Asciminib hydrochloride
Tier B — Position earlyAsciminib hydrochloride
Targets：Bcr-Abl
Brand：Scemblix
Indications (approved)：Chronic myeloid leukaemia
Regional status
Synthetic routes & intermediates1 routes
Routes are ordered originator first, then optimised / process (non-patent) routes; each lists steps, overall yield and the intermediate table (code / CAS / name) — ready for supplier sourcing and RFQ. Rendered by this site from structured data; no third-party route graphics used.
| Code | CAS No. | Intermediate |
|---|---|---|
| ASCIM-001 | 29241-62-1Available | 5-bromo-6-chloronicotinic acid |
| ASCIM-002 | 39065-95-7Available | 4-(chlorodifluoromethoxy)aniline |
| ASCIM-003 | 1491150-22-1Available | 5-bromo-6-chloro-N-(4-(chlorodifluoromethoxy)phenyl)nicotinamide |
| ASCIM-004 | 2799-21-5Available | (R)-pyrrolidin-3-ol |
| ASCIM-005 | 1491150-21-0Available | (R)-5-bromo-N-(4-(chlorodifluoromethoxy)phenyl)-6-(3-hydroxypyrrolidin-1-yl)nicotinamide |
| ASCIM-006 | 903550-12-9Available | 5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1-((2-(trimethylsilyl)ethoxy)methyl)-1H-pyrazole |
| ASCIM-007 | 1598430-18-2Available | (R)-N-(4-(chlorodifluoromethoxy)phenyl)-6-(3-hydroxypyrrolidin-1-yl)-5-(1-((2-(trimethylsilyl)ethoxy)methyl)-1H-pyrazol-5-yl)nicotinamide |
| Asciminib | - | (R)-N-(4-(chlorodifluoromethoxy)phenyl)-6-(3-hydroxypyrrolidin-1-yl)-5-(1H-pyrazol-5-yl)nicotinamide |
Frequently asked questions
What are the approved indications of Asciminib hydrochloride?
Approved indications include: Chronic myeloid leukaemia.
When does the Asciminib hydrochloride patent expire?
No public expiry year is available for Asciminib hydrochloride yet; this page updates once verified.
How many synthesis routes are recorded for Asciminib hydrochloride?
1 synthesis routes are recorded; the shortest is 4 steps with / total yield. Intermediates in each route carry codes and CAS numbers.
Where can I buy Asciminib hydrochloride intermediates?
7 intermediate CAS of Asciminib hydrochloride are available through the Unibest supply network — see the route tables on this page and request a quote per CAS.
How do I get a quote for Asciminib hydrochloride intermediates?
Open the CAS profile of the target intermediate from this page, or submit an RFQ directly — the CAS enters the matching flow automatically and the supply network responds with quotes.
Source: cross-verified data (structured fields only) · 2026-09-29