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Enalapril Maleate
Tier C — Watch / tradeEnalapril Maleate
Bausch Health Companies Inc
Originator
1985
First approval
-
Expiry (public)
No sales data
Peak sales
Small molecule
Type
Targets：ACE
Brand：Epaned, Ednit, Xanef, Crinoren, Enalaped, Innovace Melt (freeze-dried oral wafer), Dabonal, Naprilene, Enapren, Ditensor, Renivace, Benalapril, Baripril, Innovace, Renitec
Indications (approved)：Heart failure, Hypertension, Myocardial infarction, Angina pectoris, Left ventricular dysfunction
Regional status
US
Approved
1985-12-24
EU
Approved
2023-11-15
China
Approved
2000-12-15
Japan
-
Factories producing this API2
Factories registered as producing this API in our sourcing network (RFQ records + product master), sorted by RFQ activity; the snapshot carries no cost or customer data.
2 producing factories on file — sign in to view the named list (factory details are not shown to guests).
Sign in to view factories →Synthetic routes & intermediates14 routes
Originator routes × 0Optimised (non-patent) × 14Process routes × 0
Routes are ordered originator first, then optimised / process (non-patent) routes; each lists steps, overall yield and the intermediate table (code / CAS / name) — ready for supplier sourcing and RFQ. Rendered by this site from structured data; no third-party route graphics used.
OptimisedRoute 1Steps 1 · Total yield /
Enalapril-00164920-29-2Enalapril-00213485-59-1API · Enalapril Maleate
| Code | CAS No. | Intermediate |
|---|---|---|
| Enalapril-001 | 64920-29-2 | Ethyl 2-oxo-4-phenylbutyrate |
| Enalapril-002 | 13485-59-1 | L-Alanyl-L-proline |
OptimisedRoute 2Steps 2 · Total yield 4.2g(Enalapril)
Enalapril-00382717-96-2Enalapril-004147-85-3Enalapril-00575847-73-3Enalapril-006110-17-8API · Enalapril Maleate
| Code | CAS No. | Intermediate |
|---|---|---|
| Enalapril-003 | 82717-96-2 | N-[1-Ethoxy-1-oxo-4-phenylbutan-2(S)-yl]-L-alanine |
| Enalapril-004 | 147-85-3 | (-)-L-Proline<-fgf->L-Proline |
| Enalapril-005 | 75847-73-3 | (S)-1-[N-[1-(Ethoxycarbonyl)-3-phenylpropyl]-L-alanyl]-L-proline |
| Enalapril-006 | 110-17-8Available | trans-2-Butenedioic acid |
OptimisedRoute 3Steps 9 · Total yield /
Enalapril-00753279-92-8Enalapril-008120999-41-9Enalapril-009138566-24-2Enalapril-010—Enalapril-0111142-20-7Enalapril-01290315-82-5Enalapril-01388767-98-0Enalapril-01429375-30-2Enalapril-015108428-39-3Enalapril-0162812-46-6Enalapril-01727544-35-0API · Enalapril Maleate
| Code | CAS No. | Intermediate |
|---|---|---|
| Enalapril-007 | 53279-92-8 | 2-Hydroxy-4-phenylbutanenitrile |
| Enalapril-008 | 120999-41-9 | 2(R)-Hydroxy-4-phenylbutanenitrile |
| Enalapril-009 | 138566-24-2 | 4-Phenyl-2(R)-(tetrahydropyran-2-yloxy)butanenitrile |
| Enalapril-010 | - | 4-Phenyl-2(R)-(tetrahydropyran-2-yloxy)butyric acid |
| Enalapril-011 | 1142-20-7 | N-[(Benzyloxy)carbonyl]-L-alanine |
| Enalapril-012 | 90315-82-5 | Ethyl (R)-(-)-2-hydroxy-4-phenylbutyrate |
| Enalapril-013 | 88767-98-0 | 4-Phenyl-2(R)-(trifluoromethylsulfonyloxy)butyric acid ethyl ester |
| Enalapril-014 | 29375-30-2 | L-Alanyl-L-proline tert-butyl ester |
| Enalapril-015 | 108428-39-3 | N-[1-Ethoxy-1-oxo-4-phenylbutan-2(S)-yl]-L-alanyl-L-proline tert-butyl ester |
| Enalapril-016 | 2812-46-6 | N-Boc-proline |
| Enalapril-017 | 27544-35-0 | N-(Benzyloxycarbonyl)-L-alanyl-L-proline tert-butyl ester |
OptimisedRoute 4Steps 4 · Total yield 4.11g(Enalapril)
Enalapril-01880828-26-8Enalapril-019103377-40-8Enalapril-02016652-71-4Enalapril-021120924-94-9Enalapril-00382717-96-2API · Enalapril Maleate
| Code | CAS No. | Intermediate |
|---|---|---|
| Enalapril-018 | 80828-26-8 | N-[(2S)-1-Ethoxy-1-oxo-4-phenylbutan-2-yl]-L-alanine hydrochloride |
| Enalapril-019 | 103377-40-8 | Ethyl (2S)-2-[[(2S)-1-chloro-1-oxopropan-2-yl]amino]-4-phenylbutanoate |
| Enalapril-020 | 16652-71-4 | Benzyl L-prolinate hydrochloride |
| Enalapril-021 | 120924-94-9 | Benzyl N-[(2S)-1-ethoxy-1-oxo-4-phenylbutan-2-yl]-L-alanyl-L-prolinate |
| Enalapril-003 | 82717-96-2 | N-[1-Ethoxy-1-oxo-4-phenylbutan-2(S)-yl]-L-alanine |
OptimisedRoute 5Steps 1 · Total yield /
Enalapril-02288098-09-3Enalapril-00575847-73-3API · Enalapril Maleate
| Code | CAS No. | Intermediate |
|---|---|---|
| Enalapril-022 | 88098-09-3 | N-[(2S)-1-Ethoxy-1,4-dioxo-4-phenylbutan-2-yl]-L-alanyl-L-proline |
| Enalapril-005 | 75847-73-3 | (S)-1-[N-[1-(Ethoxycarbonyl)-3-phenylpropyl]-L-alanyl]-L-proline |
OptimisedRoute 6Steps 6 · Total yield 174mg(Enalapril-033)
Enalapril-023103-63-9Enalapril-0243277-89-2Enalapril-02595-92-1Enalapril-02664920-29-2Enalapril-027108607-75-6Enalapril-02856-41-7Enalapril-029877932-98-4Enalapril-0306066-82-6Enalapril-031—Enalapril-032—Enalapril-033—API · Enalapril Maleate
| Code | CAS No. | Intermediate |
|---|---|---|
| Enalapril-023 | 103-63-9 | (2-Bromoethyl)benzene |
| Enalapril-024 | 3277-89-2 | Bromido(2-phenylethyl)magnesium |
| Enalapril-025 | 95-92-1 | Oxalic acid diethyl diester |
| Enalapril-026 | 64920-29-2 | 2-Oxo-4-phenylbutyric acid ethyl ester |
| Enalapril-027 | 108607-75-6 | 4,5-Ditritium-L-proline |
| Enalapril-028 | 56-41-7 | L-Alanine |
| Enalapril-029 | 877932-98-4 | N-(1-Ethoxy-1-oxo-4-phenylbutan-2-yl)-L-alanine |
| Enalapril-030 | 6066-82-6 | N-Hydroxysuccinimide |
| Enalapril-031 | - | Ethyl 2-([(2S)-1-[(2,5-dioxopyrrolidin-1-yl)oxy]-1-oxopropan-2-yl]amino)-4-phenylbutanoate |
| Enalapril-032 | - | N-(1-Ethoxy-1-oxo-4-phenylbutan-2-yl)-L-alanyl-4,5-ditritium-L-proline |
| Enalapril-033 | - | (2Z)-But-2-enedioic acid N-[(2S)-1-ethoxy-1-oxo-4-phenylbutan-2-yl]-L-alanyl-4,5-ditritium-L-proline |
OptimisedRoute 7Steps 11 · Total yield /
Enalapril-03415186-48-8Enalapril-03510065-72-2Enalapril-0361411634-44-0Enalapril-03719810-31-2Enalapril-0381100-88-5Enalapril-039533931-02-1Enalapril-040533931-01-0Enalapril-041533931-03-2Enalapril-04216721-45-2Enalapril-043—Enalapril-044—Enalapril-04541324-66-7Enalapril-046533931-05-4Enalapril-047533931-06-5Enalapril-0481516-08-1,64-17-5Enalapril-00575847-73-3API · Enalapril Maleate
| Code | CAS No. | Intermediate |
|---|---|---|
| Enalapril-034 | 15186-48-8Available | 2,2-Dimethyl-1,3-dioxolane-4(R)-carbaldehyde |
| Enalapril-035 | 10065-72-2 | L-Alanine methyl ester |
| Enalapril-036 | 1411634-44-0 | Methyl (Z)-N-[[(4S)-2,2-dimethyl-1,3-dioxolan-4-yl]methylidene]-L-alaninate |
| Enalapril-037 | 19810-31-2 | Benzyloxyacetyl chloride |
| Enalapril-038 | 1100-88-5 | Triphenyl(phenylmethyl)phosphonium chloride |
| Enalapril-039 | 533931-02-1 | Methyl (2S)-2-[(2S,3R)-3-(benzyloxy)-2-[(4S)-2,2-dimethyl-1,3-dioxolan-4-yl]-4-oxoazetidin-1-yl]propanoate |
| Enalapril-040 | 533931-01-0 | Methyl (2S)-2-[(2S,3R)-3-(benzyloxy)-2-[(1S)-1,2-dihydroxyethyl]-4-oxoazetidin-1-yl]propanoate |
| Enalapril-041 | 533931-03-2 | Methyl (2S)-2-[(2R,3R)-3-(benzyloxy)-2-formyl-4-oxoazetidin-1-yl]propanoate |
| Enalapril-042 | 16721-45-2 | Benzylidene(triphenyl)-lambda5-phosphane |
| Enalapril-043 | - | Methyl (2S)-2-[(3R,4S)-3-(benzyloxy)-2-oxo-4-[(E)-2-phenylethenyl]azetidin-1-yl]propanoate |
| Enalapril-044 | - | (2S)-2-[(3R,4S)-3-Hydroxy-2-oxo-4-(2-phenylethyl)azetidin-1-yl]propanoic acid |
| Enalapril-045 | 41324-66-7 | Benzyl L-prolinate |
| Enalapril-046 | 533931-05-4 | Benzyl 1-[(2S)-2-[(3R,4S)-3-hydroxy-2-oxo-4-(2-phenylethyl)azetidin-1-yl]propanoyl]-L-prolinate |
| Enalapril-047 | 533931-06-5 | Benzyl 1-[(2S)-2-[(4S)-2,5-dioxo-4-(2-phenylethyl)-1,3-oxazolidin-3-yl]propanoyl]-L-prolinate |
| Enalapril-048 | 1516-08-1,64-17-5 | Ethyl alcohol |
| Enalapril-005 | 75847-73-3 | (S)-1-[N-[1-(Ethoxycarbonyl)-3-phenylpropyl]-L-alanyl]-L-proline |
OptimisedRoute 8Steps 4 · Total yield 3.28g(Enalapril-054)
Enalapril-049100-52-7Enalapril-050127-17-3Enalapril-051—Enalapril-052128573-54-6Enalapril-05329678-81-7Enalapril-05490315-82-5API · Enalapril Maleate
| Code | CAS No. | Intermediate |
|---|---|---|
| Enalapril-049 | 100-52-7Available | Bitter almond |
| Enalapril-050 | 127-17-3 | 2-Oxopropionic acid |
| Enalapril-051 | - | Potassium (3E)-2-oxo-4-phenylbut-3-enoate |
| Enalapril-052 | 128573-54-6 | (2R,3E)-2-Hydroxy-4-phenylbut-3-enoic acid |
| Enalapril-053 | 29678-81-7 | 2(R)-Hydroxy-4-phenylbutyric acid |
| Enalapril-054 | 90315-82-5 | Ethyl (R)-(-)-2-hydroxy-4-phenylbutyrate |
OptimisedRoute 9Steps 7 · Total yield /
Enalapril-05517451-19-3Enalapril-05675-64-9Enalapril-05710017-37-5Enalapril-0581190946-81-6Enalapril-059586396-58-9Enalapril-060586396-61-4Enalapril-061115016-95-0Enalapril-062125639-64-7Enalapril-049100-52-7Enalapril-050127-17-3Enalapril-0481516-08-1,64-17-5API · Enalapril Maleate
| Code | CAS No. | Intermediate |
|---|---|---|
| Enalapril-055 | 17451-19-3 | (3E)-2-Oxo-4-phenylbut-3-enoic acid |
| Enalapril-056 | 75-64-9Available | 2-Methylpropan-2-amine |
| Enalapril-057 | 10017-37-5 | 2-Methylpropan-2-amine hydrogen chloride |
| Enalapril-058 | 1190946-81-6 | 3(E)-N-(tert-Butyl)-2-oxo-4-phenylbutenamide |
| Enalapril-059 | 586396-58-9 | (2S,3E)-N-tert-Butyl-2-hydroxy-4-phenylbut-3-enamide |
| Enalapril-060 | 586396-61-4 | (2S)-N-tert-Butyl-2-hydroxy-4-phenylbutanamide |
| Enalapril-061 | 115016-95-0 | (2S)-2-Hydroxy-4-phenylbutanoic acid |
| Enalapril-062 | 125639-64-7 | Ethyl 2(S)-hydroxy-4-phenylbutyrate |
| Enalapril-049 | 100-52-7Available | Benzaldehyde |
| Enalapril-050 | 127-17-3 | 2-Oxopropanoic acid |
| Enalapril-048 | 1516-08-1,64-17-5 | Non-denatured ethanol |
OptimisedRoute 10Steps 5 · Total yield 206.58g(Enalapril)
Enalapril-063123-75-1Enalapril-0642252296-25-4Enalapril-0657364-47-8Enalapril-066273750-74-6Enalapril-00575847-73-3Enalapril-00382717-96-2Enalapril-004147-85-3API · Enalapril Maleate
| Code | CAS No. | Intermediate |
|---|---|---|
| Enalapril-063 | 123-75-1 | Pyrrolidine |
| Enalapril-064 | 2252296-25-4 | Ethyl (2S)-2-[[(2S)-1-oxo-1-(pyrrolidin-1-yl)propan-2-yl]amino]-4-phenylbutanoate |
| Enalapril-065 | 7364-47-8 | Trimethylsilyl 1-(trimethylsilyl)-L-prolinate |
| Enalapril-066 | 273750-74-6 | Trimethylsilyl N-[(2S)-1-ethoxy-1-oxo-4-phenylbutan-2-yl]-L-alanyl-L-prolinate |
| Enalapril-005 | 75847-73-3 | (S)-1-[N-[1-(Ethoxycarbonyl)-3-phenylpropyl]-L-alanyl]-L-proline |
| Enalapril-003 | 82717-96-2 | N-[(S)-(+)-1-(Ethoxycarbonyl)-3-phenylpropyl]-L-alanine |
| Enalapril-004 | 147-85-3 | (S)-(-)-Proline |
OptimisedRoute 11Steps 3 · Total yield 20.9g(Enalapril)
Enalapril-00382717-96-2Enalapril-004147-85-3Enalapril-00575847-73-3API · Enalapril Maleate
| Code | CAS No. | Intermediate |
|---|---|---|
| Enalapril-003 | 82717-96-2 | N-[1-Ethoxy-1-oxo-4-phenylbutan-2(S)-yl]-L-alanine |
| Enalapril-004 | 147-85-3 | (S)-(-)-Proline |
| Enalapril-005 | 75847-73-3 | (S)-1-[N-[1-(Ethoxycarbonyl)-3-phenylpropyl]-L-alanyl]-L-proline |
OptimisedRoute 12Steps 5 · Total yield 3.9g(Enalapril-073)
Enalapril-06756-84-8Enalapril-06832213-95-9Enalapril-069116393-72-7Enalapril-070100-39-0Enalapril-071885357-46-0Enalapril-072871123-99-8Enalapril-073943-73-7API · Enalapril Maleate
| Code | CAS No. | Intermediate |
|---|---|---|
| Enalapril-067 | 56-84-8 | (S)-Aminobutanedioic acid |
| Enalapril-068 | 32213-95-9 | Dimethyl L-aspartate hydrogen chloride |
| Enalapril-069 | 116393-72-7 | Dimethyl N-(triphenylmethyl)-L-aspartate |
| Enalapril-070 | 100-39-0 | 1-(Bromomethyl)benzene |
| Enalapril-071 | 885357-46-0 | Dimethyl 3-benzyl-N-(triphenylmethyl)-L-aspartate |
| Enalapril-072 | 871123-99-8 | (3R)-3-Benzyl-L-aspartic acid |
| Enalapril-073 | 943-73-7 | 2(S)-Amino-4-phenylbutanoic acid |
OptimisedRoute 13Steps 8 · Total yield /
Enalapril-07456-41-7Enalapril-07515761-38-3Enalapril-076—Enalapril-0772133-40-6Enalapril-07833300-71-9Enalapril-07933300-72-0Enalapril-004147-85-3Enalapril-00213485-59-1Enalapril-02664920-29-2Enalapril-00575847-73-3API · Enalapril Maleate
| Code | CAS No. | Intermediate |
|---|---|---|
| Enalapril-074 | 56-41-7 | L-Alanine |
| Enalapril-075 | 15761-38-3 | N-Boc-2(S)-aminopropanoic acid |
| Enalapril-076 | - | (4R)-4-Amino-1,3-oxazolidine-2,5-dione |
| Enalapril-077 | 2133-40-6 | Methyl L-prolinate hydrogen chloride |
| Enalapril-078 | 33300-71-9 | Methyl N-(tert-butoxycarbonyl)-L-alanyl-L-prolinate |
| Enalapril-079 | 33300-72-0 | N-(tert-Butoxycarbonyl)-L-alanyl-L-proline |
| Enalapril-004 | 147-85-3 | L-Proline |
| Enalapril-002 | 13485-59-1 | L-Alanyl-L-proline |
| Enalapril-026 | 64920-29-2 | 2-Oxo-4-phenylbutyric acid ethyl ester |
| Enalapril-005 | 75847-73-3 | (S)-1-[N-[1-(Ethoxycarbonyl)-3-phenylpropyl]-L-alanyl]-L-proline |
OptimisedRoute 14Steps 3 · Total yield 37.9g(Enalapril-054)
Enalapril-080104-53-0Enalapril-081—Enalapril-008120999-41-9Enalapril-05490315-82-5API · Enalapril Maleate
| Code | CAS No. | Intermediate |
|---|---|---|
| Enalapril-080 | 104-53-0 | 3-Phenylpropionaldehyde |
| Enalapril-081 | - | Ethyl 2-oxo-4-phenylbut-3-enoate |
| Enalapril-008 | 120999-41-9 | 2(R)-Hydroxy-4-phenylbutanenitrile |
| Enalapril-054 | 90315-82-5 | Ethyl (R)-(-)-2-hydroxy-4-phenylbutyrate |
Frequently asked questions
What are the approved indications of Enalapril Maleate?
Approved indications include: Heart failure, Hypertension, Myocardial infarction, Angina pectoris, Left ventricular dysfunction.
When does the Enalapril Maleate patent expire?
No public expiry year is available for Enalapril Maleate yet; this page updates once verified.
How many synthesis routes are recorded for Enalapril Maleate?
14 synthesis routes are recorded; the shortest is 1 steps with / total yield. Intermediates in each route carry codes and CAS numbers.
Where can I buy Enalapril Maleate intermediates?
4 intermediate CAS of Enalapril Maleate are available through the Unibest supply network — see the route tables on this page and request a quote per CAS.
How do I get a quote for Enalapril Maleate intermediates?
Open the CAS profile of the target intermediate from this page, or submit an RFQ directly — the CAS enters the matching flow automatically and the supply network responds with quotes.
Source: cross-verified data (structured fields only) · 2026-09-29