Leriglitazone

Tier C — Watch / trade

Leriglitazone

Pfizer Inc.

Originator

First approval

Expiry (public)

No sales data

Peak sales

Small molecule

Type

Targets：PPARγ

Brand：Nezglyal, NEZGLYAL

Indications (approved)：肾上腺脑白质营养不良, Friedreich's ataxia

Regional status

Phase III

2017-12-08

Phase III

2017-12-08

China

Japan

Synthetic routes & intermediates1 routes

Originator routes × 0Optimised (non-patent) × 1Process routes × 0

Routes are ordered originator first, then optimised / process (non-patent) routes; each lists steps, overall yield and the intermediate table (code / CAS / name) — ready for supplier sourcing and RFQ. Rendered by this site from structured data; no third-party route graphics used.

OptimisedRoute 1Steps 8 · Total yield 0.43 g

HYPIL-010184766-39-0Hydroxypioglitazone—HYPIL-0015470-70-2HYPIL-00236357-38-7HYPIL-003100189-16-0HYPIL-004146062-57-9HYPIL-005146062-58-0HYPIL-006123-08-0HYPIL-007184766-25-4HYPIL-0082295-31-0HYPIL-009184766-32-3API · Leriglitazone

Code	CAS No.	Intermediate
HYPIL-010	184766-39-0	5-(4-(2-(5-(1-(methoxymethoxy)ethyl)pyridin-2-yl)ethoxy)benzyl)thiazolidine-2,4-dione
Hydroxypioglitazone	-	-
HYPIL-001	5470-70-2	methyl 6-methylnicotinate
HYPIL-002	36357-38-7	1-(6-methylpyridin-3-yl)ethanone
HYPIL-003	100189-16-0	1-(6-methylpyridin-3-yl)ethanol
HYPIL-004	146062-57-9	5-(1-(methoxymethoxy)ethyl)-2-methylpyridine
HYPIL-005	146062-58-0	2-(5-(1-(methoxymethoxy)ethyl)pyridin-2-yl)ethanol
HYPIL-006	123-08-0 Available	4-hydroxybenzaldehyde
HYPIL-007	184766-25-4	4-(2-(5-(1-(methoxymethoxy)ethyl)pyridin-2-yl)ethoxy)benzaldehyde
HYPIL-008	2295-31-0	thiazolidine-2,4-dione
HYPIL-009	184766-32-3	(E)-5-(4-(2-(5-(1-(methoxymethoxy)ethyl)pyridin-2-yl)ethoxy)benzylidene)thiazolidine-2,4-dione

Frequently asked questions

What are the approved indications of Leriglitazone?

Approved indications include: 肾上腺脑白质营养不良, Friedreich's ataxia.

When does the Leriglitazone patent expire?

No public expiry year is available for Leriglitazone yet; this page updates once verified.

How many synthesis routes are recorded for Leriglitazone?

1 synthesis routes are recorded; the shortest is 8 steps with 0.43 g total yield. Intermediates in each route carry codes and CAS numbers.

Where can I buy Leriglitazone intermediates?

1 intermediate CAS of Leriglitazone are available through the Unibest supply network — see the route tables on this page and request a quote per CAS.

How do I get a quote for Leriglitazone intermediates?

Open the CAS profile of the target intermediate from this page, or submit an RFQ directly — the CAS enters the matching flow automatically and the supply network responds with quotes.

Source: cross-verified data (structured fields only) · 2026-10-09