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Pralsetinib
Tier C — Watch / tradePralsetinib · all drugs expiring in 2031 →
Blueprint Medicines Corp
Originator
2020
First approval
2031
Expiry (public)
$0.3B *
Peak sales
Small molecule
Type
Targets：RET
Brand：Pujihua, GAVRETO, Gavreto
Indications (approved)：Non-small cell lung cancer, Thyroid cancer, Medullary thyroid cancer
Regional status
US
Approved
2020-09-04
EU
Approved
2021-11-18
China
Approved
2021-03-24
Japan
Discontinued
2020-07-24
Factories producing this API2
Factories registered as producing this API in our sourcing network (RFQ records + product master), sorted by RFQ activity; the snapshot carries no cost or customer data.
2 producing factories on file — sign in to view the named list (factory details are not shown to guests).
Sign in to view factories →Synthetic routes & intermediates7 routes
Originator routes × 0Optimised (non-patent) × 7Process routes × 0
Routes are ordered originator first, then optimised / process (non-patent) routes; each lists steps, overall yield and the intermediate table (code / CAS / name) — ready for supplier sourcing and RFQ. Rendered by this site from structured data; no third-party route graphics used.
OptimisedRoute 1Steps 8 · Total yield /
| Code | CAS No. | Intermediate |
|---|---|---|
| (I)1024528-1-a,(I)1024528-1-d | 4746-97-8 | 1,4 Cyclohexanedione ethylene ketal |
| (II)1024528-1-a | 2097133-36-1 | Methyl 8-methoxy-1,4-dioxaspiro[4.5]decane-8-carboxylate |
| (III)1024528-1-a | 1622928-67-9 | Methyl 1-methoxy-4-oxocyclohexane-1-carboxylate |
| (IV)1024528-1-a | 2097133-42-9 | Methyl 4-hydroxy-1-methoxycyclohexane-1-carboxylate |
| (V)1024528-1-a | 2097133-18-9 | Methyl 4-iodo-1-methoxycyclohexane-1-carboxylate |
| (VI)1024528-1-a | 89466-59-1 | 2-Chloro-4-methyl-6-(methylsulfanyl)pyrimidine |
| (VII)1024528-1-a | 5424-21-5 | 2,4-Dichloro-6-methylpyrimidine |
| (VIII)1024528-1-a | 2742918-71-2 | Methyl 1-methoxy-4-[4-methyl-6-(methylsulfanyl)pyrimidin-2-yl]cyclohexane-1-carboxylate |
| (IX)1024528-1-a | 2097133-29-2 | Methyl 4-[4-(methanesulfonyl)-6-methylpyrimidin-2-yl]-1-methoxycyclohexane-1-carboxylate |
| (X)1024528-1-a,(X)1024528-1-d | 2097133-30-5 | Methyl 1-methoxy-4-(4-methyl-6-oxo-1,6-dihydropyrimidin-2-yl)cyclohexane-1-carboxylate |
| (XI)1024528-1-a,(XI)1024528-1-b | 2097133-31-6 | Methyl 4-(4-chloro-6-methylpyrimidin-2-yl)-1-methoxycyclohexane-1-carboxylate |
OptimisedRoute 2Steps 4 · Total yield /
| Code | CAS No. | Intermediate |
|---|---|---|
| (XI)1024528-1-a,(XI)1024528-1-b | 2097133-31-6 | Methyl 4-(4-chloro-6-methylpyrimidin-2-yl)-1-methoxycyclohexane-1-carboxylate |
| (XII)1024528-1-b | 31230-17-8 | 3-Amino-5-methylpyrazole |
| (XIII)1024528-1-b | 2097133-32-7 | Methyl 1-methoxy-4-[4-methyl-6-[(5-methyl-1H-pyrazol-3-yl)amino]pyrimidin-2-yl]cyclohexane-1-carboxylate |
| (XIV)1024528-1-b | 2459966-45-9 | 1-Methoxy-4-[4-methyl-6-[(5-methyl-1H-pyrazol-3-yl)amino]pyrimidin-2-yl]cyclohexane-1-carboxylic acid |
| (XIX)1024528-1-b,(XIX)1024528-1-c | 1980023-94-6 | 1-[6-(4-Fluoro-1H-pyrazol-1-yl)pyridin-3-yl]ethan-1-one |
| (XV)1024528-1-b | 139042-59-4 | 1-(6-Bromopyridin-3-yl)ethan-1-one |
| (XVa)1024528-1-b | 2097133-17-8 | (1S)-1-[6-(4-Fluoro-1H-pyrazol-1-yl)pyridin-3-yl]ethan-1-amine hydrogen chloride |
| (XVb)1024528-1-b | 1980023-96-8 | (1S)-1-[6-(4-Fluoro-1H-pyrazol-1-yl)pyridin-3-yl]ethan-1-amine |
| (XVc)1024528-1-b | - | (1S)-1-[6-(4-Fluoro-1H-pyrazol-1-yl)pyridin-3-yl]ethan-1-amine hydrogen chloride (1/2) |
| (XVII)1024528-1-b,(XVII)1024528-1-c | 35277-02-2 | 4-Fluoro-1H-pyrazole |
| (XVIII)1024528-1-b | 102-52-3 | 1,1,3,3-Tetrakis(methyloxy)propane |
| (XX)1024528-1-b | 196929-78-9 | (R)-(+)-2-Methyl-2-propanesulfinamide |
| (XXI)1024528-1-b | 1980023-95-7 | (SR)-N-[(1S)-1-[6-(4-Fluoro-1H-pyrazol-1-yl)pyridin-3-yl]ethyl]-2-methylpropane-2-sulfinamide |
OptimisedRoute 3Steps 7 · Total yield /
| Code | CAS No. | Intermediate |
|---|---|---|
| (XIX)1024528-1-b,(XIX)1024528-1-c | 1980023-94-6 | 1-[6-(4-Fluoro-1H-pyrazol-1-yl)pyridin-3-yl]ethan-1-one |
| (XVII)1024528-1-b,(XVII)1024528-1-c | 35277-02-2 | 4-Fluoro-1H-pyrazole |
| (XXII)1024528-1-c | 76-37-9 | 2,2,3,3-Tetrafluoropropan-1-ol |
| (XXIII)1024528-1-c | 343331-58-8 | 4-(2,2,3,3-Tetrafluoropropyl)morpholine |
| (XXIV)1024528-1-c | 1438425-76-3 | 4-Methyl-4-(2,2,3,3-tetrafluoropropyl)morpholin-4-ium mesylate |
| (XXIX)1024528-1-c | 288-13-1Available | 1,2-Diazole |
| (XXV)1024528-1-c | - | 4-Methyl-4-[(1Z)-2,3,3-trifluoroprop-1-en-1-yl]morpholin-4-ium methanesulfonate |
| (XXVI)1024528-1-c | - | (2Z)-2-Fluoro-3-(morpholin-4-yl)prop-2-enal |
| (XXVII)1024528-1-c | 5341-61-7 | Hydrazine dihydrochloride |
| (XXVIII)1024528-1-c | - | 4-Fluoro-1H-pyrazole hydrogen chloride |
| (XXX)1024528-1-c | 53939-30-3Available | 5-Bromo-2-chloropyridine |
| (XXXI)1024528-1-c | 108-24-7 | Acetic acid acetic anhydride |
| (XXXII)1024528-1-c | 55676-22-7 | 1-(6-Chloropyridin-3-yl)ethanone |
OptimisedRoute 4Steps 6 · Total yield /
| Code | CAS No. | Intermediate |
|---|---|---|
| (I)1024528-1-a,(I)1024528-1-d | 4746-97-8 | 1,4 Cyclohexanedione ethylene ketal |
| (X)1024528-1-a,(X)1024528-1-d | 2097133-30-5 | Methyl 1-methoxy-4-(4-methyl-6-oxo-1,6-dihydropyrimidin-2-yl)cyclohexane-1-carboxylate |
| (XXXIII)1024528-1-d | 69947-09-7 | 1,4-Dioxaspiro[4.5]decane-8-carbonitrile |
| (XXXIV)1024528-1-d | 1252690-12-2 | N-Hydroxy-1,4-dioxaspiro[4.5]decane-8-carboximidamide |
| (XXXV)1024528-1-d | 1252973-00-4 | 1,4-Dioxaspiro[4.5]decane-8-carboximidamide |
| (XXXVI)1024528-1-d | 141-97-9Available | 1-Ethoxybutane-1,3-dione |
| (XXXVII)1024528-1-d | - | 2-(1,4-Dioxaspiro[4.5]decan-8-yl)-6-methylpyrimidin-4-ol |
| (XXXVIII)1024528-1-d | - | 4-(4-Hydroxy-6-methylpyrimidin-2-yl)cyclohexan-1-one |
OptimisedRoute 5Steps 5 · Total yield /
| Code | CAS No. | Intermediate |
|---|---|---|
| (I)1024528-2-a | 14394-60-6 | 2-Chloro-6-methylpyrimidin-4-amine |
| (II)1024528-2-a | 2675521-17-0 | tert-Butyl (2-chloro-6-methylpyrimidin-4-yl)carbamate |
| (III)1024528-2-a | 2097133-18-9 | Methyl 4-iodo-1-methoxycyclohexane-1-carboxylate |
| (IV)1024528-2-a | 2675521-16-9 | Methyl 4-[4-[(tert-butoxycarbonyl)amino]-6-methylpyrimidin-2-yl]-1-methoxycyclohexane-1-carboxylate |
| (V)1024528-2-a | 2097133-30-5 | Methyl 1-methoxy-4-(4-methyl-6-oxo-1,6-dihydropyrimidin-2-yl)cyclohexane-1-carboxylate |
| (VI)1024528-2-a | 578008-32-9 | 3-Amino-1-Boc-5-methyl-1H-pyrazole |
| (VII)1024528-2-a | 2097133-32-7 | Methyl 1-methoxy-4-[4-methyl-6-[(5-methyl-1H-pyrazol-3-yl)amino]pyrimidin-2-yl]cyclohexane-1-carboxylate |
| (VIII)1024528-2-a | 1980023-96-8 | (1S)-1-[6-(4-Fluoro-1H-pyrazol-1-yl)pyridin-3-yl]ethan-1-amine |
OptimisedRoute 6Steps 7 · Total yield /
| Code | CAS No. | Intermediate |
|---|---|---|
| (I)1024528-3-a,(I)1024528-3-b | 2778223-41-7 | Methyl 4-cyano-1-methoxycyclohexane-1-carboxylate |
| (II)1024528-3-a | - | Methyl 4-[imino(methoxy)methyl]-1-methoxycyclohexane-1-carboxylate hydrogen chloride |
| (III)1024528-3-a | - | Methyl trans-4-carbamimidoyl-1-methoxycyclohexane-1-carboxylate |
| (IV)1024528-3-a | 105-45-3Available | 1-Methoxybutane-1,3-dione |
| (V)1024528-3-a | 2097133-30-5 | Methyl 1-methoxy-4-(4-methyl-6-oxo-1,6-dihydropyrimidin-2-yl)cyclohexane-1-carboxylate |
| (VI)1024528-3-a | - | Methyl trans-4-[4-[(methanesulfonyl)oxy]-6-methylpyrimidin-2-yl]-1-methoxycyclohexane-1-carboxylate |
| (VII)1024528-3-a | 31230-17-8 | 3-Amino-5-methylpyrazole |
| (VIII)1024528-3-a | - | Methyl (1s,4s)-1-methoxy-4-[4-methyl-6-[(5-methyl-1H-pyrazol-3-yl)amino]pyrimidin-2-yl]cyclohexane-1-carboxylate |
| (IX)1024528-3-a | - | (1s,4s)-1-Methoxy-4-[4-methyl-6-[(5-methyl-1H-pyrazol-3-yl)amino]pyrimidin-2-yl]cyclohexane-1-carboxylic acid |
| (Xa)1024528-3-a | 1980023-96-8 | (1S)-1-[6-(4-Fluoro-1H-pyrazol-1-yl)pyridin-3-yl]ethan-1-amine |
| (Xb)1024528-3-a | 2097133-17-8 | (1S)-1-[6-(4-Fluoro-1H-pyrazol-1-yl)pyridin-3-yl]ethan-1-amine hydrogen chloride |
OptimisedRoute 7Steps 3 · Total yield /
| Code | CAS No. | Intermediate |
|---|---|---|
| (I)1024528-3-a,(I)1024528-3-b | 2778223-41-7 | Methyl 4-cyano-1-methoxycyclohexane-1-carboxylate |
| (Xb)1024528-3-a | 2097133-17-8 | (1S)-1-[6-(4-Fluoro-1H-pyrazol-1-yl)pyridin-3-yl]ethan-1-amine hydrogen chloride |
| (XI)1024528-3-b | 4746-97-8 | 1,4 Cyclohexanedione ethylene ketal |
| (XII)1024528-3-b | 2097133-36-1 | Methyl 8-methoxy-1,4-dioxaspiro[4.5]decane-8-carboxylate |
| (XIII)1024528-3-b | 1622928-67-9 | Methyl 1-methoxy-4-oxocyclohexane-1-carboxylate |
| (XIV)1024528-3-b | 69947-09-7 | 1,4-Dioxaspiro[4.5]decane-8-carbonitrile |
| (XV)1024528-3-b | 34916-10-4 | 4-Oxocyclohexane-1-carbonitrile |
Frequently asked questions
What are the approved indications of Pralsetinib?
Approved indications include: Non-small cell lung cancer, Thyroid cancer, Medullary thyroid cancer.
When does the Pralsetinib patent expire?
Based on public sources, the Pralsetinib patent expires in 2031.
How many synthesis routes are recorded for Pralsetinib?
7 synthesis routes are recorded; the shortest is 3 steps with / total yield. Intermediates in each route carry codes and CAS numbers.
Where can I buy Pralsetinib intermediates?
4 intermediate CAS of Pralsetinib are available through the Unibest supply network — see the route tables on this page and request a quote per CAS.
How do I get a quote for Pralsetinib intermediates?
Open the CAS profile of the target intermediate from this page, or submit an RFQ directly — the CAS enters the matching flow automatically and the supply network responds with quotes.
Source: cross-verified data (structured fields only) · 2026-09-29