Risdiplam

Tier B — Position early

Risdiplam

Ptc Therapeutics Inc

Originator

2020

First approval

Expiry (public)

$2.13B ▲

Peak sales

Small molecule

Type

Targets：SMN

Brand：EVRYSDI

Indications (approved)：Spinal muscular atrophy

Regional status

Approved

2020-08-07

Approved

2021-03-26

China

Approved

2021-06-16

Japan

Approved

2021-06-23

Factories producing this API1

Factories registered as producing this API in our sourcing network (RFQ records + product master), sorted by RFQ activity; the snapshot carries no cost or customer data.

1 producing factories on file — sign in to view the named list (factory details are not shown to guests).

Synthetic routes & intermediates2 routes

Originator routes × 0Optimised (non-patent) × 2Process routes × 0

Routes are ordered originator first, then optimised / process (non-patent) routes; each lists steps, overall yield and the intermediate table (code / CAS / name) — ready for supplier sourcing and RFQ. Rendered by this site from structured data; no third-party route graphics used.

OptimisedRoute 1Steps 7 · Total yield 12 mg (Risdiplam)

RISD-00119064-64-3RISD-00266346-87-0RISD-00364068-00-4RISD-004126-38-5RISD-00517412-23-6RISD-00673183-34-3RISD-0071825352-86-0RISD-0081449598-86-0RISD-0091825352-87-1RISD-010145122-56-1RISD-01121717-96-4RISD-012108-59-8RISD-0131449598-85-9API · Risdiplam

Code	CAS No.	Intermediate
RISD-001	19064-64-3 Available	3,6-dichloro-4-methylpyridazine
RISD-002	66346-87-0 Available	6-chloro-5-methylpyridazin-3-amine
RISD-003	64068-00-4 Available	6-chloro-4-methylpyridazin-3-amine
RISD-004	126-38-5 Available	1-bromo-2,2-dimethoxypropane
RISD-005	17412-23-6 Available	6-chloro-2,8-dimethylimidazo[1,2-b]pyridazine
RISD-006	73183-34-3 Available	4,4,4',4',5,5,5',5'-octamethyl-2,2'-bi(1,3,2-dioxaborolane)
RISD-007	1825352-86-0 Available	2,8-dimethyl-6-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)imidazo[1,2-b]pyridazine
RISD-008	1449598-86-0 Available	2-chloro-7-fluoro-4H-pyrido[1,2-a]pyrimidin-4-one
RISD-009	1825352-87-1 Available	2-(2,8-dimethylimidazo[1,2-b]pyridazin-6-yl)-7-fluoro-4H-pyrido[1,2-a]pyrimidin-4-one
RISD-010	145122-56-1 Available	4,7-diazaspiro[2.5]octane hydrogen chloride
RISD-011	21717-96-4 Available	5-fluoropyridin-2-amine
RISD-012	108-59-8 Available	dimethyl malonate
RISD-013	1449598-85-9 Available	7-fluoro-2-hydroxy-4H-pyrido[1,2-a]pyrimidin-4-one

OptimisedRoute 2Steps 17 · Total yield 19.7 g (Risdiplam)

RISD-01422059-21-8RISD-01542303-42-4RISD-01679-04-9RISD-0171279815-30-3RISD-0181222106-43-5RISD-0191222106-45-7RISD-020674792-03-1RISD-0216153-56-6RISD-0222173992-48-6RISD-023674792-08-6RISD-02453939-30-3RISD-0252304625-40-7RISD-0261838704-83-8RISD-027541-16-2RISD-0282133298-72-1RISD-0292133298-73-2RISD-0071825352-86-0RISD-0302133298-74-3RISD-0315469-69-2RISD-032446273-59-2RISD-00364068-00-4RISD-033108-21-4RISD-00517412-23-6API · Risdiplam

Code	CAS No.	Intermediate
RISD-014	22059-21-8 Available	1-aminocyclopropanecarboxylic acid
RISD-015	42303-42-4 Available	ethyl 1-aminocyclopropanecarboxylate hydrochloride
RISD-016	79-04-9 Available	2-chloroacetyl chloride
RISD-017	1279815-30-3 Available	ethyl 1-(2-chloroacetamido)cyclopropanecarboxylate
RISD-018	1222106-43-5 Available	7-benzyl-4,7-diazaspiro[2.5]octane-5,8-dione
RISD-019	1222106-45-7 Available	7-benzyl-4,7-diazaspiro[2.5]octane
RISD-020	674792-03-1 Available	tert-butyl 7-benzyl-4,7-diazaspiro[2.5]octane-4-carboxylate
RISD-021	6153-56-6 Available	oxalic acid
RISD-022	2173992-48-6 Available	tert-butyl 4,7-diazaspiro[2.5]octane-4-carboxylate hemioxalate
RISD-023	674792-08-6 Available	tert-butyl 4,7-diazaspiro[2.5]octane-4-carboxylate
RISD-024	53939-30-3 Available	5-bromo-2-chloropyridine
RISD-025	2304625-40-7 Available	tert-butyl 7-(6-chloropyridin-3-yl)-4,7-diazaspiro[2.5]octane-4-carboxylate
RISD-026	1838704-83-8 Available	tert-butyl 7-(6-aminopyridin-3-yl)-4,7-diazaspiro[2.5]octane-4-carboxylate
RISD-027	541-16-2 Available	di-tert-butyl malonate
RISD-028	2133298-72-1 Available	tert-butyl 7-(2-hydroxy-4-oxo-4H-pyrido[1,2-a]pyrimidin-7-yl)-4,7-diazaspiro[2.5]octane-4-carboxylate
RISD-029	2133298-73-2 Available	tert-butyl 7-(4-oxo-2-(tosyloxy)-4H-pyrido[1,2-a]pyrimidin-7-yl)-4,7-diazaspiro[2.5]octane-4-carboxylate
RISD-007	1825352-86-0 Available	2,8-dimethyl-6-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)imidazo[1,2-b]pyridazine
RISD-030	2133298-74-3 Available	tert-butyl 7-(2-(2,8-dimethylimidazo[1,2-b]pyridazin-6-yl)-4-oxo-4H-pyrido[1,2-a]pyrimidin-7-yl)-4,7-diazaspiro[2.5]octane-4-carboxylate
RISD-031	5469-69-2 Available	6-chloropyridazin-3-amine
RISD-032	446273-59-2 Available	4-bromo-6-chloropyridazin-3-amine
RISD-003	64068-00-4 Available	6-chloro-4-methylpyridazin-3-amine
RISD-033	108-21-4 Available	isopropyl acetate
RISD-005	17412-23-6 Available	6-chloro-2,8-dimethylimidazo[1,2-b]pyridazine

Frequently asked questions

What are the approved indications of Risdiplam?

Approved indications include: Spinal muscular atrophy.

When does the Risdiplam patent expire?

No public expiry year is available for Risdiplam yet; this page updates once verified.

How many synthesis routes are recorded for Risdiplam?

2 synthesis routes are recorded; the shortest is 7 steps with 12 mg (Risdiplam) total yield. Intermediates in each route carry codes and CAS numbers.

Where can I buy Risdiplam intermediates?

33 intermediate CAS of Risdiplam are available through the Unibest supply network — see the route tables on this page and request a quote per CAS.

How do I get a quote for Risdiplam intermediates?

Open the CAS profile of the target intermediate from this page, or submit an RFQ directly — the CAS enters the matching flow automatically and the supply network responds with quotes.

Source: cross-verified data (structured fields only) · 2026-09-29