Alprazolam

Tier C — Watch / trade

Alprazolam

Pfizer Inc.

Originator

First approval

Expiry (public)

$0.3B ▲

Peak sales

Small molecule

Type

Targets：GABAAR

Brand：Tafil, Xanax/Xanax XR, Zamoprax, Xanax XR, Xanax, Panistat, Niravam

Indications (approved)：Anxiety disorder, Panic disorder

Regional status

Approved

1981-10-16

Approved

China

Approved

1988-01-01

Japan

Approved

1984-07-01

Synthetic routes & intermediates3 routes

Originator routes × 0Optimised (non-patent) × 3Process routes × 0

Routes are ordered originator first, then optimised / process (non-patent) routes; each lists steps, overall yield and the intermediate table (code / CAS / name) — ready for supplier sourcing and RFQ. Rendered by this site from structured data; no third-party route graphics used.

OptimisedRoute 1Steps 8 · Total yield 142mg(Alprazolam (Free))

Alprazolam-00178-39-7Alprazolam-00210352-30-4Alprazolam-00327537-93-5Alprazolam-00436916-18-4Alprazolam-00536916-20-8Alprazolam-00636916-19-5Alprazolam-00738150-27-5Alprazolam-00838150-28-6API · Alprazolam

Code	CAS No.	Intermediate
Alprazolam-001	78-39-7 Available	1,1,1-Triethoxyethane
Alprazolam-002	10352-30-4	2,6-dichloro-4-phenylquinoline
Alprazolam-003	27537-93-5	6-chloro-2-hydrazinyl-4-phenylquinoline
Alprazolam-004	36916-18-4	11-chloro-3-methyl-8-phenyl-2,4,5-triazatricyclo[7.4.0.0(2,6)]trideca-1(9),3,5,7,10,12-hexaene
Alprazolam-005	36916-20-8	4-(2-benzoyl-4-chlorophenyl)-5-methyl-4H-1,2,4-triazole-3-carbaldehyde
Alprazolam-006	36916-19-5	4-(2-benzoyl-4-chlorophenyl)-3-methyl-1,2,4-triazole
Alprazolam-007	38150-27-5	1-[5-Chloro-2-[3-(hydroxymethyl)-5-methyl-4H-1,2,4-triazol-4-yl]phenyl]-1-phenylmethanone
Alprazolam-008	38150-28-6	4-(2-benzoyl-4-chlorophenyl)-3-(bromomethyl)-5-methyl-4H-1,2,4-triazole

OptimisedRoute 2Steps 2 · Total yield 80mg(Alprazolam (Free))

Alprazolam-0094547-02-8Alprazolam-0101068-57-1Alprazolam-01128910-89-6API · Alprazolam

Code	CAS No.	Intermediate
Alprazolam-009	4547-02-8	7-Chloro-5-phenyl-2,3-dihydro-1,4-benzodiazepine-2-thione
Alprazolam-010	1068-57-1	Acethydrazide
Alprazolam-011	28910-89-6	N'-[(2Z)-7-chloro-5-phenyl-2,3-dihydro-1H-1,4-benzodiazepin-2-ylidene]acetohydrazide

OptimisedRoute 3Steps 2 · Total yield 50mg(Alprazolam (Free))

Alprazolam-012—Alprazolam-01375-07-0Alprazolam-014—API · Alprazolam

Code	CAS No.	Intermediate
Alprazolam-012	-	(2Z)-7-chloro-2-hydrazinylidene-5-phenyl-1,3-dihydro-1,4-benzodiazepine
Alprazolam-013	75-07-0	Ethanal
Alprazolam-014	-	(2Z)-7-chloro-2-[(2E)-2-ethylidenehydrazin-1-ylidene]-5-phenyl-2,3-dihydro-1H-1,4-benzodiazepine

Frequently asked questions

What are the approved indications of Alprazolam?

Approved indications include: Anxiety disorder, Panic disorder.

When does the Alprazolam patent expire?

No public expiry year is available for Alprazolam yet; this page updates once verified.

How many synthesis routes are recorded for Alprazolam?

3 synthesis routes are recorded; the shortest is 2 steps with 80mg(Alprazolam (Free)) total yield. Intermediates in each route carry codes and CAS numbers.

Where can I buy Alprazolam intermediates?

1 intermediate CAS of Alprazolam are available through the Unibest supply network — see the route tables on this page and request a quote per CAS.

How do I get a quote for Alprazolam intermediates?

Open the CAS profile of the target intermediate from this page, or submit an RFQ directly — the CAS enters the matching flow automatically and the supply network responds with quotes.

Source: cross-verified data (structured fields only) · 2026-09-29