Indacaterol Maleate/Glycopyrronium Bromide

Tier B — Position early

Novartis

Originator

2013

First approval

Expiry (public)

$1.2B ▲

Peak sales

Small molecule

Type

Targets：mAChRs, ADRB2

Brand：Utibron Neohaler, Ultibro Breezhaler

Indications (approved)：Chronic obstructive pulmonary disease

Regional status

Withdrawn

Approved

2013-09-18

China

Approved

2017-12-28

Japan

Approved

2013-09-20

Factories producing this API10

Factories registered as producing this API in our sourcing network (RFQ records + product master), sorted by RFQ activity; the snapshot carries no cost or customer data.

10 producing factories on file — sign in to view the named list (factory details are not shown to guests).

Synthetic routes & intermediates6 routes

Originator routes × 1Optimised (non-patent) × 5Process routes × 0

Routes are ordered originator first, then optimised / process (non-patent) routes; each lists steps, overall yield and the intermediate table (code / CAS / name) — ready for supplier sourcing and RFQ. Rendered by this site from structured data; no third-party route graphics used.

OriginatorRoute 1Steps 4 · Total yield 22.7 g

GLYC-00115206-55-0GLYC-002137-43-9GLYC-00319833-96-6GLYC-004427-49-6GLYC-00513220-33-2GLYC-00613118-11-1API · Indacaterol Maleate/Glycopyrronium Bromide

Code	CAS No.	Intermediate
GLYC-001	15206-55-0	methyl 2-oxo-2-phenylacetate
GLYC-002	137-43-9	bromocyclopentane
GLYC-003	19833-96-6	methyl 2-cyclopentyl-2-hydroxy-2-phenylacetate
GLYC-004	427-49-6	2-cyclopentyl-2-hydroxy-2-phenylacetic acid
GLYC-005	13220-33-2	1-methylpyrrolidin-3-ol
GLYC-006	13118-11-1	1-methylpyrrolidin-3-yl 2-cyclopentyl-2-hydroxy-2-phenylacetate

OptimisedRoute 2Steps 3 · Total yield 361 g

GLYC-004427-49-6GLYC-00513220-33-2GLYC-0073140-73-6GLYC-0081392109-02-2GLYC-00613118-11-1API · Indacaterol Maleate/Glycopyrronium Bromide

Code	CAS No.	Intermediate
GLYC-004	427-49-6	2-cyclopentyl-2-hydroxy-2-phenylacetic acid
GLYC-005	13220-33-2	1-methylpyrrolidin-3-ol
GLYC-007	3140-73-6	2-chloro-4,6-dimethoxy-1,3,5-triazine
GLYC-008	1392109-02-2	4,6-dimethoxy-1,3,5-triazin-2-yl 2-cyclopentyl-2-hydroxy-2-phenylacetate
GLYC-006	13118-11-1	1-methylpyrrolidin-3-yl 2-cyclopentyl-2-hydroxy-2-phenylacetate

OptimisedRoute 3Steps 5 · Total yield 1.6 g

GLYC-002137-43-9GLYC-00917199-29-0GLYC-01081036-97-7GLYC-011937179-77-6GLYC-01264471-43-8GLYC-013860644-54-8GLYC-014104641-60-3GLYC-015937179-78-7API · Indacaterol Maleate/Glycopyrronium Bromide

Code	CAS No.	Intermediate
GLYC-002	137-43-9	bromocyclopentane
GLYC-009	17199-29-0 Available	(S)-2-hydroxy-2-phenylacetic acid
GLYC-010	81036-97-7	(2S,5S)-2-(tert-butyl)-5-phenyl-1,3-dioxolan-4-one
GLYC-011	937179-77-6	(2S,5S)-2-(tert-butyl)-5-cyclopentyl-5-phenyl-1,3-dioxolan-4-one
GLYC-012	64471-43-8	(S)-2-cyclopentyl-2-hydroxy-2-phenylacetic acid
GLYC-013	860644-54-8	methyl (S)-2-cyclopentyl-2-hydroxy-2-phenylacetate
GLYC-014	104641-60-3	(R)-1-methylpyrrolidin-3-ol
GLYC-015	937179-78-7	(R)-1-methylpyrrolidin-3-yl (S)-2-cyclopentyl-2-hydroxy-2-phenylacetate

OptimisedRoute 4Steps 3 · Total yield /

GLYC-00513220-33-2GLYC-00613118-11-1GLYC-0165763-56-4GLYC-0172243594-57-0GLYC-018108-86-1API · Indacaterol Maleate/Glycopyrronium Bromide

Code	CAS No.	Intermediate
GLYC-005	13220-33-2	1-methylpyrrolidin-3-ol
GLYC-006	13118-11-1	1-methylpyrrolidin-3-yl 2-cyclopentyl-2-hydroxy-2-phenylacetate
GLYC-016	5763-56-4	2-cyclopentyl-2-oxoacetic acid
GLYC-017	2243594-57-0	1-methylpyrrolidin-3-yl 2-cyclopentyl-2-oxoacetate
GLYC-018	108-86-1	bromobenzene

OptimisedRoute 5Steps 4 · Total yield 144 g (Glycopyrronium Bromide)

GLYC-004427-49-6GLYC-00513220-33-2GLYC-00613118-11-1GLYC-019106650-00-4GLYC-0202220140-66-7API · Indacaterol Maleate/Glycopyrronium Bromide

Code	CAS No.	Intermediate
GLYC-004	427-49-6	2-cyclopentyl-2-hydroxy-2-phenylacetic acid
GLYC-005	13220-33-2	1-methylpyrrolidin-3-ol
GLYC-006	13118-11-1	1-methylpyrrolidin-3-yl 2-cyclopentyl-2-hydroxy-2-phenylacetate
GLYC-019	106650-00-4	2-(benzyloxy)-2-cyclopentyl-2-phenylacetic acid
GLYC-020	2220140-66-7	1-methylpyrrolidin-3-yl 2-(benzyloxy)-2-cyclopentyl-2-phenylacetate

OptimisedRoute 6Steps 4 · Total yield 3.9 g (Glycopyrronium Bromide)

GLYC-002137-43-9GLYC-00319833-96-6GLYC-004427-49-6GLYC-00513220-33-2GLYC-00613118-11-1GLYC-022611-73-4API · Indacaterol Maleate/Glycopyrronium Bromide

Code	CAS No.	Intermediate
GLYC-002	137-43-9	bromocyclopentane
GLYC-003	19833-96-6	methyl 2-cyclopentyl-2-hydroxy-2-phenylacetate
GLYC-004	427-49-6	2-cyclopentyl-2-hydroxy-2-phenylacetic acid
GLYC-005	13220-33-2	1-methylpyrrolidin-3-ol
GLYC-006	13118-11-1	1-methylpyrrolidin-3-yl 2-cyclopentyl-2-hydroxy-2-phenylacetate
GLYC-022	611-73-4	2-oxo-2-phenylacetic acid

Frequently asked questions

What are the approved indications of Indacaterol Maleate/Glycopyrronium Bromide?

Approved indications include: Chronic obstructive pulmonary disease.

When does the Indacaterol Maleate/Glycopyrronium Bromide patent expire?

No public expiry year is available for Indacaterol Maleate/Glycopyrronium Bromide yet; this page updates once verified.

How many synthesis routes are recorded for Indacaterol Maleate/Glycopyrronium Bromide?

6 synthesis routes are recorded; the shortest is 3 steps with 361 g total yield. Intermediates in each route carry codes and CAS numbers.

Where can I buy Indacaterol Maleate/Glycopyrronium Bromide intermediates?

1 intermediate CAS of Indacaterol Maleate/Glycopyrronium Bromide are available through the Unibest supply network — see the route tables on this page and request a quote per CAS.

How do I get a quote for Indacaterol Maleate/Glycopyrronium Bromide intermediates?

Open the CAS profile of the target intermediate from this page, or submit an RFQ directly — the CAS enters the matching flow automatically and the supply network responds with quotes.

Source: cross-verified data (structured fields only) · 2026-09-29