Olmesartan Medoxomil/Amlodipine orotate

Tier C — Watch / trade

Dong-A ST Co Ltd

Originator

2014

First approval

Expiry (public)

No sales data

Peak sales

Small molecule

Type

Targets：AT1, VDCCs

Brand：Sevisartan

Indications (approved)：Hypertension

Regional status

China

Japan

Synthetic routes & intermediates16 routes

Originator routes × 1Optimised (non-patent) × 15Process routes × 0

Routes are ordered originator first, then optimised / process (non-patent) routes; each lists steps, overall yield and the intermediate table (code / CAS / name) — ready for supplier sourcing and RFQ. Rendered by this site from structured data; no third-party route graphics used.

OriginatorRoute 1Steps 7 · Total yield 16.6 g

OLME-0011187-42-4OLME-00243083-12-1OLME-00351802-42-7OLME-004144689-94-1OLME-005144689-93-0OLME-006124750-51-2OLME-007144690-33-5OLME-0081114761-92-0OLME-00980841-78-7OLME-010144690-92-6API · Olmesartan Medoxomil/Amlodipine orotate

Code	CAS No.	Intermediate
OLME-001	1187-42-4	(2R,3R,4R,5S)-2-((benzoyloxy)methyl)-5-bromotetrahydrofuran-3,4-diyl dibenzoate
OLME-002	43083-12-1	1,1,1-trimethoxybutane
OLME-003	51802-42-7	2-propyl-1H-imidazole-4,5-dicarbonitrile
OLME-004	144689-94-1	diethyl 2-propyl-1H-imidazole-4,5-dicarboxylate
OLME-005	144689-93-0	ethyl 4-(2-hydroxypropan-2-yl)-2-propyl-1H-imidazole-5-carboxylate
OLME-006	124750-51-2	5-(4'-(bromomethyl)-[1,1'-biphenyl]-2-yl)-1-trityl-1H-tetrazole
OLME-007	144690-33-5	ethyl 4-(2-hydroxypropan-2-yl)-2-propyl-1-((2'-(1-trityl-1H-tetrazol-5-yl)-[1,1'-biphenyl]-4-yl)methyl)-1H-imidazole-5-carboxylate
OLME-008	1114761-92-0	lithium 4-(2-hydroxypropan-2-yl)-2-propyl-1-((2'-(1-trityl-1H-tetrazol-5-yl)-[1,1'-biphenyl]-4-yl)methyl)-1H-imidazole-5-carboxylate
OLME-009	80841-78-7	4-(chloromethyl)-5-methyl-1,3-dioxol-2-one
OLME-010	144690-92-6	(5-methyl-2-oxo-1,3-dioxol-4-yl)methyl 4-(2-hydroxypropan-2-yl)-2-propyl-1-((2'-(1-trityl-1H-tetrazol-5-yl)-[1,1'-biphenyl]-4-yl)methyl)-1H-imidazole-5-carboxylate

OptimisedRoute 2Steps 5 · Total yield /

OLME-004144689-94-1OLME-005144689-93-0OLME-00980841-78-7OLME-010144690-92-6OLME-011114772-54-2OLME-012144690-96-0OLME-013144689-24-7API · Olmesartan Medoxomil/Amlodipine orotate

Code	CAS No.	Intermediate
OLME-004	144689-94-1	diethyl 2-propyl-1H-imidazole-4,5-dicarboxylate
OLME-005	144689-93-0	ethyl 4-(2-hydroxypropan-2-yl)-2-propyl-1H-imidazole-5-carboxylate
OLME-009	80841-78-7	4-(chloromethyl)-5-methyl-1,3-dioxol-2-one
OLME-010	144690-92-6	(5-methyl-2-oxo-1,3-dioxol-4-yl)methyl 4-(2-hydroxypropan-2-yl)-2-propyl-1-((2'-(1-trityl-1H-tetrazol-5-yl)-[1,1'-biphenyl]-4-yl)methyl)-1H-imidazole-5-carboxylate
OLME-011	114772-54-2	4'-(bromomethyl)-[1,1'-biphenyl]-2-carbonitrile
OLME-012	144690-96-0	ethyl 1-((2'-cyano-[1,1'-biphenyl]-4-yl)methyl)-4-(2-hydroxypropan-2-yl)-2-propyl-1H-imidazole-5-carboxylate
OLME-013	144689-24-7	1-((2'-(1H-tetrazol-5-yl)-[1,1'-biphenyl]-4-yl)methyl)-4-(2-hydroxypropan-2-yl)-2-propyl-1H-imidazole-5-carboxylic acid

OptimisedRoute 3Steps 3 · Total yield /

OLME-005144689-93-0OLME-006124750-51-2OLME-00980841-78-7OLME-010144690-92-6OLME-014144690-04-0OLME-015—API · Olmesartan Medoxomil/Amlodipine orotate

Code	CAS No.	Intermediate
OLME-005	144689-93-0	ethyl 4-(2-hydroxypropan-2-yl)-2-propyl-1H-imidazole-5-carboxylate
OLME-006	124750-51-2	5-(4'-(bromomethyl)-[1,1'-biphenyl]-2-yl)-1-trityl-1H-tetrazole
OLME-009	80841-78-7	4-(chloromethyl)-5-methyl-1,3-dioxol-2-one
OLME-010	144690-92-6	(5-methyl-2-oxo-1,3-dioxol-4-yl)methyl 4-(2-hydroxypropan-2-yl)-2-propyl-1-((2'-(1-trityl-1H-tetrazol-5-yl)-[1,1'-biphenyl]-4-yl)methyl)-1H-imidazole-5-carboxylate
OLME-014	144690-04-0	4-(2-hydroxypropan-2-yl)-2-propyl-1H-imidazole-5-carboxylic acid
OLME-015	-	(5-methyl-2-oxo-1,3-dioxol-4-yl)methyl 4-(2-hydroxypropan-2-yl)-2-propyl-1H-imidazole-5-carboxylate

OptimisedRoute 4Steps 5 · Total yield 40 mg

OLME-005144689-93-0OLME-00980841-78-7OLME-016589-15-1OLME-017685091-51-4OLME-018—OLME-019—OLME-020—OLME-021—API · Olmesartan Medoxomil/Amlodipine orotate

Code	CAS No.	Intermediate
OLME-005	144689-93-0	ethyl 4-(2-hydroxypropan-2-yl)-2-propyl-1H-imidazole-5-carboxylate
OLME-009	80841-78-7	4-(chloromethyl)-5-methyl-1,3-dioxol-2-one
OLME-016	589-15-1	1-bromo-4-(bromomethyl)benzene
OLME-017	685091-51-4	ethyl 1-(4-bromobenzyl)-4-(2-hydroxypropan-2-yl)-2-propyl-1H-imidazole-5-carboxylate
OLME-018	-	(2-(1-(2-phenylpropan-2-yl)-1H-tetrazol-5-yl)phenyl)boronic acid
OLME-019	-	ethyl 4-(2-hydroxypropan-2-yl)-1-((2'-(1-(2-phenylpropan-2-yl)-1H-tetrazol-5-yl)-[1,1'-biphenyl]-4-yl)methyl)-2-propyl-1H-imidazole-5-carboxylate
OLME-020	-	4-(2-hydroxypropan-2-yl)-1-((2'-(1-(2-phenylpropan-2-yl)-1H-tetrazol-5-yl)-[1,1'-biphenyl]-4-yl)methyl)-2-propyl-1H-imidazole-5-carboxylic acid
OLME-021	-	(5-methyl-2-oxo-1,3-dioxol-4-yl)methyl 4-(2-hydroxypropan-2-yl)-1-((2'-(1-(2-phenylpropan-2-yl)-1H-tetrazol-5-yl)-[1,1'-biphenyl]-4-yl)methyl)-2-propyl-1H-imidazole-5-carboxylate

OptimisedRoute 5Steps 5 · Total yield /

OLME-00980841-78-7OLME-011114772-54-2OLME-022—OLME-023—OLME-0241309566-95-7OLME-0251199807-52-7OLME-0261993494-83-9API · Olmesartan Medoxomil/Amlodipine orotate

Code	CAS No.	Intermediate
OLME-009	80841-78-7	4-(chloromethyl)-5-methyl-1,3-dioxol-2-one
OLME-011	114772-54-2	4'-(bromomethyl)-[1,1'-biphenyl]-2-carbonitrile
OLME-022	-	4-(2-hydroxypropan-2-yl)-2-propyl-1H-imidazole-5-carbonitrile
OLME-023	-	4,4-dimethyl-2-propyl-4,6-dihydro-1H-furo[3,4-d]imidazol-6-ol
OLME-024	1309566-95-7	4'-((6-hydroxy-4,4-dimethyl-2-propyl-4,6-dihydro-1H-furo[3,4-d]imidazol-1-yl)methyl)-[1,1'-biphenyl]-2-carbonitrile
OLME-025	1199807-52-7	1-((2'-cyano-[1,1'-biphenyl]-4-yl)methyl)-4-(2-hydroxypropan-2-yl)-2-propyl-1H-imidazole-5-carboxylic acid
OLME-026	1993494-83-9	(5-methyl-2-oxo-1,3-dioxol-4-yl)methyl 1-((2'-cyano-[1,1'-biphenyl]-4-yl)methyl)-4-(2-hydroxypropan-2-yl)-2-propyl-1H-imidazole-5-carboxylate

OptimisedRoute 1Steps 3 · Total yield /

(I)109067-1-a638-07-3(II)109067-1-a1517-05-1(III)109067-1-a88150-45-2(IV)109067-1-a14205-39-1(V)109067-1-a89-98-5(VI)109067-1-a88150-46-3API · Olmesartan Medoxomil/Amlodipine orotate

Code	CAS No.	Intermediate
(I)109067-1-a	638-07-3	Ethyl 4-chloro-3-oxobutanoate
(II)109067-1-a	1517-05-1	2-azidoethan-1-ol
(III)109067-1-a	88150-45-2	ethyl 4-(2-azidoethoxy)-3-oxobutanoate
(IV)109067-1-a	14205-39-1	3-Amino-2-butenoic acid methyl ester
(V)109067-1-a	89-98-5	2-Chlorobenzaldehyde
(VI)109067-1-a	88150-46-3	3-ethyl 5-methyl 2-[(2-azidoethoxy)methyl]-4-(2-chlorophenyl)-6-methyl-1,4-dihydropyridine-3,5-dicarboxylate

OptimisedRoute 2Steps 4 · Total yield /

(I)109067-2-a638-07-3(II)109067-2-a2222844-70-2(III)109067-2-a3891-07-4(IV)109067-2-a88150-75-8(V)109067-2-a—(VI)109067-2-a1170036-31-3(VII)109067-2-a103094-30-0,88150-62-3API · Olmesartan Medoxomil/Amlodipine orotate

Code	CAS No.	Intermediate
(I)109067-2-a	638-07-3	Ethyl 4-chloro-3-oxobutanoate
(II)109067-2-a	2222844-70-2	Ethyl 4-[(4-methylbenzene-1-sulfonyl)oxy]-3-oxobutanoate
(III)109067-2-a	3891-07-4	N-(2-Hydroxyethyl)phthalimide
(IV)109067-2-a	88150-75-8	Ethyl 4-(2-phthalimidoethoxy)acetoacetate
(V)109067-2-a	-	Ethyl (2Z)-3-amino-4-[2-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)ethoxy]but-2-enoate
(VI)109067-2-a	1170036-31-3	Methyl (2Z)-2-[(2-chlorophenyl)methylidene]-3-oxobutanoate
(VII)109067-2-a	103094-30-0,88150-62-3	3-Ethyl 5-methyl (4RS)-4-(2-chlorophenyl)-2-[[2-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)ethoxy]methyl]-6-methyl-1,4-dihydropyridine-3,5-dicarboxylate

OptimisedRoute 3Steps 3 · Total yield /

(I)109067-3-a638-07-3(II)109067-3-a1517-05-1(III)109067-3-a88150-45-2(IV)109067-3-a1170036-31-3(V)109067-3-a88150-46-3API · Olmesartan Medoxomil/Amlodipine orotate

Code	CAS No.	Intermediate
(I)109067-3-a	638-07-3	4-Chloro-3-oxobutyric acid ethyl ester
(II)109067-3-a	1517-05-1	2-azidoethan-1-ol
(III)109067-3-a	88150-45-2	ethyl 4-(2-azidoethoxy)-3-oxobutanoate
(IV)109067-3-a	1170036-31-3	Methyl (2Z)-2-[(2-chlorophenyl)methylidene]-3-oxobutanoate
(V)109067-3-a	88150-46-3	3-ethyl 5-methyl 2-[(2-azidoethoxy)methyl]-4-(2-chlorophenyl)-6-methyl-1,4-dihydropyridine-3,5-dicarboxylate

OptimisedRoute 4Steps 6 · Total yield /

(I)109067-4-a6065-82-3(II)109067-4-a621-63-6(III)109067-4-a638-07-3(IV)109067-4-a225939-10-6(V)109067-4-a89-98-5(VI)109067-4-a—(VII)109067-4-a14205-39-1(VIII)109067-4-a194472-23-6(IX)109067-4-a—(X)109067-4-a—(XI)109067-4-a1170036-31-3API · Olmesartan Medoxomil/Amlodipine orotate

Code	CAS No.	Intermediate
(I)109067-4-a	6065-82-3	Diethoxyacetic acid ethyl ester
(II)109067-4-a	621-63-6	2,2-Diethoxyethanol
(III)109067-4-a	638-07-3	4-Chloro-3-oxobutyric acid ethyl ester
(IV)109067-4-a	225939-10-6	ethyl 4-(2,2-diethoxyethoxy)-3-oxobutanoate
(V)109067-4-a	89-98-5	2-Chlorobenzaldehyde
(VI)109067-4-a	-	ethyl (2Z)-2-[(2-chlorophenyl)methylidene]-4-(2,2-dimethoxyethoxy)-3-oxobutanoate
(VII)109067-4-a	14205-39-1	Methyl 3-amino-2-butenoate
(VIII)109067-4-a	194472-23-6	3-ethyl 5-methyl 4-(2-chlorophenyl)-2-[(2,2-dimethoxyethoxy)methyl]-6-methyl-1,4-dihydropyridine-3,5-dicarboxylate
(IX)109067-4-a	-	3-ethyl 5-methyl 4-(2-chlorophenyl)-2-{[(2E)-2-(hydroxyimino)ethoxy]methyl}-6-methyl-1,4-dihydropyridine-3,5-dicarboxylate
(X)109067-4-a	-	ethyl (2E)-3-amino-4-(2,2-diethoxyethoxy)but-2-enoate
(XI)109067-4-a	1170036-31-3	Methyl (2Z)-2-[(2-chlorophenyl)methylidene]-3-oxobutanoate

OptimisedRoute 5Steps 4 · Total yield /

(I)109067-5-a141-43-5(II)109067-5-a33885-01-7(III)109067-5-a24070-16-4(IV)109067-5-a638-07-3(V)109067-5-a156366-26-6(VI)109067-5-a89-98-5(VII)109067-5-a14205-39-1(VIII)109067-5-a156366-27-7API · Olmesartan Medoxomil/Amlodipine orotate

Code	CAS No.	Intermediate
(I)109067-5-a	141-43-5 Available	2-Aminoethanol
(II)109067-5-a	33885-01-7	(2-chloro-1,1-diphenylethyl)benzene
(III)109067-5-a	24070-16-4	2-[(triphenylmethyl)amino]ethan-1-ol
(IV)109067-5-a	638-07-3	Ethyl 4-chloroacetoacetate
(V)109067-5-a	156366-26-6	ethyl 3-oxo-4-{2-[(triphenylmethyl)amino]ethoxy}butanoate
(VI)109067-5-a	89-98-5	2-Chlorobenzaldehyde
(VII)109067-5-a	14205-39-1	3-Amino-2-butenoic acid methyl ester
(VIII)109067-5-a	156366-27-7	3-ethyl 5-methyl 4-(2-chlorophenyl)-6-methyl-2-({2-[(triphenylmethyl)amino]ethoxy}methyl)-1,4-dihydropyridine-3,5-dicarboxylate

OptimisedRoute 6Steps 8 · Total yield /

(I)109067-6-a1517-05-1(II)109067-6-a79-11-8(III)109067-6-a79598-48-4(IV)109067-6-a2033-24-1(V)109067-6-a109-78-4(VI)109067-6-a103069-47-2(VII)109067-6-a89-98-5(VIII)109067-6-a14205-39-1(IX)109067-6-a134471-46-8(X)109067-6-a134471-71-9(XI)109067-6-a66051-01-2(XII)109067-6-a—(XIII)109067-6-a103094-34-4(XIV)109067-6-a125711-60-6(XV)109067-6-a103129-82-4API · Olmesartan Medoxomil/Amlodipine orotate

Code	CAS No.	Intermediate
(I)109067-6-a	1517-05-1	2-azidoethan-1-ol
(II)109067-6-a	79-11-8	2-Chloroacetic acid
(III)109067-6-a	79598-48-4	2-(2-azidoethoxy)acetic acid
(IV)109067-6-a	2033-24-1	2,2-Dimethyl-1,3-dioxane-4,6-dione
(V)109067-6-a	109-78-4 Available	3-Hydroxypropionitrile
(VI)109067-6-a	103069-47-2	2-cyanoethyl 4-(2-azidoethoxy)-3-oxobutanoate
(VII)109067-6-a	89-98-5	2-Chlorobenzaldehyde
(VIII)109067-6-a	14205-39-1	3-Amino-2-butenoic acid methyl ester
(IX)109067-6-a	134471-46-8	3-(2-cyanoethyl) 5-methyl 2-[(2-azidoethoxy)methyl]-4-(2-chlorophenyl)-6-methyl-1,4-dihydropyridine-3,5-dicarboxylate
(X)109067-6-a	134471-71-9	2-[(2-azidoethoxy)methyl]-4-(2-chlorophenyl)-5-(methoxycarbonyl)-6-methyl-1,4-dihydropyridine-3-carboxylic acid
(XI)109067-6-a	66051-01-2	(2S)-2-methoxy-2-phenylethan-1-ol
(XII)109067-6-a	-	3-(2S)-2-methoxy-2-phenylethyl 5-methyl 2-[(2-azidoethoxy)methyl]-4-(2-chlorophenyl)-6-methyl-1,4-dihydropyridine-3,5-dicarboxylate
(XIII)109067-6-a	103094-34-4	3-[(2S)-2-Methoxy-2-phenylethyl] 5-methyl (4S)-2-[(2-azidoethoxy)methyl]-4-(2-chlorophenyl)-6-methyl-1,4-dihydropyridine-3,5-dicarboxylate
(XIV)109067-6-a	125711-60-6	3-Ethyl 5-methyl (4S)-2-[(2-azidoethoxy)methyl]-4-(2-chlorophenyl)-6-methyl-1,4-dihydropyridine-3,5-dicarboxylate
(XV)109067-6-a	103129-82-4	3-Ethyl 5-methyl (4S)-2-[(2-aminoethoxy)methyl]-4-(2-chlorophenyl)-6-methyl-1,4-dihydropyridine-3,5-dicarboxylate

OptimisedRoute 7Steps 6 · Total yield /

(I)109067-8-a—(II)109067-8-a,(II)109067-8-b638-07-3(III)109067-8-a194472-29-2(IV)109067-8-a,(IV)109067-8-b89-98-5(V)109067-8-a,(V)109067-8-b14205-39-1(VI)109067-8-a194472-10-1(VII)109067-8-a194472-12-3(VIII)109067-8-a,(VIII)109067-8-b194472-14-5(IX)109067-8-a,(IX)109067-8-b—API · Olmesartan Medoxomil/Amlodipine orotate

Code	CAS No.	Intermediate
(I)109067-8-a	-	[5-(hydroxymethyl)-2,2-dimethyl-1,3-dioxolan-4-yl]methanol
(II)109067-8-a,(II)109067-8-b	638-07-3	4-Chloro-3-oxobutyric acid ethyl ester
(III)109067-8-a	194472-29-2	ethyl 4-({5-[(4-ethoxy-2,4-dioxobutoxy)methyl]-2,2-dimethyl-1,3-dioxolan-4-yl}methoxy)-3-oxobutanoate
(IV)109067-8-a,(IV)109067-8-b	89-98-5	2-Chlorobenzaldehyde
(V)109067-8-a,(V)109067-8-b	14205-39-1	3-Amino-2-butenoic acid methyl ester
(VI)109067-8-a	194472-10-1	3-ethyl 5-methyl 4-(2-chlorophenyl)-2-({[5-({[4-(2-chlorophenyl)-3-(ethoxycarbonyl)-5-(methoxycarbonyl)-6-methyl-1,4-dihydropyridin-2-yl]methoxy}methyl)-2,2-dimethyl-1,3-dioxolan-4-yl]methoxy}methyl)-6-methyl-1,4-dihydropyridine-3,5-dicarboxylate
(VII)109067-8-a	194472-12-3	3-ethyl 5-methyl 4-(2-chlorophenyl)-2-[(4-{[4-(2-chlorophenyl)-3-(ethoxycarbonyl)-5-(methoxycarbonyl)-6-methyl-1,4-dihydropyridin-2-yl]methoxy}-2,3-dihydroxybutoxy)methyl]-6-methyl-1,4-dihydropyridine-3,5-dicarboxylate
(VIII)109067-8-a,(VIII)109067-8-b	194472-14-5	3-ethyl 5-methyl 4-(2-chlorophenyl)-6-methyl-2-[(2-oxoethoxy)methyl]-1,4-dihydropyridine-3,5-dicarboxylate
(IX)109067-8-a,(IX)109067-8-b	-	3-ethyl 5-methyl 4-(2-chlorophenyl)-2-{[(2E)-2-(hydroxyimino)ethoxy]methyl}-6-methyl-1,4-dihydropyridine-3,5-dicarboxylate

OptimisedRoute 8Steps 4 · Total yield /

(II)109067-8-a,(II)109067-8-b638-07-3(IV)109067-8-a,(IV)109067-8-b89-98-5(V)109067-8-a,(V)109067-8-b14205-39-1(VIII)109067-8-a,(VIII)109067-8-b194472-14-5(IX)109067-8-a,(IX)109067-8-b—(X)109067-8-b22323-82-6(XI)109067-8-b110464-45-4(XII)109067-8-b—(XIII)109067-8-b194472-30-5API · Olmesartan Medoxomil/Amlodipine orotate

Code	CAS No.	Intermediate
(II)109067-8-a,(II)109067-8-b	638-07-3	4-Chloro-3-oxobutyric acid ethyl ester
(IV)109067-8-a,(IV)109067-8-b	89-98-5	2-Chlorobenzaldehyde
(V)109067-8-a,(V)109067-8-b	14205-39-1	3-Amino-2-butenoic acid methyl ester
(VIII)109067-8-a,(VIII)109067-8-b	194472-14-5	3-ethyl 5-methyl 4-(2-chlorophenyl)-6-methyl-2-[(2-oxoethoxy)methyl]-1,4-dihydropyridine-3,5-dicarboxylate
(IX)109067-8-a,(IX)109067-8-b	-	3-ethyl 5-methyl 4-(2-chlorophenyl)-2-{[(2E)-2-(hydroxyimino)ethoxy]methyl}-6-methyl-1,4-dihydropyridine-3,5-dicarboxylate
(X)109067-8-b	22323-82-6	[(4S)-2,2-Dimethyl-1,3-dioxolan-4-yl]methanol
(XI)109067-8-b	110464-45-4	ethyl 4-[(2,2-dimethyl-1,3-dioxolan-4-yl)methoxy]-3-oxobutanoate
(XII)109067-8-b	-	3-ethyl 5-methyl 4-(2-chlorophenyl)-2-{[(2,2-dimethyl-1,3-dioxolan-4-yl)methoxy]methyl}-6-methyl-1,4-dihydropyridine-3,5-dicarboxylate
(XIII)109067-8-b	194472-30-5	3-ethyl 5-methyl 4-(2-chlorophenyl)-2-[(2,3-dihydroxypropoxy)methyl]-6-methyl-1,4-dihydropyridine-3,5-dicarboxylate

OptimisedRoute 9Steps 5 · Total yield /

(I)109067-9-a23326-27-4(II)109067-9-a100-46-9(III)109067-9-a24405-35-4(IV)109067-9-a—(V)109067-9-a39562-06-6(VI)109067-9-a1309115-67-0(VII)109067-9-a1517-05-1(VIII)109067-9-a—API · Olmesartan Medoxomil/Amlodipine orotate

Code	CAS No.	Intermediate
(I)109067-9-a	23326-27-4	2-Butynoic acid methyl ester
(II)109067-9-a	100-46-9 Available	1-Phenylmethylamine
(III)109067-9-a	24405-35-4	ethyl (2Z)-2-[(2-chlorophenyl)methylidene]-3-oxobutanoate
(IV)109067-9-a	-	3-methyl 5-propyl 1-benzyl-4-(2-chlorophenyl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate
(V)109067-9-a	39562-06-6	3-ethyl 5-methyl 4-(2-chlorophenyl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate
(VI)109067-9-a	1309115-67-0	3-ethyl 5-methyl 2-(bromomethyl)-4-(2-chlorophenyl)-6-methyl-1,4-dihydropyridine-3,5-dicarboxylate
(VII)109067-9-a	1517-05-1	2-azidoethan-1-ol
(VIII)109067-9-a	-	3-methyl 5-propyl 6-[(2-azidoethoxy)methyl]-4-(2-chlorophenyl)-2-methyl-1,4-dihydropyridine-3,5-dicarboxylate

OptimisedRoute 10Steps 2 · Total yield /

(I)158395-3-a2032-35-1(II)158395-3-a—(III)158395-3-a621-63-6API · Olmesartan Medoxomil/Amlodipine orotate

Code	CAS No.	Intermediate
(I)158395-3-a	2032-35-1	2-Bromo-1,1-diethoxyethane
(II)158395-3-a	-	2,2-Diethoxyethyl acetate
(III)158395-3-a	621-63-6	2,2-Diethoxyethanol

OptimisedRoute 11Steps 1 · Total yield /

(I)180072-57-a674-82-8(II)180072-57-a—API · Olmesartan Medoxomil/Amlodipine orotate

Code	CAS No.	Intermediate
(I)180072-57-a	674-82-8 Available	4-Methyleneoxetan-2-one
(II)180072-57-a	-	4-Chloro-3-oxobutanoic acid

Frequently asked questions

What are the approved indications of Olmesartan Medoxomil/Amlodipine orotate?

Approved indications include: Hypertension.

When does the Olmesartan Medoxomil/Amlodipine orotate patent expire?

No public expiry year is available for Olmesartan Medoxomil/Amlodipine orotate yet; this page updates once verified.

How many synthesis routes are recorded for Olmesartan Medoxomil/Amlodipine orotate?

16 synthesis routes are recorded; the shortest is 1 steps with / total yield. Intermediates in each route carry codes and CAS numbers.

Where can I buy Olmesartan Medoxomil/Amlodipine orotate intermediates?

4 intermediate CAS of Olmesartan Medoxomil/Amlodipine orotate are available through the Unibest supply network — see the route tables on this page and request a quote per CAS.

How do I get a quote for Olmesartan Medoxomil/Amlodipine orotate intermediates?

Open the CAS profile of the target intermediate from this page, or submit an RFQ directly — the CAS enters the matching flow automatically and the supply network responds with quotes.

Source: cross-verified data (structured fields only) · 2026-09-29