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Rabeprazole Sodium/Metronidazole/Amoxicillin
Tier C — Watch / tradeRabeprazole Sodium/Metronidazole/Amoxicillin
Eisai Co., Ltd.
Originator
2013
First approval
-
Expiry (public)
No sales data
Peak sales
Small molecule
Type
Targets：Proton pump, PBPs
Brand：Rabefine
Indications (approved)：Duodenal ulcer, Immune thrombocytopenic purpura, Gastric ulcer, Gastritis, Helicobacter pylori infection
Regional status
US
-
EU
-
China
-
Japan
Approved
2013-08-15
Factories producing this API12
Factories registered as producing this API in our sourcing network (RFQ records + product master), sorted by RFQ activity; the snapshot carries no cost or customer data.
12 producing factories on file — sign in to view the named list (factory details are not shown to guests).
Sign in to view factories →Synthetic routes & intermediates13 routes
Originator routes × 1Optimised (non-patent) × 12Process routes × 0
Routes are ordered originator first, then optimised / process (non-patent) routes; each lists steps, overall yield and the intermediate table (code / CAS / name) — ready for supplier sourcing and RFQ. Rendered by this site from structured data; no third-party route graphics used.
OriginatorRoute 1Steps 4 · Total yield 530 mg
RABE-0011589-49-7RABE-00259886-90-7RABE-003117977-18-1RABE-004117977-20-5RABE-005583-39-1RABE-006117977-21-6API · Rabeprazole Sodium/Metronidazole/Amoxicillin
| Code | CAS No. | Intermediate |
|---|---|---|
| RABE-001 | 1589-49-7 | 3-methoxypropan-1-ol |
| RABE-002 | 59886-90-7 | 4-chloro-2,3-dimethylpyridine 1-oxide |
| RABE-003 | 117977-18-1 | 4-(3-methoxypropoxy)-2,3-dimethylpyridine 1-oxide |
| RABE-004 | 117977-20-5 | 2-(chloromethyl)-4-(3-methoxypropoxy)-3-methylpyridine |
| RABE-005 | 583-39-1 | 1H-benzo[d]imidazole-2-thiol |
| RABE-006 | 117977-21-6 | 2-(((4-(3-methoxypropoxy)-3-methylpyridin-2-yl)methyl)thio)-1H-benzo[d]imidazole |
OptimisedRoute 1Steps 6 · Total yield /
Amoxicillin-001922-68-9Amoxicillin-0022627-86-3Amoxicillin-0033082-62-0Amoxicillin-004—Amoxicillin-005—Amoxicillin-006108-95-2Amoxicillin-007—Amoxicillin-008—Amoxicillin-009—Amoxicillin-010—Amoxicillin-01157591-61-4Amoxicillin-01237763-23-8Amoxicillin-013551-16-6API · Rabeprazole Sodium/Metronidazole/Amoxicillin
| Code | CAS No. | Intermediate |
|---|---|---|
| Amoxicillin-001 | 922-68-9 | Methyl glyoxylate |
| Amoxicillin-002 | 2627-86-3 | (S)-(-)-1-Phenylethylamine |
| Amoxicillin-003 | 3082-62-0 | (1S)-1-(2-Naphthyl)ethanamine |
| Amoxicillin-004 | - | Methyl (2Z)-[[(1S)-1-phenylethyl]imino]acetate |
| Amoxicillin-005 | - | Methyl (2Z)-[[(1S)-1-(naphthalen-2-yl)ethyl]imino]acetate |
| Amoxicillin-006 | 108-95-2Available | Carbolic acid |
| Amoxicillin-007 | - | Methyl (2R)-(4-hydroxyphenyl)[(1-phenylethyl)amino]acetate |
| Amoxicillin-008 | - | Methyl (2R)-(4-hydroxyphenyl)[[1-(naphthalen-2-yl)ethyl]amino]acetate |
| Amoxicillin-009 | - | Methyl (2R)-(4-hydroxyphenyl)[(1-phenylethyl)amino]acetate hydrogen chloride (1/1) |
| Amoxicillin-010 | - | Methyl (2R)-(4-hydroxyphenyl)[[1-(naphthalen-2-yl)ethyl]amino]acetate hydrogen chloride (1/1) |
| Amoxicillin-011 | 57591-61-4 | D-p-Hydroxyphenylglycine methyl ester hydrochloride |
| Amoxicillin-012 | 37763-23-8 | D-p-yHdroxyphenylglycine methyl ester |
| Amoxicillin-013 | 551-16-6Available | (+)-6-Aminopenicillanic acid |
OptimisedRoute 2Steps 4 · Total yield /
Amoxicillin-01436747-66-7Amoxicillin-01526787-75-7Amoxicillin-013551-16-6Amoxicillin-01676953-81-6Amoxicillin-017—API · Rabeprazole Sodium/Metronidazole/Amoxicillin
| Code | CAS No. | Intermediate |
|---|---|---|
| Amoxicillin-014 | 36747-66-7 | [[(Benzyloxy)carbonyl]amino](4-hydroxyphenyl)acetic acid |
| Amoxicillin-015 | 26787-75-7 | (2R)-[[(Benzyloxy)carbonyl]amino](4-hydroxyphenyl)acetic acid |
| Amoxicillin-013 | 551-16-6Available | (+)-6-Aminopenicillanic acid |
| Amoxicillin-016 | 76953-81-6 | (2S,5R,6R)-6-[[(2R)-2-[[(Benzyloxy)carbonyl]amino]-2-(4-hydroxyphenyl)acetyl]amino]-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid |
| Amoxicillin-017 | - | Sodium (2S,5R,6R)-6-[[(2R)-2-[[(benzyloxy)carbonyl]amino]-2-(4-hydroxyphenyl)acetyl]amino]-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylate |
OptimisedRoute 3Steps 5 · Total yield /
Amoxicillin-01526787-75-7Amoxicillin-01822818-40-2Amoxicillin-019105-45-3Amoxicillin-020—Amoxicillin-021—Amoxicillin-022—Amoxicillin-013551-16-6API · Rabeprazole Sodium/Metronidazole/Amoxicillin
| Code | CAS No. | Intermediate |
|---|---|---|
| Amoxicillin-015 | 26787-75-7 | (2R)-[[(Benzyloxy)carbonyl]amino](4-hydroxyphenyl)acetic acid |
| Amoxicillin-018 | 22818-40-2 | (2R)-2-Amino-2-(4-hydroxyphenyl)acetic acid |
| Amoxicillin-019 | 105-45-3Available | 1-Methoxybutane-1,3-dione |
| Amoxicillin-020 | - | Sodium (2R)-(4-hydroxyphenyl)[[(2E)-4-methoxy-4-oxobut-2-en-2-yl]amino]acetate |
| Amoxicillin-021 | - | Sodium (2S,5R,6R)-6-amino-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylate |
| Amoxicillin-022 | - | Potassium (2S,5R,6R)-6-amino-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylate |
| Amoxicillin-013 | 551-16-6Available | (+)-6-Aminopenicillanic acid |
OptimisedRoute 4Steps 6 · Total yield /
Amoxicillin-01526787-75-7Amoxicillin-02126889-95-2Amoxicillin-013551-16-6Amoxicillin-02228645-17-2Amoxicillin-01822818-40-2Amoxicillin-02351431-08-4API · Rabeprazole Sodium/Metronidazole/Amoxicillin
| Code | CAS No. | Intermediate |
|---|---|---|
| Amoxicillin-015 | 26787-75-7 | (2R)-[[(Benzyloxy)carbonyl]amino](4-hydroxyphenyl)acetic acid |
| Amoxicillin-021 | 26889-95-2 | (2R)-[[(Benzyloxy)carbonyl]amino](4-[[(benzyloxy)carbonyl]oxy]phenyl)acetic acid |
| Amoxicillin-013 | 551-16-6Available | (+)-6-Aminopenicillanic acid |
| Amoxicillin-022 | 28645-17-2 | (2S,5R,6R)-6-[[(2R)-2-Amino-2-(4-[[(benzyloxy)carbonyl]oxy]phenyl)acetyl]amino]-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid |
| Amoxicillin-018 | 22818-40-2 | (2R)-2-Amino-2-(4-hydroxyphenyl)acetic acid |
| Amoxicillin-023 | 51431-08-4 | (2R)-Amino(4-hydroxyphenyl)acetyl chloride hydrogen chloride |
OptimisedRoute 5Steps 3 · Total yield /
Amoxicillin-02432401-82-4Amoxicillin-013551-16-6Amoxicillin-02553726-38-8Amoxicillin-026—Amoxicillin-02738083-36-2API · Rabeprazole Sodium/Metronidazole/Amoxicillin
| Code | CAS No. | Intermediate |
|---|---|---|
| Amoxicillin-024 | 32401-82-4 | [[(Benzyloxy)carbonyl]amino](4-[[(benzyloxy)carbonyl]oxy]phenyl)acetic acid |
| Amoxicillin-013 | 551-16-6Available | (+)-6-Aminopenicillanic acid |
| Amoxicillin-025 | 53726-38-8 | (2S,5R,6R)-6-[[[[(Benzyloxy)carbonyl]amino](4-[[(benzyloxy)carbonyl]oxy]phenyl)acetyl]amino]-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid |
| Amoxicillin-026 | - | Sodium (2S,5R,6R)-6-[[[[(benzyloxy)carbonyl]amino](4-[[(benzyloxy)carbonyl]oxy]phenyl)acetyl]amino]-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylate |
| Amoxicillin-027 | 38083-36-2 | (2S,5R,6R)-6-[[Amino(4-hydroxyphenyl)acetyl]amino]-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid |
OptimisedRoute 6Steps 3 · Total yield /
Amoxicillin-01822818-40-2Amoxicillin-028178119-93-2Amoxicillin-013551-16-6Amoxicillin-0292171277-86-2API · Rabeprazole Sodium/Metronidazole/Amoxicillin
| Code | CAS No. | Intermediate |
|---|---|---|
| Amoxicillin-018 | 22818-40-2 | (2R)-2-Amino-2-(4-hydroxyphenyl)acetic acid |
| Amoxicillin-028 | 178119-93-2 | (2R)-([[(9H-Fluoren-9-yl)methoxy]carbonyl]amino)(4-hydroxyphenyl)acetic acid |
| Amoxicillin-013 | 551-16-6Available | (+)-6-Aminopenicillanic acid |
| Amoxicillin-029 | 2171277-86-2 | (2S,5R,6R)-6-[[(2R)-2-([[(9H-Fluoren-9-yl)methoxy]carbonyl]amino)-2-(4-hydroxyphenyl)acetyl]amino]-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid |
OptimisedRoute 7Steps 1 · Total yield /
Amoxicillin-030113-98-4Amoxicillin-03147294-44-0,47294-41-7,70019-71-5,61-33-6,30411-69-9,7005-30-3Amoxicillin-01157591-61-4Amoxicillin-01237763-23-8Amoxicillin-03254397-23-8API · Rabeprazole Sodium/Metronidazole/Amoxicillin
| Code | CAS No. | Intermediate |
|---|---|---|
| Amoxicillin-030 | 113-98-4 | (2S,5R,6R)-3,3-Dimethyl-7-oxo-6-(2-phenylacetamido)-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid potassium salt |
| Amoxicillin-031 | 47294-44-0,47294-41-7,70019-71-5,61-33-6,30411-69-9,7005-30-3 | (2S-(2alpha,5alpha,6beta))-3,3-Dimethyl-7-oxo-6-((phenylacetyl)amino)-4-thia-1-azabicyclo(3.2.0)heptane-2-carboxylic acid |
| Amoxicillin-011 | 57591-61-4 | D-p-Hydroxyphenylglycine methyl ester hydrochloride |
| Amoxicillin-012 | 37763-23-8 | D-p-yHdroxyphenylglycine methyl ester |
| Amoxicillin-032 | 54397-23-8 | (2R)-2-Amino-2-(4-hydroxyphenyl)acetamide |
OptimisedRoute 2Steps 3 · Total yield 40.32 kg
RABE-005583-39-1RABE-006117977-21-6RABE-007153259-31-5RABE-008117976-89-3API · Rabeprazole Sodium/Metronidazole/Amoxicillin
| Code | CAS No. | Intermediate |
|---|---|---|
| RABE-005 | 583-39-1 | 1H-benzo[d]imidazole-2-thiol |
| RABE-006 | 117977-21-6 | 2-(((4-(3-methoxypropoxy)-3-methylpyridin-2-yl)methyl)thio)-1H-benzo[d]imidazole |
| RABE-007 | 153259-31-5 | 2-(chloromethyl)-4-(3-methoxypropoxy)-3-methylpyridine hydrochloride |
| RABE-008 | 117976-89-3 | 2-(((4-(3-methoxypropoxy)-3-methylpyridin-2-yl)methyl)sulfinyl)-1H-benzo[d]imidazole |
OptimisedRoute 3Steps 1 · Total yield /
RABE-006117977-21-6API · Rabeprazole Sodium/Metronidazole/Amoxicillin
| Code | CAS No. | Intermediate |
|---|---|---|
| RABE-006 | 117977-21-6 | 2-(((4-(3-methoxypropoxy)-3-methylpyridin-2-yl)methyl)thio)-1H-benzo[d]imidazole |
OptimisedRoute 4Steps 1 · Total yield 92.4 g
RABE-005583-39-1RABE-009117977-20-5API · Rabeprazole Sodium/Metronidazole/Amoxicillin
| Code | CAS No. | Intermediate |
|---|---|---|
| RABE-005 | 583-39-1 | 1H-benzo[d]imidazole-2-thiol |
| RABE-009 | 117977-20-5 | 2-(chloromethyl)-4-(3-methoxypropoxy)-3-methylpyridine |
OptimisedRoute 5Steps 2 · Total yield /
RABE-004117977-20-5RABE-005583-39-1RABE-008117976-89-3RABE-010924663-39-8API · Rabeprazole Sodium/Metronidazole/Amoxicillin
| Code | CAS No. | Intermediate |
|---|---|---|
| RABE-004 | 117977-20-5 | 2-(chloromethyl)-4-(3-methoxypropoxy)-3-methylpyridine |
| RABE-005 | 583-39-1 | 1H-benzo[d]imidazole-2-thiol |
| RABE-008 | 117976-89-3 | 2-(((4-(3-methoxypropoxy)-3-methylpyridin-2-yl)methyl)sulfinyl)-1H-benzo[d]imidazole |
| RABE-010 | 924663-39-8 | 2-(chloromethyl)-4-(3-methoxypropoxy)-3-methylpyridine 1-oxide |
OptimisedRoute 1Steps 6 · Total yield 8.5g(Metronidazole (Free))
Metronidazole hydrochloride-001107-22-2Metronidazole hydrochloride-00275-07-0Metronidazole hydrochloride-003693-98-1Metronidazole hydrochloride-004696-23-1Metronidazole hydrochloride-005107-07-3Metronidazole hydrochloride-00675-05-8Metronidazole hydrochloride-007—Metronidazole hydrochloride-00822483-09-6Metronidazole hydrochloride-009—API · Rabeprazole Sodium/Metronidazole/Amoxicillin
| Code | CAS No. | Intermediate |
|---|---|---|
| Metronidazole hydrochloride-001 | 107-22-2Available | Glyoxal |
| Metronidazole hydrochloride-002 | 75-07-0 | Ethanal |
| Metronidazole hydrochloride-003 | 693-98-1 | 2-Methylglyoxaline |
| Metronidazole hydrochloride-004 | 696-23-1 | 2-Methyl-4(5)-nitroimidazole |
| Metronidazole hydrochloride-005 | 107-07-3 | Ethylene chlorohydrin |
| Metronidazole hydrochloride-006 | 75-05-8 | Ethyl nitrile |
| Metronidazole hydrochloride-007 | - | Methyl ethanimidoate hydrochloride |
| Metronidazole hydrochloride-008 | 22483-09-6 | 2,2-Dimethoxyethanamine |
| Metronidazole hydrochloride-009 | - | N-(2,2-Dimethoxyethyl)ethanimidamide |
Frequently asked questions
What are the approved indications of Rabeprazole Sodium/Metronidazole/Amoxicillin?
Approved indications include: Duodenal ulcer, Immune thrombocytopenic purpura, Gastric ulcer, Gastritis, Helicobacter pylori infection.
When does the Rabeprazole Sodium/Metronidazole/Amoxicillin patent expire?
No public expiry year is available for Rabeprazole Sodium/Metronidazole/Amoxicillin yet; this page updates once verified.
How many synthesis routes are recorded for Rabeprazole Sodium/Metronidazole/Amoxicillin?
13 synthesis routes are recorded; the shortest is 1 steps with / total yield. Intermediates in each route carry codes and CAS numbers.
Where can I buy Rabeprazole Sodium/Metronidazole/Amoxicillin intermediates?
4 intermediate CAS of Rabeprazole Sodium/Metronidazole/Amoxicillin are available through the Unibest supply network — see the route tables on this page and request a quote per CAS.
How do I get a quote for Rabeprazole Sodium/Metronidazole/Amoxicillin intermediates?
Open the CAS profile of the target intermediate from this page, or submit an RFQ directly — the CAS enters the matching flow automatically and the supply network responds with quotes.
Source: cross-verified data (structured fields only) · 2026-09-29