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Fenofibrate/Simvastatin
Tier C — Watch / tradeFenofibrate/Simvastatin
Mylan Nv
Originator
2013
First approval
-
Expiry (public)
No sales data
Peak sales
Small molecule
Type
Targets：PPAR, HMGCR
Brand：Cholib
Indications (approved)：Dyslipidaemia
Regional status
US
-
EU
Approved
2013-08-26
China
-
Japan
-
Factories producing this API9
Factories registered as producing this API in our sourcing network (RFQ records + product master), sorted by RFQ activity; the snapshot carries no cost or customer data.
9 producing factories on file — sign in to view the named list (factory details are not shown to guests).
Sign in to view factories →Synthetic routes & intermediates9 routes
Originator routes × 0Optimised (non-patent) × 9Process routes × 0
Routes are ordered originator first, then optimised / process (non-patent) routes; each lists steps, overall yield and the intermediate table (code / CAS / name) — ready for supplier sourcing and RFQ. Rendered by this site from structured data; no third-party route graphics used.
OptimisedRoute 1Steps 2 · Total yield /
FENOF-00142019-78-3FENOF-00242017-89-0API · Fenofibrate/Simvastatin
| Code | CAS No. | Intermediate |
|---|---|---|
| FENOF-001 | 42019-78-3 | (4-chlorophenyl)(4-hydroxyphenyl)methanone |
| FENOF-002 | 42017-89-0 | 2-(4-(4-chlorobenzoyl)phenoxy)-2-methylpropanoic acid |
OptimisedRoute 2Steps 1 · Total yield 220 g (Fenofibrate)
FENOF-00142019-78-3FENOF-00351368-55-9API · Fenofibrate/Simvastatin
| Code | CAS No. | Intermediate |
|---|---|---|
| FENOF-001 | 42019-78-3 | (4-chlorophenyl)(4-hydroxyphenyl)methanone |
| FENOF-003 | 51368-55-9 | isopropyl 2-bromo-2-methylpropanoate |
OptimisedRoute 3Steps 1 · Total yield 149.7 mg (Fenofibrate)
FENOF-0045123-08-0FENOF-0051581307-35-8API · Fenofibrate/Simvastatin
| Code | CAS No. | Intermediate |
|---|---|---|
| FENOF-004 | 5123-08-0 | 2-(4-chlorophenyl)-1,3,6,2-dioxazaborocane |
| FENOF-005 | 1581307-35-8 | isopropyl 2-(4-bromophenoxy)-2-methylpropanoate |
OptimisedRoute 1Steps 2 · Total yield /
(I)122234-5-a79902-31-1(II)122234-5-a595-37-9(III)122234-5-a79902-59-3API · Fenofibrate/Simvastatin
| Code | CAS No. | Intermediate |
|---|---|---|
| (I)122234-5-a | 79902-31-1 | (4R,6R)-4-[[tert-Butyl(dimethyl)silyl]oxy]-6-[2-[(1S,2S,6R,8S,8aR)-8-hydroxy-2,6-dimethyl-1,2,6,7,8,8a-hexahydronaphthalen-1-yl]ethyl]oxan-2-one |
| (II)122234-5-a | 595-37-9 | 2,2-dimethylbutanoic acid |
| (III)122234-5-a | 79902-59-3 | (1S,3R,7S,8S,8aR)-8-[2-[(2R,4R)-4-[[tert-Butyl(dimethyl)silyl]oxy]-6-oxooxan-2-yl]ethyl]-3,7-dimethyl-1,2,3,7,8,8a-hexahydronaphthalen-1-yl 2,2-dimethylbutanoate |
OptimisedRoute 2Steps 1 · Total yield /
(I)122234-12-a132748-10-8(II)122234-12-a79952-42-4(III)122234-12-a5856-77-9API · Fenofibrate/Simvastatin
| Code | CAS No. | Intermediate |
|---|---|---|
| (I)122234-12-a | 132748-10-8 | 3(R),5(R)-Dihydroxy-7-[(1S,2S,6R,8S,8aR)-8-hydroxy-2,6-dimethyl-1,2,6,7,8,8a-hexahydronaphthalen-1-yl]heptanoic acid |
| (II)122234-12-a | 79952-42-4 | 4(R)-Hydroxy-6(R)-[2-[(1S,2S,6R,8S,8aR)-8-hydroxy-2,6-dimethyl-1,2,6,7,8,8a-hexahydronaphthalenyl]ethyl]tetrahydropyran-2-one |
| (III)122234-12-a | 5856-77-9 | 2,2-Dimethylbutanoyl chloride |
OptimisedRoute 3Steps 3 · Total yield /
(I)122234-13-a79952-42-4(IIa)122234-13-a149-73-5(IIb)122234-13-a122-51-0(IIIa)122234-13-a1198221-93-0(IIIb)122234-13-a1198221-97-4(IV)122234-13-a5856-77-9(Va)122234-13-a1198221-95-2(Vb)122234-13-a1198221-99-6(VI)122234-13-a139893-43-9API · Fenofibrate/Simvastatin
| Code | CAS No. | Intermediate |
|---|---|---|
| (I)122234-13-a | 79952-42-4 | 4(R)-Hydroxy-6(R)-[2-[(1S,2S,6R,8S,8aR)-8-hydroxy-2,6-dimethyl-1,2,6,7,8,8a-hexahydronaphthalenyl]ethyl]tetrahydropyran-2-one |
| (IIa)122234-13-a | 149-73-5 | Orthoformic acid trimethyl ester |
| (IIb)122234-13-a | 122-51-0Available | (Diethoxymethoxy)ethane |
| (IIIa)122234-13-a | 1198221-93-0 | Methyl [(4R,6R)-6-[2-[(1S,2S,6R,8S,8aR)-8-hydroxy-2,6-dimethyl-1,2,6,7,8,8a-hexahydronaphthalen-1-yl]ethyl]-2-methoxy-1,3-dioxan-4-yl]acetate |
| (IIIb)122234-13-a | 1198221-97-4 | Ethyl [(4R,6R)-2-ethoxy-6-[2-[(1S,2S,6R,8S,8aR)-8-hydroxy-2,6-dimethyl-1,2,6,7,8,8a-hexahydronaphthalen-1-yl]ethyl]-1,3-dioxan-4-yl]acetate |
| (IV)122234-13-a | 5856-77-9 | 2,2-Dimethylbutanoyl chloride |
| (Va)122234-13-a | 1198221-95-2 | (1S,3R,7S,8S,8aR)-8-[2-[(4R,6R)-2-Methoxy-6-(2-methoxy-2-oxoethyl)-1,3-dioxan-4-yl]ethyl]-3,7-dimethyl-1,2,3,7,8,8a-hexahydronaphthalen-1-yl 2,2-dimethylbutanoate |
| (Vb)122234-13-a | 1198221-99-6 | (1S,3R,7S,8S,8aR)-8-[2-[(4R,6R)-2-Ethoxy-6-(2-ethoxy-2-oxoethyl)-1,3-dioxan-4-yl]ethyl]-3,7-dimethyl-1,2,3,7,8,8a-hexahydronaphthalen-1-yl 2,2-dimethylbutanoate |
| (VI)122234-13-a | 139893-43-9 | (betaR,deltaR,1S,2S,6R,8S,8aR)-8-(2,2-Dimethyl-1-oxobutoxy)-1,2,6,7,8,8a-hexahydro-beta,delta-dihydroxy-2,6-dimethyl-1-naphthaleneheptanoic acid ammonium salt |
OptimisedRoute 4Steps 3 · Total yield /
(I)122234-14-a5856-77-9(II)122234-14-a1608487-07-5(III)122234-14-a1604678-79-6(IV)122234-14-a132748-10-8(V)122234-14-a139893-43-9API · Fenofibrate/Simvastatin
| Code | CAS No. | Intermediate |
|---|---|---|
| (I)122234-14-a | 5856-77-9 | 2,2-Dimethylbutanoyl chloride |
| (II)122234-14-a | 1608487-07-5 | S-(2-Hydroxyethyl) 2,2-dimethylbutanethioate |
| (III)122234-14-a | 1604678-79-6 | 2-[(2,2-Dimethylbutanoyl)sulfanyl]ethyl acetate |
| (IV)122234-14-a | 132748-10-8 | 3(R),5(R)-Dihydroxy-7-[(1S,2S,6R,8S,8aR)-8-hydroxy-2,6-dimethyl-1,2,6,7,8,8a-hexahydronaphthalen-1-yl]heptanoic acid |
| (V)122234-14-a | 139893-43-9 | (betaR,deltaR,1S,2S,6R,8S,8aR)-8-(2,2-Dimethyl-1-oxobutoxy)-1,2,6,7,8,8a-hexahydro-beta,delta-dihydroxy-2,6-dimethyl-1-naphthaleneheptanoic acid ammonium salt |
OptimisedRoute 5Steps 2 · Total yield /
(I)122234-16-a139893-43-9(II)122234-16-a121009-77-6API · Fenofibrate/Simvastatin
| Code | CAS No. | Intermediate |
|---|---|---|
| (I)122234-16-a | 139893-43-9 | (betaR,deltaR,1S,2S,6R,8S,8aR)-8-(2,2-Dimethyl-1-oxobutoxy)-1,2,6,7,8,8a-hexahydro-beta,delta-dihydroxy-2,6-dimethyl-1-naphthaleneheptanoic acid ammonium salt |
| (II)122234-16-a | 121009-77-6 | (3R,5R)-7-[(1S,2S,6R,8S,8aR)-8-[(2,2-Dimethylbutanoyl)oxy]-2,6-dimethyl-1,2,6,7,8,8a-hexahydronaphthalen-1-yl]-3,5-dihydroxyheptanoic acid |
OptimisedRoute 6Steps 2 · Total yield /
(I)122234-19-a595-37-9(II)122234-19-a5856-77-9(III)122234-19-a2935-90-2(IV)122234-19-a938063-63-9API · Fenofibrate/Simvastatin
| Code | CAS No. | Intermediate |
|---|---|---|
| (I)122234-19-a | 595-37-9 | 2,2-dimethylbutanoic acid |
| (II)122234-19-a | 5856-77-9 | 2,2-Dimethylbutanoyl chloride |
| (III)122234-19-a | 2935-90-2 | 3-Mercaptopropionic acid methyl ester |
| (IV)122234-19-a | 938063-63-9 | Methyl 3-[(2,2-dimethylbutanoyl)sulfanyl]propanoate |
Frequently asked questions
What are the approved indications of Fenofibrate/Simvastatin?
Approved indications include: Dyslipidaemia.
When does the Fenofibrate/Simvastatin patent expire?
No public expiry year is available for Fenofibrate/Simvastatin yet; this page updates once verified.
How many synthesis routes are recorded for Fenofibrate/Simvastatin?
9 synthesis routes are recorded; the shortest is 1 steps with 220 g (Fenofibrate) total yield. Intermediates in each route carry codes and CAS numbers.
Where can I buy Fenofibrate/Simvastatin intermediates?
1 intermediate CAS of Fenofibrate/Simvastatin are available through the Unibest supply network — see the route tables on this page and request a quote per CAS.
How do I get a quote for Fenofibrate/Simvastatin intermediates?
Open the CAS profile of the target intermediate from this page, or submit an RFQ directly — the CAS enters the matching flow automatically and the supply network responds with quotes.
Source: cross-verified data (structured fields only) · 2026-09-29