Salmeterol xinafoate

Tier C — Watch / trade

GSK

Originator

1994

First approval

Expiry (public)

No sales data

Peak sales

Small molecule

Type

Targets：ADRB2

Brand：Serevent Diskus, Salmetedur, Serevent Diskhaler, Inaspir, Aeromax, Beglan, Serevent

Indications (approved)：Chronic obstructive pulmonary disease, Asthma, Exercise-induced asthma, Bronchospasm

Regional status

Approved

1994-02-04

China

Approved

1998-01-01

Japan

Approved

2004-02-25

Synthetic routes & intermediates5 routes

Originator routes × 1Optimised (non-patent) × 4Process routes × 0

Routes are ordered originator first, then optimised / process (non-patent) routes; each lists steps, overall yield and the intermediate table (code / CAS / name) — ready for supplier sourcing and RFQ. Rendered by this site from structured data; no third-party route graphics used.

OriginatorRoute 3Steps 8 · Total yield 100 g (Salmeterol xinafoate)

SALM-001629-03-8SALM-0023360-41-6SALM-00394749-73-2SALM-015163923-18-0SALM-01627475-14-5SALM-0171351281-52-1SALM-018943969-38-8SALM-01916475-90-4SALM-02027475-09-8API · Salmeterol xinafoate

Code	CAS No.	Intermediate
SALM-001	629-03-8	1,6-dibromohexane
SALM-002	3360-41-6	4-phenylbutan-1-ol
SALM-003	94749-73-2	(4-((6-bromohexyl)oxy)butyl)benzene
SALM-015	163923-18-0	N-benzyl-6-(4-phenylbutoxy)hexan-1-amine hydrochloride
SALM-016	27475-14-5	methyl 2-(benzyloxy)-5-(2-bromoacetyl)benzoate
SALM-017	1351281-52-1	methyl 5-(2-(benzyl(6-(4-phenylbutoxy)hexyl)amino)acetyl)-2-(benzyloxy)benzoate
SALM-018	943969-38-8	2-(benzyl(6-(4-phenylbutoxy)hexyl)amino)-1-(4-(benzyloxy)-3-(hydroxymethyl)phenyl)ethanol
SALM-019	16475-90-4	methyl 5-acetyl-2-hydroxybenzoate
SALM-020	27475-09-8	methyl 5-acetyl-2-(benzyloxy)benzoate

OptimisedRoute 1Steps 8 · Total yield 0.24 g (Salmeterol)

SALM-001629-03-8SALM-0023360-41-6SALM-00394749-73-2SALM-00422483-09-6SALM-005736916-92-0SALM-006262856-97-3SALM-007262856-99-5SALM-00852113-69-6SALM-009262857-00-1SALM-010262857-01-2SALM-0112316-64-5API · Salmeterol xinafoate

Code	CAS No.	Intermediate
SALM-001	629-03-8	1,6-dibromohexane
SALM-002	3360-41-6	4-phenylbutan-1-ol
SALM-003	94749-73-2	(4-((6-bromohexyl)oxy)butyl)benzene
SALM-004	22483-09-6	2,2-dimethoxyethanamine
SALM-005	736916-92-0	N-(2,2-dimethoxyethyl)-6-(4-phenylbutoxy)hexan-1-amine
SALM-006	262856-97-3	benzyl (2,2-dimethoxyethyl)(6-(4-phenylbutoxy)hexyl)carbamate
SALM-007	262856-99-5	benzyl (2-oxoethyl)(6-(4-phenylbutoxy)hexyl)carbamate
SALM-008	52113-69-6	6-bromo-2,2-dimethyl-4H-benzo[d][1,3]dioxine
SALM-009	262857-00-1	benzyl (2-(2,2-dimethyl-4H-benzo[d][1,3]dioxin-6-yl)-2-hydroxyethyl)(6-(4-phenylbutoxy)hexyl)carbamate
SALM-010	262857-01-2	1-(2,2-dimethyl-4H-benzo[d][1,3]dioxin-6-yl)-2-((6-(4-phenylbutoxy)hexyl)amino)ethanol
SALM-011	2316-64-5	4-bromo-2-(hydroxymethyl)phenol

OptimisedRoute 2Steps 2 · Total yield /

SALM-012115787-50-3SALM-01397664-55-6SALM-014163923-19-1API · Salmeterol xinafoate

Code	CAS No.	Intermediate
SALM-012	115787-50-3	5-(2-bromoacetyl)-2-hydroxybenzaldehyde
SALM-013	97664-55-6	N-benzyl-6-(4-phenylbutoxy)hexan-1-amine
SALM-014	163923-19-1	5-(2-(benzyl(6-(4-phenylbutoxy)hexyl)amino)acetyl)-2-hydroxybenzaldehyde

OptimisedRoute 4Steps 5 · Total yield 204 g (Salmeterol xinafoate)

SALM-00394749-73-2SALM-0212084873-61-8SALM-0221690350-72-1SALM-0231995868-17-1SALM-024934842-69-0API · Salmeterol xinafoate

Code	CAS No.	Intermediate
SALM-003	94749-73-2	(4-((6-bromohexyl)oxy)butyl)benzene
SALM-021	2084873-61-8	2-acetoxy-5-(2-(benzylamino)acetyl)benzyl acetate
SALM-022	1690350-72-1	2-acetoxy-5-(2-(benzyl(6-(4-phenylbutoxy)hexyl)amino)acetyl)benzyl acetate
SALM-023	1995868-17-1	2-(benzyl(6-(4-phenylbutoxy)hexyl)amino)-1-(4-hydroxy-3-(hydroxymethyl)phenyl)ethanone
SALM-024	934842-69-0	4-(2-(benzyl(6-(4-phenylbutoxy)hexyl)amino)-1-hydroxyethyl)-2-(hydroxymethyl)phenol

OptimisedRoute 5Steps 11 · Total yield 1.3 g (Salmeterol xinafoate)

SALM-025119-36-8SALM-01916475-90-4SALM-02665033-21-8SALM-02765033-21-8SALM-01397664-55-6SALM-02871-43-2SALM-029108-30-5SALM-0302051-95-8SALM-0311821-12-1SALM-0322046-17-5SALM-0023360-41-6SALM-03313633-25-5SALM-034629-11-8API · Salmeterol xinafoate

Code	CAS No.	Intermediate
SALM-025	119-36-8	-
SALM-019	16475-90-4	methyl 5-acetyl-2-hydroxybenzoate
SALM-026	65033-21-8	-
SALM-027	65033-21-8	-
SALM-013	97664-55-6	N-benzyl-6-(4-phenylbutoxy)hexan-1-amine
SALM-028	71-43-2	-
SALM-029	108-30-5	-
SALM-030	2051-95-8	-
SALM-031	1821-12-1	-
SALM-032	2046-17-5	-
SALM-002	3360-41-6	4-phenylbutan-1-ol
SALM-033	13633-25-5	-
SALM-034	629-11-8	-

Frequently asked questions

What are the approved indications of Salmeterol xinafoate?

Approved indications include: Chronic obstructive pulmonary disease, Asthma, Exercise-induced asthma, Bronchospasm.

When does the Salmeterol xinafoate patent expire?

No public expiry year is available for Salmeterol xinafoate yet; this page updates once verified.

How many synthesis routes are recorded for Salmeterol xinafoate?

5 synthesis routes are recorded; the shortest is 2 steps with / total yield. Intermediates in each route carry codes and CAS numbers.

Where can I buy Salmeterol xinafoate intermediates?

All intermediates in Salmeterol xinafoate routes have CAS profiles — you can submit an RFQ per CAS and it enters the Unibest matching pool.

How do I get a quote for Salmeterol xinafoate intermediates?

Open the CAS profile of the target intermediate from this page, or submit an RFQ directly — the CAS enters the matching flow automatically and the supply network responds with quotes.

Source: cross-verified data (structured fields only) · 2026-09-29