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Lazertinib Mesylate
Tier C — Watch / tradeLazertinib Mesylate
Oscotec Inc
Originator
2021
First approval
-
Expiry (public)
No sales data
Peak sales
Small molecule
Type
Targets：EGFR T790M, EGFR L858R, EGFR 19del, VEGFR
Brand：Lazcluze, Leclaza
Indications (approved)：Non-small cell lung cancer
Regional status
US
Approved
2024-08-20
EU
Approved
2025-01-20
China
Approved
2025-07-29
Japan
Approved
2025-03-27
Synthetic routes & intermediates5 routes
Originator routes × 1Optimised (non-patent) × 4Process routes × 0
Routes are ordered originator first, then optimised / process (non-patent) routes; each lists steps, overall yield and the intermediate table (code / CAS / name) — ready for supplier sourcing and RFQ. Rendered by this site from structured data; no third-party route graphics used.
OriginatorRoute 1Steps 5 · Total yield /
(I) 920279-1-a1075705-01-9(II) 920279-1-a—(III) 920279-1-a1903010-37-6(IV) 920279-1-a110-91-8(V) 920279-1-a1903010-39-8(VI) 920279-1-a—(VII) 920279-1-a1903009-55-1(VIII) 920279-1-a1903009-56-2(IX) 920279-1-a814-68-6(X) 920279-1-a—API · Lazertinib Mesylate
| Code | CAS No. | Intermediate |
|---|---|---|
| (I) 920279-1-a | 1075705-01-9Available | 2-Amino-5-fluoro-4-nitroanisole |
| (II) 920279-1-a | - | 1-(2-Iodopyrimidin-4-yl)-3-phenyl-1H-pyrazole-4-carbaldehyde |
| (III) 920279-1-a | 1903010-37-6Available | 1-[2-(4-Fluoro-2-methoxy-5-nitroanilino)pyrimidin-4-yl]-3-phenyl-1H-pyrazole-4-carbaldehyde |
| (IV) 920279-1-a | 110-91-8Available | 1-Oxa-4-azacyclohexane |
| (V) 920279-1-a | 1903010-39-8Available | 1-[2-[2-Methoxy-4-(morpholin-4-yl)-5-nitroanilino]pyrimidin-4-yl]-3-phenyl-1H-pyrazole-4-carbaldehyde |
| (VI) 920279-1-a | - | Dimethylamine anhydrous |
| (VII) 920279-1-a | 1903009-55-1Available | 4-[4-[(Dimethylamino)methyl]-3-phenyl-1H-pyrazol-1-yl]-N-[2-methoxy-4-(morpholin-4-yl)-5-nitrophenyl]pyrimidin-2-amine |
| (VIII) 920279-1-a | 1903009-56-2Available | N1-[4-[4-[(Dimethylamino)methyl]-3-phenyl-1H-pyrazol-1-yl]pyrimidin-2-yl]-6-methoxy-4-(morpholin-4-yl)benzene-1,3-diamine |
| (IX) 920279-1-a | 814-68-6Available | 2-Propenoyl chloride; Acrylic acid chloride; Acrylic chloride; Acryloyl chloride |
| (X) 920279-1-a | - | N-[5-[(4-[4-[(dimethylamino)methyl]-3-phenyl-1H-pyrazol-1-yl]pyrimidin-2-yl)amino]-4-methoxy-2-(morpholin-4-yl)phenyl]prop-2-enamide |
OptimisedRoute 2Steps 8 · Total yield /
(I) 920279-2-a1075705-01-9(II) 920279-2-a1802924-13-5(III) 920279-2-a110-91-8(IV) 920279-2-a2226199-40-0(V) 920279-2-a2226198-97-4(VI) 920279-2-a625-36-5(VII) 920279-2-a2270204-97-0(VIII) 920279-2-a2226388-61-8(IX) 920279-2-a2226199-23-9(X) 920279-2-a,(X) 920279-2-b1903010-38-7(XI) 920279-2-a2270204-98-1(XII) 920279-2-a506-59-2(XIII) 920279-2-a—API · Lazertinib Mesylate
| Code | CAS No. | Intermediate |
|---|---|---|
| (I) 920279-2-a | 1075705-01-9Available | 2-Amino-5-fluoro-4-nitroanisole |
| (II) 920279-2-a | 1802924-13-5Available | N-Boc-4-Fluoro-2-methoxy-5-nitroaniline |
| (III) 920279-2-a | 110-91-8Available | 1-Oxa-4-azacyclohexane |
| (IV) 920279-2-a | 2226199-40-0Available | N-Boc-2-Methoxy-4-morpholin-4-yl-5-nitroaniline |
| (V) 920279-2-a | 2226198-97-4Available | tert-Butyl [5-amino-2-methoxy-4-(morpholin-4-yl)phenyl]carbamate |
| (VI) 920279-2-a | 625-36-5Available | (Chloromethyl)acetyl chloride |
| (VII) 920279-2-a | 2270204-97-0Available | tert-Butyl [5-(3-chloropropanamido)-2-methoxy-4-(morpholin-4-yl)phenyl]carbamate |
| (VIII) 920279-2-a | 2226388-61-8Available | N-(5-N-Boc-Amino-4-methoxy-2-morpholin-4-ylphenyl)acrylamide |
| (IX) 920279-2-a | 2226199-23-9Available | N-[5-Amino-4-methoxy-2-(morpholin-4-yl)phenyl]prop-2-enamide |
| (X) 920279-2-a,(X) 920279-2-b | 1903010-38-7Available | 1-(2-Chloropyrimidin-4-yl)-3-phenyl-1H-pyrazole-4-carbaldehyde |
| (XI) 920279-2-a | 2270204-98-1Available | N-[5-[[4-(4-Formyl-3-phenyl-1H-pyrazol-1-yl)pyrimidin-2-yl]amino]-4-methoxy-2-(morpholin-4-yl)phenyl]prop-2-enamide |
| (XII) 920279-2-a | 506-59-2Available | Dimethylamine hydrochloride |
| (XIII) 920279-2-a | - | N-[5-[(4-[4-[(dimethylamino)methyl]-3-phenyl-1H-pyrazol-1-yl]pyrimidin-2-yl)amino]-4-methoxy-2-(morpholin-4-yl)phenyl]prop-2-enamide |
OptimisedRoute 3Steps 1 · Total yield /
(X) 920279-2-a,(X) 920279-2-b1903010-38-7(XIV) 920279-2-b3934-20-1(XV) 920279-2-b26033-20-5API · Lazertinib Mesylate
| Code | CAS No. | Intermediate |
|---|---|---|
| (X) 920279-2-a,(X) 920279-2-b | 1903010-38-7Available | 1-(2-Chloropyrimidin-4-yl)-3-phenyl-1H-pyrazole-4-carbaldehyde |
| (XIV) 920279-2-b | 3934-20-1Available | 2-Chloropyrimidin-4-yl chloride |
| (XV) 920279-2-b | 26033-20-5Available | 3-Phenyl-1H-pyrazole-4-carbaldehyde |
OptimisedRoute 4Steps 7 · Total yield /
(I) 920279-3-a1075705-01-9(II) 920279-3-a110-91-8(III) 920279-3-a1903010-18-3(IV) 920279-3-a1903009-70-0(V) 920279-3-a2270865-21-7(VI) 920279-3-a625-36-5(VII) 920279-3-a2270865-25-1(VIII) 920279-3-a2270865-24-0(IX) 920279-3-a2270865-23-9(X) 920279-3-a2270204-98-1(XI) 920279-3-a506-59-2(XII) 920279-3-a—(XIII) 920279-3-a26033-20-5(XIV) 920279-3-a49844-90-8(XV) 920279-3-a2270865-22-8API · Lazertinib Mesylate
| Code | CAS No. | Intermediate |
|---|---|---|
| (I) 920279-3-a | 1075705-01-9Available | 2-Amino-5-fluoro-4-nitroanisole |
| (II) 920279-3-a | 110-91-8Available | 1-Oxa-4-azacyclohexane |
| (III) 920279-3-a | 1903010-18-3Available | 2-Methoxy-4-(morpholin-4-yl)-5-nitroaniline |
| (IV) 920279-3-a | 1903009-70-0Available | 2-Methoxy-4-morpholin-4-yl-5-nitrophenylformamide |
| (V) 920279-3-a | 2270865-21-7Available | 5-Amino-2-methoxy-4-morpholin-4-ylphenylformamide |
| (VI) 920279-3-a | 625-36-5Available | (Chloromethyl)acetyl chloride |
| (VII) 920279-3-a | 2270865-25-1Available | 3-Chloro-N-[5-formamido-4-methoxy-2-(morpholin-4-yl)phenyl]propanamide |
| (VIII) 920279-3-a | 2270865-24-0Available | N-[5-(Formylamino)-4-methoxy-2-morpholin-4-ylphenyl]acrylamide |
| (IX) 920279-3-a | 2270865-23-9Available | 1-[2-(Methanesulfonyl)pyrimidin-4-yl]-3-phenyl-1H-pyrazole-4-carbaldehyde |
| (X) 920279-3-a | 2270204-98-1Available | N-[5-[[4-(4-Formyl-3-phenyl-1H-pyrazol-1-yl)pyrimidin-2-yl]amino]-4-methoxy-2-(morpholin-4-yl)phenyl]prop-2-enamide |
| (XI) 920279-3-a | 506-59-2Available | Dimethylamine hydrochloride |
| (XII) 920279-3-a | - | N-[5-[(4-[4-[(dimethylamino)methyl]-3-phenyl-1H-pyrazol-1-yl]pyrimidin-2-yl)amino]-4-methoxy-2-(morpholin-4-yl)phenyl]prop-2-enamide |
| (XIII) 920279-3-a | 26033-20-5Available | 3-Phenyl-1H-pyrazole-4-carbaldehyde |
| (XIV) 920279-3-a | 49844-90-8Available | 4-Chloro-2-(methylsulfanyl)pyrimidine |
| (XV) 920279-3-a | 2270865-22-8Available | 1-[2-(Methylsulfanyl)pyrimidin-4-yl]-3-phenyl-1H-pyrazole-4-carbaldehyde |
OptimisedRoute 5Steps 7 · Total yield /
(I) 920279-4-a49844-90-8(II) 920279-4-a97229-11-3(III) 920279-4-a1903009-70-0(IV) 920279-4-a2270944-70-0(V) 920279-4-a26033-20-5(VI) 920279-4-a1903010-39-8(VII) 920279-4-a2270865-23-9(VIII) 920279-4-a506-59-2(IX) 920279-4-a1903009-55-1(X) 920279-4-a1903009-56-2(XIa) 920279-4-a625-36-5(XIb) 920279-4-a15486-96-1(XIIa) 920279-4-a2270944-72-2(XIIb) 920279-4-a2270944-73-3(XIII) 920279-4-a—API · Lazertinib Mesylate
| Code | CAS No. | Intermediate |
|---|---|---|
| (I) 920279-4-a | 49844-90-8Available | 4-Chloro-2-(methylsulfanyl)pyrimidine |
| (II) 920279-4-a | 97229-11-3Available | 4-Chloro-2-(methanesulfonyl)pyrimidine |
| (III) 920279-4-a | 1903009-70-0Available | 2-Methoxy-4-morpholin-4-yl-5-nitrophenylformamide |
| (IV) 920279-4-a | 2270944-70-0Available | 4-Chloro-N-[2-methoxy-4-(morpholin-4-yl)-5-nitrophenyl]pyrimidin-2-amine |
| (V) 920279-4-a | 26033-20-5Available | 3-Phenyl-1H-pyrazole-4-carbaldehyde |
| (VI) 920279-4-a | 1903010-39-8Available | 1-[2-[2-Methoxy-4-(morpholin-4-yl)-5-nitroanilino]pyrimidin-4-yl]-3-phenyl-1H-pyrazole-4-carbaldehyde |
| (VII) 920279-4-a | 2270865-23-9Available | 1-[2-(Methanesulfonyl)pyrimidin-4-yl]-3-phenyl-1H-pyrazole-4-carbaldehyde |
| (VIII) 920279-4-a | 506-59-2Available | Dimethylamine hydrochloride |
| (IX) 920279-4-a | 1903009-55-1Available | 4-[4-[(Dimethylamino)methyl]-3-phenyl-1H-pyrazol-1-yl]-N-[2-methoxy-4-(morpholin-4-yl)-5-nitrophenyl]pyrimidin-2-amine |
| (X) 920279-4-a | 1903009-56-2Available | N1-[4-[4-[(Dimethylamino)methyl]-3-phenyl-1H-pyrazol-1-yl]pyrimidin-2-yl]-6-methoxy-4-(morpholin-4-yl)benzene-1,3-diamine |
| (XIa) 920279-4-a | 625-36-5Available | (Chloromethyl)acetyl chloride |
| (XIb) 920279-4-a | 15486-96-1Available | 3-Bromopropanoyl chloride |
| (XIIa) 920279-4-a | 2270944-72-2Available | 3-Chloro-N-[5-[(4-[4-[(dimethylamino)methyl]-3-phenyl-1H-pyrazol-1-yl]pyrimidin-2-yl)amino]-4-methoxy-2-(morpholin-4-yl)phenyl]propanamide |
| (XIIb) 920279-4-a | 2270944-73-3Available | 3-Bromo-N-[5-[(4-[4-[(dimethylamino)methyl]-3-phenyl-1H-pyrazol-1-yl]pyrimidin-2-yl)amino]-4-methoxy-2-(morpholin-4-yl)phenyl]propanamide |
| (XIII) 920279-4-a | - | N-[5-[(4-[4-[(dimethylamino)methyl]-3-phenyl-1H-pyrazol-1-yl]pyrimidin-2-yl)amino]-4-methoxy-2-(morpholin-4-yl)phenyl]prop-2-enamide |
Frequently asked questions
What are the approved indications of Lazertinib Mesylate?
Approved indications include: Non-small cell lung cancer.
When does the Lazertinib Mesylate patent expire?
No public expiry year is available for Lazertinib Mesylate yet; this page updates once verified.
How many synthesis routes are recorded for Lazertinib Mesylate?
5 synthesis routes are recorded; the shortest is 1 steps with / total yield. Intermediates in each route carry codes and CAS numbers.
Where can I buy Lazertinib Mesylate intermediates?
32 intermediate CAS of Lazertinib Mesylate are available through the Unibest supply network — see the route tables on this page and request a quote per CAS.
How do I get a quote for Lazertinib Mesylate intermediates?
Open the CAS profile of the target intermediate from this page, or submit an RFQ directly — the CAS enters the matching flow automatically and the supply network responds with quotes.
Source: cross-verified data (structured fields only) · 2026-09-29