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Avibactam Sodium/Ceftazidime
Tier C — Watch / tradeAvibactam Sodium/Ceftazidime
Allergan
Originator
2015
First approval
-
Expiry (public)
$0.64B ▲
Peak sales
Small molecule
Type
Targets：PBPs, Beta Lactamase
Brand：Zavicefta, Avycaz
Indications (approved)：Cystitis, Cholecystitis, Peritonitis, Intra-abdominal infection, Liver abscess, Sepsis, Pyelonephritis, Bacterial pneumonia
Regional status
US
Approved
2015-02-25
EU
Approved
2016-06-23
China
Approved
2019-05-21
Japan
Approved
2024-06-24
Factories producing this API9
Factories registered as producing this API in our sourcing network (RFQ records + product master), sorted by RFQ activity; the snapshot carries no cost or customer data.
9 producing factories on file — sign in to view the named list (factory details are not shown to guests).
Sign in to view factories →Synthetic routes & intermediates11 routes
Originator routes × 1Optimised (non-patent) × 10Process routes × 0
Routes are ordered originator first, then optimised / process (non-patent) routes; each lists steps, overall yield and the intermediate table (code / CAS / name) — ready for supplier sourcing and RFQ. Rendered by this site from structured data; no third-party route graphics used.
OriginatorRoute 1Steps 10 · Total yield /
Ceftazidime-001141-97-9Ceftazidime-002109-95-5Ceftazidime-0031516-08-1,64-17-5Ceftazidime-0045408-04-8Ceftazidime-00562-56-6Ceftazidime-00660845-81-0Ceftazidime-00766338-99-6Ceftazidime-00823877-12-5Ceftazidime-00968672-65-1Ceftazidime-01068672-66-2Ceftazidime-011957-68-6Ceftazidime-012127664-87-3Ceftazidime-01373443-60-4Ceftazidime-014110-86-1API · Avibactam Sodium/Ceftazidime
| Code | CAS No. | Intermediate |
|---|---|---|
| Ceftazidime-001 | 141-97-9Available | ethyl 3-oxobutanoate |
| Ceftazidime-002 | 109-95-5 | Ethyl nitrite |
| Ceftazidime-003 | 1516-08-1,64-17-5 | Non-denatured ethanol |
| Ceftazidime-004 | 5408-04-8 | ethyl (E)-2-(hydroxyimino)-3-oxobutanoate |
| Ceftazidime-005 | 62-56-6Available | thiourea |
| Ceftazidime-006 | 60845-81-0 | ethyl (Z)-2-(2-aminothiazol-4-yl)-2-(hydroxyimino)acetate |
| Ceftazidime-007 | 66338-99-6 | Ethyl (2Z)-(hydroxyimino)[2-[(triphenylmethyl)amino]-1,3-thiazol-4-yl]acetate |
| Ceftazidime-008 | 23877-12-5 | tert-Butyl 2-bromo-2-methylpropionate |
| Ceftazidime-009 | 68672-65-1 | tert-Butyl 2-[[(Z)-(2-ethoxy-2-oxo-1-[2-[(triphenylmethyl)amino]-1,3-thiazol-4-yl]ethylidene)amino]oxy]-2-methylpropanoate |
| Ceftazidime-010 | 68672-66-2 | (2Z)-[[(1-tert-Butoxy-2-methyl-1-oxopropan-2-yl)oxy]imino][2-[(triphenylmethyl)amino]-1,3-thiazol-4-yl]acetic acid |
| Ceftazidime-011 | 957-68-6 | (6R,7R)-3-(Acetoxymethyl)-7-amino-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid |
| Ceftazidime-012 | 127664-87-3 | (6R,7R)-3-[(Acetyloxy)methyl]-7-[[(2Z)-2-[[(1-tert-butoxy-2-methyl-1-oxopropan-2-yl)oxy]imino]-2-[2-[(triphenylmethyl)amino]-1,3-thiazol-4-yl]acetyl]amino]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid |
| Ceftazidime-013 | 73443-60-4 | (6R,7R)-3-[(Acetyloxy)methyl]-7-[[(2Z)-2-(2-amino-1,3-thiazol-4-yl)-2-[[(2-carboxypropan-2-yl)oxy]imino]acetyl]amino]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid |
| Ceftazidime-014 | 110-86-1 | pyridine |
OptimisedRoute 2Steps 11 · Total yield /
Ceftazidime-011957-68-6Ceftazidime-01531461-04-8Ceftazidime-016106134-67-2Ceftazidime-014110-86-1Ceftazidime-01798445-42-2Ceftazidime-01896752-43-1Ceftazidime-0191040394-00-0Ceftazidime-02089604-92-2Ceftazidime-021102772-66-7API · Avibactam Sodium/Ceftazidime
| Code | CAS No. | Intermediate |
|---|---|---|
| Ceftazidime-011 | 957-68-6 | (6R,7R)-3-(Acetoxymethyl)-7-amino-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid |
| Ceftazidime-015 | 31461-04-8 | Trimethylsilyl 7-(trimethylsilylamino)cephalosporanate |
| Ceftazidime-016 | 106134-67-2 | Trimethylsilyl (6R,7R)-3-(iodomethyl)-8-oxo-7-[(trimethylsilyl)amino]-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate |
| Ceftazidime-014 | 110-86-1 | Pyridine |
| Ceftazidime-017 | 98445-42-2 | 1-[[(6R,7R)-8-Oxo-7-[(trimethylsilyl)amino]-2-[[(trimethylsilyl)oxy]carbonyl]-5-thia-1-azabicyclo[4.2.0]oct-2-en-3-yl]methyl]pyridin-1-ium iodide |
| Ceftazidime-018 | 96752-43-1 | (6R,7R)-7-Amino-8-oxo-3-(pyridinium-1-ylmethyl)-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate dihydrochloride |
| Ceftazidime-019 | 1040394-00-0 | 2-[[(Z)-[1-(2-Amino-1,3-thiazol-4-yl)-2-[(1,3-benzothiazol-2-yl)sulfanyl]-2-oxoethylidene]amino]oxy]-2-methylpropanoic acid |
| Ceftazidime-020 | 89604-92-2 | tert-Butyl 2-[[(Z)-[1-(2-amino-1,3-thiazol-4-yl)-2-[(1,3-benzothiazol-2-yl)sulfanyl]-2-oxoethylidene]amino]oxy]-2-methylpropanoate |
| Ceftazidime-021 | 102772-66-7 | (6R,7R)-7-[[(2Z)-2-(2-Amino-1,3-thiazol-4-yl)-2-[[(1-tert-butoxy-2-methyl-1-oxopropan-2-yl)oxy]imino]acetyl]amino]-8-oxo-3-[(pyridin-1-ium-1-yl)methyl]-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylat e |
OptimisedRoute 3Steps 1 · Total yield /
Ceftazidime-02089604-92-2Ceftazidime-02286299-46-9Ceftazidime-023120-78-5Ceftazidime-02486299-47-0API · Avibactam Sodium/Ceftazidime
| Code | CAS No. | Intermediate |
|---|---|---|
| Ceftazidime-020 | 89604-92-2 | tert-Butyl 2-[[(Z)-[1-(2-amino-1,3-thiazol-4-yl)-2-[(1,3-benzothiazol-2-yl)sulfanyl]-2-oxoethylidene]amino]oxy]-2-methylpropanoate |
| Ceftazidime-022 | 86299-46-9 | tert-Butyl 2-([(Z)-[1-(2-amino-1,3-thiazol-4-yl)-2-ethoxy-2-oxoethylidene]amino]oxy)-2-methylpropanoate |
| Ceftazidime-023 | 120-78-5 | 2-(1,3-Benzothiazol-2-yldisulfanyl)-1,3-benzothiazole |
| Ceftazidime-024 | 86299-47-0 | (2Z)-(2-Amino-1,3-thiazol-4-yl)[[(1-tert-butoxy-2-methyl-1-oxopropan-2-yl)oxy]imino]acetic acid |
OptimisedRoute 4Steps 6 · Total yield /
Ceftazidime-02579-31-2Ceftazidime-0262052-01-9Ceftazidime-00823877-12-5Ceftazidime-02760845-81-0Ceftazidime-02286299-46-9Ceftazidime-02486299-47-0Ceftazidime-028354808-44-9Ceftazidime-029100988-63-4API · Avibactam Sodium/Ceftazidime
| Code | CAS No. | Intermediate |
|---|---|---|
| Ceftazidime-025 | 79-31-2Available | 2-Methylpropionic acid |
| Ceftazidime-026 | 2052-01-9 | 2-Bromo-2-methylpropanoic acid |
| Ceftazidime-008 | 23877-12-5 | t-Butyl 2-bromo isobutyrate |
| Ceftazidime-027 | 60845-81-0 | 2(Z)-(2-Aminothiazol-4-yl)-2-(hydroxyimino)acetic acid ethyl ester |
| Ceftazidime-022 | 86299-46-9 | tert-Butyl 2-([(Z)-[1-(2-amino-1,3-thiazol-4-yl)-2-ethoxy-2-oxoethylidene]amino]oxy)-2-methylpropanoate |
| Ceftazidime-024 | 86299-47-0 | (2Z)-(2-Amino-1,3-thiazol-4-yl)[[(1-tert-butoxy-2-methyl-1-oxopropan-2-yl)oxy]imino]acetic acid |
| Ceftazidime-028 | 354808-44-9 | 2-([[(1Z)-1-(2-Amino-1,3-thiazol-4-yl)-2-chloro-2-oxoethylidene]amino]oxy)-2-methylpropanoic acid hydrochloride |
| Ceftazidime-029 | 100988-63-4 | (6R,7R)-7-Amino-8-oxo-3-(pyridinium-1-ylmethyl)-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate hydroiodide |
OptimisedRoute 5Steps 2 · Total yield /
Ceftazidime-030149-30-4Ceftazidime-02089604-92-2Ceftazidime-023120-78-5Ceftazidime-02286299-46-9API · Avibactam Sodium/Ceftazidime
| Code | CAS No. | Intermediate |
|---|---|---|
| Ceftazidime-030 | 149-30-4Available | 2-Mercaptobenzothiazole |
| Ceftazidime-020 | 89604-92-2 | tert-Butyl 2-[[(Z)-[1-(2-amino-1,3-thiazol-4-yl)-2-[(1,3-benzothiazol-2-yl)sulfanyl]-2-oxoethylidene]amino]oxy]-2-methylpropanoate |
| Ceftazidime-023 | 120-78-5 | 2-(1,3-Benzothiazol-2-yldisulfanyl)-1,3-benzothiazole |
| Ceftazidime-022 | 86299-46-9 | tert-Butyl 2-([(Z)-[1-(2-amino-1,3-thiazol-4-yl)-2-ethoxy-2-oxoethylidene]amino]oxy)-2-methylpropanoate |
OptimisedRoute 6Steps 3 · Total yield /
Ceftazidime-036619-60-3Ceftazidime-031—Ceftazidime-033128378-10-9Ceftazidime-0341879943-41-5Ceftazidime-035123-30-8Ceftazidime-02486299-47-0Ceftazidime-014110-86-1Ceftazidime-032113479-65-5API · Avibactam Sodium/Ceftazidime
| Code | CAS No. | Intermediate |
|---|---|---|
| Ceftazidime-036 | 619-60-3 | 4-(Dimethylamino)phenol |
| Ceftazidime-031 | - | tert-Butyl (5Z)-5-(2-amino-1,3-thiazol-4-yl)-8,8-dimethyl-4-oxo-3,7-dioxa-2-thia-6-azanon-5-en-9-oate 2,2-dioxide |
| Ceftazidime-033 | 128378-10-9 | 4-Methoxybenzyl (6R,7R)-7-[[(2Z)-2-(2-amino-1,3-thiazol-4-yl)-2-[[(1-tert-butoxy-2-methyl-1-oxopropan-2-yl)oxy]imino]acetyl]amino]-3-(chloromethyl)-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate |
| Ceftazidime-034 | 1879943-41-5 | 1-[[(6R,7R)-7-[[(2Z)-2-(2-Amino-1,3-thiazol-4-yl)-2-[[(1-tert-butoxy-2-methyl-1-oxopropan-2-yl)oxy]imino]acetyl]amino]-2-[[(4-methoxybenzyl)oxy]carbonyl]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-en-3-yl]methyl]pyridinium chloride |
| Ceftazidime-035 | 123-30-8Available | 4-Hydroxyaniline |
| Ceftazidime-024 | 86299-47-0 | (2Z)-(2-Amino-1,3-thiazol-4-yl)[[(1-tert-butoxy-2-methyl-1-oxopropan-2-yl)oxy]imino]acetic acid |
| Ceftazidime-014 | 110-86-1 | Pyridine |
| Ceftazidime-032 | 113479-65-5 | 4-Methoxybenzyl (6R,7R)-7-amino-3-(chloromethyl)-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate hydrochloride |
OptimisedRoute 7Steps 1 · Total yield /
Ceftazidime-023120-78-5Ceftazidime-038—Ceftazidime-037102507-85-7API · Avibactam Sodium/Ceftazidime
| Code | CAS No. | Intermediate |
|---|---|---|
| Ceftazidime-023 | 120-78-5 | Bis(benzothiazol-2-yl)disulfide |
| Ceftazidime-038 | - | S-1,3-Benzothiazol-2-yl 2-[[(Z)-[1-(2-amino-1,3-thiazol-4-yl)-2-[(1,3-benzothiazol-2-yl)sulfanyl]-2-oxoethylidene]amino]oxy]-2-methylpropanethioate |
| Ceftazidime-037 | 102507-85-7 | 2-{[(Z)-[(2-amino-1,3-thiazol-4-yl)(carboxy)methylidene]amino]oxy}-2-methylpropanoic acid |
OptimisedRoute 8Steps 2 · Total yield /
Ceftazidime-03998445-42-2Ceftazidime-028354808-44-9Ceftazidime-0401809092-47-4API · Avibactam Sodium/Ceftazidime
| Code | CAS No. | Intermediate |
|---|---|---|
| Ceftazidime-039 | 98445-42-2 | 1-[[(6R,7R)-8-Oxo-7-[(trimethylsilyl)amino]-2-[[(trimethylsilyl)oxy]carbonyl]-5-thia-1-azabicyclo[4.2.0]oct-2-en-3-yl]methyl]pyridin-1-ium iodide |
| Ceftazidime-028 | 354808-44-9 | 2-([[(1Z)-1-(2-Amino-1,3-thiazol-4-yl)-2-chloro-2-oxoethylidene]amino]oxy)-2-methylpropanoic acid hydrochloride |
| Ceftazidime-040 | 1809092-47-4 | 1-[[(6R,7R)-7-[[(2Z)-2-(2-Amino-1,3-thiazol-4-yl)-2-[[(2-carboxypropan-2-yl)oxy]imino]acetyl]amino]-8-oxo-2-[[(trimethylsilyl)oxy]carbonyl]-5-thia-1-azabicyclo[4.2.0]oct-2-en-3-yl]methyl]pyridin-1-ium iodide |
OptimisedRoute 9Steps 4 · Total yield /
Ceftazidime-02486299-47-0Ceftazidime-029100988-63-4Ceftazidime-00660845-81-0Ceftazidime-00823877-12-5Ceftazidime-041—Ceftazidime-044—Ceftazidime-021102772-66-7Ceftazidime-042—Ceftazidime-043—API · Avibactam Sodium/Ceftazidime
| Code | CAS No. | Intermediate |
|---|---|---|
| Ceftazidime-024 | 86299-47-0 | (2Z)-(2-Amino-1,3-thiazol-4-yl)[[(1-tert-butoxy-2-methyl-1-oxopropan-2-yl)oxy]imino]acetic acid |
| Ceftazidime-029 | 100988-63-4 | (6R,7R)-7-Amino-8-oxo-3-(pyridinium-1-ylmethyl)-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate hydroiodide |
| Ceftazidime-006 | 60845-81-0 | 2(Z)-(2-Aminothiazol-4-yl)-2-(hydroxyimino)acetic acid ethyl ester |
| Ceftazidime-008 | 23877-12-5 | tert-Butyl 2-bromo-2-methylpropionate<-fgf->2-Bromo-2-methylpropionic acid tert-butyl ester |
| Ceftazidime-041 | - | Sodium (2Z)-(2-amino-1,3-thiazol-4-yl)(hydroxyimino)acetate |
| Ceftazidime-044 | - | tert-Butyl 2-[[(Z)-[1-(2-amino-1,3-thiazol-4-yl)-2-[[(4-methylphenyl)sulfonyl]oxy]-2-oxoethylidene]amino]oxy]-2-methylpropanoate |
| Ceftazidime-021 | 102772-66-7 | (6R,7R)-7-[[(2Z)-2-(2-Amino-1,3-thiazol-4-yl)-2-[[(1-tert-butoxy-2-methyl-1-oxopropan-2-yl)oxy]imino]acetyl]amino]-8-oxo-3-[(pyridin-1-ium-1-yl)methyl]-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylat e |
| Ceftazidime-042 | - | Potassium (2Z)-(2-amino-1,3-thiazol-4-yl)(hydroxyimino)acetate |
| Ceftazidime-043 | - | Lithium (2Z)-(2-amino-1,3-thiazol-4-yl)(hydroxyimino)acetate |
OptimisedRoute 10Steps 1 · Total yield /
Ceftazidime-04518820-82-1Ceftazidime-014110-86-1API · Avibactam Sodium/Ceftazidime
| Code | CAS No. | Intermediate |
|---|---|---|
| Ceftazidime-045 | 18820-82-1 | Pyridine hydrobromide |
| Ceftazidime-014 | 110-86-1 | Pyridine |
OptimisedRoute 11Steps 1 · Total yield /
Ceftazidime-04666338-95-2Ceftazidime-04762-56-6Ceftazidime-04864513-00-4API · Avibactam Sodium/Ceftazidime
| Code | CAS No. | Intermediate |
|---|---|---|
| Ceftazidime-046 | 66338-95-2 | Ethyl (2Z)-4-chloro-2-(hydroxyimino)-3-oxobutanoate |
| Ceftazidime-047 | 62-56-6Available | Thiocarbamide |
| Ceftazidime-048 | 64513-00-4 | Ethyl (2E)-(2-amino-1,3-thiazol-4-yl)(hydroxyimino)acetate |
Frequently asked questions
What are the approved indications of Avibactam Sodium/Ceftazidime?
Approved indications include: Cystitis, Cholecystitis, Peritonitis, Intra-abdominal infection, Liver abscess, Sepsis, Pyelonephritis, Bacterial pneumonia.
When does the Avibactam Sodium/Ceftazidime patent expire?
No public expiry year is available for Avibactam Sodium/Ceftazidime yet; this page updates once verified.
How many synthesis routes are recorded for Avibactam Sodium/Ceftazidime?
11 synthesis routes are recorded; the shortest is 1 steps with / total yield. Intermediates in each route carry codes and CAS numbers.
Where can I buy Avibactam Sodium/Ceftazidime intermediates?
5 intermediate CAS of Avibactam Sodium/Ceftazidime are available through the Unibest supply network — see the route tables on this page and request a quote per CAS.
How do I get a quote for Avibactam Sodium/Ceftazidime intermediates?
Open the CAS profile of the target intermediate from this page, or submit an RFQ directly — the CAS enters the matching flow automatically and the supply network responds with quotes.
Source: cross-verified data (structured fields only) · 2026-09-29