |
| Dalpiciclib Isethionate-013 | 1980822-15-8 | tert-Butyl 4-[6-[(6-acetyl-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidin-2-yl)amino]pyridin-3-yl]piperidine-1-carboxylate |
| Dalpiciclib Isethionate-014 | 1980822-14-7 | 2-Hydroxyethane-1-sulfonic acid 6-acetyl-8-cyclopentyl-5-methyl-2-[[5-(piperidin-4-yl)pyridin-2-yl]amino]pyrido[2,3-d]pyrimidin-7(8H)-one |
| Dalpiciclib Isethionate-015 | 1637781-10-2 | 2-Amino-6-bromo-8-cyclopentyl-5-methylpyrido[2,3-d]pyrimidin-7(8H)-one |
| Dalpiciclib Isethionate-016 | 1637781-11-3 | 2-Amino-6-(1-butoxyethenyl)-8-cyclopentyl-5-methylpyrido[2,3-d]pyrimidin-7(8H)-one |
| Dalpiciclib Isethionate-017 | - | tert-Butyl 6-chloro-3',6'-dihydro[3,4'-bipyridine]-1'(2'H)-carboxylate |
| Dalpiciclib Isethionate-018 | 53939-30-3Available | 5-Bromo-2-chloropyridine |
| Dalpiciclib Isethionate-019 | 286961-14-6 | tert-Butyl 4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-3,6-dihydropyridine-1(2H)-carboxylate |
| Dalpiciclib Isethionate-020 | - | tert-Butyl 6-[[6-(1-butoxyethenyl)-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidin-2-yl]amino]-3',6'-dihydro[3,4'-bipyridine]-1'(2'H)-carboxylate |
OptimisedRoute 3Steps 2 · Total yield 19.4g(Dalpiciclib Isethionate-008)
Dalpiciclib Isethionate-0081198408-35-3Dalpiciclib Isethionate-021—Dalpiciclib Isethionate-02279099-07-3Dalpiciclib Isethionate-023—API · Dalpiciclib Isethionate
| Code | CAS No. | Intermediate |
|---|---|---|
| Dalpiciclib Isethionate-008 | 1198408-35-3 | tert-Butyl 4-(6-aminopyridin-3-yl)piperidine-1-carboxylate |
| Dalpiciclib Isethionate-021 | - | (9H-Fluoren-9-yl)methyl (5-bromopyridin-2-yl)carbamate |
| Dalpiciclib Isethionate-022 | 79099-07-3Available | tert-Butyl 4-oxopiperidine-1-carboxylate |
| Dalpiciclib Isethionate-023 | - | tert-Butyl 4-[6-([[(9H-fluoren-9-yl)methoxy]carbonyl]amino)pyridin-3-yl]-4-hydroxypiperidine-1-carboxylate |
OptimisedRoute 4Steps 4 · Total yield 52g(Dalpiciclib Isethionate-008)
Dalpiciclib Isethionate-004228710-82-5Dalpiciclib Isethionate-0081198408-35-3Dalpiciclib Isethionate-024—Dalpiciclib Isethionate-025110-86-1Dalpiciclib Isethionate-026—Dalpiciclib Isethionate-027—API · Dalpiciclib Isethionate
| Code | CAS No. | Intermediate |
|---|---|---|
| Dalpiciclib Isethionate-004 | 228710-82-5 | 5-Bromo-2-(2,5-dimethyl-1H-pyrrol-1-yl)pyridine |
| Dalpiciclib Isethionate-008 | 1198408-35-3 | tert-Butyl 4-(6-aminopyridin-3-yl)piperidine-1-carboxylate |
| Dalpiciclib Isethionate-024 | - | Chlorido[6-(2,5-dimethyl-1H-pyrrol-1-yl)pyridin-3-yl]magnesium |
| Dalpiciclib Isethionate-025 | 110-86-1 | Pyridine |
| Dalpiciclib Isethionate-026 | - | tert-Butyl 6-(2,5-dimethyl-1H-pyrrol-1-yl)[3,4'-bipyridine]-1'(4'H)-carboxylate |
| Dalpiciclib Isethionate-027 | - | tert-Butyl 4-[6-(2,5-dimethyl-1H-pyrrol-1-yl)pyridin-3-yl]piperidine-1-carboxylate |
ProcessRoute 1Steps 8 · Total yield 707g(Dalpiciclib Isethionate (Free))
Dalpiciclib Isethionate-0013612-20-2Dalpiciclib Isethionate-0021576-35-8Dalpiciclib Isethionate-00341780-52-3Dalpiciclib Isethionate-004228710-82-5Dalpiciclib Isethionate-0052348367-87-1Dalpiciclib Isethionate-0062348367-88-2Dalpiciclib Isethionate-0071159822-13-5Dalpiciclib Isethionate-0081198408-35-3Dalpiciclib Isethionate-0091016636-76-2Dalpiciclib Isethionate-0101637781-16-8API · Dalpiciclib Isethionate
| Code | CAS No. | Intermediate |
|---|---|---|
| Dalpiciclib Isethionate-001 | 3612-20-2 | 1-Benzylpiperidin-4-one |
| Dalpiciclib Isethionate-002 | 1576-35-8 | 4-Methylbenzenesulfonhydrazide |
| Dalpiciclib Isethionate-003 | 41780-52-3 | N'-(1-Benzylpiperidin-4-ylidene)-4-methylbenzene-1-sulfonohydrazide |
| Dalpiciclib Isethionate-004 | 228710-82-5 | 5-Bromo-2-(2,5-dimethyl-1H-pyrrol-1-yl)pyridine |
| Dalpiciclib Isethionate-005 | 2348367-87-1 | 1'-Benzyl-6-(2,5-dimethyl-1H-pyrrol-1-yl)-1',2',3',6'-tetrahydro-3,4'-bipyridine |
| Dalpiciclib Isethionate-006 | 2348367-88-2 | 1'-Benzyl-1',2',3',6'-tetrahydro[3,4'-bipyridin]-6-amine |
| Dalpiciclib Isethionate-007 | 1159822-13-5 | 5-(Piperidin-4-yl)pyridin-2-amine |
| Dalpiciclib Isethionate-008 | 1198408-35-3 | tert-Butyl 4-(6-aminopyridin-3-yl)piperidine-1-carboxylate |
| Dalpiciclib Isethionate-009 | 1016636-76-2Available | 6-Bromo-2-chloro-8-cyclopentyl-5-methylpyrido[2,3-d]pyrimidin-7-one |
| Dalpiciclib Isethionate-010 | 1637781-16-8 | tert-Butyl 4-[6-[(6-bromo-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidin-2-yl)amino]pyridin-3-yl]piperidine-1-carboxylate |
Frequently asked questions
What are the approved indications of Dalpiciclib Isethionate?
Approved indications include: Breast cancer, Metastatic breast cancer.
When does the Dalpiciclib Isethionate patent expire?
No public expiry year is available for Dalpiciclib Isethionate yet; this page updates once verified.
How many synthesis routes are recorded for Dalpiciclib Isethionate?
4 synthesis routes are recorded; the shortest is 2 steps with 19.4g(Dalpiciclib Isethionate-008) total yield. Intermediates in each route carry codes and CAS numbers.
Where can I buy Dalpiciclib Isethionate intermediates?
4 intermediate CAS of Dalpiciclib Isethionate are available through the Unibest supply network — see the route tables on this page and request a quote per CAS.
How do I get a quote for Dalpiciclib Isethionate intermediates?
Open the CAS profile of the target intermediate from this page, or submit an RFQ directly — the CAS enters the matching flow automatically and the supply network responds with quotes.
Source: cross-verified data (structured fields only) · 2026-09-29