Pregabalin
Tier B — Position earlyPregabalin
Targets：CACNA2D1
Brand：Regabatin, Lyrica
Indications (approved)：Fibromyalgia, Seizure, Postherpetic neuralgia, 神经痛, Partial-onset seizure, Diabetic neuropathy, Epilepsy, Anxiety disorder
Regional status
Factories producing this API2
Factories registered as producing this API in our sourcing network (RFQ records + product master), sorted by RFQ activity; the snapshot carries no cost or customer data.
2 producing factories on file — sign in to view the named list (factory details are not shown to guests).
Sign in to view factories →Synthetic routes & intermediates5 routes
Routes are ordered originator first, then optimised / process (non-patent) routes; each lists steps, overall yield and the intermediate table (code / CAS / name) — ready for supplier sourcing and RFQ. Rendered by this site from structured data; no third-party route graphics used.
| Code | CAS No. | Intermediate |
|---|---|---|
| PREG-001 | 646-07-1 | 4-methylpentanoic acid |
| PREG-002 | 38136-29-7 | 4-methylpentanoyl chloride |
| PREG-003 | 96021-65-7 | lithium (4R,5S)-4-methyl-2-oxo-5-phenyloxazolidin-3-ide |
| PREG-004 | 134458-52-9 | (4R,5S)-4-methyl-3-(4-methylpentanoyl)-5-phenyloxazolidin-2-one |
| PREG-005 | 5437-45-6 | benzyl 2-bromoacetate |
| PREG-006 | 156048-93-0 | benzyl (S)-5-methyl-3-((4R,5S)-4-methyl-2-oxo-5-phenyloxazolidine-3-carbonyl)hexanoate |
| PREG-007 | 156048-94-1 | (S)-2-(2-(benzyloxy)-2-oxoethyl)-4-methylpentanoic acid |
| PREG-008 | 156048-95-2 | benzyl (S)-3-(hydroxymethyl)-5-methylhexanoate |
| PREG-009 | 156048-96-3 | benzyl (S)-5-methyl-3-((tosyloxy)methyl)hexanoate |
| PREG-010 | 156048-97-4 | benzyl (S)-3-(azidomethyl)-5-methylhexanoate |
| Code | CAS No. | Intermediate |
|---|---|---|
| PREG-011 | 590-86-3 | 3-methylbutanal |
| PREG-015 | 128013-69-4 | 3-(aminomethyl)-5-methylhexanoic acid |
| PREG-017 | 105-56-6Available | ethyl 2-cyanoacetate |
| PREG-018 | 294885-98-6 | diethyl 3-isobutylpentanedioate |
| PREG-019 | 75143-89-4 | 3-isobutylpentanedioic acid |
| PREG-020 | 916982-10-0 | 4-isobutylpiperidine-2,6-dione |
| Code | CAS No. | Intermediate |
|---|---|---|
| PREG-024 | 61-90-5 | (S)-2-amino-4-methylpentanoic acid |
| PREG-025 | 28659-87-2 | (S)-2-bromo-4-methylpentanoic acid |
| PREG-026 | 927828-01-1 | tert-butyl (S)-2-bromo-4-methylpentanoate |
| PREG-027 | - | 2-(tert-butyl) 1,1-diethyl (S)-4-methylpentane-1,1,2-tricarboxylate |
| PREG-028 | - | (S)-2-(1,3-diethoxy-1,3-dioxopropan-2-yl)-4-methylpentanoic acid |
| PREG-029 | 172796-26-8 | (S)-4-isobutyldihydrofuran-2(3H)-one |
| PREG-030 | - | ethyl (S)-3-(iodomethyl)-5-methylhexanoate |
| PREG-031 | 951792-40-8 | ethyl (S)-3-(azidomethyl)-5-methylhexanoate |
| PREG-032 | 157422-27-0 | (S)-3-(azidomethyl)-5-methylhexanoic acid |
| Code | CAS No. | Intermediate |
|---|---|---|
| PREG-011 | 590-86-3 | 3-methylbutanal |
| PREG-012 | 105-53-3Available | diethyl malonate |
| PREG-013 | 51615-30-6 | diethyl 2-(3-methylbutylidene)malonate |
| PREG-014 | 186038-82-4 | diethyl 2-(1-cyano-3-methylbutyl)malonate |
| PREG-015 | 128013-69-4 | 3-(aminomethyl)-5-methylhexanoic acid |
| PREG-016 | 185815-62-7 | (S)-2-(carboxymethyl)-4-methylpentan-1-aminium (S)-2-hydroxy-2-phenylacetate |
| Code | CAS No. | Intermediate |
|---|---|---|
| PREG-014 | 186038-82-4 | diethyl 2-(1-cyano-3-methylbutyl)malonate |
| PREG-021 | - | sodium (3S)-3-cyano-2-(ethoxycarbonyl)-5-methylhexanoate |
| PREG-022 | 181289-39-4 | ethyl (S)-3-cyano-5-methylhexanoate |
| PREG-023 | 350801-73-9 | potassium (S)-3-cyano-5-methylhexanoate |
Frequently asked questions
What are the approved indications of Pregabalin?
Approved indications include: Fibromyalgia, Seizure, Postherpetic neuralgia, 神经痛, Partial-onset seizure, Diabetic neuropathy, Epilepsy, Anxiety disorder.
When does the Pregabalin patent expire?
No public expiry year is available for Pregabalin yet; this page updates once verified.
How many synthesis routes are recorded for Pregabalin?
5 synthesis routes are recorded; the shortest is 4 steps with 1431 kg total yield. Intermediates in each route carry codes and CAS numbers.
Where can I buy Pregabalin intermediates?
2 intermediate CAS of Pregabalin are available through the Unibest supply network — see the route tables on this page and request a quote per CAS.
How do I get a quote for Pregabalin intermediates?
Open the CAS profile of the target intermediate from this page, or submit an RFQ directly — the CAS enters the matching flow automatically and the supply network responds with quotes.
Source: cross-verified data (structured fields only) · 2026-09-29