Ibuprofen/Diphenhydramine Hydrochloride
Tier C — Watch / tradeIbuprofen/Diphenhydramine Hydrochloride
Targets：HRH1, COXs
Brand：Advil Pm
Indications (approved)：Insomnia and sleep disorders, Pain
Regional status
Factories producing this API11
Factories registered as producing this API in our sourcing network (RFQ records + product master), sorted by RFQ activity; the snapshot carries no cost or customer data.
11 producing factories on file — sign in to view the named list (factory details are not shown to guests).
Sign in to view factories →Synthetic routes & intermediates4 routes
Routes are ordered originator first, then optimised / process (non-patent) routes; each lists steps, overall yield and the intermediate table (code / CAS / name) — ready for supplier sourcing and RFQ. Rendered by this site from structured data; no third-party route graphics used.
| Code | CAS No. | Intermediate |
|---|---|---|
| IBUP-001 | 36039-36-8 | 2-(4-isobutylphenyl)propan-1-ol |
| Ibuprofen | 15687-27-1 | 2-(4-isobutylphenyl)propanoic acid |
| Code | CAS No. | Intermediate |
|---|---|---|
| IBUP-002 | 38861-78-8 | 1-(4-isobutylphenyl)ethan-1-one |
| IBUP-003 | 34352-86-8 | 1-isobutyl-4-(prop-1-en-2-yl)benzene |
| IBUP-004 | 1424343-26-9 | 2-(4-isobutylphenyl)prop-2-en-1-ol |
| IBUP-005 | 51407-46-6 | 2-(4-isobutylphenyl)propanal |
| Code | CAS No. | Intermediate |
|---|---|---|
| IBUP-006 | 80336-64-7 | 2-bromo-1-(4-isobutylphenyl)propan-1-one |
| IBUP-007 | 126-30-7 | 2,2-dimethylpropane-1,3-diol |
| Code | CAS No. | Intermediate |
|---|---|---|
| IBUP-008 | 538-93-2 | isobutylbenzene |
| IBUP-009 | 40150-92-3 | 1-(4-isobutylphenyl)ethan-1-ol |
| IBUP-010 | 1186634-35-4 | 1-(4-isobutylphenyl)ethyl methanesulfonate |
| IBUP-011 | 58609-73-7 | 2-(4-isobutylphenyl)propanenitrile |
Frequently asked questions
What are the approved indications of Ibuprofen/Diphenhydramine Hydrochloride?
Approved indications include: Insomnia and sleep disorders, Pain.
When does the Ibuprofen/Diphenhydramine Hydrochloride patent expire?
No public expiry year is available for Ibuprofen/Diphenhydramine Hydrochloride yet; this page updates once verified.
How many synthesis routes are recorded for Ibuprofen/Diphenhydramine Hydrochloride?
4 synthesis routes are recorded; the shortest is 1 steps with / total yield. Intermediates in each route carry codes and CAS numbers.
Where can I buy Ibuprofen/Diphenhydramine Hydrochloride intermediates?
All intermediates in Ibuprofen/Diphenhydramine Hydrochloride routes have CAS profiles — you can submit an RFQ per CAS and it enters the Unibest matching pool.
How do I get a quote for Ibuprofen/Diphenhydramine Hydrochloride intermediates?
Open the CAS profile of the target intermediate from this page, or submit an RFQ directly — the CAS enters the matching flow automatically and the supply network responds with quotes.
Source: cross-verified data (structured fields only) · 2026-09-29