Sofosbuvir/Velpatasvir
Tier B — Position earlySofosbuvir/Velpatasvir
Targets：NS5B, NS5A
Brand：Epclusa
Indications (approved)：Hepatitis C, Chronic hepatitis C
Regional status
Factories producing this API9
Factories registered as producing this API in our sourcing network (RFQ records + product master), sorted by RFQ activity; the snapshot carries no cost or customer data.
9 producing factories on file — sign in to view the named list (factory details are not shown to guests).
Sign in to view factories →Synthetic routes & intermediates3 routes
Routes are ordered originator first, then optimised / process (non-patent) routes; each lists steps, overall yield and the intermediate table (code / CAS / name) — ready for supplier sourcing and RFQ. Rendered by this site from structured data; no third-party route graphics used.
| Code | CAS No. | Intermediate |
|---|---|---|
| SOFO-004 | 863329-66-2Available | 1-((2R,3R,4R,5R)-3-fluoro-4-hydroxy-5-(hydroxymethyl)-3-methyltetrahydrofuran-2-yl)pyrimidine-2,4(1H,3H)-dione |
| SOFO-008 | 62062-65-1Available | (S)-isopropyl 2-aminopropanoate hydrochloride |
| SOFO-009 | 1160557-97-0Available | 1-((2R,3R,4R,5R)-5-(((tert-butyldimethylsilyl)oxy)methyl)-3-fluoro-4-hydroxy-3-methyltetrahydrofuran-2-yl)pyrimidine-2,4(1H,3H)-dione |
| SOFO-010 | 40608-06-8Available | 4-oxopentanoic anhydride |
| SOFO-011 | 1256490-32-0Available | (2R,3R,4R,5R)-2-(((tert-butyldimethylsilyl)oxy)methyl)-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-4-fluoro-4-methyltetrahydrofuran-3-yl 4-oxopentanoate |
| SOFO-012 | 1256490-53-5Available | (2R,3R,4R,5R)-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-4-fluoro-2-(hydroxymethyl)-4-methyltetrahydrofuran-3-yl 4-oxopentanoate |
| SOFO-013 | 1256490-49-9Available | (S)-isopropyl 2-(((R)-(4-nitrophenoxy)(phenoxy)phosphoryl)amino)propanoate |
| SOFO-014 | 1256490-33-1Available | (2R,3R,4R,5R)-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-4-fluoro-2-((((S)-(((S)-1-isopropoxy-1-oxopropan-2-yl)amino)(phenoxy)phosphoryl)oxy)methyl)-4-methyltetrahydrofuran-3-yl 4-oxopentanoate |
| SOFO-015 | 108-95-2Available | phenol |
| SOFO-016 | 777-52-6Available | 4-nitrophenyl phosphorodichloridate |
| Code | CAS No. | Intermediate |
|---|---|---|
| SOFO-001 | 817204-33-4Available | 4-amino-1-((2R,3R,4R,5R)-3-fluoro-4-hydroxy-5-(hydroxymethyl)-3-methyltetrahydrofuran-2-yl)pyrimidin-2(1H)-one |
| SOFO-002 | 817204-32-3Available | (2R,3R,4R,5R)-5-(4-benzamido-2-oxopyrimidin-1(2H)-yl)-2-((benzoyloxy)methyl)-4-fluoro-4-methyltetrahydrofuran-3-yl benzoate |
| SOFO-003 | 863329-65-1Available | ((2R,3R,4R,5R)-3-(benzoyloxy)-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-4-fluoro-4-methyltetrahydrofuran-2-yl)methyl benzoate |
| SOFO-004 | 863329-66-2Available | 1-((2R,3R,4R,5R)-3-fluoro-4-hydroxy-5-(hydroxymethyl)-3-methyltetrahydrofuran-2-yl)pyrimidine-2,4(1H,3H)-dione |
| SOFO-005 | 261909-49-3Available | (2S)-isopropyl 2-((chloro(phenoxy)phosphoryl)amino)propanoate |
| SOFO-006 | 1190307-88-0Available | (2S)-isopropyl 2-(((((2R,3R,4R,5R)-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-4-fluoro-3-hydroxy-4-methyltetrahydrofuran-2-yl)methoxy)(phenoxy)phosphoryl)amino)propanoate |
| SOFO-007 | 770-12-7Available | phenyl phosphorodichloridate |
| SOFO-008 | 62062-65-1Available | (S)-isopropyl 2-aminopropanoate hydrochloride |
| Code | CAS No. | Intermediate |
|---|---|---|
| SOFO-002 | 817204-32-3Available | (2R,3R,4R,5R)-5-(4-benzamido-2-oxopyrimidin-1(2H)-yl)-2-((benzoyloxy)methyl)-4-fluoro-4-methyltetrahydrofuran-3-yl benzoate |
| SOFO-003 | 863329-65-1Available | ((2R,3R,4R,5R)-3-(benzoyloxy)-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-4-fluoro-4-methyltetrahydrofuran-2-yl)methyl benzoate |
| SOFO-004 | 863329-66-2Available | 1-((2R,3R,4R,5R)-3-fluoro-4-hydroxy-5-(hydroxymethyl)-3-methyltetrahydrofuran-2-yl)pyrimidine-2,4(1H,3H)-dione |
| SOFO-007 | 770-12-7Available | phenyl phosphorodichloridate |
| SOFO-008 | 62062-65-1Available | (S)-isopropyl 2-aminopropanoate hydrochloride |
| SOFO-017 | 15186-48-8Available | (R)-2,2-dimethyl-1,3-dioxolane-4-carbaldehyde |
| SOFO-018 | 5717-37-3Available | ethyl 2-(triphenylphosphoranylidene)propanoate |
| SOFO-019 | 81997-76-4Available | (S,E)-ethyl 3-(2,2-dimethyl-1,3-dioxolan-4-yl)-2-methylacrylate |
| SOFO-020 | 93635-76-8Available | (2S,3R)-ethyl 3-((R)-2,2-dimethyl-1,3-dioxolan-4-yl)-2,3-dihydroxy-2-methylpropanoate |
| SOFO-021 | 1033394-83-0Available | (2R,3R)-ethyl 3-((R)-2,2-dimethyl-1,3-dioxolan-4-yl)-2-fluoro-3-hydroxy-2-methylpropanoate |
| SOFO-022 | 879551-04-9Available | (3R,4R,5R)-3-fluoro-4-hydroxy-5-(hydroxymethyl)-3-methyldihydrofuran-2(3H)-one |
| SOFO-023 | 874638-80-9Available | ((2R,3R,4R)-3-(benzoyloxy)-4-fluoro-4-methyl-5-oxotetrahydrofuran-2-yl)methyl benzoate |
| SOFO-024 | 1199809-23-8Available | ((2R,3R,4R)-3-(benzoyloxy)-5-chloro-4-fluoro-4-methyltetrahydrofuran-2-yl)methyl benzoate |
| SOFO-025 | 26661-13-2Available | N-(2-oxo-1,2-dihydropyrimidin-4-yl)benzamide |
| SOFO-026 | 1334513-02-8Available | (S)-isopropyl 2-(((S)-(perfluorophenoxy)(phenoxy)phosphoryl)amino)propanoate |
Frequently asked questions
What are the approved indications of Sofosbuvir/Velpatasvir?
Approved indications include: Hepatitis C, Chronic hepatitis C.
When does the Sofosbuvir/Velpatasvir patent expire?
No public expiry year is available for Sofosbuvir/Velpatasvir yet; this page updates once verified.
How many synthesis routes are recorded for Sofosbuvir/Velpatasvir?
3 synthesis routes are recorded; the shortest is 6 steps with 10.5 g total yield. Intermediates in each route carry codes and CAS numbers.
Where can I buy Sofosbuvir/Velpatasvir intermediates?
26 intermediate CAS of Sofosbuvir/Velpatasvir are available through the Unibest supply network — see the route tables on this page and request a quote per CAS.
How do I get a quote for Sofosbuvir/Velpatasvir intermediates?
Open the CAS profile of the target intermediate from this page, or submit an RFQ directly — the CAS enters the matching flow automatically and the supply network responds with quotes.
Source: cross-verified data (structured fields only) · 2026-09-29