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Cefcamate Pivoxil Hydrochloride
Tier C — Watch / tradeCefcamate Pivoxil Hydrochloride
Shionogi & Co., Ltd.
Originator
1997
First approval
-
Expiry (public)
No sales data
Peak sales
Small molecule
Type
Targets：PBPs
Brand：Flomox, Flumax
Indications (approved)：Bacterial infection
Regional status
US
-
EU
-
China
Approved
2010-12-31
Japan
Approved
1997-06-01
Synthetic routes & intermediates7 routes
Originator routes × 0Optimised (non-patent) × 7Process routes × 0
Routes are ordered originator first, then optimised / process (non-patent) routes; each lists steps, overall yield and the intermediate table (code / CAS / name) — ready for supplier sourcing and RFQ. Rendered by this site from structured data; no third-party route graphics used.
OptimisedRoute 1Steps 7 · Total yield 120.1g(Cefcamate Pivoxil Hydrochloride (API))
Cefcamate Pivoxil Hydrochloride-001943222-09-1Cefcamate Pivoxil Hydrochloride-002—Cefcamate Pivoxil Hydrochloride-003158743-37-4Cefcamate Pivoxil Hydrochloride-00486978-24-7Cefcamate Pivoxil Hydrochloride-00515690-38-7Cefcamate Pivoxil Hydrochloride-006—Cefcamate Pivoxil Hydrochloride-007153012-25-0Cefcamate Pivoxil Hydrochloride-0081189-71-5Cefcamate Pivoxil Hydrochloride-0093019-71-4Cefcamate Pivoxil Hydrochloride-010153012-37-4Cefcamate Pivoxil Hydrochloride-011—Cefcamate Pivoxil Hydrochloride-012105890-10-6Cefcamate Pivoxil Hydrochloride-013135889-00-8Cefcamate Pivoxil Hydrochloride-0142227302-44-3Cefcamate Pivoxil Hydrochloride-01553064-79-2Cefcamate Pivoxil Hydrochloride-016105889-45-0API · Cefcamate Pivoxil Hydrochloride
| Code | CAS No. | Intermediate |
|---|---|---|
| Cefcamate Pivoxil Hydrochloride-001 | 943222-09-1 | Ethyl2-(bromoacetyl)pent-2-enoate |
| Cefcamate Pivoxil Hydrochloride-002 | - | tert-Butylcarbamothioylcarbamatehydrobromide |
| Cefcamate Pivoxil Hydrochloride-003 | 158743-37-4 | Ethyl(2Z)-2-[2-[(tert-butoxycarbonyl)amino]-1,3-thiazol-4-yl]pent-2-enoate |
| Cefcamate Pivoxil Hydrochloride-004 | 86978-24-7 | 2-[2(Z)-2-Boc-amino-1,3-thiazol-4-yl]pent-2-enoicacid |
| Cefcamate Pivoxil Hydrochloride-005 | 15690-38-7 | (6R,7R)-7-Amino-3-(hydroxymethyl)-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylicacid |
| Cefcamate Pivoxil Hydrochloride-006 | - | (6R,7R)-7-[[(2Z)-2-[2-[(tert-Butoxycarbonyl)amino]-1,3-thiazol-4-yl]pent-2-enoyl]amino]-3-(hydroxymethyl)-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylicacidN,N,N',N'-tetramethylguanidine(11) |
| Cefcamate Pivoxil Hydrochloride-007 | 153012-25-0 | (6R,7R)-7-[[(2Z)-2-[2-[(tert-Butoxycarbonyl)amino]-1,3-thiazol-4-yl]pent-2-enoyl]amino]-3-(hydroxymethyl)-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylicacid |
| Cefcamate Pivoxil Hydrochloride-008 | 1189-71-5 | Chlorosulfonicacidisocyanate |
| Cefcamate Pivoxil Hydrochloride-009 | 3019-71-4 | Trichloroacetylisocyanate |
| Cefcamate Pivoxil Hydrochloride-010 | 153012-37-4 | (6R,7R)-7-[[(2Z)-2-[2-[(tert-Butoxycarbonyl)amino]-1,3-thiazol-4-yl]pent-2-enoyl]amino]-3-[(carbamoyloxy)methyl]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylicacidN-(propan-2-yl)propan-2-amine |
| Cefcamate Pivoxil Hydrochloride-011 | - | Sodium(6R,7R)-7-[[(2Z)-2-[2-[(tert-butoxycarbonyl)amino]-1,3-thiazol-4-yl]pent-2-enoyl]amino]-3-[(carbamoyloxy)methyl]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate |
| Cefcamate Pivoxil Hydrochloride-012 | 105890-10-6 | (6R,7R)-7-[[(2Z)-2-[2-[(tert-Butoxycarbonyl)amino]-1,3-thiazol-4-yl]pent-2-enoyl]amino]-3-[(carbamoyloxy)methyl]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylicacid |
| Cefcamate Pivoxil Hydrochloride-013 | 135889-00-8 | (6R,7R)-7-[(Z)-2-(2-Aminothiazol-4-yl)-2-pentenoylamino]-3-(carbamoyloxymethyl)-3-cephem-4-carboxylicacid |
| Cefcamate Pivoxil Hydrochloride-014 | 2227302-44-3 | (6R,7R)-7-[[(2Z)-2-(2-Amino-1,3-thiazol-4-yl)pent-2-enoyl]amino]-3-[(carbamoyloxy)methyl]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylicacidhydrogenchloride |
| Cefcamate Pivoxil Hydrochloride-015 | 53064-79-2Available | Iodomethylpivalate |
| Cefcamate Pivoxil Hydrochloride-016 | 105889-45-0 | [(2,2-Dimethylpropanoyl)oxy]methyl(6R,7R)-7-[[(2Z)-2-(2-amino-1,3-thiazol-4-yl)pent-2-enoyl]amino]-3-[(carbamoyloxy)methyl]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate |
OptimisedRoute 2Steps 5 · Total yield 23.5g(Cefcamate Pivoxil Hydrochloride-013)
Cefcamate Pivoxil Hydrochloride-00515690-38-7Cefcamate Pivoxil Hydrochloride-0081189-71-5Cefcamate Pivoxil Hydrochloride-013135889-00-8Cefcamate Pivoxil Hydrochloride-017267881-71-0Cefcamate Pivoxil Hydrochloride-018—Cefcamate Pivoxil Hydrochloride-019—Cefcamate Pivoxil Hydrochloride-020—Cefcamate Pivoxil Hydrochloride-021—API · Cefcamate Pivoxil Hydrochloride
| Code | CAS No. | Intermediate |
|---|---|---|
| Cefcamate Pivoxil Hydrochloride-005 | 15690-38-7 | (6R,7R)-7-Amino-3-(hydroxymethyl)-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylicacid |
| Cefcamate Pivoxil Hydrochloride-008 | 1189-71-5 | Chlorosulfonicacidisocyanate |
| Cefcamate Pivoxil Hydrochloride-013 | 135889-00-8 | (6R,7R)-7-[(Z)-2-(2-Aminothiazol-4-yl)-2-pentenoylamino]-3-(carbamoyloxymethyl)-3-cephem-4-carboxylicacid |
| Cefcamate Pivoxil Hydrochloride-017 | 267881-71-0 | Methyl(2Z)-2-(2-amino-1,3-thiazol-4-yl)pent-2-enoate |
| Cefcamate Pivoxil Hydrochloride-018 | - | Methyl(2Z)-2-[2-(2-phenylacetamido)-1,3-thiazol-4-yl]pent-2-enoate |
| Cefcamate Pivoxil Hydrochloride-019 | - | (2Z)-2-[2-(2-Phenylacetamido)-1,3-thiazol-4-yl]pent-2-enoicacid |
| Cefcamate Pivoxil Hydrochloride-020 | - | (6R)-3-[(Carbamoyloxy)methyl]-8-oxo-7-([(2Z)-2-[2-(2-phenylacetamido)-1,3-thiazol-4-yl]pent-2-enoyl]amino)-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylicacid--N-(propan-2-yl)propan-2-amine(11) |
| Cefcamate Pivoxil Hydrochloride-021 | - | Sodium(6R)-3-[(carbamoyloxy)methyl]-8-oxo-7-([(2Z)-2-[2-(2-phenylacetamido)-1,3-thiazol-4-yl]pent-2-enoyl]amino)-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate |
OptimisedRoute 3Steps 7 · Total yield 6.375g(Cefcamate Pivoxil Hydrochloride (API))
Cefcamate Pivoxil Hydrochloride-001943222-09-1Cefcamate Pivoxil Hydrochloride-002—Cefcamate Pivoxil Hydrochloride-003158743-37-4Cefcamate Pivoxil Hydrochloride-00486978-24-7Cefcamate Pivoxil Hydrochloride-00515690-38-7Cefcamate Pivoxil Hydrochloride-007153012-25-0Cefcamate Pivoxil Hydrochloride-011—Cefcamate Pivoxil Hydrochloride-012105890-10-6Cefcamate Pivoxil Hydrochloride-013135889-00-8Cefcamate Pivoxil Hydrochloride-0142227302-44-3Cefcamate Pivoxil Hydrochloride-01553064-79-2Cefcamate Pivoxil Hydrochloride-016105889-45-0API · Cefcamate Pivoxil Hydrochloride
| Code | CAS No. | Intermediate |
|---|---|---|
| Cefcamate Pivoxil Hydrochloride-001 | 943222-09-1 | Ethyl2-(bromoacetyl)pent-2-enoate |
| Cefcamate Pivoxil Hydrochloride-002 | - | tert-Butylcarbamothioylcarbamatehydrobromide |
| Cefcamate Pivoxil Hydrochloride-003 | 158743-37-4 | Ethyl(2Z)-2-[2-[(tert-butoxycarbonyl)amino]-1,3-thiazol-4-yl]pent-2-enoate |
| Cefcamate Pivoxil Hydrochloride-004 | 86978-24-7 | 2-[2(Z)-2-Boc-amino-1,3-thiazol-4-yl]pent-2-enoicacid |
| Cefcamate Pivoxil Hydrochloride-005 | 15690-38-7 | (6R,7R)-7-Amino-3-(hydroxymethyl)-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylicacid |
| Cefcamate Pivoxil Hydrochloride-007 | 153012-25-0 | (6R,7R)-7-[[(2Z)-2-[2-[(tert-Butoxycarbonyl)amino]-1,3-thiazol-4-yl]pent-2-enoyl]amino]-3-(hydroxymethyl)-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylicacid |
| Cefcamate Pivoxil Hydrochloride-011 | - | Sodium(6R,7R)-7-[[(2Z)-2-[2-[(tert-butoxycarbonyl)amino]-1,3-thiazol-4-yl]pent-2-enoyl]amino]-3-[(carbamoyloxy)methyl]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate |
| Cefcamate Pivoxil Hydrochloride-012 | 105890-10-6 | (6R,7R)-7-[[(2Z)-2-[2-[(tert-Butoxycarbonyl)amino]-1,3-thiazol-4-yl]pent-2-enoyl]amino]-3-[(carbamoyloxy)methyl]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylicacid |
| Cefcamate Pivoxil Hydrochloride-013 | 135889-00-8 | (6R,7R)-7-[(Z)-2-(2-Aminothiazol-4-yl)-2-pentenoylamino]-3-(carbamoyloxymethyl)-3-cephem-4-carboxylicacid |
| Cefcamate Pivoxil Hydrochloride-014 | 2227302-44-3 | (6R,7R)-7-[[(2Z)-2-(2-Amino-1,3-thiazol-4-yl)pent-2-enoyl]amino]-3-[(carbamoyloxy)methyl]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylicacidhydrogenchloride |
| Cefcamate Pivoxil Hydrochloride-015 | 53064-79-2Available | Iodomethylpivalate |
| Cefcamate Pivoxil Hydrochloride-016 | 105889-45-0 | [(2,2-Dimethylpropanoyl)oxy]methyl(6R,7R)-7-[[(2Z)-2-(2-amino-1,3-thiazol-4-yl)pent-2-enoyl]amino]-3-[(carbamoyloxy)methyl]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate |
OptimisedRoute 4Steps 8 · Total yield 14.6g(Cefcamate Pivoxil Hydrochloride (API))
Cefcamate Pivoxil Hydrochloride-00486978-24-7Cefcamate Pivoxil Hydrochloride-022153012-24-9Cefcamate Pivoxil Hydrochloride-023—Cefcamate Pivoxil Hydrochloride-024957-68-6Cefcamate Pivoxil Hydrochloride-025107185-27-3Cefcamate Pivoxil Hydrochloride-007153012-25-0Cefcamate Pivoxil Hydrochloride-00515690-38-7Cefcamate Pivoxil Hydrochloride-0081189-71-5Cefcamate Pivoxil Hydrochloride-010153012-37-4Cefcamate Pivoxil Hydrochloride-01553064-79-2Cefcamate Pivoxil Hydrochloride-026105889-80-3API · Cefcamate Pivoxil Hydrochloride
| Code | CAS No. | Intermediate |
|---|---|---|
| Cefcamate Pivoxil Hydrochloride-004 | 86978-24-7 | 2-[2(Z)-2-Boc-amino-1,3-thiazol-4-yl]pent-2-enoicacid |
| Cefcamate Pivoxil Hydrochloride-022 | 153012-24-9 | tert-Butyl[4-[(2Z)-1-oxo-1-[(methylsulfonyl)oxy]pent-2-en-2-yl]-1,3-thiazol-2-yl]carbamate |
| Cefcamate Pivoxil Hydrochloride-023 | - | Methyl(2Z)-2-[2-[(tert-butoxycarbonyl)amino]-1,3-thiazol-4-yl]pent-2-enoatehydrogenchloride |
| Cefcamate Pivoxil Hydrochloride-024 | 957-68-6 | (6R,7R)-3-(Acetoxymethyl)-7-amino-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid |
| Cefcamate Pivoxil Hydrochloride-025 | 107185-27-3 | (6R,7R)-3-[(Acetyloxy)methyl]-7-[[(2Z)-2-[2-[(tert-butoxycarbonyl)amino]-1,3-thiazol-4-yl]pent-2-enoyl]amino]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylicacid |
| Cefcamate Pivoxil Hydrochloride-007 | 153012-25-0 | (6R,7R)-7-[[(2Z)-2-[2-[(tert-Butoxycarbonyl)amino]-1,3-thiazol-4-yl]pent-2-enoyl]amino]-3-(hydroxymethyl)-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylicacid |
| Cefcamate Pivoxil Hydrochloride-005 | 15690-38-7 | Hydroxymethyl-7-aminocephalosporanicacid |
| Cefcamate Pivoxil Hydrochloride-008 | 1189-71-5 | N-Carbonylsulfamylchloride |
| Cefcamate Pivoxil Hydrochloride-010 | 153012-37-4 | (6R,7R)-7-[[(2Z)-2-[2-[(tert-Butoxycarbonyl)amino]-1,3-thiazol-4-yl]pent-2-enoyl]amino]-3-[(carbamoyloxy)methyl]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylicacidN-(propan-2-yl)propan-2-amine |
| Cefcamate Pivoxil Hydrochloride-015 | 53064-79-2Available | Iodomethylpivalate |
| Cefcamate Pivoxil Hydrochloride-026 | 105889-80-3 | Boc-cefcapenepivoxil |
OptimisedRoute 5Steps 1 · Total yield 184g(Cefcamate Pivoxil Hydrochloride-004)
Cefcamate Pivoxil Hydrochloride-027105-36-2Cefcamate Pivoxil Hydrochloride-02862-56-6Cefcamate Pivoxil Hydrochloride-029123-38-6Cefcamate Pivoxil Hydrochloride-00486978-24-7API · Cefcamate Pivoxil Hydrochloride
| Code | CAS No. | Intermediate |
|---|---|---|
| Cefcamate Pivoxil Hydrochloride-027 | 105-36-2Available | 2-Bromoaceticacidethylester |
| Cefcamate Pivoxil Hydrochloride-028 | 62-56-6Available | Thiocarbamide |
| Cefcamate Pivoxil Hydrochloride-029 | 123-38-6Available | Propanal |
| Cefcamate Pivoxil Hydrochloride-004 | 86978-24-7 | 2-[2(Z)-2-Boc-amino-1,3-thiazol-4-yl]pent-2-enoicacid |
OptimisedRoute 6Steps 3 · Total yield 48.6g(Cefcamate Pivoxil Hydrochloride-004)
Cefcamate Pivoxil Hydrochloride-00486978-24-7Cefcamate Pivoxil Hydrochloride-030674-82-8Cefcamate Pivoxil Hydrochloride-03117790-81-7Cefcamate Pivoxil Hydrochloride-029123-38-6Cefcamate Pivoxil Hydrochloride-02862-56-6Cefcamate Pivoxil Hydrochloride-017267881-71-0Cefcamate Pivoxil Hydrochloride-03224424-99-5API · Cefcamate Pivoxil Hydrochloride
| Code | CAS No. | Intermediate |
|---|---|---|
| Cefcamate Pivoxil Hydrochloride-004 | 86978-24-7 | 2-[2(Z)-2-Boc-amino-1,3-thiazol-4-yl]pent-2-enoicacid |
| Cefcamate Pivoxil Hydrochloride-030 | 674-82-8Available | 4-Methyleneoxetan-2-one |
| Cefcamate Pivoxil Hydrochloride-031 | 17790-81-7 | Methyl4-bromo-3-oxobutanoate |
| Cefcamate Pivoxil Hydrochloride-029 | 123-38-6Available | Propanal |
| Cefcamate Pivoxil Hydrochloride-028 | 62-56-6Available | Thiocarbamide |
| Cefcamate Pivoxil Hydrochloride-017 | 267881-71-0 | Methyl(2Z)-2-(2-amino-1,3-thiazol-4-yl)pent-2-enoate |
| Cefcamate Pivoxil Hydrochloride-032 | 24424-99-5 | Di(tert-butyl)dicarbonate |
OptimisedRoute 7Steps 6 · Total yield 65-70g(Cefcamate Pivoxil Hydrochloride (API))
Cefcamate Pivoxil Hydrochloride-00515690-38-7Cefcamate Pivoxil Hydrochloride-033101182-24-5Cefcamate Pivoxil Hydrochloride-00486978-24-7Cefcamate Pivoxil Hydrochloride-0341093349-61-1Cefcamate Pivoxil Hydrochloride-0081189-71-5Cefcamate Pivoxil Hydrochloride-011—Cefcamate Pivoxil Hydrochloride-01553064-79-2Cefcamate Pivoxil Hydrochloride-03518997-19-8Cefcamate Pivoxil Hydrochloride-026105889-80-3API · Cefcamate Pivoxil Hydrochloride
| Code | CAS No. | Intermediate |
|---|---|---|
| Cefcamate Pivoxil Hydrochloride-005 | 15690-38-7 | (6R,7R)-7-Amino-3-(hydroxymethyl)-3-cephem-4-carboxylicacid |
| Cefcamate Pivoxil Hydrochloride-033 | 101182-24-5 | Trimethylsilyl(6R,7R)-7-amino-8-oxo-3-[[(trimethylsilyl)oxy]methyl]-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate |
| Cefcamate Pivoxil Hydrochloride-004 | 86978-24-7 | 2-[2(Z)-2-Boc-amino-1,3-thiazol-4-yl]pent-2-enoicacid |
| Cefcamate Pivoxil Hydrochloride-034 | 1093349-61-1 | Trimethylsilyl(6R,7R)-7-[[2-[2-[(tert-butoxycarbonyl)amino]-1,3-thiazol-4-yl]pent-2-enoyl]amino]-8-oxo-3-[[(trimethylsilyl)oxy]methyl]-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate |
| Cefcamate Pivoxil Hydrochloride-008 | 1189-71-5 | Chlorosulfonicacidisocyanate |
| Cefcamate Pivoxil Hydrochloride-011 | - | Sodium(6R,7R)-7-[[(2Z)-2-[2-[(tert-butoxycarbonyl)amino]-1,3-thiazol-4-yl]pent-2-enoyl]amino]-3-[(carbamoyloxy)methyl]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate |
| Cefcamate Pivoxil Hydrochloride-015 | 53064-79-2Available | Iodomethylpivalate |
| Cefcamate Pivoxil Hydrochloride-035 | 18997-19-8 | Chloromethylpivalate |
| Cefcamate Pivoxil Hydrochloride-026 | 105889-80-3 | Boc-cefcapenepivoxil |
Frequently asked questions
What are the approved indications of Cefcamate Pivoxil Hydrochloride?
Approved indications include: Bacterial infection.
When does the Cefcamate Pivoxil Hydrochloride patent expire?
No public expiry year is available for Cefcamate Pivoxil Hydrochloride yet; this page updates once verified.
How many synthesis routes are recorded for Cefcamate Pivoxil Hydrochloride?
7 synthesis routes are recorded; the shortest is 1 steps with 184g(Cefcamate Pivoxil Hydrochloride-004) total yield. Intermediates in each route carry codes and CAS numbers.
Where can I buy Cefcamate Pivoxil Hydrochloride intermediates?
5 intermediate CAS of Cefcamate Pivoxil Hydrochloride are available through the Unibest supply network — see the route tables on this page and request a quote per CAS.
How do I get a quote for Cefcamate Pivoxil Hydrochloride intermediates?
Open the CAS profile of the target intermediate from this page, or submit an RFQ directly — the CAS enters the matching flow automatically and the supply network responds with quotes.
Source: cross-verified data (structured fields only) · 2026-09-29