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Solifenacin Succinate

Tier B — Position early

Solifenacin Succinate

Astellas Pharma Inc.
Originator
2004
First approval
-
Expiry (public)
$1.34B ▲
Peak sales
Small molecule
Type

Targets:CHRM3

Brand:Vesikur, Vesicare OD, Vesicare

Indications (approved):Overactive bladder

Regional status

US
Withdrawn
EU
Discontinued
2003-07-01
China
Approved
2009-05-22
Japan
Approved
2006-04-20

Factories producing this API1

Factories registered as producing this API in our sourcing network (RFQ records + product master), sorted by RFQ activity; the snapshot carries no cost or customer data.

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Synthetic routes & intermediates5 routes

Originator routes × 1Optimised (non-patent) × 2Process routes × 2

Routes are ordered originator first, then optimised / process (non-patent) routes; each lists steps, overall yield and the intermediate table (code / CAS / name) — ready for supplier sourcing and RFQ. Rendered by this site from structured data; no third-party route graphics used.

OriginatorRoute 1Steps 2 · Total yield 10.1 g
SOLIF-001118864-75-8SOLIF-002541-41-3SOLIF-003180468-42-2SOLIF-00425333-42-0API · Solifenacin Succinate
CodeCAS No.Intermediate
SOLIF-001118864-75-8(S)-1-phenyl-1,2,3,4-tetrahydroisoquinoline
SOLIF-002541-41-3ethyl carbonochloridate
SOLIF-003180468-42-2ethyl (S)-1-phenyl-3,4-dihydroisoquinoline-2(1H)-carboxylate
SOLIF-00425333-42-0(R)-quinuclidin-3-ol
OptimisedRoute 3Steps 5 · Total yield 142.8 mg
SOLIF-001118864-75-8SOLIF-00425333-42-0SOLIF-00824388-23-6SOLIF-009313374-39-9SOLIF-01057600-98-3SOLIF-011119357-98-1SOLIF-0121229227-02-4SOLIF-0137693-46-1SOLIF-0141229227-22-8API · Solifenacin Succinate
CodeCAS No.Intermediate
SOLIF-001118864-75-8(S)-1-phenyl-1,2,3,4-tetrahydroisoquinoline
SOLIF-00425333-42-0(R)-quinuclidin-3-ol
SOLIF-00824388-23-64,4,5,5-tetramethyl-2-phenyl-1,3,2-dioxaborolane
SOLIF-009313374-39-9ethyl(phenyl)zinc
SOLIF-01057600-98-33,4-dihydroisoquinoline 2-oxide
SOLIF-011119357-98-1tert-butyl ((2S,3S)-3-methyl-1-morpholinopentan-2-yl)carbamate
SOLIF-0121229227-02-4(S)-1-phenyl-3,4-dihydroisoquinolin-2(1H)-ol
SOLIF-0137693-46-14-nitrophenyl carbonochloridate
SOLIF-0141229227-22-84-nitrophenyl (S)-1-phenyl-3,4-dihydroisoquinoline-2(1H)-carboxylate
OptimisedRoute 5Steps 2 · Total yield 1.1 g
SOLIF-001118864-75-8SOLIF-00425333-42-0SOLIF-017106-94-5SOLIF-018—API · Solifenacin Succinate
CodeCAS No.Intermediate
SOLIF-001118864-75-8(S)-1-phenyl-1,2,3,4-tetrahydroisoquinoline
SOLIF-00425333-42-0(R)-quinuclidin-3-ol
SOLIF-017106-94-5Available1-bromopropane
SOLIF-018-propyl (S)-1-phenyl-3,4-dihydroisoquinoline-2(1H)-carboxylate
ProcessRoute 2Steps 3 · Total yield 270 g
SOLIF-001118864-75-8SOLIF-00425333-42-0SOLIF-0055070-13-3SOLIF-0061243274-81-8SOLIF-007110-15-6API · Solifenacin Succinate
CodeCAS No.Intermediate
SOLIF-001118864-75-8(S)-1-phenyl-1,2,3,4-tetrahydroisoquinoline
SOLIF-00425333-42-0(R)-quinuclidin-3-ol
SOLIF-0055070-13-3bis(4-nitrophenyl) carbonate
SOLIF-0061243274-81-8(R)-4-nitrophenyl quinuclidin-3-yl carbonate
SOLIF-007110-15-6succinic acid
ProcessRoute 4Steps 3 · Total yield 390.2 g
SOLIF-001118864-75-8SOLIF-00425333-42-0SOLIF-007110-15-6SOLIF-015—SOLIF-0161459721-13-1API · Solifenacin Succinate
CodeCAS No.Intermediate
SOLIF-001118864-75-8(S)-1-phenyl-1,2,3,4-tetrahydroisoquinoline
SOLIF-00425333-42-0(R)-quinuclidin-3-ol
SOLIF-007110-15-6succinic acid
SOLIF-015-perfluorophenyl (2,3,4,5-tetrafluorophenyl) carbonate
SOLIF-0161459721-13-1(R)-perfluorophenyl quinuclidin-3-yl carbonate

Frequently asked questions

What are the approved indications of Solifenacin Succinate?

Approved indications include: Overactive bladder.

When does the Solifenacin Succinate patent expire?

No public expiry year is available for Solifenacin Succinate yet; this page updates once verified.

How many synthesis routes are recorded for Solifenacin Succinate?

5 synthesis routes are recorded; the shortest is 2 steps with 10.1 g total yield. Intermediates in each route carry codes and CAS numbers.

Where can I buy Solifenacin Succinate intermediates?

1 intermediate CAS of Solifenacin Succinate are available through the Unibest supply network — see the route tables on this page and request a quote per CAS.

How do I get a quote for Solifenacin Succinate intermediates?

Open the CAS profile of the target intermediate from this page, or submit an RFQ directly — the CAS enters the matching flow automatically and the supply network responds with quotes.

Source: cross-verified data (structured fields only) · 2026-09-29