Tirbanibulin
Tier C — Watch / tradeTirbanibulin
Targets：Tubulin, SRC
Brand：Klisyri, KLISYRI
Indications (approved)：Actinic keratosis
Regional status
Synthetic routes & intermediates2 routes
Routes are ordered originator first, then optimised / process (non-patent) routes; each lists steps, overall yield and the intermediate table (code / CAS / name) — ready for supplier sourcing and RFQ. Rendered by this site from structured data; no third-party route graphics used.
| Code | CAS No. | Intermediate |
|---|---|---|
| KX-01-001 | 622-40-2 | 2-morpholinoethan-1-ol |
| KX-01-002 | 269409-70-3 | 4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenol |
| KX-01-003 | 690636-28-3 | 4-(2-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenoxy)ethyl)morpholine |
| KX-01-004 | 897016-93-2 | N-benzyl-2-(5-bromopyridin-2-yl)acetamide |
| KX-01-005 | 192642-83-4 | 5-(5-bromopyridin-2(1H)-ylidene)-2,2-dimethyl-1,3-dioxane-4,6-dione |
| Code | CAS No. | Intermediate |
|---|---|---|
| KX-01-006 | 3240-94-6 | 4-(2-chloroethyl)morpholine |
| KX-01-007 | 106-41-2 | 4-bromophenol |
| KX-01-008 | 836-59-9 | 4-(2-(4-bromophenoxy)ethyl)morpholine |
| KX-01-009 | 351019-18-6 | (6-fluoropyridin-3-yl)boronic acid |
| KX-01-010 | 1038395-62-8 | 4-(2-(4-(6-fluoropyridin-3-yl)phenoxy)ethyl)morpholine |
| KX-01-011 | 1038395-63-9 | 2-(5-(4-(2-morpholinoethoxy)phenyl)pyridin-2-yl)acetonitrile |
| KX-01-012 | 1038395-64-0 | methyl 2-(5-(4-(2-morpholinoethoxy)phenyl)pyridin-2-yl)acetate |
Frequently asked questions
What are the approved indications of Tirbanibulin?
Approved indications include: Actinic keratosis.
When does the Tirbanibulin patent expire?
No public expiry year is available for Tirbanibulin yet; this page updates once verified.
How many synthesis routes are recorded for Tirbanibulin?
2 synthesis routes are recorded; the shortest is 3 steps with 137 mg total yield. Intermediates in each route carry codes and CAS numbers.
Where can I buy Tirbanibulin intermediates?
All intermediates in Tirbanibulin routes have CAS profiles — you can submit an RFQ per CAS and it enters the Unibest matching pool.
How do I get a quote for Tirbanibulin intermediates?
Open the CAS profile of the target intermediate from this page, or submit an RFQ directly — the CAS enters the matching flow automatically and the supply network responds with quotes.
Source: cross-verified data (structured fields only) · 2026-09-29