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Emitasvir Phosphate
Tier C — Watch / tradeEmitasvir Phosphate
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Originator
2020
First approval
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Expiry (public)
No sales data
Peak sales
Small molecule
Type
Targets：NS5A
Indications (approved)：Hepatitis C
Regional status
US
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EU
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China
Approved
2020-12-21
Japan
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Factories producing this API3
Factories registered as producing this API in our sourcing network (RFQ records + product master), sorted by RFQ activity; the snapshot carries no cost or customer data.
3 producing factories on file — sign in to view the named list (factory details are not shown to guests).
Sign in to view factories →Synthetic routes & intermediates4 routes
Originator routes × 0Optimised (non-patent) × 4Process routes × 0
Routes are ordered originator first, then optimised / process (non-patent) routes; each lists steps, overall yield and the intermediate table (code / CAS / name) — ready for supplier sourcing and RFQ. Rendered by this site from structured data; no third-party route graphics used.
OptimisedRoute 1Steps 6 · Total yield 230.40mg(Emitasvir Phosphate (API))
Emitasvir Phosphate-0011575-37-7Emitasvir Phosphate-00215761-39-4Emitasvir Phosphate-0031208007-67-3Emitasvir Phosphate-0041208009-37-3Emitasvir Phosphate-0051959593-66-8Emitasvir Phosphate-0061959593-27-1Emitasvir Phosphate-0071959593-25-9Emitasvir Phosphate-008—Emitasvir Phosphate-00974761-42-5Emitasvir Phosphate-0101959593-23-7API · Emitasvir Phosphate
| Code | CAS No. | Intermediate |
|---|---|---|
| Emitasvir Phosphate-001 | 1575-37-7 | 2-Amino-4-bromophenylamine |
| Emitasvir Phosphate-002 | 15761-39-4 | N-Boc-L-proline |
| Emitasvir Phosphate-003 | 1208007-67-3 | tert-Butyl 2(S)-(5-bromo-2-benzimidazolyl)pyrrolidine-1-carboxylate |
| Emitasvir Phosphate-004 | 1208009-37-3 | tert-Butyl (2S)-2-[5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-benzimidazol-2-yl]pyrrolidine-1-carboxylate |
| Emitasvir Phosphate-005 | 1959593-66-8 | tert-Butyl (2S)-2-[4-(4-[(1S,4R)-8-[(trifluoromethanesulfonyl)oxy]-1,2,3,4-tetrahydro-1,4-methanonaphthalen-5-yl]phenyl)-1H-imidazol-2-yl]pyrrolidine-1-carboxylate |
| Emitasvir Phosphate-006 | 1959593-27-1 | tert-Butyl (2S)-2-(4-[4-[(1S,4R)-8-[2-[(2S)-1-(tert-butoxycarbonyl)pyrrolidin-2-yl]-1H-benzimidazol-5-yl]-1,2,3,4-tetrahydro-1,4-methanonaphthalen-5-yl]phenyl]-1H-imidazol-2-yl)pyrrolidine-1-carboxyla te |
| Emitasvir Phosphate-007 | 1959593-25-9 | 2-[(2S)-Pyrrolidin-2-yl]-5-[(1R,4S)-8-(4-[2-[(2S)-pyrrolidin-2-yl]-1H-imidazol-4-yl]phenyl)-1,2,3,4-tetrahydro-1,4-methanonaphthalen-5-yl]-1H-benzimidazole |
| Emitasvir Phosphate-008 | - | 2-[(2S)-Pyrrolidin-2-yl]-5-[(1R,4S)-8-(4-[2-[(2S)-pyrrolidin-2-yl]-1H-imidazol-5-yl]phenyl)-1,2,3,4-tetrahydro-1,4-methanonaphthalen-5-yl]-1H-benzimidazole tetrahydrogen chloride |
| Emitasvir Phosphate-009 | 74761-42-5 | N-(Methoxycarbonyl)-L-valine |
| Emitasvir Phosphate-010 | 1959593-23-7 | Methyl [(2S)-1-[(2S)-2-[5-[(1R,4S)-8-(4-[2-[(2S)-1-[(2S)-2-[(methoxycarbonyl)amino]-3-methylbutanoyl]pyrrolidin-2-yl]-1H-imidazol-4-yl]phenyl)-1,2,3,4-tetrahydro-1,4-methanonaphthalen-5-yl]-1H-benzimi dazol-2-yl]pyrrolidin-1-yl]-3-methyl-1-oxobutan-2-yl]carbamate |
OptimisedRoute 2Steps 10 · Total yield 697mg(Emitasvir Phosphate-005)
Emitasvir Phosphate-00215761-39-4Emitasvir Phosphate-0051959593-66-8Emitasvir Phosphate-01199-90-1Emitasvir Phosphate-01299-73-0Emitasvir Phosphate-013128120-93-4Emitasvir Phosphate-0141007882-04-3Emitasvir Phosphate-015—Emitasvir Phosphate-0161401068-73-2Emitasvir Phosphate-0171560642-34-3Emitasvir Phosphate-018106-51-4Emitasvir Phosphate-019542-92-7Emitasvir Phosphate-0201200-89-1Emitasvir Phosphate-0213090-47-9Emitasvir Phosphate-02216144-91-5API · Emitasvir Phosphate
| Code | CAS No. | Intermediate |
|---|---|---|
| Emitasvir Phosphate-002 | 15761-39-4 | N-Boc-L-proline |
| Emitasvir Phosphate-005 | 1959593-66-8 | tert-Butyl (2S)-2-[4-(4-[(1S,4R)-8-[(trifluoromethanesulfonyl)oxy]-1,2,3,4-tetrahydro-1,4-methanonaphthalen-5-yl]phenyl)-1H-imidazol-2-yl]pyrrolidine-1-carboxylate |
| Emitasvir Phosphate-011 | 99-90-1 | 1-Acetyl-4-bromobenzene |
| Emitasvir Phosphate-012 | 99-73-0 | 4'-Bromophenacyl bromide |
| Emitasvir Phosphate-013 | 128120-93-4 | 2-[2-(4-Bromophenyl)-2-oxoethyl] 1-tert-butyl (2S)-pyrrolidine-1,2-dicarboxylate |
| Emitasvir Phosphate-014 | 1007882-04-3 | (S)-tert-Butyl 2-(5-(4-bromophenyl)-1h-imidazol-2-yl)pyrrolidine-1-carboxylate |
| Emitasvir Phosphate-015 | - | tert-Butyl (2S)-2-[4-[4-(3,3,4,4-tetramethylborolan-1-yl)phenyl]-1H-imidazol-2-yl]pyrrolidine-1-carboxylate |
| Emitasvir Phosphate-016 | 1401068-73-2 | 1,2,3,4-Tetrahydro-1,4-methanonaphthalene-5,8-diyl bis(trifluoromethanesulfonate) |
| Emitasvir Phosphate-017 | 1560642-34-3 | tert-Butyl (2S)-2-[4-(4-[8-[(trifluoromethanesulfonyl)oxy]-1,2,3,4-tetrahydro-1,4-methanonaphthalen-5-yl]phenyl)-1H-imidazol-2-yl]pyrrolidine-1-carboxylate |
| Emitasvir Phosphate-018 | 106-51-4 | Quinone |
| Emitasvir Phosphate-019 | 542-92-7 | Cyclopenta-1,3-diene |
| Emitasvir Phosphate-020 | 1200-89-1 | Tricyclo[6.2.1.0,2,7]undeca-4,9-diene-3,6-dione |
| Emitasvir Phosphate-021 | 3090-47-9 | 1,4-Dihydro-1,4-methanonaphthalene-5,8-diol |
| Emitasvir Phosphate-022 | 16144-91-5 | 1,2,3,4-Tetrahydro-1,4-methanonaphthalene-5,8-diol |
OptimisedRoute 3Steps 5 · Total yield 31.6g(Emitasvir Phosphate-005)
Emitasvir Phosphate-0051959593-66-8Emitasvir Phosphate-015—Emitasvir Phosphate-02216144-91-5Emitasvir Phosphate-02316144-90-4Emitasvir Phosphate-0242379279-46-4Emitasvir Phosphate-0252765664-85-3Emitasvir Phosphate-0262765664-73-9API · Emitasvir Phosphate
| Code | CAS No. | Intermediate |
|---|---|---|
| Emitasvir Phosphate-005 | 1959593-66-8 | tert-Butyl (2S)-2-[4-(4-[(1S,4R)-8-[(trifluoromethanesulfonyl)oxy]-1,2,3,4-tetrahydro-1,4-methanonaphthalen-5-yl]phenyl)-1H-imidazol-2-yl]pyrrolidine-1-carboxylate |
| Emitasvir Phosphate-015 | - | tert-Butyl (2S)-2-[4-[4-(3,3,4,4-tetramethylborolan-1-yl)phenyl]-1H-imidazol-2-yl]pyrrolidine-1-carboxylate |
| Emitasvir Phosphate-022 | 16144-91-5 | 1,2,3,4-Tetrahydro-1,4-methanonaphthalene-5,8-diol |
| Emitasvir Phosphate-023 | 16144-90-4 | 1,2,3,4-Tetrahydro-1,4-methanonaphthalene-5,8-diyl diacetate |
| Emitasvir Phosphate-024 | 2379279-46-4 | (1R,4S)-8-Hydroxy-1,2,3,4-tetrahydro-1,4-methanonaphthalen-5-yl acetate |
| Emitasvir Phosphate-025 | 2765664-85-3 | (1R,4S)-8-[(Trifluoromethanesulfonyl)oxy]-1,2,3,4-tetrahydro-1,4-methanonaphthalen-5-yl acetate |
| Emitasvir Phosphate-026 | 2765664-73-9 | tert-Butyl (2S)-2-(4-[4-[(1S,4R)-8-hydroxy-1,2,3,4-tetrahydro-1,4-methanonaphthalen-5-yl]phenyl]-1H-imidazol-2-yl)pyrrolidine-1-carboxylate |
OptimisedRoute 4Steps 2 · Total yield 4.9g(Emitasvir Phosphate-029)
Emitasvir Phosphate-02216144-91-5Emitasvir Phosphate-02779-03-8Emitasvir Phosphate-0282361304-37-0Emitasvir Phosphate-0292365512-64-5API · Emitasvir Phosphate
| Code | CAS No. | Intermediate |
|---|---|---|
| Emitasvir Phosphate-022 | 16144-91-5 | 1,2,3,4-Tetrahydro-1,4-methanonaphthalene-5,8-diol |
| Emitasvir Phosphate-027 | 79-03-8 | Propanoyl chloride |
| Emitasvir Phosphate-028 | 2361304-37-0 | 1,2,3,4-Tetrahydro-1,4-methanonaphthalene-5,8-diyl dipropanoate |
| Emitasvir Phosphate-029 | 2365512-64-5 | (1S,4R)-8-Hydroxy-1,2,3,4-tetrahydro-1,4-methanonaphthalen-5-yl propanoate |
Frequently asked questions
What are the approved indications of Emitasvir Phosphate?
Approved indications include: Hepatitis C.
When does the Emitasvir Phosphate patent expire?
No public expiry year is available for Emitasvir Phosphate yet; this page updates once verified.
How many synthesis routes are recorded for Emitasvir Phosphate?
4 synthesis routes are recorded; the shortest is 2 steps with 4.9g(Emitasvir Phosphate-029) total yield. Intermediates in each route carry codes and CAS numbers.
Where can I buy Emitasvir Phosphate intermediates?
All intermediates in Emitasvir Phosphate routes have CAS profiles — you can submit an RFQ per CAS and it enters the Unibest matching pool.
How do I get a quote for Emitasvir Phosphate intermediates?
Open the CAS profile of the target intermediate from this page, or submit an RFQ directly — the CAS enters the matching flow automatically and the supply network responds with quotes.
Source: cross-verified data (structured fields only) · 2026-09-29