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Tetrodotoxin

Tier C — Watch / trade

Tetrodotoxin

Virios Therapeutics Inc
Originator
-
First approval
-
Expiry (public)
No sales data
Peak sales
Small molecule
Type

Targets：Nav1.2, Nav1.5, Nav1.1

Brand：Tectin, Tocudin, Tetrodin

Indications (approved)：神经痛, 海洛因依赖, Cancer pain, Pain, 中毒

Regional status

US
Phase II
2025-02-21
EU
-
China
Phase II
2014-05-07
Japan
-

Synthetic routes & intermediates2 routes

Originator routes × 2Optimised (non-patent) × 0Process routes × 0

Routes are ordered originator first, then optimised / process (non-patent) routes; each lists steps, overall yield and the intermediate table (code / CAS / name) — ready for supplier sourcing and RFQ. Rendered by this site from structured data; no third-party route graphics used.

OriginatorRoute 1Steps 39 · Total yield 1.9 mg
TETRO-026—TETRO-031588694-02-4TETRO-032588694-04-6TETRO-033588694-06-8TETRO-034588694-08-0TETRO-035588694-10-4TETRO-036107819-90-9TETRO-037588694-14-8TETRO-038—TETRO-039588694-16-0TETRO-040—TETRO-041588694-18-2TETRO-0427724-39-2TETRO-04313072-89-4TETRO-044616225-39-9TETRO-011(4a-S)588693-41-8TETRO-013(4a-S)588693-43-0TETRO-014(4a-S)588693-45-2TETRO-015(4a-S)588693-49-6TETRO-017(4a-S)1026479-97-9TETRO-019(4a-S)588693-57-6TETRO-020(4a-S)588693-60-1TETRO-021(4a-S)588693-65-6TETRO-022(4a-S)588693-67-8TETRO-023(4a-S)588693-75-8TETRO-027(4a-S)588693-83-8TETRO-028(4a-S)588693-87-2TETRO-029(4a-S)588693-94-1TETRO-030(4a-S)588693-98-5TETRO-0013366-47-0TETRO-00293662-86-3TETRO-003115352-42-6TETRO-004588693-26-9TETRO-005—TETRO-0061066-54-2TETRO-007588693-32-7TETRO-008116-11-0TETRO-009588693-35-0TETRO-010588693-37-2TETRO-012—TETRO-016588693-51-0TETRO-018588693-53-2TETRO-024588693-77-0TETRO-025588693-79-2API · Tetrodotoxin
CodeCAS No.Intermediate
TETRO-026-(1S,5R,6R)-6-((benzyloxy)methoxy)-8-(((tert-butyldiphenylsilyl)oxy)methyl)-9-((S)-2,2-dimethyl-1,3-dioxolan-4-yl)-5-(2-((4-methoxyphenyl)diphenylmethoxy)ethyl)-2-oxa-4-azabicyclo[3.3.1]non-7-en-3-one
TETRO-031588694-02-4((1S,5R,6R,7R,8S,9S)-7-acetoxy-9-((benzyloxy)methoxy)-5-((tert-butoxycarbonyl)amino)-6-(2,2-dimethyl-1,3-dioxolan-4-yl)-8-hydroxy-2-oxabicyclo[3.3.1]non-3-en-8-yl)methyl benzoate
TETRO-032588694-04-6((1S,5R,6R,7R,8S,9S)-7-acetoxy-9-((benzyloxy)methoxy)-5-((tert-butoxycarbonyl)amino)-6-(2,2-dimethyl-1,3-dioxolan-4-yl)-8-hydroxy-3,4-dioxo-2-oxabicyclo[3.3.1]nonan-8-yl)methyl benzoate
TETRO-033588694-06-8((1S,4R,5S,6R,7R,8S,9S)-7-acetoxy-9-((benzyloxy)methoxy)-5-((tert-butoxycarbonyl)amino)-6-(2,2-dimethyl-1,3-dioxolan-4-yl)-4,8-dihydroxy-3-oxo-2-oxabicyclo[3.3.1]nonan-8-yl)methyl benzoate
TETRO-034588694-08-0(1R,3S,5S,6S,7R,8R,9S,10R)-3-(benzoyloxy)-9-((benzoyloxy)methyl)-6-((benzyloxy)methoxy)-7-((tert-butoxycarbonyl)amino)-8-(2,2-dimethyl-1,3-dioxolan-4-yl)-2,4-dioxaadamantane-9,10-diyl diacetate
TETRO-035588694-10-4(1R,3S,5S,6S,7R,8R,9S,10R)-3-(benzoyloxy)-9-((benzoyloxy)methyl)-7-((tert-butoxycarbonyl)amino)-8-(2,2-dimethyl-1,3-dioxolan-4-yl)-2,4-dioxaadamantane-6,9,10-triyl triacetate
TETRO-036107819-90-9 tert-butyl N-[[(2-methylpropan-2-yl)oxycarbonylamino]-methylsulfanylmethylidene]carbamate
TETRO-037588694-14-8(1R,3S,5S,6S,7R,8R,9S,10R)-3-(benzoyloxy)-9-((benzoyloxy)methyl)-7-((Z)-2,3-bis(tert-butoxycarbonyl)guanidino)-8-(1,2-dihydroxyethyl)-2,4-dioxaadamantane-6,9,10-triyl triacetate
TETRO-038-(4R,4aR,5R,6S,7S,9S,10R,10aR,11S)-9-(benzoyloxy)-6-((benzoyloxy)methyl)-2-((tert-butoxycarbonyl)amino)-4-hydroxy-1,4,4a,5,6,7,9,10-octahydro-5,9-epoxy-7,10a-methanooxocino[4,5-d]pyrimidine-6,10,11-triyl triacetate
TETRO-039588694-16-0(4R,4aR,5R,6S,7S,9S,10R,10aS,11S)-2-amino-9-(benzoyloxy)-6-((benzoyloxy)methyl)-4,10-dihydroxy-1,4,4a,5,6,7,9,10-octahydro-5,9-epoxy-7,10a-methanooxocino[4,5-d]pyrimidine-6,11-diyl diacetate
TETRO-040-(4R,4aR,5R,6S,7S,9S,10R,10aS,11S)-2-amino-9-(benzoyloxy)-6-((benzoyloxy)methyl)-10-hydroxy-4-methoxy-1,4,4a,5,6,7,9,10-octahydro-5,9-epoxy-7,10a-methanooxocino[4,5-d]pyrimidine-6,11-diyl diacetate
TETRO-041588694-18-2(4R,4aR,5R,6S,7S,9S,10R,10aR,11S,Z)-1,3-diacetyl-2-(acetylimino)-9-(benzoyloxy)-6-((benzoyloxy)methyl)-4-methoxydecahydro-5,9-epoxy-7,10a-methanooxocino[4,5-d]pyrimidine-6,10,11-triyl triacetate
TETRO-0427724-39-2(4R,4aR,5R,6S,7S,9S,10R,10aR,11S)-2-amino-6-(hydroxymethyl)-4-methoxy-1,4,4a,5,6,7,9,10-octahydro-5,9-epoxy-7,10a-methanooxocino[4,5-d]pyrimidine-6,9,10,11-tetraol
TETRO-04313072-89-4(4S,6S,8R,9S,10S,11S,11aR,12R)-2-amino-9-(hydroxymethyl)-1,4,5a,6,8,9,10,11-octahydro-4,8,11a-(epimethanetriyl)-6,10-epoxyoxocino[4,3-f][1,3,5]oxadiazepine-6,9,11-triol
TETRO-044616225-39-9(R)-2-((tert-butyldimethylsilyl)oxy)-2-((R)-2,2-dimethyl-1,3-dioxolan-4-yl)-N,N-dimethylacetamide
TETRO-011(4a-S)588693-41-81-((2S,6S)-2-(((tert-butyldimethylsilyl)oxy)methyl)-4-ethynyl-6-isopropoxy-3,6-dihydro-2H-pyran-3-yl)-3-hydroxypropan-2-one
TETRO-013(4a-S)588693-43-0(Z)-3-((2S,6S)-2-(((tert-butyldimethylsilyl)oxy)methyl)-4-ethynyl-6-isopropoxy-3,6-dihydro-2H-pyran-3-yl)-2-(methoxymethoxy)prop-2-en-1-ol
TETRO-014(4a-S)588693-45-2(1S)-1-((2S,6S)-2-(((tert-butyldimethylsilyl)oxy)methyl)-4-ethynyl-6-isopropoxy-3,6-dihydro-2H-pyran-3-yl)-1,3-dihydroxypropan-2-one
TETRO-015(4a-S)588693-49-6(1S)-1-((2S,6S)-2-(((tert-butyldimethylsilyl)oxy)methyl)-4-ethynyl-6-isopropoxy-3,6-dihydro-2H-pyran-3-yl)-3-((tert-butyldiphenylsilyl)oxy)-2-oxopropyl benzoate
TETRO-017(4a-S)1026479-97-9(1S)-1-((2S,6S)-2-(((tert-butyldimethylsilyl)oxy)methyl)-4-(1-((tert-butyldimethylsilyl)oxy)vinyl)-6-methoxy-3,6-dihydro-2H-pyran-3-yl)-3-((tert-butyldiphenylsilyl)oxy)-2-oxopropyl benzoate
TETRO-019(4a-S)588693-57-6(1S,3S,5R,8S)-5-((benzyloxy)methoxy)-1-(((tert-butyldimethylsilyl)oxy)methyl)-7-(((tert-butyldiphenylsilyl)oxy)methyl)-3-methoxy-3,5,8,8a-tetrahydro-1H-isochromen-8-yl benzoate
TETRO-020(4a-S)588693-60-1(1S,5R,8S)-1-(acetoxymethyl)-5-((benzyloxy)methoxy)-7-(((tert-butyldiphenylsilyl)oxy)methyl)-3-methoxy-3,5,8,8a-tetrahydro-1H-isochromen-8-yl benzoate
TETRO-021(4a-S)588693-65-6(1S,5R,8S)-5-((benzyloxy)methoxy)-7-(((tert-butyldiphenylsilyl)oxy)methyl)-3-hydroxy-1-(hydroxymethyl)-3,5,8,8a-tetrahydro-1H-isochromen-8-yl benzoate
TETRO-022(4a-S)588693-67-8(1S,4R,E)-4-((benzyloxy)methoxy)-2-(((tert-butyldiphenylsilyl)oxy)methyl)-6-((S)-2,2-dimethyl-1,3-dioxolan-4-yl)-5-(2-hydroxyethylidene)cyclohex-2-en-1-yl benzoate
TETRO-023(4a-S)588693-75-8(E)-methyl 2-((2R,5S)-2-((benzyloxy)methoxy)-4-(((tert-butyldiphenylsilyl)oxy)methyl)-6-((S)-2,2-dimethyl-1,3-dioxolan-4-yl)-5-hydroxycyclohex-3-en-1-ylidene)acetate
TETRO-027(4a-S)588693-83-8tert-butyl ((1R,2R,5S)-2-((benzyloxy)methoxy)-6-((S)-2,2-dimethyl-1,3-dioxolan-4-yl)-5-hydroxy-4-(hydroxymethyl)-1-(2-((4-methoxyphenyl)diphenylmethoxy)ethyl)cyclohex-3-en-1-yl)carbamate
TETRO-028(4a-S)588693-87-2((1S,2S,4R,5S,6R)-5-((benzyloxy)methoxy)-4-((tert-butoxycarbonyl)amino)-3-((S)-2,2-dimethyl-1,3-dioxolan-4-yl)-2-hydroxy-4-(2-((4-methoxyphenyl)diphenylmethoxy)ethyl)-7-oxabicyclo[4.1.0]heptan-1-yl)methyl benzoate
TETRO-029(4a-S)588693-94-1((1S,2R,4R,5S,6R)-2-acetoxy-5-((benzyloxy)methoxy)-4-((tert-butoxycarbonyl)amino)-3-((S)-2,2-dimethyl-1,3-dioxolan-4-yl)-4-(2-((4-methoxyphenyl)diphenylmethoxy)ethyl)-7-oxabicyclo[4.1.0]heptan-1-yl)methyl benzoate
TETRO-030(4a-S)588693-98-5((1S,2R,4R,5S,6R)-2-acetoxy-5-((benzyloxy)methoxy)-4-((tert-butoxycarbonyl)amino)-3-((S)-2,2-dimethyl-1,3-dioxolan-4-yl)-4-(2-oxoethyl)-7-oxabicyclo[4.1.0]heptan-1-yl)methyl benzoate
TETRO-0013366-47-0(2R,3R,4S)-2-(acetoxymethyl)-3,4-dihydro-2H-pyran-3,4,5-triyl triacetate
TETRO-00293662-86-3(2R,3S,6S)-2-(acetoxymethyl)-6-isopropoxy-3,6-dihydro-2H-pyran-3,5-diyl diacetate
TETRO-003115352-42-6(2S,3R,6S)-6-(hydroxymethyl)-2-isopropoxy-3,6-dihydro-2H-pyran-3-ol
TETRO-004588693-26-9(2S,6S)-6-(((tert-butyldimethylsilyl)oxy)methyl)-2-isopropoxy-2H-pyran-3(6H)-one
TETRO-005-(2S,3R,6S)-6-(((tert-butyldimethylsilyl)oxy)methyl)-2-isopropoxy-4-methyl-3,6-dihydro-2H-pyran-3-ol
TETRO-0061066-54-2Availableethynyltrimethylsilane
TETRO-007588693-32-7(2S,3R,6S)-6-(((tert-butyldimethylsilyl)oxy)methyl)-2-isopropoxy-4-((trimethylsilyl)ethynyl)-3,6-dihydro-2H-pyran-3-ol
TETRO-008116-11-02-methoxyprop-1-ene
TETRO-009588693-35-0tert-butyl(((2S,5R,6S)-6-isopropoxy-5-(prop-1-en-2-yloxy)-4-((trimethylsilyl)ethynyl)-5,6-dihydro-2H-pyran-2-yl)methoxy)dimethylsilane
TETRO-010588693-37-21-((2S,3S,6S)-2-(((tert-butyldimethylsilyl)oxy)methyl)-6-isopropoxy-4-((trimethylsilyl)ethynyl)-3,6-dihydro-2H-pyran-3-yl)propan-2-one
TETRO-012-(Z)-3-((2S,6S)-2-(((tert-butyldimethylsilyl)oxy)methyl)-4-ethynyl-6-isopropoxy-3,6-dihydro-2H-pyran-3-yl)-2-hydroxyacrylaldehyde
TETRO-016588693-51-0(2S,5S,6S,8aS)-4-acetyl-6-(((tert-butyldiphenylsilyl)oxy)methyl)-6-hydroxy-2-methoxy-2,4a,5,6,8,8a-hexahydropyrano[3,4-b]pyran-5-yl benzoate
TETRO-018588693-53-2(1S,3S,8S)-1-(((tert-butyldimethylsilyl)oxy)methyl)-7-(((tert-butyldiphenylsilyl)oxy)methyl)-3-methoxy-5-oxo-3,5,8,8a-tetrahydro-1H-isochromen-8-yl benzoate
TETRO-024588693-77-0(E)-methyl 2-((2R,5S,6R)-2-((benzyloxy)methoxy)-4-(((tert-butyldiphenylsilyl)oxy)methyl)-5-(carbamoyloxy)-6-((S)-2,2-dimethyl-1,3-dioxolan-4-yl)cyclohex-3-en-1-ylidene)acetate
TETRO-025588693-79-2methyl 2-(6-((benzyloxy)methoxy)-8-(((tert-butyldiphenylsilyl)oxy)methyl)-9-((S)-2,2-dimethyl-1,3-dioxolan-4-yl)-3-oxo-2-oxa-4-azabicyclo[3.3.1]non-7-en-5-yl)acetate
OriginatorRoute 2Steps 16 · Total yield /
TETRO-045108275-53-2TETRO-046616225-40-2TETRO-047616225-41-3TETRO-048616225-42-4TETRO-049616225-43-5TETRO-050616225-44-6TETRO-051616225-45-7TETRO-052616225-46-8TETRO-053616225-46-8TETRO-054616225-48-0TETRO-055616225-49-1TETRO-056616225-50-4TETRO-057616225-51-5TETRO-058616225-52-6TETRO-059616225-53-7API · Tetrodotoxin
CodeCAS No.Intermediate
TETRO-045108275-53-2(R)-2-((tert-butyldimethylsilyl)oxy)-2-((R)-2,2-dimethyl-1,3-dioxolan-4-yl)acetaldehyde
TETRO-046616225-40-2(S)-benzyl 2-((S)-((tert-butyldimethylsilyl)oxy)((R)-2,2-dimethyl-1,3-dioxolan-4-yl)methyl)-4-hydroxy-5-oxo-2,5-dihydrofuran-3-carboxylate
TETRO-047616225-41-3(S)-benzyl 2-((S)-((tert-butyldimethylsilyl)oxy)((R)-2,2-dimethyl-1,3-dioxolan-4-yl)methyl)-5-oxo-4-(pivaloyloxy)-2,5-dihydrofuran-3-carboxylate
TETRO-048616225-42-4(S)-5-((S)-((tert-butyldimethylsilyl)oxy)((R)-2,2-dimethyl-1,3-dioxolan-4-yl)methyl)-4-(2-diazoacetyl)-2-oxo-2,5-dihydrofuran-3-yl pivalate
TETRO-049616225-43-5(4'R,7S,7aS)-7-((tert-butyldimethylsilyl)oxy)-2',2'-dimethyl-2,4-dioxo-4,5,7,7a-tetrahydro-2H-spiro[benzofuran-6,4'-[1,3]dioxolan]-3-yl pivalate
TETRO-050616225-44-6(3aS,4R,5aS,8S,8aS,8bS)-2,2,2',2'-tetramethyl-7-oxohexahydro-3aH-spiro[[1,3]dioxolo[4,5-e]benzofuran-4,4'-[1,3]dioxolan]-8-yl pivalate
TETRO-051616225-45-7(S)-2-(dimethylamino)-2-oxo-1-((3aS,4R,7S,7aS)-2,2,2',2'-tetramethyl-6-methylenetetrahydro-3aH-spiro[benzo[d][1,3]dioxole-4,4'-[1,3]dioxolan]-7-yl)ethyl pivalate
TETRO-052616225-46-8(S)-1-((3aS,4S,5R,6R,7S,7aS)-6-allyl-5-hydroxy-2,2,2',2'-tetramethyltetrahydro-3aH-spiro[benzo[d][1,3]dioxole-4,4'-[1,3]dioxolan]-7-yl)-2-(dimethylamino)-2-oxoethyl pivalate
TETRO-053616225-46-8(S)-1-((3aS,4S,5R,6R,7S,7aS)-6-allyl-5-hydroxy-2,2,2',2'-tetramethyltetrahydro-3aH-spiro[benzo[d][1,3]dioxole-4,4'-[1,3]dioxolan]-7-yl)-2-(dimethylamino)-2-oxoethyl pivalate
TETRO-054616225-48-0(3aS,4S,5R,8S,9S,9aS,10R)-10-allyl-2,2,2',2'-tetramethyl-7-oxohexahydrospiro[5,9-methano[1,3]dioxolo[4,5-d]oxocine-4,4'-[1,3]dioxolan]-8-yl pivalate
TETRO-055616225-49-1(3aS,4S,5R,8S,9R,9aS,10R)-10-allyl-8-hydroxy-2,2,2',2'-tetramethyltetrahydrospiro[5,9-methano[1,3]dioxolo[4,5-d]oxocine-4,4'-[1,3]dioxolan]-7(3aH)-one
TETRO-056616225-50-4(3aS,4S,5R,8S,9S,9aS,10R)-10-(2-chloroethyl)-2,2,2',2'-tetramethyl-7-oxohexahydrospiro[5,9-methano[1,3]dioxolo[4,5-d]oxocine-4,4'-[1,3]dioxolan]-8-yl carbamate
TETRO-057616225-51-5(3aS,4'S,6R,7aS,10aS,10bR,11R)-11-(2-chloroethyl)-2',2',9,9-tetramethyldihydro-1H-spiro[6,10b-methano[1,3]dioxolo[4',5':5,6]oxocino[4,3-d]oxazole-7,4'-[1,3]dioxolane]-2,4(3aH,6H)-dione
TETRO-058616225-52-6tert-butyl ((3aS,4S,5R,8S,9S,9aS,10R)-8-hydroxy-2,2,2',2'-tetramethyl-7-oxo-10-vinylhexahydrospiro[5,9-methano[1,3]dioxolo[4,5-d]oxocine-4,4'-[1,3]dioxolan]-9-yl)carbamate
TETRO-059616225-53-7(3aS,4S,5R,8S,9S,9aS,10R)-9-amino-8-hydroxy-2,2,2',2'-tetramethyl-10-vinyltetrahydrospiro[5,9-methano[1,3]dioxolo[4,5-d]oxocine-4,4'-[1,3]dioxolan]-7(3aH)-one

Frequently asked questions

What are the approved indications of Tetrodotoxin?

Approved indications include: 神经痛, 海洛因依赖, Cancer pain, Pain, 中毒.

When does the Tetrodotoxin patent expire?

No public expiry year is available for Tetrodotoxin yet; this page updates once verified.

How many synthesis routes are recorded for Tetrodotoxin?

2 synthesis routes are recorded; the shortest is 16 steps with / total yield. Intermediates in each route carry codes and CAS numbers.

Where can I buy Tetrodotoxin intermediates?

1 intermediate CAS of Tetrodotoxin are available through the Unibest supply network — see the route tables on this page and request a quote per CAS.

How do I get a quote for Tetrodotoxin intermediates?

Open the CAS profile of the target intermediate from this page, or submit an RFQ directly — the CAS enters the matching flow automatically and the supply network responds with quotes.

Source: cross-verified data (structured fields only) · 2026-10-12