Simvastatin
Tier C — Watch / tradeSimvastatin
Targets：HMGCR
Brand：Colemin, Lodalès, Lipex, Lipovas, Zocord, Sinvacor, Denan, Zocor, Simvast CR, Pantok, Sivastin, Medipo
Indications (approved)：Hyperlipidaemia, Myocardial infarction, Dyslipidaemia, Heterozygous familial hypercholesterolaemia, Stroke, Hypercholesterolaemia, Hyperlipoproteinaemia type V, Coronary artery disease
Regional status
Factories producing this API1
Factories registered as producing this API in our sourcing network (RFQ records + product master), sorted by RFQ activity; the snapshot carries no cost or customer data.
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Sign in to view factories →Synthetic routes & intermediates6 routes
Routes are ordered originator first, then optimised / process (non-patent) routes; each lists steps, overall yield and the intermediate table (code / CAS / name) — ready for supplier sourcing and RFQ. Rendered by this site from structured data; no third-party route graphics used.
| Code | CAS No. | Intermediate |
|---|---|---|
| (I)122234-5-a | 79902-31-1 | (4R,6R)-4-[[tert-Butyl(dimethyl)silyl]oxy]-6-[2-[(1S,2S,6R,8S,8aR)-8-hydroxy-2,6-dimethyl-1,2,6,7,8,8a-hexahydronaphthalen-1-yl]ethyl]oxan-2-one |
| (II)122234-5-a | 595-37-9 | 2,2-dimethylbutanoic acid |
| (III)122234-5-a | 79902-59-3 | (1S,3R,7S,8S,8aR)-8-[2-[(2R,4R)-4-[[tert-Butyl(dimethyl)silyl]oxy]-6-oxooxan-2-yl]ethyl]-3,7-dimethyl-1,2,3,7,8,8a-hexahydronaphthalen-1-yl 2,2-dimethylbutanoate |
| Code | CAS No. | Intermediate |
|---|---|---|
| (I)122234-12-a | 132748-10-8 | 3(R),5(R)-Dihydroxy-7-[(1S,2S,6R,8S,8aR)-8-hydroxy-2,6-dimethyl-1,2,6,7,8,8a-hexahydronaphthalen-1-yl]heptanoic acid |
| (II)122234-12-a | 79952-42-4 | 4(R)-Hydroxy-6(R)-[2-[(1S,2S,6R,8S,8aR)-8-hydroxy-2,6-dimethyl-1,2,6,7,8,8a-hexahydronaphthalenyl]ethyl]tetrahydropyran-2-one |
| (III)122234-12-a | 5856-77-9 | 2,2-Dimethylbutanoyl chloride |
| Code | CAS No. | Intermediate |
|---|---|---|
| (I)122234-13-a | 79952-42-4 | 4(R)-Hydroxy-6(R)-[2-[(1S,2S,6R,8S,8aR)-8-hydroxy-2,6-dimethyl-1,2,6,7,8,8a-hexahydronaphthalenyl]ethyl]tetrahydropyran-2-one |
| (IIa)122234-13-a | 149-73-5 | Orthoformic acid trimethyl ester |
| (IIb)122234-13-a | 122-51-0Available | (Diethoxymethoxy)ethane |
| (IIIa)122234-13-a | 1198221-93-0 | Methyl [(4R,6R)-6-[2-[(1S,2S,6R,8S,8aR)-8-hydroxy-2,6-dimethyl-1,2,6,7,8,8a-hexahydronaphthalen-1-yl]ethyl]-2-methoxy-1,3-dioxan-4-yl]acetate |
| (IIIb)122234-13-a | 1198221-97-4 | Ethyl [(4R,6R)-2-ethoxy-6-[2-[(1S,2S,6R,8S,8aR)-8-hydroxy-2,6-dimethyl-1,2,6,7,8,8a-hexahydronaphthalen-1-yl]ethyl]-1,3-dioxan-4-yl]acetate |
| (IV)122234-13-a | 5856-77-9 | 2,2-Dimethylbutanoyl chloride |
| (Va)122234-13-a | 1198221-95-2 | (1S,3R,7S,8S,8aR)-8-[2-[(4R,6R)-2-Methoxy-6-(2-methoxy-2-oxoethyl)-1,3-dioxan-4-yl]ethyl]-3,7-dimethyl-1,2,3,7,8,8a-hexahydronaphthalen-1-yl 2,2-dimethylbutanoate |
| (Vb)122234-13-a | 1198221-99-6 | (1S,3R,7S,8S,8aR)-8-[2-[(4R,6R)-2-Ethoxy-6-(2-ethoxy-2-oxoethyl)-1,3-dioxan-4-yl]ethyl]-3,7-dimethyl-1,2,3,7,8,8a-hexahydronaphthalen-1-yl 2,2-dimethylbutanoate |
| (VI)122234-13-a | 139893-43-9 | (betaR,deltaR,1S,2S,6R,8S,8aR)-8-(2,2-Dimethyl-1-oxobutoxy)-1,2,6,7,8,8a-hexahydro-beta,delta-dihydroxy-2,6-dimethyl-1-naphthaleneheptanoic acid ammonium salt |
| Code | CAS No. | Intermediate |
|---|---|---|
| (I)122234-14-a | 5856-77-9 | 2,2-Dimethylbutanoyl chloride |
| (II)122234-14-a | 1608487-07-5 | S-(2-Hydroxyethyl) 2,2-dimethylbutanethioate |
| (III)122234-14-a | 1604678-79-6 | 2-[(2,2-Dimethylbutanoyl)sulfanyl]ethyl acetate |
| (IV)122234-14-a | 132748-10-8 | 3(R),5(R)-Dihydroxy-7-[(1S,2S,6R,8S,8aR)-8-hydroxy-2,6-dimethyl-1,2,6,7,8,8a-hexahydronaphthalen-1-yl]heptanoic acid |
| (V)122234-14-a | 139893-43-9 | (betaR,deltaR,1S,2S,6R,8S,8aR)-8-(2,2-Dimethyl-1-oxobutoxy)-1,2,6,7,8,8a-hexahydro-beta,delta-dihydroxy-2,6-dimethyl-1-naphthaleneheptanoic acid ammonium salt |
| Code | CAS No. | Intermediate |
|---|---|---|
| (I)122234-16-a | 139893-43-9 | (betaR,deltaR,1S,2S,6R,8S,8aR)-8-(2,2-Dimethyl-1-oxobutoxy)-1,2,6,7,8,8a-hexahydro-beta,delta-dihydroxy-2,6-dimethyl-1-naphthaleneheptanoic acid ammonium salt |
| (II)122234-16-a | 121009-77-6 | (3R,5R)-7-[(1S,2S,6R,8S,8aR)-8-[(2,2-Dimethylbutanoyl)oxy]-2,6-dimethyl-1,2,6,7,8,8a-hexahydronaphthalen-1-yl]-3,5-dihydroxyheptanoic acid |
| Code | CAS No. | Intermediate |
|---|---|---|
| (I)122234-19-a | 595-37-9 | 2,2-dimethylbutanoic acid |
| (II)122234-19-a | 5856-77-9 | 2,2-Dimethylbutanoyl chloride |
| (III)122234-19-a | 2935-90-2 | 3-Mercaptopropionic acid methyl ester |
| (IV)122234-19-a | 938063-63-9 | Methyl 3-[(2,2-dimethylbutanoyl)sulfanyl]propanoate |
Frequently asked questions
What are the approved indications of Simvastatin?
Approved indications include: Hyperlipidaemia, Myocardial infarction, Dyslipidaemia, Heterozygous familial hypercholesterolaemia, Stroke, Hypercholesterolaemia, Hyperlipoproteinaemia type V, Coronary artery disease.
When does the Simvastatin patent expire?
No public expiry year is available for Simvastatin yet; this page updates once verified.
How many synthesis routes are recorded for Simvastatin?
6 synthesis routes are recorded; the shortest is 1 steps with / total yield. Intermediates in each route carry codes and CAS numbers.
Where can I buy Simvastatin intermediates?
1 intermediate CAS of Simvastatin are available through the Unibest supply network — see the route tables on this page and request a quote per CAS.
How do I get a quote for Simvastatin intermediates?
Open the CAS profile of the target intermediate from this page, or submit an RFQ directly — the CAS enters the matching flow automatically and the supply network responds with quotes.
Source: cross-verified data (structured fields only) · 2026-09-29