Unibest
← Back to patent-cliff list

Edoxaban Tosilate Hydrate

Tier B — Position early

Edoxaban Tosilate Hydrate · all drugs expiring in 2028 →

Daiichi Sankyo Co., Ltd.
Originator
2011
First approval
2028
Expiry (public)
$1.79B ▲
Peak sales
Small molecule
Type

Targets：F10

Brand：Lixiana/Savaysa, Lixiana, Savaysa, Roteas

Indications (approved)：Pulmonary embolism, Venous thromboembolism, Stroke, Embolism, Venous thrombosis, Ischaemic stroke

Regional status

US
Approved
2015-01-08
EU
Approved
2015-06-19
China
Approved
2018-12-25
Japan
Approved
2011-04-22

Factories producing this API2

Factories registered as producing this API in our sourcing network (RFQ records + product master), sorted by RFQ activity; the snapshot carries no cost or customer data.

2 producing factories on file — sign in to view the named list (factory details are not shown to guests).

Sign in to view factories →

Synthetic routes & intermediates6 routes

Originator routes × 1Optimised (non-patent) × 5Process routes × 0

Routes are ordered originator first, then optimised / process (non-patent) routes; each lists steps, overall yield and the intermediate table (code / CAS / name) — ready for supplier sourcing and RFQ. Rendered by this site from structured data; no third-party route graphics used.

OriginatorRoute 1Steps 13 · Total yield 7.4 g
Synthetic routes & intermediates Route 1
CodeCAS No.Intermediate
EDOX-0014771-80-6cyclohex-3-ene-1-carboxylic acid
EDOX-0025708-19-0Available(S)-cyclohex-3-ene-1-carboxylic acid
EDOX-003123536-66-3(1S,4S,5S)-4-iodo-6-oxabicyclo[3.2.1]octan-7-one
EDOX-004365997-31-5ethyl (1S,3S,6R)-7-oxabicyclo[4.1.0]heptane-3-carboxylate
EDOX-005365997-32-6ethyl (1S,3R,4R)-3-azido-4-hydroxycyclohexane-1-carboxylate
EDOX-006365997-33-7ethyl (1S,3R,4R)-3-((tert-butoxycarbonyl)amino)-4-hydroxycyclohexane-1-carboxylate
EDOX-007365997-34-8ethyl (1S,3R,4S)-4-azido-3-((tert-butoxycarbonyl)amino)cyclohexane-1-carboxylate
EDOX-008-(1S,3R,4S)-4-azido-3-((tert-butoxycarbonyl)amino)cyclohexane-1-carboxylic acid
EDOX-009480450-69-9tert-butyl ((1R,2S,5S)-2-azido-5-(dimethylcarbamoyl)cyclohexyl)carbamate
EDOX-010-(1S,3R,4S)-3-amino-4-azido-N,N-dimethylcyclohexane-1-carboxamide
EDOX-011-lithium 5-methyl-4,5,6,7-tetrahydrothiazolo[5,4-c]pyridine-2-carboxylate
EDOX-012480450-70-2N-((1R,2S,5S)-2-azido-5-(dimethylcarbamoyl)cyclohexyl)-5-methyl-4,5,6,7-tetrahydrothiazolo[5,4-c]pyridine-2-carboxamide
EDOX-013480450-71-3N-((1R,2S,5S)-2-amino-5-(dimethylcarbamoyl)cyclohexyl)-5-methyl-4,5,6,7-tetrahydrothiazolo[5,4-c]pyridine-2-carboxamide
EDOX-014-sodium 2-((5-chloropyridin-2-yl)amino)-2-oxoacetate
OptimisedRoute 2Steps 5 · Total yield /
Synthetic routes & intermediates Route 2
CodeCAS No.Intermediate
EDOX-011-lithium 5-methyl-4,5,6,7-tetrahydrothiazolo[5,4-c]pyridine-2-carboxylate
EDOX-015504-24-5pyridin-4-amine
EDOX-01698400-69-2tert-butyl pyridin-4-ylcarbamate
EDOX-017365996-04-9tert-butyl (3-mercaptopyridin-4-yl)carbamate
EDOX-018273-70-1thiazolo[5,4-c]pyridine
EDOX-019259809-24-05-methyl-4,5,6,7-tetrahydrothiazolo[5,4-c]pyridine
OptimisedRoute 3Steps 5 · Total yield /
Synthetic routes & intermediates Route 3
CodeCAS No.Intermediate
EDOX-011-lithium 5-methyl-4,5,6,7-tetrahydrothiazolo[5,4-c]pyridine-2-carboxylate
EDOX-02079099-07-3Availabletert-butyl 4-oxopiperidine-1-carboxylate
EDOX-021365996-05-0tert-butyl 2-amino-6,7-dihydrothiazolo[5,4-c]pyridine-5(4H)-carboxylate
EDOX-022365996-06-1tert-butyl 2-bromo-6,7-dihydrothiazolo[5,4-c]pyridine-5(4H)-carboxylate
EDOX-023365996-07-22-bromo-4,5,6,7-tetrahydrothiazolo[5,4-c]pyridine
EDOX-024143150-92-9Available2-bromo-5-methyl-4,5,6,7-tetrahydrothiazolo[5,4-c]pyridine
OptimisedRoute 4Steps 10 · Total yield /
Synthetic routes & intermediates Route 4
CodeCAS No.Intermediate
EDOX-011-lithium 5-methyl-4,5,6,7-tetrahydrothiazolo[5,4-c]pyridine-2-carboxylate
EDOX-02570-23-5ethyl 3-bromo-2-oxopropanoate
EDOX-02622031-64-7cinnamamide
EDOX-027132629-37-9ethyl (E)-2-styryloxazole-4-carboxylate
EDOX-028259809-67-1(E)-2-styryloxazole-4-carbaldehyde
EDOX-0291779-49-3methyltriphenylphosphonium bromide
EDOX-030259809-68-2(E)-2-styryl-4-vinyloxazole
EDOX-031259809-69-3(E)-2-(2-styryloxazol-4-yl)ethan-1-ol
EDOX-032259809-70-6(E)-2-(2-(2-styryloxazol-4-yl)ethyl)isoindoline-1,3-dione
EDOX-033259809-71-7tert-butyl (E)-(2-(2-styryloxazol-4-yl)ethyl)carbamate
EDOX-034259809-72-8tert-butyl (E)-2-styryl-6,7-dihydrooxazolo[5,4-c]pyridine-5(4H)-carboxylate
EDOX-035259809-73-9tert-butyl 2-formyl-6,7-dihydrooxazolo[5,4-c]pyridine-5(4H)-carboxylate
EDOX-036259809-74-05-(tert-butyl) 2-methyl 6,7-dihydrooxazolo[5,4-c]pyridine-2,5(4H)-dicarboxylate
OptimisedRoute 5Steps 4 · Total yield /
Synthetic routes & intermediates Route 5
CodeCAS No.Intermediate
EDOX-009480450-69-9tert-butyl ((1R,2S,5S)-2-azido-5-(dimethylcarbamoyl)cyclohexyl)carbamate
EDOX-011-lithium 5-methyl-4,5,6,7-tetrahydrothiazolo[5,4-c]pyridine-2-carboxylate
EDOX-014-sodium 2-((5-chloropyridin-2-yl)amino)-2-oxoacetate
EDOX-037365998-36-3Availabletert-butyl ((1R,2S,5S)-2-amino-5-(dimethylcarbamoyl)cyclohexyl)carbamate
EDOX-038480452-36-6tert-butyl ((1R,2S,5S)-2-(2-((5-chloropyridin-2-yl)amino)-2-oxoacetamido)-5-(dimethylcarbamoyl)cyclohexyl)carbamate
EDOX-039482375-18-8N1-((1S,2R,4S)-2-amino-4-(dimethylcarbamoyl)cyclohexyl)-N2-(5-chloropyridin-2-yl)oxalamide
OptimisedRoute 6Steps 5 · Total yield /
Synthetic routes & intermediates Route 6
CodeCAS No.Intermediate
EDOX-007365997-34-8ethyl (1S,3R,4S)-4-azido-3-((tert-butoxycarbonyl)amino)cyclohexane-1-carboxylate
EDOX-037365998-36-3Availabletert-butyl ((1R,2S,5S)-2-amino-5-(dimethylcarbamoyl)cyclohexyl)carbamate
EDOX-040480449-84-1ethyl (1S,3R,4S)-4-amino-3-((tert-butoxycarbonyl)amino)cyclohexane-1-carboxylate
EDOX-041365998-33-0ethyl (1S,3R,4S)-4-(((benzyloxy)carbonyl)amino)-3-((tert-butoxycarbonyl)amino)cyclohexane-1-carboxylate
EDOX-042-(1S,3R,4S)-4-(((benzyloxy)carbonyl)amino)-3-((tert-butoxycarbonyl)amino)cyclohexane-1-carboxylic acid
EDOX-043-benzyl tert-butyl ((1S,2R,4S)-4-(dimethylcarbamoyl)cyclohexane-1,2-diyl)dicarbamate

Frequently asked questions

What are the approved indications of Edoxaban Tosilate Hydrate?

Approved indications include: Pulmonary embolism, Venous thromboembolism, Stroke, Embolism, Venous thrombosis, Ischaemic stroke.

When does the Edoxaban Tosilate Hydrate patent expire?

Based on public sources, the Edoxaban Tosilate Hydrate patent expires in 2028.

How many synthesis routes are recorded for Edoxaban Tosilate Hydrate?

6 synthesis routes are recorded; the shortest is 4 steps with / total yield. Intermediates in each route carry codes and CAS numbers.

Where can I buy Edoxaban Tosilate Hydrate intermediates?

4 intermediate CAS of Edoxaban Tosilate Hydrate are available through the Unibest supply network — see the route tables on this page and request a quote per CAS.

How do I get a quote for Edoxaban Tosilate Hydrate intermediates?

Open the CAS profile of the target intermediate from this page, or submit an RFQ directly — the CAS enters the matching flow automatically and the supply network responds with quotes.

Source: cross-verified data (structured fields only) · 2026-09-29