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Diclofenac Sodium/Eperisone Hydrochloride
Tier C — Watch / tradeDiclofenac Sodium/Eperisone Hydrochloride
Eisai Co., Ltd.
Originator
2012
First approval
-
Expiry (public)
No sales data
Peak sales
Small molecule
Type
Targets：VDCCs, COXs
Brand：Eprisan D SR
Indications (approved)：Back pain
Regional status
US
-
EU
-
China
-
Japan
-
Factories producing this API10
Factories registered as producing this API in our sourcing network (RFQ records + product master), sorted by RFQ activity; the snapshot carries no cost or customer data.
10 producing factories on file — sign in to view the named list (factory details are not shown to guests).
Sign in to view factories →Synthetic routes & intermediates11 routes
Originator routes × 0Optimised (non-patent) × 10Process routes × 1
Routes are ordered originator first, then optimised / process (non-patent) routes; each lists steps, overall yield and the intermediate table (code / CAS / name) — ready for supplier sourcing and RFQ. Rendered by this site from structured data; no third-party route graphics used.
OptimisedRoute 1Steps 6 · Total yield /
(I)91353-2-a59473-45-9(II)91353-2-a106130-20-5(III)91353-2-a106112-65-6(IV)91353-2-a106112-66-7(V)91353-2-a608-31-1(VI)91353-2-a106112-69-0(VII)91353-2-a106112-68-9(VIII)91353-2-a—API · Diclofenac Sodium/Eperisone Hydrochloride
| Code | CAS No. | Intermediate |
|---|---|---|
| (I)91353-2-a | 59473-45-9 | 1-(Chloromethyl)-2-iodobenzene |
| (II)91353-2-a | 106130-20-5 | 2-(2-Iodophenyl)[14C]acetonitrile |
| (III)91353-2-a | 106112-65-6 | 2-(2-Iodophenyl)[14C]acetic acid |
| (IV)91353-2-a | 106112-66-7 | 2-(2-Iodophenyl)[14C]acetic acid methyl ester |
| (V)91353-2-a | 608-31-1 | 2,6-Dichloroaniline |
| (VI)91353-2-a | 106112-69-0 | 2-[2-(2,6-Dichlorophenylamino)phenyl][14C]acetic acid methyl ester |
| (VII)91353-2-a | 106112-68-9 | 2-[2-(2,6-Dichlorophenylamino)phenyl][14C]acetic acid |
| (VIII)91353-2-a | - | 2-[2-(2,6-Dichlorophenylamino)phenyl][14C]acetic acid sodium salt |
OptimisedRoute 2Steps 5 · Total yield /
(I)91353-3-a15307-93-4(II)91353-3-a35928-65-5(III)91353-3-a83281-93-0(IV)91353-3-a83281-96-3(IX)91353-3-a83281-95-2(V)91353-3-a83281-94-1(VI)91353-3-a—(VII)91353-3-a15362-40-0(VIII)91353-3-a15307-86-5API · Diclofenac Sodium/Eperisone Hydrochloride
| Code | CAS No. | Intermediate |
|---|---|---|
| (I)91353-3-a | 15307-93-4 | 2,6-Dichloro-N-phenylphenylamine |
| (II)91353-3-a | 35928-65-5 | 2-(Methylsulfanyl)acetyl chloride |
| (III)91353-3-a | 83281-93-0 | N-(2,6-Dichlorophenyl)-2-(methylsulfanyl)-N-phenylacetamide |
| (IV)91353-3-a | 83281-96-3 | N-(2,6-Dichlorophenyl)-2-(methylsulfinyl)-N-phenylacetamide |
| (IX)91353-3-a | 83281-95-2 | 2-[2-(2,6-Dichlorophenylamino)phenyl]-2-(methylsulfanyl)acetic acid |
| (V)91353-3-a | 83281-94-1 | 1-(2,6-Dichlorophenyl)-3-(methylsulfanyl)-2,3-dihydro-1H-indol-2-one |
| (VI)91353-3-a | - | 2-Chloro-N-(2,6-dichlorophenyl)-2-(methylsulfanyl)-N-phenylacetamide |
| (VII)91353-3-a | 15362-40-0 | 1-(2,6-Dichlorophenyl)-2,3-dihydro-1H-indol-2-one |
| (VIII)91353-3-a | 15307-86-5 | 2-[2-(2,6-Dichlorophenylamino)phenyl]acetic acid |
OptimisedRoute 3Steps 4 · Total yield /
(I)91353-4-a608-31-1(II)91353-4-a103-80-0(III)91353-4-a304884-75-1(IV)91353-4-a1443460-18-1(V)91353-4-a15362-40-0(VI)91353-4-a15308-01-7API · Diclofenac Sodium/Eperisone Hydrochloride
| Code | CAS No. | Intermediate |
|---|---|---|
| (I)91353-4-a | 608-31-1 | 2,6-Dichloroaniline |
| (II)91353-4-a | 103-80-0 | 2-Phenylacetyl chloride |
| (III)91353-4-a | 304884-75-1 | N-(2,6-Dichlorophenyl)-2-phenylacetamide |
| (IV)91353-4-a | 1443460-18-1 | N-Chloro-N-(2,6-dichlorophenyl)-2-phenylacetamide |
| (V)91353-4-a | 15362-40-0 | 1-(2,6-Dichlorophenyl)-2,3-dihydro-1H-indol-2-one |
| (VI)91353-4-a | 15308-01-7 | 2-Chloro-N-(2,6-dichlorophenyl)-N-phenylacetamide |
OptimisedRoute 4Steps 2 · Total yield /
(I)91353-5-a608-31-1(IIa)91353-5-a57486-69-8(IIb)91353-5-a57486-68-7(III)91353-5-a15307-78-5API · Diclofenac Sodium/Eperisone Hydrochloride
| Code | CAS No. | Intermediate |
|---|---|---|
| (I)91353-5-a | 608-31-1 | 2,6-Dichloroaniline |
| (IIa)91353-5-a | 57486-69-8 | Methyl (2-bromophenyl)acetate |
| (IIb)91353-5-a | 57486-68-7 | Methyl (2-chlorophenyl)acetate |
| (III)91353-5-a | 15307-78-5 | 2-[2-(2,6-Dichlorophenylamino)phenyl]acetic acid methyl ester |
OptimisedRoute 5Steps 3 · Total yield /
(Ia)91353-6-a611-19-8(Ib)91353-6-a611-17-6(II)91353-6-a64-18-6(III)91353-6-a2444-36-2(IV)91353-6-a95-49-8(V)91353-6-a608-31-1(VI)91353-6-a15307-86-5API · Diclofenac Sodium/Eperisone Hydrochloride
| Code | CAS No. | Intermediate |
|---|---|---|
| (Ia)91353-6-a | 611-19-8 | 2-Chlorobenzyl chloride |
| (Ib)91353-6-a | 611-17-6 | 1-(Bromomethyl)-2-chlorobenzene |
| (II)91353-6-a | 64-18-6 | Formic acid |
| (III)91353-6-a | 2444-36-2 | (2-Chlorophenyl)acetic acid |
| (IV)91353-6-a | 95-49-8 | 1-Chloranyl-2-methylbenzene |
| (V)91353-6-a | 608-31-1 | 2,6-Dichloroaniline |
| (VI)91353-6-a | 15307-86-5 | 2-[2-(2,6-Dichlorophenylamino)phenyl]acetic acid |
OptimisedRoute 6Steps 6 · Total yield /
(I)91353-7-a101-41-7(II)91353-7-a30095-98-8(III)91353-7-a35613-44-6(IV)91353-7-a3559-26-0(V)91353-7-a87-65-0(VI)91353-7-a2270982-77-7(VII)91353-7-a2270982-78-8API · Diclofenac Sodium/Eperisone Hydrochloride
| Code | CAS No. | Intermediate |
|---|---|---|
| (I)91353-7-a | 101-41-7 | 2-Phenylacetic acid methyl ester |
| (II)91353-7-a | 30095-98-8 | Methyl (2-nitrophenyl)acetate |
| (III)91353-7-a | 35613-44-6 | Methyl (2-aminophenyl)acetate |
| (IV)91353-7-a | 3559-26-0 | Methyl (2-benzamidophenyl)acetate |
| (V)91353-7-a | 87-65-0 | 2,6-Dichlorophenol |
| (VI)91353-7-a | 2270982-77-7 | Methyl (2-[(E)-[(2,6-dichlorophenoxy)(phenyl)methylidene]amino]phenyl)acetate |
| (VII)91353-7-a | 2270982-78-8 | Methyl [2-[benzoyl(2,6-dichlorophenyl)amino]phenyl]acetate |
OptimisedRoute 7Steps 3 · Total yield /
(I)91353-8-a3342-78-7(II)91353-8-a35613-44-6(III)91353-8-a2376804-75-8(IV)91353-8-a87-65-0(V)91353-8-a15307-86-5API · Diclofenac Sodium/Eperisone Hydrochloride
| Code | CAS No. | Intermediate |
|---|---|---|
| (I)91353-8-a | 3342-78-7 | (2-Aminophenyl)acetic acid |
| (II)91353-8-a | 35613-44-6 | Methyl (2-aminophenyl)acetate |
| (III)91353-8-a | 2376804-75-8 | Methyl [2-(2-bromopropanamido)phenyl]acetate |
| (IV)91353-8-a | 87-65-0 | 2,6-Dichlorophenol |
| (V)91353-8-a | 15307-86-5 | 2-[2-(2,6-Dichlorophenylamino)phenyl]acetic acid |
OptimisedRoute 8Steps 5 · Total yield /
(I)91353-9-a62-53-3(II)91353-9-a79-04-9(III)91353-9-a587-65-5(IV)91353-9-a87-65-0(V)91353-9-a15307-93-4(VI)91353-9-a15308-01-7(VII)91353-9-a15362-40-0API · Diclofenac Sodium/Eperisone Hydrochloride
| Code | CAS No. | Intermediate |
|---|---|---|
| (I)91353-9-a | 62-53-3Available | Aminobenzene |
| (II)91353-9-a | 79-04-9Available | 2-Chloranylethanoyl chloride |
| (III)91353-9-a | 587-65-5 | 2-Chloro-N-phenylacetamide |
| (IV)91353-9-a | 87-65-0 | 2,6-Dichlorophenol |
| (V)91353-9-a | 15307-93-4 | 2,6-Dichloro-N-phenylphenylamine |
| (VI)91353-9-a | 15308-01-7 | 2-Chloro-N-(2,6-dichlorophenyl)-N-phenylacetamide |
| (VII)91353-9-a | 15362-40-0 | 1-(2,6-Dichlorophenyl)-2,3-dihydro-1H-indol-2-one |
OptimisedRoute 9Steps 4 · Total yield /
(I)91353-10-a101-41-7(II)91353-10-a30095-98-8(III)91353-10-a35613-44-6(IV)91353-10-a3336-41-2(V)91353-10-a87-65-0(VI)91353-10-a105-39-5(VII)91353-10-a40311-72-6(VIII)91353-10-a79-04-9API · Diclofenac Sodium/Eperisone Hydrochloride
| Code | CAS No. | Intermediate |
|---|---|---|
| (I)91353-10-a | 101-41-7 | 2-Phenylacetic acid methyl ester |
| (II)91353-10-a | 30095-98-8 | Methyl (2-nitrophenyl)acetate |
| (III)91353-10-a | 35613-44-6 | Methyl (2-aminophenyl)acetate |
| (IV)91353-10-a | 3336-41-2 | 3,5-Dichloro-4-hydroxybenzoic acid |
| (V)91353-10-a | 87-65-0 | 2,6-Dichlorophenol |
| (VI)91353-10-a | 105-39-5 | 2-Chloroacetic acid ethyl ester |
| (VII)91353-10-a | 40311-72-6 | Ethyl (2,6-dichlorophenoxy)acetate |
| (VIII)91353-10-a | 79-04-9Available | 2-Chloranylethanoyl chloride |
OptimisedRoute 10Steps 6 · Total yield /
(I)91353-11-a62-53-3(II)91353-11-a79-11-8(III)91353-11-a587-65-5(IV)91353-11-a87-65-0(V)91353-11-a146607-19-4(VI)91353-11-a210979-27-4(VII)91353-11-a15308-01-7(VIII)91353-11-a15362-40-0API · Diclofenac Sodium/Eperisone Hydrochloride
| Code | CAS No. | Intermediate |
|---|---|---|
| (I)91353-11-a | 62-53-3Available | Aminobenzene |
| (II)91353-11-a | 79-11-8 | 2-Chloroacetic acid |
| (III)91353-11-a | 587-65-5 | 2-Chloro-N-phenylacetamide |
| (IV)91353-11-a | 87-65-0 | 2,6-Dichlorophenol |
| (V)91353-11-a | 146607-19-4 | 2-(2,6-Dichlorophenoxy)-N-phenylacetamide |
| (VI)91353-11-a | 210979-27-4 | N-(2,6-Dichlorophenyl)-2-hydroxy-N-phenylacetamide |
| (VII)91353-11-a | 15308-01-7 | 2-Chloro-N-(2,6-dichlorophenyl)-N-phenylacetamide |
| (VIII)91353-11-a | 15362-40-0 | 1-(2,6-Dichlorophenyl)-2,3-dihydro-1H-indol-2-one |
ProcessRoute 1Steps 6 · Total yield /
Eperisone Hydrochloride-00127465-51-6Eperisone Hydrochloride-0026091-44-7Eperisone Hydrochloride-003110-89-4Eperisone Hydrochloride-00471979-24-3Eperisone Hydrochloride-00571777-24-7Eperisone Hydrochloride-006111-24-0Eperisone Hydrochloride-007100-41-4Eperisone Hydrochloride-008—Eperisone Hydrochloride-00970639-76-8API · Diclofenac Sodium/Eperisone Hydrochloride
| Code | CAS No. | Intermediate |
|---|---|---|
| Eperisone Hydrochloride-001 | 27465-51-6 | 1-(4-ethylphenyl)propan-1-one |
| Eperisone Hydrochloride-002 | 6091-44-7 | Piperidine hydrochloride |
| Eperisone Hydrochloride-003 | 110-89-4 | Hexahydropyridine |
| Eperisone Hydrochloride-004 | 71979-24-3 | 3-chloro-1-(4-ethylphenyl)-2-methylpropan-1-one |
| Eperisone Hydrochloride-005 | 71777-24-7 | 3-amino-1-(4-ethylphenyl)-2-methylpropan-1-one |
| Eperisone Hydrochloride-006 | 111-24-0 | 1,5-Dibromopentane |
| Eperisone Hydrochloride-007 | 100-41-4 | Ethylbenzene |
| Eperisone Hydrochloride-008 | - | 2-methyl-3-(piperidin-1-yl)propanoyl chloride |
| Eperisone Hydrochloride-009 | 70639-76-8 | 1-(4-ethylphenyl)-2-methylprop-2-en-1-one |
Frequently asked questions
What are the approved indications of Diclofenac Sodium/Eperisone Hydrochloride?
Approved indications include: Back pain.
When does the Diclofenac Sodium/Eperisone Hydrochloride patent expire?
No public expiry year is available for Diclofenac Sodium/Eperisone Hydrochloride yet; this page updates once verified.
How many synthesis routes are recorded for Diclofenac Sodium/Eperisone Hydrochloride?
11 synthesis routes are recorded; the shortest is 2 steps with / total yield. Intermediates in each route carry codes and CAS numbers.
Where can I buy Diclofenac Sodium/Eperisone Hydrochloride intermediates?
2 intermediate CAS of Diclofenac Sodium/Eperisone Hydrochloride are available through the Unibest supply network — see the route tables on this page and request a quote per CAS.
How do I get a quote for Diclofenac Sodium/Eperisone Hydrochloride intermediates?
Open the CAS profile of the target intermediate from this page, or submit an RFQ directly — the CAS enters the matching flow automatically and the supply network responds with quotes.
Source: cross-verified data (structured fields only) · 2026-09-29