Entacapone

Tier C — Watch / trade

Entacapone

Orion Corporation

Originator

1998

First approval

Expiry (public)

$0.02B ▲

Peak sales

Small molecule

Type

Targets：COMT

Brand：Comtess, Comtan

Indications (approved)：Parkinson's disease

Regional status

Approved

1999-10-19

Approved

1998-09-16

China

Approved

2004-05-08

Japan

Approved

2007-01-26

Synthetic routes & intermediates5 routes

Originator routes × 1Optimised (non-patent) × 4Process routes × 0

Routes are ordered originator first, then optimised / process (non-patent) routes; each lists steps, overall yield and the intermediate table (code / CAS / name) — ready for supplier sourcing and RFQ. Rendered by this site from structured data; no third-party route graphics used.

OriginatorRoute 1Steps 1 · Total yield 2.23 g

ENTA-001116313-85-0ENTA-00226391-06-0ENTA-003618-42-8API · Entacapone

Code	CAS No.	Intermediate
ENTA-001	116313-85-0	3,4-dihydroxy-5-nitrobenzaldehyde
ENTA-002	26391-06-0	2-cyano-N,N-diethylacetamide
ENTA-003	618-42-8	1-(piperidin-1-yl)ethanone

OptimisedRoute 2Steps 3 · Total yield 4.00 g

ENTA-001116313-85-0ENTA-004372-09-8ENTA-005160391-70-8ENTA-0061291066-63-1ENTA-007109-89-7API · Entacapone

Code	CAS No.	Intermediate
ENTA-001	116313-85-0	3,4-dihydroxy-5-nitrobenzaldehyde
ENTA-004	372-09-8 Available	2-cyanoacetic acid
ENTA-005	160391-70-8	(E)-2-cyano-3-(3,4-dihydroxy-5-nitrophenyl)acrylic acid
ENTA-006	1291066-63-1	(E)-2-cyano-3-(3,4-dihydroxy-5-nitrophenyl)acryloyl chloride
ENTA-007	109-89-7	diethylamine

OptimisedRoute 3Steps 3 · Total yield 0.90 g

ENTA-008203861-62-5ENTA-00953793-77-4ENTA-010893419-47-1ENTA-011857629-78-8API · Entacapone

Code	CAS No.	Intermediate
ENTA-008	203861-62-5	4-iodo-2-methoxyphenol
ENTA-009	53793-77-4	2-cyano-N,N-diethylacrylamide
ENTA-010	893419-47-1	(E)-2-cyano-N,N-diethyl-3-(4-hydroxy-3-methoxyphenyl)acrylamide
ENTA-011	857629-78-8	(E)-2-cyano-N,N-diethyl-3-(4-hydroxy-3-methoxy-5-nitrophenyl)acrylamide

OptimisedRoute 4Steps 4 · Total yield 105.00 mg

ENTA-00226391-06-0ENTA-01291004-48-7ENTA-013134610-30-3ENTA-0141067233-92-4ENTA-0151067233-93-5API · Entacapone

Code	CAS No.	Intermediate
ENTA-002	26391-06-0	2-cyano-N,N-diethylacetamide
ENTA-012	91004-48-7	3,4-dimethoxy-5-nitrobenzoic acid
ENTA-013	134610-30-3	3,4-dimethoxy-5-nitrobenzoyl chloride
ENTA-014	1067233-92-4	(Z)-2-cyano-3-(3,4-dimethoxy-5-nitrophenyl)-N,N-diethyl-3-hydroxyacrylamide
ENTA-015	1067233-93-5	(E)-2-cyano-3-(3,4-dimethoxy-5-nitrophenyl)-N,N-diethylacrylamide

OptimisedRoute 5Steps 3 · Total yield 9.45 g

ENTA-001116313-85-0ENTA-00226391-06-0ENTA-004372-09-8ENTA-0166635-20-7API · Entacapone

Code	CAS No.	Intermediate
ENTA-001	116313-85-0	3,4-dihydroxy-5-nitrobenzaldehyde
ENTA-002	26391-06-0	2-cyano-N,N-diethylacetamide
ENTA-004	372-09-8 Available	2-cyanoacetic acid
ENTA-016	6635-20-7	4-hydroxy-3-methoxy-5-nitrobenzaldehyde

Frequently asked questions

What are the approved indications of Entacapone?

Approved indications include: Parkinson's disease.

When does the Entacapone patent expire?

No public expiry year is available for Entacapone yet; this page updates once verified.

How many synthesis routes are recorded for Entacapone?

5 synthesis routes are recorded; the shortest is 1 steps with 2.23 g total yield. Intermediates in each route carry codes and CAS numbers.

Where can I buy Entacapone intermediates?

1 intermediate CAS of Entacapone are available through the Unibest supply network — see the route tables on this page and request a quote per CAS.

How do I get a quote for Entacapone intermediates?

Open the CAS profile of the target intermediate from this page, or submit an RFQ directly — the CAS enters the matching flow automatically and the supply network responds with quotes.

Source: cross-verified data (structured fields only) · 2026-09-29