Cofrogliptin

Tier C — Watch / trade

Cofrogliptin

Originator

2024

First approval

Expiry (public)

No sales data

Peak sales

Small molecule

Type

Targets：DPP4

Indications (approved)：Type 2 diabetes

Regional status

China

Approved

2024-06-18

Japan

Synthetic routes & intermediates1 routes

Originator routes × 0Optimised (non-patent) × 1Process routes × 0

Routes are ordered originator first, then optimised / process (non-patent) routes; each lists steps, overall yield and the intermediate table (code / CAS / name) — ready for supplier sourcing and RFQ. Rendered by this site from structured data; no third-party route graphics used.

OptimisedRoute 1Steps 5 · Total yield /

(I)908111-1-a1280210-79-8(II)908111-1-a124-63-0(III)908111-1-a1226781-82-3(IV)908111-1-a1226781-80-1(V)908111-1-a951127-25-6(VI)908111-1-a1844874-05-0(VII)908111-1-a2156634-82-9(VIII)908111-1-a1844874-17-4API · Cofrogliptin

Code	CAS No.	Intermediate
(I)908111-1-a	1280210-79-8	tert-Butyl 2,6-dihydropyrrolo[3,4-c]pyrazole-5(4H)-carboxylate
(II)908111-1-a	124-63-0	Chloro methyl sulfone
(III)908111-1-a	1226781-82-3	tert-Butyl 2-(methylsulfonyl)-2,6-dihydropyrrolo[3,4-c]pyrazole-5(4H)-carboxylate
(IV)908111-1-a	1226781-80-1	2-(Methanesulfonyl)-2,4,5,6-tetrahydropyrrolo[3,4-c]pyrazole
(V)908111-1-a	951127-25-6	tert-Butyl [(2R,3S)-2-(2,5-difluorophenyl)-5-oxotetrahydro-2H-pyran-3-yl]carbamate
(VI)908111-1-a	1844874-05-0	(2xi,6R)-2,6-Anhydro-5-[(tert-butoxycarbonyl)amino]-1,4,5-trideoxy-6-(2,5-difluorophenyl)-1,1,1-trifluoro-D-glycero-hex-3-ulose
(VII)908111-1-a	2156634-82-9	(6R)-2,6-Anhydro-5-[(tert-butoxycarbonyl)amino]-1,3,4,5-tetradeoxy-6-(2,5-difluorophenyl)-1,1,1-trifluoro-3-[2-(methanesulfonyl)-2,6-dihydropyrrolo[3,4-c]pyrazol-5(4H)-yl]-D-threo-hex-3-enitol
(VIII)908111-1-a	1844874-17-4	(6R)-2,6-Anhydro-5-[(tert-butoxycarbonyl)amino]-1,3,4,5-tetradeoxy-6-(2,5-difluorophenyl)-1,1,1-trifluoro-3-[2-(methanesulfonyl)-2,6-dihydropyrrolo[3,4-c]pyrazol-5(4H)-yl]-D-arabino-hexitol

Frequently asked questions

What are the approved indications of Cofrogliptin?

Approved indications include: Type 2 diabetes.

When does the Cofrogliptin patent expire?

No public expiry year is available for Cofrogliptin yet; this page updates once verified.

How many synthesis routes are recorded for Cofrogliptin?

1 synthesis routes are recorded; the shortest is 5 steps with / total yield. Intermediates in each route carry codes and CAS numbers.

Where can I buy Cofrogliptin intermediates?

All intermediates in Cofrogliptin routes have CAS profiles — you can submit an RFQ per CAS and it enters the Unibest matching pool.

How do I get a quote for Cofrogliptin intermediates?

Open the CAS profile of the target intermediate from this page, or submit an RFQ directly — the CAS enters the matching flow automatically and the supply network responds with quotes.

Source: cross-verified data (structured fields only) · 2026-09-29