Avapritinib
Tier C — Watch / tradeAvapritinib · all drugs expiring in 2032 →
Targets：KIT, PDGFR-α
Brand：Ayvakit, Ayvakyt, Taijihua
Indications (approved)：Systemic mastocytosis, Gastrointestinal stromal tumour, Mast cell leukaemia
Regional status
Synthetic routes & intermediates1 routes
Routes are ordered originator first, then optimised / process (non-patent) routes; each lists steps, overall yield and the intermediate table (code / CAS / name) — ready for supplier sourcing and RFQ. Rendered by this site from structured data; no third-party route graphics used.
| Code | CAS No. | Intermediate |
|---|---|---|
| AVAPR-015 | 1703794-88-0Available | 1-(4-fluorophenyl)-1-(2-(4-(6-(1-methyl-1H-pyrazol-4-yl)pyrrolo[2,1-f][1,2,4]triazin-4-yl)piperazin-1-yl)pyrimidin-5-yl)ethan-1-amine |
| AVAPR-016 | 888721-83-3Available | 6-bromopyrrolo[2,1-f][1,2,4]triazin-4(3H)-one |
| AVAPR-017 | 761446-44-0Available | 1-methyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole |
| AVAPR-018 | 1703794-32-4Available | 6-(1-methyl-1H-pyrazol-4-yl)pyrrolo[2,1-f][1,2,4]triazin-4(3H)-one |
| Avapritinib | - | (S)-1-(4-fluorophenyl)-1-(2-(4-(6-(1-methyl-1H-pyrazol-4-yl)pyrrolo[2,1-f][1,2,4]triazin-4-yl)piperazin-1-yl)pyrimidin-5-yl)ethan-1-amine |
| AVAPR-001 | 89793-12-4Available | ethyl 2-chloropyrimidine-5-carboxylate |
| AVAPR-002 | 57260-71-6Available | tert-butyl piperazine-1-carboxylate |
| AVAPR-003 | 253315-69-4Available | ethyl 2-(4-(tert-butoxycarbonyl)piperazin-1-yl)pyrimidine-5-carboxylate |
| AVAPR-004 | 253315-11-6Available | 2-(4-(tert-butoxycarbonyl)piperazin-1-yl)pyrimidine-5-carboxylic acid |
| AVAPR-005 | 1117-97-1Available | N,O-dimethylhydroxylamine |
| AVAPR-006 | 1703794-70-0Available | tert-butyl 4-(5-(methoxy(methyl)carbamoyl)pyrimidin-2-yl)piperazine-1-carboxylate |
| AVAPR-007 | 352-13-6Available | (4-fluorophenyl)magnesium bromide |
| AVAPR-008 | 1703794-73-3Available | tert-butyl 4-(5-(4-fluorobenzoyl)pyrimidin-2-yl)piperazine-1-carboxylate |
| AVAPR-009 | 1703795-52-1Available | (4-fluorophenyl)(2-(piperazin-1-yl)pyrimidin-5-yl)methanone hydrochloride |
| AVAPR-010 | 1703794-33-5Available | 4-chloro-6-(1-methyl-1H-pyrazol-4-yl)pyrrolo[2,1-f][1,2,4]triazine |
| AVAPR-011 | 1703794-85-7Available | (4-fluorophenyl)(2-(4-(6-(1-methyl-1H-pyrazol-4-yl)pyrrolo[2,1-f][1,2,4]triazin-4-yl)piperazin-1-yl)pyrimidin-5-yl)methanone |
| AVAPR-012 | 343338-28-3Available | (S)-2-methylpropane-2-sulfinamide |
| AVAPR-013 | 1703794-86-8Available | (Z)-N-((4-fluorophenyl)(2-(4-(6-(1-methyl-1H-pyrazol-4-yl)pyrrolo[2,1-f][1,2,4]triazin-4-yl)piperazin-1-yl)pyrimidin-5-yl)methylene)-2-methylpropane-2-sulfinamide |
| AVAPR-014 | 1703794-87-9Available | N-(1-(4-fluorophenyl)-1-(2-(4-(6-(1-methyl-1H-pyrazol-4-yl)pyrrolo[2,1-f][1,2,4]triazin-4-yl)piperazin-1-yl)pyrimidin-5-yl)ethyl)-2-methylpropane-2-sulfinamide |
Frequently asked questions
What are the approved indications of Avapritinib?
Approved indications include: Systemic mastocytosis, Gastrointestinal stromal tumour, Mast cell leukaemia.
When does the Avapritinib patent expire?
Based on public sources, the Avapritinib patent expires in 2032.
How many synthesis routes are recorded for Avapritinib?
1 synthesis routes are recorded; the shortest is 12 steps with 32.1 mg total yield. Intermediates in each route carry codes and CAS numbers.
Where can I buy Avapritinib intermediates?
18 intermediate CAS of Avapritinib are available through the Unibest supply network — see the route tables on this page and request a quote per CAS.
How do I get a quote for Avapritinib intermediates?
Open the CAS profile of the target intermediate from this page, or submit an RFQ directly — the CAS enters the matching flow automatically and the supply network responds with quotes.
Source: cross-verified data (structured fields only) · 2026-09-29