Sparsentan

Tier C — Watch / trade

Sparsentan

Bristol Myers Squibb

Originator

2023

First approval

Expiry (public)

No sales data

Peak sales

Small molecule

Type

Targets：ETAR, AT1

Brand：Filspari

Indications (approved)：局灶性节段性肾小球硬化症, 免疫球蛋白a肾病

Regional status

Approved

2023-02-17

Approved

2024-04-19

China

Japan

Synthetic routes & intermediates3 routes

Originator routes × 1Optimised (non-patent) × 2Process routes × 0

Routes are ordered originator first, then optimised / process (non-patent) routes; each lists steps, overall yield and the intermediate table (code / CAS / name) — ready for supplier sourcing and RFQ. Rendered by this site from structured data; no third-party route graphics used.

OriginatorRoute 1Steps 7 · Total yield 26 g

SPAR-001160313-69-9SPAR-002347852-72-6SPAR-003948349-66-4SPAR-004415697-58-4SPAR-0051247868-68-3SPAR-0061098924-76-5SPAR-0071026273-26-6SPAR-008138402-05-8SPAR-0091026355-73-6API · Sparsentan

Code	CAS No.	Intermediate
SPAR-001	160313-69-9 Available	ethyl 4-bromo-3-methylbenzoate
SPAR-002	347852-72-6 Available	ethyl 4-bromo-3-(bromomethyl)benzoate
SPAR-003	948349-66-4 Available	ethyl 4-bromo-3-(ethoxymethyl)benzoate
SPAR-004	415697-58-4 Available	(2-(N-(4,5-dimethylisoxazol-3-yl)-N-(methoxymethyl)sulfamoyl)phenyl)boronic acid
SPAR-005	1247868-68-3 Available	ethyl 2'-(N-(4,5-dimethylisoxazol-3-yl)-N-(methoxymethyl)sulfamoyl)-2-(ethoxymethyl)-[1,1'-biphenyl]-4-carboxylate
SPAR-006	1098924-76-5 Available	N-(4,5-dimethylisoxazol-3-yl)-2'-(ethoxymethyl)-4'-(hydroxymethyl)-N-(methoxymethyl)-[1,1'-biphenyl]-2-sulfonamide
SPAR-007	1026273-26-6 Available	4'-(bromomethyl)-N-(4,5-dimethylisoxazol-3-yl)-2'-(ethoxymethyl)-N-(methoxymethyl)-[1,1'-biphenyl]-2-sulfonamide
SPAR-008	138402-05-8 Available	2-butyl-1,3-diazaspiro[4.4]non-1-en-4-one
SPAR-009	1026355-73-6 Available	4'-((2-butyl-4-oxo-1,3-diazaspiro[4.4]non-1-en-3-yl)methyl)-N-(4,5-dimethylisoxazol-3-yl)-2'-(ethoxymethyl)-N-(methoxymethyl)-[1,1'-biphenyl]-2-sulfonamide

OptimisedRoute 2Steps 5 · Total yield /

SPAR-003948349-66-4SPAR-008138402-05-8SPAR-0101255948-71-0SPAR-0111255948-72-1SPAR-0121255948-74-3SPAR-013415697-56-2API · Sparsentan

Code	CAS No.	Intermediate
SPAR-003	948349-66-4 Available	ethyl 4-bromo-3-(ethoxymethyl)benzoate
SPAR-008	138402-05-8 Available	2-butyl-1,3-diazaspiro[4.4]non-1-en-4-one
SPAR-010	1255948-71-0 Available	(4-bromo-3-(ethoxymethyl)phenyl)methanol
SPAR-011	1255948-72-1 Available	4-bromo-3-(ethoxymethyl)benzyl methanesulfonate
SPAR-012	1255948-74-3 Available	3-(4-bromo-3-(ethoxymethyl)benzyl)-2-butyl-1,3-diazaspiro[4.4]non-1-en-4-one dioxalate
SPAR-013	415697-56-2 Available	N-(4,5-dimethylisoxazol-3-yl)-N-(methoxymethyl)-2-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzenesulfonamide

OptimisedRoute 3Steps 7 · Total yield /

SPAR-008138402-05-8SPAR-014583-70-0SPAR-0151324003-62-4SPAR-0161255948-65-2SPAR-0171255948-66-3SPAR-0181255948-67-4SPAR-0191255948-68-5SPAR-0201255948-69-6SPAR-0211255948-70-9SPAR-02213999-39-8API · Sparsentan

Code	CAS No.	Intermediate
SPAR-008	138402-05-8 Available	2-butyl-1,3-diazaspiro[4.4]non-1-en-4-one
SPAR-014	583-70-0 Available	1-bromo-2,4-dimethylbenzene
SPAR-015	1324003-62-4 Available	isopropyl 2-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzenesulfonate
SPAR-016	1255948-65-2 Available	isopropyl 2',4'-dimethyl-[1,1'-biphenyl]-2-sulfonate
SPAR-017	1255948-66-3 Available	2',4'-dimethyl-[1,1'-biphenyl]-2-sulfonic acid
SPAR-018	1255948-67-4 Available	9-(bromomethyl)-7H-dibenzo[c,e][1,2]oxathiepine 5,5-dioxide
SPAR-019	1255948-68-5 Available	4'-(bromomethyl)-2'-(ethoxymethyl)-[1,1'-biphenyl]-2-sulfonic acid
SPAR-020	1255948-69-6 Available	4'-((2-butyl-4-oxo-1,3-diazaspiro[4.4]non-1-en-3-yl)methyl)-2'-(ethoxymethyl)-[1,1'-biphenyl]-2-sulfonic acid
SPAR-021	1255948-70-9 Available	4'-((2-butyl-4-oxo-1,3-diazaspiro[4.4]non-1-en-3-yl)methyl)-2'-(ethoxymethyl)-[1,1'-biphenyl]-2-sulfonyl chloride
SPAR-022	13999-39-8 Available	4,5-dimethylisoxazol-3-amine

Frequently asked questions

What are the approved indications of Sparsentan?

Approved indications include: 局灶性节段性肾小球硬化症, 免疫球蛋白a肾病.

When does the Sparsentan patent expire?

No public expiry year is available for Sparsentan yet; this page updates once verified.

How many synthesis routes are recorded for Sparsentan?

3 synthesis routes are recorded; the shortest is 5 steps with / total yield. Intermediates in each route carry codes and CAS numbers.

Where can I buy Sparsentan intermediates?

22 intermediate CAS of Sparsentan are available through the Unibest supply network — see the route tables on this page and request a quote per CAS.

How do I get a quote for Sparsentan intermediates?

Open the CAS profile of the target intermediate from this page, or submit an RFQ directly — the CAS enters the matching flow automatically and the supply network responds with quotes.

Source: cross-verified data (structured fields only) · 2026-09-29