Maralixibat Chloride
Tier C — Watch / tradeMaralixibat Chloride
Targets：IBAT
Brand：LIVMARLI
Indications (approved)：Pruritus, 进行性家族性肝内胆汁淤积症, Alagille综合征
Regional status
Synthetic routes & intermediates2 routes
Routes are ordered originator first, then optimised / process (non-patent) routes; each lists steps, overall yield and the intermediate table (code / CAS / name) — ready for supplier sourcing and RFQ. Rendered by this site from structured data; no third-party route graphics used.
| Code | CAS No. | Intermediate |
|---|---|---|
| Lopix-001 | 596-75-8 | diethyl 2,2-dibutylmalonate |
| Lopix-002 | 24765-57-9 | 2,2-dibutylpropane-1,3-diol |
| Lopix-003 | 3670-91-5 | 1,3,2-Dioxathiane, 5,5-dibutyl-, 2-oxide |
| Lopix-004 | 197378-20-4 | 1,3,2-Dioxathiane, 5,5-dibutyl-, 2,2-dioxide |
| Lopix-005 | 228113-57-3 | 4-fluoro-2-(4-methoxybenzyl)benzenethiol |
| Lopix-006 | 228113-59-5 | 2-butyl-2-((4-fluoro-2-(4-methoxybenzyl)phenylthio)methyl)hexan-1-ol |
| Lopix-007 | 228113-60-8 | 2-butyl-2-((4-fluoro-2-(4-methoxybenzyl)phenylsulfinyl)methyl)hexan-1-ol |
| Lopix-008 | 228113-61-9 | 2-butyl-2-((4-fluoro-2-(4-methoxybenzyl)phenylsulfinyl)methyl)hexanal |
| Lopix-009 | 228113-62-0 | 1-Benzothiepin-4-ol, 3,3-dibutyl-7-fluoro-2,3,4,5-tetrahydro-5-(4-methoxyphenyl)-, 1-oxide, (4R,5R) |
| Lopix-010 | 228113-63-1 | 1-Benzothiepin-4-ol, 3,3-dibutyl-7-fluoro-2,3,4,5-tetrahydro-5-(4-methoxyphenyl)-, 1,1-dioxide, (4R,5R) |
| Lopix-011 | 197373-42-5 | 1-Benzothiepin-4-ol, 3,3-dibutyl-7-(dimethylamino)-2,3,4,5-tetrahydro-5-(4-methoxyphenyl)-, 1,1-dioxide, (4R,5R)-rel |
| Lopix-012 | 228113-65-3 | 1-Benzothiepin-4-ol, 3,3-dibutyl-7-(dimethylamino)-2,3,4,5-tetrahydro-5-(4-hydroxyphenyl)-, 1,1-dioxide, (4R,5R) |
| Lopix-013 | 623-25-6 | 1,4-bis(chloromethyl)benzene |
| Lopix-014 | 289038-78-4 | 1-Benzothiepin-4-ol, 3,3-dibutyl-5-[4-[[4-(chloromethyl)phenyl]methoxy]phenyl]-7-(dimethylamino)-2,3,4,5-tetrahydro-, 1,1-dioxide, (4R,5R) |
| Lopix-015 | 371-41-5 | 4-fluorophenol |
| Lopix-016 | 824-94-2 | 1-(chloromethyl)-4-methoxybenzene |
| Lopix-017 | 1426-54-6 | 4-fluoro-2-(4-methoxybenzyl)phenol |
| Lopix-018 | 16420-13-6 | dimethylcarbamothioic chloride |
| Lopix-019 | 228113-58-4 | O-4-fluoro-2-(4-methoxybenzyl)phenyl dimethylcarbamothioate |
| Code | CAS No. | Intermediate |
|---|---|---|
| Lopix-011 | 197373-42-5 | 1-Benzothiepin-4-ol, 3,3-dibutyl-7-(dimethylamino)-2,3,4,5-tetrahydro-5-(4-methoxyphenyl)-, 1,1-dioxide, (4R,5R)-rel |
| Lopix-012 | 228113-65-3 | 1-Benzothiepin-4-ol, 3,3-dibutyl-7-(dimethylamino)-2,3,4,5-tetrahydro-5-(4-hydroxyphenyl)-, 1,1-dioxide, (4R,5R) |
| Lopix-013 | 623-25-6 | 1,4-bis(chloromethyl)benzene |
| Lopix-014 | 289038-78-4 | 1-Benzothiepin-4-ol, 3,3-dibutyl-5-[4-[[4-(chloromethyl)phenyl]methoxy]phenyl]-7-(dimethylamino)-2,3,4,5-tetrahydro-, 1,1-dioxide, (4R,5R) |
| Lopix-020 | 2516-95-2 | 5-chloro-2-nitrobenzoic acid |
| Lopix-021 | 100-66-3Available | anisole |
| Lopix-022 | 70132-87-5 | (2-chloro-5-nitrophenyl)(4-methoxyphenyl)methanone |
| Lopix-023 | 197378-07-7 | 1-chloro-2-(4-methoxybenzyl)-4-nitrobenzene |
| Lopix-024 | 197378-29-3 | 2-butyl-2-((2-(4-methoxybenzyl)-4-nitrophenylthio)methyl)hexanal |
| Lopix-025 | 197378-31-7 | 2-butyl-2-((2-(4-methoxybenzyl)-4-nitrophenylsulfonyl)methyl)hexanal |
| Lopix-026 | - | 2-((4-amino-2-(4-methoxybenzyl)phenylsulfonyl)methyl)-2-butylhexanal |
| Lopix-027 | - | benzyl 4-(2-butyl-2-formylhexylsulfonyl)-3-(4-methoxybenzyl)phenylcarbamate |
| Lopix-028 | - | - |
| Lopix-029 | - | - |
Frequently asked questions
What are the approved indications of Maralixibat Chloride?
Approved indications include: Pruritus, 进行性家族性肝内胆汁淤积症, Alagille综合征.
When does the Maralixibat Chloride patent expire?
No public expiry year is available for Maralixibat Chloride yet; this page updates once verified.
How many synthesis routes are recorded for Maralixibat Chloride?
2 synthesis routes are recorded; the shortest is 12 steps with / total yield. Intermediates in each route carry codes and CAS numbers.
Where can I buy Maralixibat Chloride intermediates?
1 intermediate CAS of Maralixibat Chloride are available through the Unibest supply network — see the route tables on this page and request a quote per CAS.
How do I get a quote for Maralixibat Chloride intermediates?
Open the CAS profile of the target intermediate from this page, or submit an RFQ directly — the CAS enters the matching flow automatically and the supply network responds with quotes.
Source: cross-verified data (structured fields only) · 2026-09-29